Eln cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eln
Entrez Gene ID	25043
Full Name	elastin
Synonyms	RATTREL11,TREL11,Trela,Trela26
General protein information	Preferred Names elastin Names elastin Tropoelastin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	precursor of elastin, which is a major component of the elastic fibers of the extracellular matrix; confers elasticity to tissues [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012722.1	NP_036854.1	elastin precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Human umbilical cord-derived mesenchymal stem cells protect from hyperoxic lung injury by ameliorating aberrant elastin remodeling in the lung of O
Hou C, Peng D, Gao L, Tian D, Dai J, Luo Z, Liu E, Chen H, Zou L, Fu Z
Biochemical and biophysical research communications495(2)1972-1979(2018 Jan)

Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix.
Seidl SE, Pessolano LG Jr, Bishop CA, Best M, Rich CB, Stone PJ, Schreiber BM
PloS one12(3)e0171711(2017)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin.
Gil-Ortega M, Garc?a-Prieto CF, Ruiz-Hurtado G, Steireif C, Gonz?lez MC, Schulz A, Kreutz R, Fern?ndez-Alfonso MS, Arribas S, Somoza B
British journal of pharmacology172(17)4406-18(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Effects on Mmp9 and Eln mRNA expression persisted with long-term SAA treatment, resulting in decreased insoluble elastin accumulation. These data reveal a novel mechanism whereby SAA and/or infection induce changes in vascular elastin consistent with atherosclerosis.
Title: Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix.

Albuminuria is associated with increased arterial stiffness due to reduction of elastin content in the external elastic lamina.
Title: Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin.

Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.
Title: Oxygenation decreases elastin secretion from rat ductus arteriosus smooth muscle cells.

Data show that LDL-receptor related protein 1 (LRP1)-mediated cardiomyocyte intracellular cholesteryl ester accumulation alters the structural and physical characteristics of secreted tropoelastin through an increase in cathepsin S mature protein levels.
Title: Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.

Results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity.
Title: Elasto-regenerative properties of polyphenols.

The following Eln gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eln cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13296	NM_012722.1 Latest version!	Rattus norvegicus elastin (Eln), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eln ( NM_012722.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036854.1 Rattus norvegicus elastin (Eln), mRNA.

