Vav1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vav1
Entrez Gene ID	25156
Full Name	vav guanine nucleotide exchange factor 1
Synonyms	Vav
General protein information	Preferred Names vav guanine nucleotide exchange factor 1 Names proto-oncogene vav p95 vav 1 guanine nucleotide exchange factor vav 1 oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	guanine nucleotide exchange factor (GEF) from the Rho family of GTP binding proteins; plays a role in T-cell and B-cell development; can activate the c-Jun N-terminal kinase-1 (JNK1) pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012759.2	NP_036891.2	proto-oncogene vav

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VAV1	XP_512321.3
Xenopus tropicalis (tropical clawed frog)	LOC100497964	XP_002940062.1
Homo sapiens (human)	VAV1	NP_005419.2
Drosophila melanogaster (fruit fly)	vav	NP_728235.1
Mus musculus (house mouse)	Vav1	NP_035821.3
Rattus norvegicus (Norway rat)	Vav1	NP_036891.2
Canis lupus familiaris (dog)	VAV1	XP_005633021.1
Bos taurus (cattle)	VAV1	NP_001071542.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010292	XP_319489.4

Gene Ontology
Bibliography

Related articles in PubMed

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.
Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andr?oletti O, Dejean AS, Lesourne R, Fourni? GJ, Saoudi A
Journal of immunology (Baltimore, Md. : 1950)195(4)1608-16(2015 Aug)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

Radixin regulates cell migration and cell-cell adhesion through Rac1.
Valderrama F, Thevapala S, Ridley AJ
Journal of cell science125(Pt 14)3310-9(2012 Jul)

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Lawson CD, Donald S, Anderson KE, Patton DT, Welch HC
Journal of immunology (Baltimore, Md. : 1950)186(3)1467-76(2011 Feb)

Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
Wang N, Calpe S, Westcott J, Castro W, Ma C, Engel P, Schatzle JD, Terhorst C
Journal of immunology (Baltimore, Md. : 1950)185(10)5683-7(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development.
Title: An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

The following Vav1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vav1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00856	NM_012759.2 Latest version!	Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vav1 ( NM_012759.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036891.2 Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA.

