Tagln cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tagln
Entrez Gene ID	25123
Full Name	transgelin
Synonyms	Sm22
General protein information	Preferred Names transgelin Names transgelin SM22-alpha smooth muscle 22 protein smooth muscle protein 22-alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q22
Summary	acts as an actin cross-linking protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031549.2	NP_113737.1	transgelin

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tagln2	NP_963870.1
Canis lupus familiaris (dog)	TAGLN	XP_536561.2
Mus musculus (house mouse)	Tagln	NP_035656.1
Bos taurus (cattle)	TAGLN	NP_001039614.1
Rattus norvegicus (Norway rat)	Tagln	NP_113737.1
Homo sapiens (human)	TAGLN	NP_003177.2
Pan troglodytes (chimpanzee)	TAGLN	XP_003313366.1
Gallus gallus (chicken)	TAGLN	NP_990825.1
Danio rerio (zebrafish)	tagln	NP_001038932.1
Xenopus tropicalis (tropical clawed frog)	tagln	NP_001025579.1

Gene Ontology
Bibliography

Related articles in PubMed

CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Shu YN, Dong LH, Li H, Pei QQ, Miao SB, Zhang F, Zhang DD, Chen R, Yin YJ, Lin YL, Xue ZY, Lv P, Xie XL, Zhao LL, Nie X, Chen P, Han M
Cardiovascular research113(10)1198-1207(2017 Aug)

SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.
Schellekens DHSM, Reisinger KW, Lenaerts K, Hadfoune M, Olde Damink SW, Buurman WA, Dejong CHC, Derikx JPM
Annals of surgery(2017 May)

Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation.
Fujii Y, Funakoshi T, Unuma K, Noritake K, Aki T, Uemura K
The Journal of toxicological sciences41(5)645-54(2016)

TRAF6-Mediated SM22? K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo.
Dong LH, Li L, Song Y, Duan ZL, Sun SG, Lin YL, Miao SB, Yin YJ, Shu YN, Li H, Chen P, Zhao LL, Han M
Circulation research117(8)684-94(2015 Sep)

SM22? inhibits vascular inflammation via stabilization of I?B? in vascular smooth muscle cells.
Shu YN, Zhang F, Bi W, Dong LH, Zhang DD, Chen R, Lv P, Xie XL, Lin YL, Xue ZY, Li H, Miao SB, Zhao LL, Wang H, Han M
Journal of molecular and cellular cardiology84191-9(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enhancements in smooth muscle cell properties such as transgelin expression and actomyosin-mediated contractility/motility might be involved in cell survival after NaHS exposure.
Title: Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation.

TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Title: TRAF6-Mediated SM22? K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo.

SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
Title: SM22? inhibits vascular inflammation via stabilization of I?B? in vascular smooth muscle cells.

Speculate that SM22 plays an important role in the regulation of intestinal smooth muscle basal tone via Rho kinase-induced phosphorylation of SM22.
Title: Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.

Sm22 is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.

The following Tagln gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tagln cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08066	NM_031549.2 Latest version!	Rattus norvegicus transgelin (Tagln), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tagln ( NM_031549.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113737.1 Rattus norvegicus transgelin (Tagln), mRNA.