Price & Availability↑

CloneID	ORa13296
Clone ID Related Accession (Same CDS sequence)	NM_012722.1
Accession Version	NM_012722.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	elastin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085910.1. On or before Nov 22, 2004 this sequence version replaced XM_341061.1, XM_347155.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGTC TGACAGCGGC AGTCCCGCAG CCTGGCGTCT TGCTGATCCT CTTGCTCAAC 
CTCCTCCATC CCGCGCAGCC TGGAGGGGTT CCAGGAGCTG TGCCTGGTGG AGTTCCTGGC 
GGACTTCCTG GTGGAGTTCC CGGTGGAGTC TATTATCCAG GAGCTGGTAT CGGAGGAGGC 
CTGGGAGGAG GAGCTCTGGG ACCTGGAGGA AAACCGCCTA AGCCAGGTGC CGGACTTCTG 
GGAGCGTTTG GAGCAGGTCC TGGAGGACTT GGAGGTGCTG GCCCCGGGGC AGGTCTCTCC 
TATGCTTCAA GGCCAGGTGG TGTTCTGGTG CCTGGGGGAG GAGCAGGGGC TGCAGCAGCT 
TATAAAGCCG CGGCCAAAGC TGGGGCTGGG CTTGGAGGCA TTGGCGGAGT TCCAGGGGGT 
GTTGGAGTTG GTGGAGTTCC TGGGGCTGTT GGAGTTGGCG GAGTTCCTGG GGCTGTCGGT 
GGTATTGGTG GCATCGGTGG CTTAGGAGTC TCAACAGGTG CTGTGGTGCC TCAACTTGGA 
GCTGGAGTCG GAGCCGGAGG AAAGCCTGGG AAAGTTCCTG GTGTCGGTCT TCCAGGTGTA 
TACCCAGGTG GAGTGCTCCC AGGAACAGGA GCTCGGTTCC CTGGTGTGGG AGTGCTCCCT 
GGAGTTCCCA CTGGCACAGG AGTCAAGGCC AAGGTTCCGG GTGGAGGAGG TGGTGCTTTT 
TCTGGAATCC CAGGGGTCGG GCCCTTTGGG GGTCAGCAGC CTGGTGTCCC ACTGGGTTAT 
CCCATCAAAG CGCCAAAGCT GCCAGGTGGC TATGGACTGC CCTATACCAA TGGGAAACTG 
CCCTATGGAG TGGCTGGTGC AGGGGGCAAA GCTGGCTACC CAACAGGGAC AGGGGTCGGG 
TCCCAGGCAG CAGTGGCAGC AGCTAAAGCA GCGAAGTATG GTGCTGGAGG AGGTGGAGTC 
CTCCCTGGTG TTGGAGGGGG TGGCATTCCT GGTGGTGCTG GCGCAATTCC TGGGATTGGA 
GGCATTACAG GCGCTGGAAC TCCCGCAGCA GCTGCTGCTG CAAAGGCTGC CGCTAAGGCT 
GCTAAGTATG GAGCTGCTGG AGGCTTAGTG CCTGGTGGAC CAGGAGTTAG GGTCCCAGGT 
GCTGGAATCC CAGGTGTTGG GATCCCAGGT GTCGGTGGCA TTCCAGGTGT TGGTGGCATT 
CCAGGTGTTG GTGGCATCCC AGGTGTTGGG GGCCCTGGTA TCGGAGGTCC AGGCATTGTG 
GGTGGACCAG GGGCTGTGTC ACCAGCTGCA GCTGCCAAAG CTGCTGCCAA AGCTGCCAAG 
TATGGAGCCA GAGGTGGAGT TGGCATCCCG ACATACGGGG TTGGTGCTGG TGGCTTTCCT 
GGCTATGGTG TTGGAGCTGG AGCTGGACTT GGAGGTGCAA GCCAAGCTGC TGCTGCCGCT 
GCCGCTGCCA AAGCTGCCAA GTACGGTGCC GGAGGAGCTG GAACCCTGGG AGGCCTGGTG 
CCAGGTGCAG TACCAGGTGC ACTGCCAGGT GCAGTACCAG GTGCACTGCC AGGTGCAGTA 