Price & Availability↑

CloneID	ORa00856
Clone ID Related Accession (Same CDS sequence)	NM_012759.2
Accession Version	NM_012759.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2532bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene vav
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC091160.1. On Dec 11, 2007 this sequence version replaced NM_012759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906348 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCTCT GGCGACAGTG CACCCACTGG CTGATCCAGT GTCGGGTGCT GCCTCCCAGC 
CACCGTGTGA CCTGGGAGGG GGCCCAGGTG TGTGAGCTGG CACAGGCACT GCGGGATGGT 
GTCCTCCTGT GTCAACTGCT TAACAACCTG CTCCCCCACG CCATCAATCT GCGGGAAGTT 
AACTTGTGGC CCCAGATGTC CCAGTTCCTT TGTCTTAAGA ACATCCGAAC CTTCCTGTCT 
ACTTGCTGTG AGAAATTCGG CCTCAAGCGC AGCGAACTCT TTGAGGCTTT TGACCTCTTT 
GATGTGCAGG ACTTTGGAAA GGTCATCTAC ACCCTGTCTG CCCTGTCATG GACACCCATT 
GCCCAGAACA AAGGGATCAT GCCCTTCCCA ACAGAGGACA GCGCCCTGGG TGATGAAGAT 
ATTTACAGTG GCCTTTCAGA CCAGATTGAT GACACCGCAG AGGAAGATGA GGACCTTTAT 
GACTGCGTGG AGAATGAGGA GGCAGAGGGG GACGAGATCT ACGAGGACCT AATGCGCTCG 
GAGTCGGTGC CCACACCTCC CAAGATGACA GAGTACGATA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACTGAGGA GAAGTACACA GACACACTGG GCTCCATCCA GCAGCACTTC 
ATGAAGCCCC TCCAGCGATT CCTCAAGCCT CAAGACATGG AGACCATCTT TGTCAACATT 
GAGGAGCTGC TCTCTGTGCA CACCCACTTC TTAAAGGAAC TGAAGGATGC CCTGTCTGGC 
CCGGGAGCAA CGATGCTGTA TCAGGTCTTC ATCAAGTATA AGGAGAGGTT CCTTGTTTAT 
GGCCGTTATT GCAGTCAGGT GGAGTCAGCC AGCAAGCACT TGGATCAAGT GGCCACAGCA 
CGGGAGGATG TGCAGATGAA GCTGGAGGAA TGCTCTCAAA GAGCCAACAA TGGCCGCTTC 
ACCCTGCGGG ATCTGCTGAT GGTGCCTATG CAGCGGGTGC TGAAGTATCA CCTCCTCCTC 
CAGGAGCTAG TGAAACACAC ACAGGATACT ACAGAAAAGG AGAACCTGCG GTTGGCCCTG 
GACGCCATGA GGGACCTGGC GCAGTGTGTG AATGAGGTCA AGAGGGACAA TGAAACCTTA 
CGGCAGATCA CAAACTTTCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCCAACTAT 
GGCCGGCCTA AGATTGACGG TGAGCTCAAG ATTACCTCAG TGGAACGGCG CTCCAAGACA 
GACAGGTATG CCTTCCTGCT GGACAAAGCA CTGCTCATCT GTAAGCGCCG CGGGGACTCT 
TATGACCTCA AGGCCTCAGT GAACCTGCAC AGCTTCCAAG TTCGGGATGA CTCTTCCGGG 
GAGCGGGACA ACAAGAAGTG GAGCCACATG TTCCTTCTGA TTGAGGATCA AGGTGCCCAG 
GGGTATGAGC TGTTCTTCAA GACTCGGGAG CTAAAAAAGA AGTGGATGGA ACAGTTTGAA 
ATGGCCATCT CCAACATCTA CCCAGAAAAT GCTACAGCCA ATGGACATGA TTTTCAGATG 
TTCTCCTTTG AGGAGACCAC TTCCTGCAAG GCCTGCCAGA TGTTACTCAG GGGCACATTC 
TACCAGGGAT ATCGCTGTTA CAGGTGCCGT GCACCCGCAC ACAAGGAGTG TCTGGGAAGG 
GTGCCTCCAT GTGGCCGTCA AGATTTCTCA GGAACCATGA AGAAGGACAA GCTACATCGA 
AGGGCCCAGG ACAAGAAAAG GAATGAATTG GGCCTTCCTA AGATGGAGGT GTGTCAGGAA 
TACTACGGGA TCCCTCCTCC TCCCGGAGCC TTTGGGCCAT TTCTGCGGCT CAACCCTGGG 
GACATTGTGG AACTCACTAA GGCAGAGGCT GAACACAACT GGTGGGAGGG AAGAAATACA 
GCTACGAATG AAGTCGGCTG GTTTCCCTGT AACAGAGTTC GTCCCTACGT CCACGGCCCT 
CCCCAGGACC TGTCTGTGCA CCTCTGGTAT GCGGGCCCCA TGGAGCGAGC AGGCGCCGAG 
GGCATCCTCA CCAACCGCTC TGATGGGACC TACCTGGTGC GGCAAAGGGT GAAAGATACA 
GCGGAATTCG CCATCAGCAT TAAGTATAAT GTGGAGGTCA AGCATATTAA AATCATGACG 
TCAGAGGGGT TGTACCGCAT CACAGAGAAG AAGGCTTTCC GGGGCCTCCC GGAACTGGTA 
GAGTTTTATC AGCAGAATTC CCTAAAAGAT TGCTTCAAGT CGTTGGACAC CACCTTGCAG 
TTTCCTTACA AGGAACCTGA GAGGAGAGCC ATCAACAAGC CGCCGGTTGG AAGCACCAAG 
TATTTTGGCA CTGCCAAAGC CCGCTACGAC TTCTGTGCCC GGGACCGATC GGAACTGTCC 
CTTAAGGAGG GTGACATCAT CAAGATCCTC AACAAGAAGG GACAGCAAGG CTGGTGGCGT 
GGGGAGATCT ATGGCCGGAT TGGCTGGTTT CCCTCTAACT ATGTGGAGGA AGACTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036891.2
CDS	58..2589
Translation	MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_012759.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012759.2

ORF Insert Sequence:

