Egr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Egr3
Entrez Gene ID	25148
Full Name	early growth response 3
General protein information	Preferred Names early growth response 3 Names early growth response protein 3 EGR-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p11
Summary	zinc finger transcription factor; may mediate long-term, neuroplastic responses [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252240.3	XP_006252302.1	early growth response protein 3 isoform X1
NM_017086.1	NP_058782.1	early growth response protein 3

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	egr3	XP_002932749.1
Pan troglodytes (chimpanzee)	EGR3	XP_001157715.1
	EGR3	XP_002805331.1
Mus musculus (house mouse)	Egr3	NP_061251.1
Homo sapiens (human)	EGR3	NP_004421.2
Canis lupus familiaris (dog)	EGR3	XP_543247.3
Bos taurus (cattle)	EGR3	XP_002689819.2
Rattus norvegicus (Norway rat)	Egr3	NP_058782.1
Danio rerio (zebrafish)	egr3	NP_001002647.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures.
L?pez-L?pez D, G?mez-Nieto R, Herrero-Turri?n MJ, Garc?a-Cairasco N, S?nchez-Benito D, Lude?a MD, L?pez DE
Epilepsy & behavior : E&B71(Pt B)226-237(2017 Jun)

Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.
Song T, Nie B, Ma E, Che J, Sun S, Wang Y, Shan B, Liu Y, Luo S, Ma G, Li K
Biochemical and biophysical research communications460(3)678-83(2015 May)

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

Skint-1 identifies a common molecular mechanism for the development of interferon-?-secreting versus interleukin-17-secreting ?? T cells.
Turchinovich G, Hayday AC
Immunity35(1)59-68(2011 Jul)

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.
Liu D, Evans I, Britton G, Zachary I
Oncogene27(21)2989-98(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain. We then investigated the connectivity density of schizophrenia susceptible regions in rat brain using functional magnetic resonance imaging
Title: Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.

Regulates levels of GABA-A receptors in response to brain-derived neurotrophic factor.
Title: Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons.

Egr3 as a major regulator of gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 in developing neurons and in epilepsy
Title: Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.

The following Egr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Egr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02770	NM_017086.1 Latest version!	Rattus norvegicus early growth response 3 (Egr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa36819	XM_006252240.3 Latest version!	Rattus norvegicus early growth response 3 (Egr3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Egr3 ( NM_017086.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058782.1 Rattus norvegicus early growth response 3 (Egr3), mRNA.

Price & Availability↑

CloneID	ORa02770
Clone ID Related Accession (Same CDS sequence)	NM_017086.1
Accession Version	NM_017086.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	early growth response protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U12428.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U12428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGACCGGCA AACTCGCCGA GAAGCTGCCG GTGACCATGA GCAGTTTGCT AAATCAATTG 
CCTGACAATC TGTACCCCGA GGAGATCCCC AGCGCGCTCA ACCTCTTCTC CGGCAGCAGT 
GACTCGGTAG CCCATTACAC TCAGATGGCT ACAGAGAATG TGATGGACAT CGGTCTGACC 
AACGAGAAGC CCAATCCGGA ACTCTCTTAT TCGGGCTCTT TCCAGCCAGC CCCAGGCAAC 
AAGACCGTGA CCTACTTGGG AAAGTTCGCT TTCGACTCTC CTTCCAACTG GTGCCAGGAC 
AACATCATTA GCCTCATGAG TGCCGGCATC TTGGGGGTGC CCCCGGCCTC AGGGGCGCTC 
AGTACGCAGA CGACCACGGC TAGCATGGTG CAGCCTCCTC AGGGAGACGT GGAGGCCATG 
TATCCGGCGC TGCCCCCCTA TTCCAACTGC GGCGACCTCT ACTCGGAGCC GGTGTCTTTC 
CACGACCCCC AGGGGAACCC AGGGCTCGCC TATTCCCCCC AGGATTACCA ATCGGCCAAG 
CCGGCCTTGG ACAGCAATCT TTTCCCCATG ATTCCTGACT ACAACCTGTA TCACCACCCC 
AACGACATGG GCTCCATTCC AGAACACAAG CCCTTCCAGG GCATGGACCC CATTCGGGTC 
AACCCACCCC CTATTACCCC TCTGGAGACC ATCAAGGCCT TCAAAGACAA GCAGATCCAC 
CCGGGCTTCG GCAGCTTGCC CCAACCGCCG CTTACTCTCA AGCCCATCCG GCCCCGCAAG 
TACCCCAATC GGCCTAGCAA GACCCCACTC CACGAGCGGC CCCACGCGTG TCCCGCGGAA 
GGCTGTGACC GGCGTTTCAG CCGCTCGGAC GAGCTGACCC GGCACCTGCG CATCCACACG 
GGCCACAAGC CCTTCCAGTG TCGGATCTGC ATGCGCAGCT TCAGCCGCAG CGACCACCTC 
ACTACTCACA TCCGCACGCA CACCGGGGAG AAGCCCTTTG CCTGTGAGTT CTGTGGGCGC 
AAGTTTGCGC GCAGCGACGA GCGCAAGCGC CACGCCAAGA TCCACCTCAA GCAAAAGGAG 
AAGAAGTCGG AGAAAGGGGG TGCGCCCTCT GCATCCTCGG CGCCCACCGT GTCCCTGGCC 
CCTGTGGTCA CCACCTGCGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058782.1
CDS	1..1164
Translation	MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYTQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTTTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAPTVSLAPVVTTCA

Target ORF information:

RefSeq Version	NM_017086.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus early growth response 3 (Egr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017086.1

ORF Insert Sequence:

ATGACCGGCA AACTCGCCGA GAAGCTGCCG GTGACCATGA GCAGTTTGCT AAATCAATTG 
CCTGACAATC TGTACCCCGA GGAGATCCCC AGCGCGCTCA ACCTCTTCTC CGGCAGCAGT 
GACTCGGTAG CCCATTACAC TCAGATGGCT ACAGAGAATG TGATGGACAT CGGTCTGACC 
AACGAGAAGC CCAATCCGGA ACTCTCTTAT TCGGGCTCTT TCCAGCCAGC CCCAGGCAAC 
AAGACCGTGA CCTACTTGGG AAAGTTCGCT TTCGACTCTC CTTCCAACTG GTGCCAGGAC 
AACATCATTA GCCTCATGAG TGCCGGCATC TTGGGGGTGC CCCCGGCCTC AGGGGCGCTC 
AGTACGCAGA CGACCACGGC TAGCATGGTG CAGCCTCCTC AGGGAGACGT GGAGGCCATG 
TATCCGGCGC TGCCCCCCTA TTCCAACTGC GGCGACCTCT ACTCGGAGCC GGTGTCTTTC 
CACGACCCCC AGGGGAACCC AGGGCTCGCC TATTCCCCCC AGGATTACCA ATCGGCCAAG 
CCGGCCTTGG ACAGCAATCT TTTCCCCATG ATTCCTGACT ACAACCTGTA TCACCACCCC 
AACGACATGG GCTCCATTCC AGAACACAAG CCCTTCCAGG GCATGGACCC CATTCGGGTC 
AACCCACCCC CTATTACCCC TCTGGAGACC ATCAAGGCCT TCAAAGACAA GCAGATCCAC 
CCGGGCTTCG GCAGCTTGCC CCAACCGCCG CTTACTCTCA AGCCCATCCG GCCCCGCAAG 
TACCCCAATC GGCCTAGCAA GACCCCACTC CACGAGCGGC CCCACGCGTG TCCCGCGGAA 
GGCTGTGACC GGCGTTTCAG CCGCTCGGAC GAGCTGACCC GGCACCTGCG CATCCACACG 
GGCCACAAGC CCTTCCAGTG TCGGATCTGC ATGCGCAGCT TCAGCCGCAG CGACCACCTC 
ACTACTCACA TCCGCACGCA CACCGGGGAG AAGCCCTTTG CCTGTGAGTT CTGTGGGCGC 
AAGTTTGCGC GCAGCGACGA GCGCAAGCGC CACGCCAAGA TCCACCTCAA GCAAAAGGAG 
AAGAAGTCGG AGAAAGGGGG TGCGCCCTCT GCATCCTCGG CGCCCACCGT GTCCCTGGCC 
CCTGTGGTCA CCACCTGCGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Egr3 ( XM_006252240.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252302.1 Rattus norvegicus early growth response 3 (Egr3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36819
Clone ID Related Accession (Same CDS sequence)	XM_006252240.3
Accession Version	XM_006252240.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	early growth response protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252240.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GTGCGGCGTG GAGTCCCCAC GGTGGGAGAG AGAATGTGAT GGACATCGGT 
CTGACCAACG AGAAGCCCAA TCCGGAACTC TCTTATTCGG GCTCTTTCCA GCCAGCCCCA 
GGCAACAAGA CCGTGACCTA CTTGGGAAAG TTCGCTTTCG ACTCTCCTTC CAACTGGTGC 
CAGGACAACA TCATTAGCCT CATGAGTGCC GGCATCTTGG GGGTGCCCCC GGCCTCAGGG 
GCGCTCAGTA CGCAGACGAC CACGGCTAGC ATGGTGCAGC CTCCTCAGGG AGACGTGGAG 
GCCATGTATC CGGCGCTGCC CCCCTATTCC AACTGCGGCG ACCTCTACTC GGAGCCGGTG 
TCTTTCCACG ACCCCCAGGG GAACCCAGGG CTCGCCTATT CCCCCCAGGA TTACCAATCG 
GCCAAGCCGG CCTTGGACAG CAATCTTTTC CCCATGATTC CTGACTACAA CCTGTATCAC 
CACCCCAACG ACATGGGCTC CATTCCAGAA CACAAGCCCT TCCAGGGCAT GGACCCCATT 
CGGGTCAACC CACCCCCTAT TACCCCTCTG GAGACCATCA AGGCCTTCAA AGACAAGCAG 
ATCCACCCGG GCTTCGGCAG CTTGCCCCAA CCGCCGCTTA CTCTCAAGCC CATCCGGCCC 
CGCAAGTACC CCAATCGGCC TAGCAAGACC CCACTCCACG AGCGGCCCCA CGCGTGTCCC 
GCGGAAGGCT GTGACCGGCG TTTCAGCCGC TCGGACGAGC TGACCCGGCA CCTGCGCATC 
CACACGGGCC ACAAGCCCTT CCAGTGTCGG ATCTGCATGC GCAGCTTCAG CCGCAGCGAC 
CACCTCACTA CTCACATCCG CACGCACACC GGGGAGAAGC CCTTTGCCTG TGAGTTCTGT 
GGGCGCAAGT TTGCGCGCAG CGACGAGCGC AAGCGCCACG CCAAGATCCA CCTCAAGCAA 
AAGGAGAAGA AGTCGGAGAA AGGGGGTGCG CCCTCTGCAT CCTCGGCGCC CACCGTGTCC 
CTGGCCCCTG TGGTCACCAC CTGCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252302.1
CDS	463..1512
Translation	MEPCAAWSPHGGRENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTTTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAPTVSLAPVVTTCA

Target ORF information:

RefSeq Version	XM_006252240.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus early growth response 3 (Egr3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252240.3

ORF Insert Sequence:

ATGGAGCCAT GTGCGGCGTG GAGTCCCCAC GGTGGGAGAG AGAATGTGAT GGACATCGGT 
CTGACCAACG AGAAGCCCAA TCCGGAACTC TCTTATTCGG GCTCTTTCCA GCCAGCCCCA 
GGCAACAAGA CCGTGACCTA CTTGGGAAAG TTCGCTTTCG ACTCTCCTTC CAACTGGTGC 
CAGGACAACA TCATTAGCCT CATGAGTGCC GGCATCTTGG GGGTGCCCCC GGCCTCAGGG 
GCGCTCAGTA CGCAGACGAC CACGGCTAGC ATGGTGCAGC CTCCTCAGGG AGACGTGGAG 
GCCATGTATC CGGCGCTGCC CCCCTATTCC AACTGCGGCG ACCTCTACTC GGAGCCGGTG 
TCTTTCCACG ACCCCCAGGG GAACCCAGGG CTCGCCTATT CCCCCCAGGA TTACCAATCG 
GCCAAGCCGG CCTTGGACAG CAATCTTTTC CCCATGATTC CTGACTACAA CCTGTATCAC 
CACCCCAACG ACATGGGCTC CATTCCAGAA CACAAGCCCT TCCAGGGCAT GGACCCCATT 
CGGGTCAACC CACCCCCTAT TACCCCTCTG GAGACCATCA AGGCCTTCAA AGACAAGCAG 
ATCCACCCGG GCTTCGGCAG CTTGCCCCAA CCGCCGCTTA CTCTCAAGCC CATCCGGCCC 
CGCAAGTACC CCAATCGGCC TAGCAAGACC CCACTCCACG AGCGGCCCCA CGCGTGTCCC 
GCGGAAGGCT GTGACCGGCG TTTCAGCCGC TCGGACGAGC TGACCCGGCA CCTGCGCATC 
CACACGGGCC ACAAGCCCTT CCAGTGTCGG ATCTGCATGC GCAGCTTCAG CCGCAGCGAC 
CACCTCACTA CTCACATCCG CACGCACACC GGGGAGAAGC CCTTTGCCTG TGAGTTCTGT 
GGGCGCAAGT TTGCGCGCAG CGACGAGCGC AAGCGCCACG CCAAGATCCA CCTCAAGCAA 
AAGGAGAAGA AGTCGGAGAA AGGGGGTGCG CCCTCTGCAT CCTCGGCGCC CACCGTGTCC 
CTGGCCCCTG TGGTCACCAC CTGCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures.
Epilepsy & behavior : E&B71(Pt B)226-237(2017 Jun)
L?pez-L?pez D,G?mez-Nieto R,Herrero-Turri?n MJ,Garc?a-Cairasco N,S?nchez-Benito D,Lude?a MD,L?pez DE

Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.
Biochemical and biophysical research communications460(3)678-83(2015 May)
Song T,Nie B,Ma E,Che J,Sun S,Wang Y,Shan B,Liu Y,Luo S,Ma G,Li K

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

Skint-1 identifies a common molecular mechanism for the development of interferon-?-secreting versus interleukin-17-secreting ?? T cells.
Immunity35(1)59-68(2011 Jul)
Turchinovich G,Hayday AC

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.
Oncogene27(21)2989-98(2008 May)
Liu D,Evans I,Britton G,Zachary I

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Egr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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