CCAGGTGCAC TGCCAGGTGC AGTGCCAGGT GTGCCGGGCA CTGGTGGAGT GCCAGGAGCA 
GGTACCCCTG CGGCTGCAGC TGCTGCCGCC GCTGCCAAGG CAGCCGCCAA GGCAGGCCAG 
TATGGTTTGG GCCCTGGTGT TGGTGGCGTT CCCGGTGGAG TTGGTGTTGG TGGGCTTCCC 
GGTGGAGTTG GCCCTGGTGG TGTTACTGGT ATTGGAACTG GTCCTGGCAC CGGCCTTGTA 
CCTGGTGATC TTGGAGGAGC AGGGACACCA GCTGCTGCCA AATCTGCTGC TAAGGCGGCT 
GCCAAAGCCC AGTACAGGGC TGCTGCTGGG CTTGGGGCCG GTGTCCCTGG ACTTGGGGTT 
GGTGCTGGTG TCCCCGGATT TGGGGCTGGT GCTGGTGGAT TTGGGGCTGG TGCTGGTGTC 
CCTGGATTTG GAGCTGGAGC AGTTCCTGGA TCCCTGGCTG CATCCAAAGC TGCTAAATAC 
GGAGCAGCAG GTGGCCTTGG AGGGCCTGGA GGACTTGGTG GGCCTGGAGG ACTTGGTGGG 
CCCGGAGGAC TTGGTGGGCC TGGAGGACTC GGTGGGCCTG GAGGACTCGG TGGTGTTCCT 
GGTGGAGTAG CAGGAGGTGC ACCTGCTGCT GCTGCTGCTG CCAAAGCTGC CGCTAAGGCT 
GCCCAGTACG GTCTTGGTGG AGCTGGAGGA CTCGGGGCCG GTGGACTGGG AGCCGGAGGA 
CTGGGGGCCG GTGGACTGGG AGCCGGAGGA CTGGGAGCTG GTGGACTGGG GGCTGGGGGA 
GTGATCCCTG GTGCTGTAGG CCTTGGAGGT GTGTCCCCTG CTGCAGCTGC TAAGGCTGCC 
AAATATGGTG CTGCTGGCCT TGGAGGTGTC CTAGGAGCCA GGCCATTCCC AGGCGGAGGA 
GTGGCAGCAA GACCTGGGTT TGGACTTTCT CCTATCTACC CAGGTGGTGG TGCTGGGGGC 
CTGGGAGTTG GTGGAAAACC CCCGAAGCCC TATGGAGGAG CCCTTGGAGC CCTGGGATAT 
CAAGGTGGGG GCTGCTTTGG GAAATCTTGT GGCCGGAAGA GAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036854.1
CDS	6..2633
Translation	MAGLTAAVPQPGVLLILLLNLLHPAQPGGVPGAVPGGVPGGLPGGVPGGVYYPGAGIGGGLGGGALGPGGKPPKPGAGLLGAFGAGPGGLGGAGPGAGLSYASRPGGVLVPGGGAGAAAAYKAAAKAGAGLGGIGGVPGGVGVGGVPGAVGVGGVPGAVGGIGGIGGLGVSTGAVVPQLGAGVGAGGKPGKVPGVGLPGVYPGGVLPGTGARFPGVGVLPGVPTGTGVKAKVPGGGGGAFSGIPGVGPFGGQQPGVPLGYPIKAPKLPGGYGLPYTNGKLPYGVAGAGGKAGYPTGTGVGSQAAVAAAKAAKYGAGGGGVLPGVGGGGIPGGAGAIPGIGGITGAGTPAAAAAAKAAAKAAKYGAAGGLVPGGPGVRVPGAGIPGVGIPGVGGIPGVGGIPGVGGIPGVGGPGIGGPGIVGGPGAVSPAAAAKAAAKAAKYGARGGVGIPTYGVGAGGFPGYGVGAGAGLGGASQAAAAAAAAKAAKYGAGGAGTLGGLVPGAVPGALPGAVPGALPGAVPGALPGAVPGVPGTGGVPGAGTPAAAAAAAAAKAAAKAGQYGLGPGVGGVPGGVGVGGLPGGVGPGGVTGIGTGPGTGLVPGDLGGAGTPAAAKSAAKAAAKAQYRAAAGLGAGVPGLGVGAGVPGFGAGAGGFGAGAGVPGFGAGAVPGSLAASKAAKYGAAGGLGGPGGLGGPGGLGGPGGLGGPGGLGGPGGLGGVPGGVAGGAPAAAAAAKAAAKAAQYGLGGAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGVIPGAVGLGGVSPAAAAKAAKYGAAGLGGVLGARPFPGGGVAARPGFGLSPIYPGGGAGGLGVGGKPPKPYGGALGALGYQGGGCFGKSCGRKRK