ATGGAGCTCT GGCGACAGTG CACCCACTGG CTGATCCAGT GTCGGGTGCT GCCTCCCAGC 
CACCGTGTGA CCTGGGAGGG GGCCCAGGTG TGTGAGCTGG CACAGGCACT GCGGGATGGT 
GTCCTCCTGT GTCAACTGCT TAACAACCTG CTCCCCCACG CCATCAATCT GCGGGAAGTT 
AACTTGTGGC CCCAGATGTC CCAGTTCCTT TGTCTTAAGA ACATCCGAAC CTTCCTGTCT 
ACTTGCTGTG AGAAATTCGG CCTCAAGCGC AGCGAACTCT TTGAGGCTTT TGACCTCTTT 
GATGTGCAGG ACTTTGGAAA GGTCATCTAC ACCCTGTCTG CCCTGTCATG GACACCCATT 
GCCCAGAACA AAGGGATCAT GCCCTTCCCA ACAGAGGACA GCGCCCTGGG TGATGAAGAT 
ATTTACAGTG GCCTTTCAGA CCAGATTGAT GACACCGCAG AGGAAGATGA GGACCTTTAT 
GACTGCGTGG AGAATGAGGA GGCAGAGGGG GACGAGATCT ACGAGGACCT AATGCGCTCG 
GAGTCGGTGC CCACACCTCC CAAGATGACA GAGTACGATA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACTGAGGA GAAGTACACA GACACACTGG GCTCCATCCA GCAGCACTTC 
ATGAAGCCCC TCCAGCGATT CCTCAAGCCT CAAGACATGG AGACCATCTT TGTCAACATT 
GAGGAGCTGC TCTCTGTGCA CACCCACTTC TTAAAGGAAC TGAAGGATGC CCTGTCTGGC 
CCGGGAGCAA CGATGCTGTA TCAGGTCTTC ATCAAGTATA AGGAGAGGTT CCTTGTTTAT 
GGCCGTTATT GCAGTCAGGT GGAGTCAGCC AGCAAGCACT TGGATCAAGT GGCCACAGCA 
CGGGAGGATG TGCAGATGAA GCTGGAGGAA TGCTCTCAAA GAGCCAACAA TGGCCGCTTC 
ACCCTGCGGG ATCTGCTGAT GGTGCCTATG CAGCGGGTGC TGAAGTATCA CCTCCTCCTC 
CAGGAGCTAG TGAAACACAC ACAGGATACT ACAGAAAAGG AGAACCTGCG GTTGGCCCTG 
GACGCCATGA GGGACCTGGC GCAGTGTGTG AATGAGGTCA AGAGGGACAA TGAAACCTTA 
CGGCAGATCA CAAACTTTCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCCAACTAT 
GGCCGGCCTA AGATTGACGG TGAGCTCAAG ATTACCTCAG TGGAACGGCG CTCCAAGACA 
GACAGGTATG CCTTCCTGCT GGACAAAGCA CTGCTCATCT GTAAGCGCCG CGGGGACTCT 
TATGACCTCA AGGCCTCAGT GAACCTGCAC AGCTTCCAAG TTCGGGATGA CTCTTCCGGG 
GAGCGGGACA ACAAGAAGTG GAGCCACATG TTCCTTCTGA TTGAGGATCA AGGTGCCCAG 
GGGTATGAGC TGTTCTTCAA GACTCGGGAG CTAAAAAAGA AGTGGATGGA ACAGTTTGAA 
ATGGCCATCT CCAACATCTA CCCAGAAAAT GCTACAGCCA ATGGACATGA TTTTCAGATG 
TTCTCCTTTG AGGAGACCAC TTCCTGCAAG GCCTGCCAGA TGTTACTCAG GGGCACATTC 
TACCAGGGAT ATCGCTGTTA CAGGTGCCGT GCACCCGCAC ACAAGGAGTG TCTGGGAAGG 
GTGCCTCCAT GTGGCCGTCA AGATTTCTCA GGAACCATGA AGAAGGACAA GCTACATCGA 
AGGGCCCAGG ACAAGAAAAG GAATGAATTG GGCCTTCCTA AGATGGAGGT GTGTCAGGAA 
TACTACGGGA TCCCTCCTCC TCCCGGAGCC TTTGGGCCAT TTCTGCGGCT CAACCCTGGG 
GACATTGTGG AACTCACTAA GGCAGAGGCT GAACACAACT GGTGGGAGGG AAGAAATACA 
GCTACGAATG AAGTCGGCTG GTTTCCCTGT AACAGAGTTC GTCCCTACGT CCACGGCCCT 
CCCCAGGACC TGTCTGTGCA CCTCTGGTAT GCGGGCCCCA TGGAGCGAGC AGGCGCCGAG 
GGCATCCTCA CCAACCGCTC TGATGGGACC TACCTGGTGC GGCAAAGGGT GAAAGATACA 
GCGGAATTCG CCATCAGCAT TAAGTATAAT GTGGAGGTCA AGCATATTAA AATCATGACG 
TCAGAGGGGT TGTACCGCAT CACAGAGAAG AAGGCTTTCC GGGGCCTCCC GGAACTGGTA 
GAGTTTTATC AGCAGAATTC CCTAAAAGAT TGCTTCAAGT CGTTGGACAC CACCTTGCAG 
TTTCCTTACA AGGAACCTGA GAGGAGAGCC ATCAACAAGC CGCCGGTTGG AAGCACCAAG 
TATTTTGGCA CTGCCAAAGC CCGCTACGAC TTCTGTGCCC GGGACCGATC GGAACTGTCC 
CTTAAGGAGG GTGACATCAT CAAGATCCTC AACAAGAAGG GACAGCAAGG CTGGTGGCGT 
GGGGAGATCT ATGGCCGGAT TGGCTGGTTT CCCTCTAACT ATGTGGAGGA AGACTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.
Journal of immunology (Baltimore, Md. : 1950)195(4)1608-16(2015 Aug)
Pedros C,Gaud G,Bernard I,Kassem S,Chabod M,Lagrange D,Andr?oletti O,Dejean AS,Lesourne R,Fourni? GJ,Saoudi A

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

Radixin regulates cell migration and cell-cell adhesion through Rac1.
Journal of cell science125(Pt 14)3310-9(2012 Jul)
Valderrama F,Thevapala S,Ridley AJ

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Journal of immunology (Baltimore, Md. : 1950)186(3)1467-76(2011 Feb)
Lawson CD,Donald S,Anderson KE,Patton DT,Welch HC

Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
Journal of immunology (Baltimore, Md. : 1950)185(10)5683-7(2010 Nov)
Wang N,Calpe S,Westcott J,Castro W,Ma C,Engel P,Schatzle JD,Terhorst C

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Vav1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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