Htr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Htr1b
Entrez Gene ID	25075
Full Name	5-hydroxytryptamine receptor 1B
General protein information	Preferred Names 5-hydroxytryptamine receptor 1B Names 5-hydroxytryptamine receptor 1B 5-HT-1B 5-HT1B serotonin receptor 5-hydroxytryptamine (serotonin ) receptor 1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled serotonin (5-hydroxytryptamine (5HT)) receptor type 1B serotonin receptor 1B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31
Summary	G-protein coupled receptor for serotonin; may have a role in learning and memory [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022225.1	NP_071561.1	5-hydroxytryptamine receptor 1B

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HTR1B	NP_001166252.1
Caenorhabditis elegans (roundworm)	tyra-2	NP_001024521.1
Pan troglodytes (chimpanzee)	HTR1B	NP_001009102.1
	HTR1B	XP_001113679.1
Mus musculus (house mouse)	Htr1b	NP_034612.1
Xenopus tropicalis (tropical clawed frog)	LOC100495915	XP_002936251.2
Canis lupus familiaris (dog)	HTR1B	NP_001006949.1
Bos taurus (cattle)	HTR1B	XP_005210738.1
Danio rerio (zebrafish)	htr1b	NP_001122181.1
Homo sapiens (human)	HTR1B	NP_000854.1
Rattus norvegicus (Norway rat)	Htr1b	NP_071561.1

Gene Ontology
Bibliography

Related articles in PubMed

The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes.
Alter D, Beverley JA, Patel R, Bola?os-Guzm?n CA, Steiner H
Journal of psychopharmacology (Oxford, England)31(8)1078-1087(2017 Aug)

[THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Derkach KV, Moyseuk IV, Shpakova EA, Sphakov AO
Zhurnal evoliutsionnoi biokhimii i fiziologii51(4)243-50(2015 Jul-Aug)

A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.
Wallace E, Morrell NW, Yang XD, Long L, Stevens H, Nilsen M, Loughlin L, Mair KM, Baker AH, MacLean MR
American journal of respiratory and critical care medicine191(12)1432-42(2015 Jun)

The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.
Vinuela-Fernandez I, Sun L, Jerina H, Curtis J, Allchorne A, Gooding H, Rosie R, Holland P, Tas B, Mitchell R, Fleetwood-Walker S
Neuropharmacology79136-51(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH
Title: [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].

Results show that TRPM8 and the 5-HT1BR interact directly in a novel signalling complex that incorporates PLD1, which mediates the facilitatory influence by means of its product phosphatidic acid acting on PIP 5-kinase to increase production of PIP2
Title: The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.

Adaptive changes on 5-HT1B receptors induced by chronic venlafaxine administration exhibit regional brain differences, with the hypothalamus the site of drug action.
Title: Region-specific regulation of 5-HT1B receptors in the rat brain by chronic venlafaxine treatment.

5-HTB/D receptors have a role in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia. produced by antimigraine drugs in rats
Title: Role of 5-HT?B/?D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.

Single artery occlusion without significant visible infarct resulted in locally increased ETB, angiotensin type 1 and 5-hydroxytryptamine 1B receptor-mediated contractile responses only in segments located downstream of the occlusion site.
Title: Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT?B and AT? receptor-mediated contractility downstream of occlusion.

The following Htr1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htr1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12529	NM_022225.1 Latest version!	Rattus norvegicus 5-hydroxytryptamine receptor 1B (Htr1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Htr1b ( NM_022225.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071561.1 Rattus norvegicus 5-hydroxytryptamine receptor 1B (Htr1b), mRNA.

Price & Availability↑

CloneID	ORa12529
Clone ID Related Accession (Same CDS sequence)	NM_022225.1
Accession Version	NM_022225.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	5-hydroxytryptamine receptor 1B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M89954.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGAGGAGC AGGGTATTCA GTGCGCTCCG CCGCCTCCCG CCACCTCCCA GACAGGGGTA 
CCTCTCGCCA ACCTCTCCCA CAACTGCAGC GCCGACGACT ACATTTACCA GGACTCCATC 
GCCCTGCCCT GGAAAGTCCT GCTGGTTGCT TTGTTAGCGC TCATCACCTT GGCCACCACG 
CTCTCCAACG CCTTTGTAAT CGCTACGGTG TATCGGACCC GGAAGCTGCA CACCCCGGCT 
AACTACCTGA TCGCCTCGCT GGCAGTCACT GACCTGCTCG TGTCCATCCT GGTGATGCCC 
ATCAGCACCA TGTACACGGT CACTGGACGC TGGACACTAG GCCAGGTGGT CTGCGACTTC 
TGGCTGTCGT CGGATATCAC CTGTTGCACT GCTTCCATCA TGCATCTCTG TGTCATCGCC 
CTGGACCGCT ACTGGGCCAT CACTGATGCG GTGGACTATT CTGCTAAAAG AACTCCCAAA 
AGGGCGGCCA TCATGATCGT GCTGGTGTGG GTCTTCTCCA TCTCGATTTC GCTGCCACCC 
TTCTTCTGGC GTCAAGCCAA AGCGGAGGAG GAGGTGCTGG ACTGCTTTGT GAACACCGAC 
CACGTCCTCT ACACGGTCTA CTCCACGGTG GGGGCTTTCT ATTTACCCAC CCTGCTCCTC 
ATCGCCCTCT ATGGCCGTAT CTATGTGGAA GCCCGCTCTC GGATTTTGAA ACAGACACCC 
AACAAGACCG GCAAGCGCTT GACCCGAGCC CAGTTGATAA CAGACTCTCC AGGATCCACG 
TCCTCGGTCA CCTCCATTAA CTCCCGGGTT CCGGAGGTGC CCAGTGAGTC CGGGTCTCCT 
GTGTACGTGA ACCAAGTCAA AGTGCGAGTC TCAGACGCCC TGCTGGAAAA GAAGAAACTC 
ATGGCCGCTA GGGAGCGCAA AGCCACCAAG ACCCTAGGGA TCATTTTAGG AGCATTTATT 
GTGTGCTGGC TCCCCTTCTT CATCATCTCC CTGGTGATGC CTATCTGCAA GGATGCCTGC 
TGGTTTCACA TGGCCATTTT TGACTTTTTC AATTGGCTAG GCTATCTTAA CTCTCTCATC 
AACCCCATCA TCTACACCAT GTCCAATGAG GACTTCAAAC AAGCATTCCA TAAACTGATA 
CGCTTTAAGT GCACAGGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071561.1
CDS	1..1161
Translation	MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG

Target ORF information:

RefSeq Version	NM_022225.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 5-hydroxytryptamine receptor 1B (Htr1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022225.1

ORF Insert Sequence:

ATGGAGGAGC AGGGTATTCA GTGCGCTCCG CCGCCTCCCG CCACCTCCCA GACAGGGGTA 
CCTCTCGCCA ACCTCTCCCA CAACTGCAGC GCCGACGACT ACATTTACCA GGACTCCATC 
GCCCTGCCCT GGAAAGTCCT GCTGGTTGCT TTGTTAGCGC TCATCACCTT GGCCACCACG 
CTCTCCAACG CCTTTGTAAT CGCTACGGTG TATCGGACCC GGAAGCTGCA CACCCCGGCT 
AACTACCTGA TCGCCTCGCT GGCAGTCACT GACCTGCTCG TGTCCATCCT GGTGATGCCC 
ATCAGCACCA TGTACACGGT CACTGGACGC TGGACACTAG GCCAGGTGGT CTGCGACTTC 
TGGCTGTCGT CGGATATCAC CTGTTGCACT GCTTCCATCA TGCATCTCTG TGTCATCGCC 
CTGGACCGCT ACTGGGCCAT CACTGATGCG GTGGACTATT CTGCTAAAAG AACTCCCAAA 
AGGGCGGCCA TCATGATCGT GCTGGTGTGG GTCTTCTCCA TCTCGATTTC GCTGCCACCC 
TTCTTCTGGC GTCAAGCCAA AGCGGAGGAG GAGGTGCTGG ACTGCTTTGT GAACACCGAC 
CACGTCCTCT ACACGGTCTA CTCCACGGTG GGGGCTTTCT ATTTACCCAC CCTGCTCCTC 
ATCGCCCTCT ATGGCCGTAT CTATGTGGAA GCCCGCTCTC GGATTTTGAA ACAGACACCC 
AACAAGACCG GCAAGCGCTT GACCCGAGCC CAGTTGATAA CAGACTCTCC AGGATCCACG 
TCCTCGGTCA CCTCCATTAA CTCCCGGGTT CCGGAGGTGC CCAGTGAGTC CGGGTCTCCT 
GTGTACGTGA ACCAAGTCAA AGTGCGAGTC TCAGACGCCC TGCTGGAAAA GAAGAAACTC 
ATGGCCGCTA GGGAGCGCAA AGCCACCAAG ACCCTAGGGA TCATTTTAGG AGCATTTATT 
GTGTGCTGGC TCCCCTTCTT CATCATCTCC CTGGTGATGC CTATCTGCAA GGATGCCTGC 
TGGTTTCACA TGGCCATTTT TGACTTTTTC AATTGGCTAG GCTATCTTAA CTCTCTCATC 
AACCCCATCA TCTACACCAT GTCCAATGAG GACTTCAAAC AAGCATTCCA TAAACTGATA 
CGCTTTAAGT GCACAGGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes.
Journal of psychopharmacology (Oxford, England)31(8)1078-1087(2017 Aug)
Alter D,Beverley JA,Patel R,Bola?os-Guzm?n CA,Steiner H

[THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Zhurnal evoliutsionnoi biokhimii i fiziologii51(4)243-50(2015 Jul-Aug)
Derkach KV,Moyseuk IV,Shpakova EA,Sphakov AO

A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.
American journal of respiratory and critical care medicine191(12)1432-42(2015 Jun)
Wallace E,Morrell NW,Yang XD,Long L,Stevens H,Nilsen M,Loughlin L,Mair KM,Baker AH,MacLean MR

The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.
Neuropharmacology79136-51(2014 Apr)
Vinuela-Fernandez I,Sun L,Jerina H,Curtis J,Allchorne A,Gooding H,Rosie R,Holland P,Tas B,Mitchell R,Fleetwood-Walker S

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Htr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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