Dbi cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dbi
Entrez Gene ID	25045
Full Name	diazepam binding inhibitor, acyl-CoA binding protein
Synonyms	Acbp,Acoabp3,Ep,Odn,RNACOABP3,Ttn
General protein information	Preferred Names diazepam binding inhibitor, acyl-CoA binding protein Names acyl-CoA-binding protein Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein) GABA receptor modulator LRRGT00046 diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) diazepam binding inhibitor-like diazepam-binding inhibitor endozepine octadecaneuropeptide triakontatetraneuropeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q11
Summary	plays a role in the regulation of mitochondrial steroidogenesis and acyl-CoA metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031853.4	NP_114054.1	acyl-CoA-binding protein

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DBI	NP_989907.1
Saccharomyces cerevisiae (baker's yeast)	ACB1	NP_011551.3
Schizosaccharomyces pombe (fission yeast)	SPBC1539.06	NP_596820.1
Caenorhabditis elegans (roundworm)	acbp-1	NP_491412.1
Kluyveromyces lactis	KLLA0B05643g	XP_451787.2
Eremothecium gossypii	AGOS_ACL188W	NP_983216.1
Mus musculus (house mouse)	Dbi	NP_031856.1
Rattus norvegicus (Norway rat)	Dbi	NP_114054.1
Drosophila melanogaster (fruit fly)	Dbi	NP_523952.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007460	XP_001687920.1
Homo sapiens (human)	DBI	NP_001073331.1
	DBI	XP_002799453.1
Danio rerio (zebrafish)	dbi	NP_955902.1
Pan troglodytes (chimpanzee)	DBI	XP_515759.2
Bos taurus (cattle)	DBI	NP_001106792.1

Gene Ontology
Bibliography

Related articles in PubMed

Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.
Ghouili I, Bahdoudi S, Morin F, Amri F, Hamdi Y, Coly PM, Walet-Balieu ML, Leprince J, Zekri S, Vaudry H, Vaudry D, Castel H, Amri M, Tonon MC, Masmoudi-Kouki O
Molecular neurobiology(2017 Jul)

Gliotransmission and brain glucose sensing: critical role of endozepines.
Lanfray D, Arthaud S, Ouellet J, Comp?re V, Do Rego JL, Leprince J, Lefranc B, Castel H, Bouchard C, Monge-Roffarello B, Richard D, Pelletier G, Vaudry H, Tonon MC, Morin F
Diabetes62(3)801-10(2013 Mar)

Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain.
Ludewig AH, Nitz I, Klapper M, D?ring F
IUBMB life63(7)547-52(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Expression, purification and functional characterization of recombinant human acyl-CoA-binding protein (ACBP) from erythroid cells.
Augoff K, Kolondra A, Chorzalska A, Lach A, Grabowski K, Sikorski AF
Acta biochimica Polonica57(4)533-40(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that neuroglia play important role in glucose sensing in hypothalamus and may regulate energy balance/appetite control through production/secretion of endozepines (diazepam binding inhibitor and processing product, octadecaneuropeptide).
Title: Gliotransmission and brain glucose sensing: critical role of endozepines.

Data suggest that reversible phosphorylation of ACBP regulates its ability to activate calpain in phosphatase inhibitor-induced apoptosis and controls the cellular accessibility of long-chain fatty acid-CoAs for cellular signaling.
Title: Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes.

ACBP acts as an acyl-CoA pool former in transgenic rats and regulates lipid metabolism via SREBP-1 and PPAR regulation
Title: Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.

The basal transcription of ACBP is modulated by members of the PPAR and SREBP families
Title: ACBP--a PPAR and SREBP modulated housekeeping gene.

expression of ACBP in rodent hepatocytes is subject to dual metabolic regulation by PPARalpha and SREBP-1c, which may reflect the need for ACBP during lipogenic as well as lipo-oxidative conditions
Title: The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes.

The following Dbi gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dbi cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12538	NM_031853.4 Latest version!	Rattus norvegicus diazepam binding inhibitor, acyl-CoA binding protein (Dbi), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dbi ( NM_031853.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114054.1 Rattus norvegicus diazepam binding inhibitor, acyl-CoA binding protein (Dbi), mRNA.

Price & Availability↑

CloneID	ORa12538
Clone ID Related Accession (Same CDS sequence)	NM_031853.4
Accession Version	NM_031853.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	acyl-CoA-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M14201.1 and BC084717.1. On Feb 9, 2008 this sequence version replaced NM_031853.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M14201.1, CF977190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTCAGG CTGATTTCGA CAAAGCCGCT GAGGAGGTGA AGCGCCTCAA GACTCAGCCA 
ACTGATGAAG AGATGCTGTT CATCTACAGC CACTTCAAAC AAGCTACTGT GGGCGATGTA 
AACACAGATC GGCCGGGGCT GTTGGACCTC AAGGGCAAAG CCAAGTGGGA CTCGTGGAAC 
AAGCTGAAAG GAACTTCCAA GGAAAATGCC ATGAAGACCT ATGTGGAAAA GGTAGAAGAG 
CTAAAGAAGA AATATGGAAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114054.1
CDS	118..381
Translation	MSQADFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDRPGLLDLKGKAKWDSWNKLKGTSKENAMKTYVEKVEELKKKYGI

Target ORF information:

RefSeq Version	NM_031853.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus diazepam binding inhibitor, acyl-CoA binding protein (Dbi), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031853.4

ORF Insert Sequence:

ATGTCTCAGG CTGATTTCGA CAAAGCCGCT GAGGAGGTGA AGCGCCTCAA GACTCAGCCA 
ACTGATGAAG AGATGCTGTT CATCTACAGC CACTTCAAAC AAGCTACTGT GGGCGATGTA 
AACACAGATC GGCCGGGGCT GTTGGACCTC AAGGGCAAAG CCAAGTGGGA CTCGTGGAAC 
AAGCTGAAAG GAACTTCCAA GGAAAATGCC ATGAAGACCT ATGTGGAAAA GGTAGAAGAG 
CTAAAGAAGA AATATGGAAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.
Molecular neurobiology(2017 Jul)
Ghouili I,Bahdoudi S,Morin F,Amri F,Hamdi Y,Coly PM,Walet-Balieu ML,Leprince J,Zekri S,Vaudry H,Vaudry D,Castel H,Amri M,Tonon MC,Masmoudi-Kouki O

Gliotransmission and brain glucose sensing: critical role of endozepines.
Diabetes62(3)801-10(2013 Mar)
Lanfray D,Arthaud S,Ouellet J,Comp?re V,Do Rego JL,Leprince J,Lefranc B,Castel H,Bouchard C,Monge-Roffarello B,Richard D,Pelletier G,Vaudry H,Tonon MC,Morin F

Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain.
IUBMB life63(7)547-52(2011 Jul)
Ludewig AH,Nitz I,Klapper M,D?ring F

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Expression, purification and functional characterization of recombinant human acyl-CoA-binding protein (ACBP) from erythroid cells.
Acta biochimica Polonica57(4)533-40(2010)
Augoff K,Kolondra A,Chorzalska A,Lach A,Grabowski K,Sikorski AF

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Dbi cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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