Price & Availability↑

CloneID	ORa08066
Clone ID Related Accession (Same CDS sequence)	NM_031549.2
Accession Version	NM_031549.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Rattus norvegicus(Norway rat)
Product	transgelin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061770.1. On Mar 2, 2007 this sequence version replaced NM_031549.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061770.1, FQ220668.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCAACA AGGGTCCATC CTATGGCATG AGCCGTGAAG TGCAGTCCAA GATTGAGAAG 
AAGTATGATG AGGAGCTGGA GGAGCGGCTA GTGGAGTGGA TTGTAATGCA GTGTGGCCCT 
GATGTGGGCC GTCCAGATCG TGGGCGCCTG GGCTTCCAGG TGTGGCTGAA GAATGGCGTG 
ATTCTGAGCA AGTTGGTGAA CAGCCTGTAC CCCGAGGGAT CCAAGCCAGT GAAGGTGCCT 
GAGAACCCGC CCTCCATGGT CTTCAAGCAG ATGGAACAGG TGGCTCAATT CTTGAAGGCA 
GCTGAGGATT ATGGAGTCAC GAAGACTGAC ATGTTCCAGA CTGTTGACCT CTTTGAAGGA 
AAAGATATGG CAGCAGTGCA GAGGACTGTA ATGGCTTTGG GCAGTTTGGC CGTGACCAAG 
AACGATGGAC ACTACCGTGG AGATCCCAAC TGGTTTATGA AGAAAGCCCA GGAGCATAAG 
AGGGAGTTCA CAGACAGTCA ACTGCAGGAG GGGAAGCACG TCATTGGCCT TCAAATGGGC 
AGCAACAGAG GGGCCTCACA GGCTGGCATG ACAGGCTATG GGCGACCCCG GCAGATCATC 
AGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113737.1
CDS	53..658
Translation	MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIVMQCGPDVGRPDRGRLGFQVWLKNGVILSKLVNSLYPEGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVTKTDMFQTVDLFEGKDMAAVQRTVMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTDSQLQEGKHVIGLQMGSNRGASQAGMTGYGRPRQIIS

Target ORF information:

RefSeq Version	NM_031549.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transgelin (Tagln), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031549.2

ORF Insert Sequence:

ATGGCCAACA AGGGTCCATC CTATGGCATG AGCCGTGAAG TGCAGTCCAA GATTGAGAAG 
AAGTATGATG AGGAGCTGGA GGAGCGGCTA GTGGAGTGGA TTGTAATGCA GTGTGGCCCT 
GATGTGGGCC GTCCAGATCG TGGGCGCCTG GGCTTCCAGG TGTGGCTGAA GAATGGCGTG 
ATTCTGAGCA AGTTGGTGAA CAGCCTGTAC CCCGAGGGAT CCAAGCCAGT GAAGGTGCCT 
GAGAACCCGC CCTCCATGGT CTTCAAGCAG ATGGAACAGG TGGCTCAATT CTTGAAGGCA 
GCTGAGGATT ATGGAGTCAC GAAGACTGAC ATGTTCCAGA CTGTTGACCT CTTTGAAGGA 
AAAGATATGG CAGCAGTGCA GAGGACTGTA ATGGCTTTGG GCAGTTTGGC CGTGACCAAG 
AACGATGGAC ACTACCGTGG AGATCCCAAC TGGTTTATGA AGAAAGCCCA GGAGCATAAG 
AGGGAGTTCA CAGACAGTCA ACTGCAGGAG GGGAAGCACG TCATTGGCCT TCAAATGGGC 
AGCAACAGAG GGGCCTCACA GGCTGGCATG ACAGGCTATG GGCGACCCCG GCAGATCATC 
AGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Cardiovascular research113(10)1198-1207(2017 Aug)
Shu YN,Dong LH,Li H,Pei QQ,Miao SB,Zhang F,Zhang DD,Chen R,Yin YJ,Lin YL,Xue ZY,Lv P,Xie XL,Zhao LL,Nie X,Chen P,Han M

SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.
Annals of surgery(2017 May)
Schellekens DHSM,Reisinger KW,Lenaerts K,Hadfoune M,Olde Damink SW,Buurman WA,Dejong CHC,Derikx JPM

Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation.
The Journal of toxicological sciences41(5)645-54(2016)
Fujii Y,Funakoshi T,Unuma K,Noritake K,Aki T,Uemura K

TRAF6-Mediated SM22? K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo.
Circulation research117(8)684-94(2015 Sep)
Dong LH,Li L,Song Y,Duan ZL,Sun SG,Lin YL,Miao SB,Yin YJ,Shu YN,Li H,Chen P,Zhao LL,Han M

SM22? inhibits vascular inflammation via stabilization of I?B? in vascular smooth muscle cells.
Journal of molecular and cellular cardiology84191-9(2015 Jul)
Shu YN,Zhang F,Bi W,Dong LH,Zhang DD,Chen R,Lv P,Xie XL,Lin YL,Xue ZY,Li H,Miao SB,Zhao LL,Wang H,Han M

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Tagln cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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