Target ORF information:

RefSeq Version	NM_012722.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus elastin (Eln), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012722.1

ORF Insert Sequence:

ATGGCGGGTC TGACAGCGGC AGTCCCGCAG CCTGGCGTCT TGCTGATCCT CTTGCTCAAC 
CTCCTCCATC CCGCGCAGCC TGGAGGGGTT CCAGGAGCTG TGCCTGGTGG AGTTCCTGGC 
GGACTTCCTG GTGGAGTTCC CGGTGGAGTC TATTATCCAG GAGCTGGTAT CGGAGGAGGC 
CTGGGAGGAG GAGCTCTGGG ACCTGGAGGA AAACCGCCTA AGCCAGGTGC CGGACTTCTG 
GGAGCGTTTG GAGCAGGTCC TGGAGGACTT GGAGGTGCTG GCCCCGGGGC AGGTCTCTCC 
TATGCTTCAA GGCCAGGTGG TGTTCTGGTG CCTGGGGGAG GAGCAGGGGC TGCAGCAGCT 
TATAAAGCCG CGGCCAAAGC TGGGGCTGGG CTTGGAGGCA TTGGCGGAGT TCCAGGGGGT 
GTTGGAGTTG GTGGAGTTCC TGGGGCTGTT GGAGTTGGCG GAGTTCCTGG GGCTGTCGGT 
GGTATTGGTG GCATCGGTGG CTTAGGAGTC TCAACAGGTG CTGTGGTGCC TCAACTTGGA 
GCTGGAGTCG GAGCCGGAGG AAAGCCTGGG AAAGTTCCTG GTGTCGGTCT TCCAGGTGTA 
TACCCAGGTG GAGTGCTCCC AGGAACAGGA GCTCGGTTCC CTGGTGTGGG AGTGCTCCCT 
GGAGTTCCCA CTGGCACAGG AGTCAAGGCC AAGGTTCCGG GTGGAGGAGG TGGTGCTTTT 
TCTGGAATCC CAGGGGTCGG GCCCTTTGGG GGTCAGCAGC CTGGTGTCCC ACTGGGTTAT 
CCCATCAAAG CGCCAAAGCT GCCAGGTGGC TATGGACTGC CCTATACCAA TGGGAAACTG 
CCCTATGGAG TGGCTGGTGC AGGGGGCAAA GCTGGCTACC CAACAGGGAC AGGGGTCGGG 
TCCCAGGCAG CAGTGGCAGC AGCTAAAGCA GCGAAGTATG GTGCTGGAGG AGGTGGAGTC 
CTCCCTGGTG TTGGAGGGGG TGGCATTCCT GGTGGTGCTG GCGCAATTCC TGGGATTGGA 
GGCATTACAG GCGCTGGAAC TCCCGCAGCA GCTGCTGCTG CAAAGGCTGC CGCTAAGGCT 
GCTAAGTATG GAGCTGCTGG AGGCTTAGTG CCTGGTGGAC CAGGAGTTAG GGTCCCAGGT 
GCTGGAATCC CAGGTGTTGG GATCCCAGGT GTCGGTGGCA TTCCAGGTGT TGGTGGCATT 
CCAGGTGTTG GTGGCATCCC AGGTGTTGGG GGCCCTGGTA TCGGAGGTCC AGGCATTGTG 
GGTGGACCAG GGGCTGTGTC ACCAGCTGCA GCTGCCAAAG CTGCTGCCAA AGCTGCCAAG 
TATGGAGCCA GAGGTGGAGT TGGCATCCCG ACATACGGGG TTGGTGCTGG TGGCTTTCCT 
GGCTATGGTG TTGGAGCTGG AGCTGGACTT GGAGGTGCAA GCCAAGCTGC TGCTGCCGCT 
GCCGCTGCCA AAGCTGCCAA GTACGGTGCC GGAGGAGCTG GAACCCTGGG AGGCCTGGTG 
CCAGGTGCAG TACCAGGTGC ACTGCCAGGT GCAGTACCAG GTGCACTGCC AGGTGCAGTA 
CCAGGTGCAC TGCCAGGTGC AGTGCCAGGT GTGCCGGGCA CTGGTGGAGT GCCAGGAGCA 
GGTACCCCTG CGGCTGCAGC TGCTGCCGCC GCTGCCAAGG CAGCCGCCAA GGCAGGCCAG 
TATGGTTTGG GCCCTGGTGT TGGTGGCGTT CCCGGTGGAG TTGGTGTTGG TGGGCTTCCC 
GGTGGAGTTG GCCCTGGTGG TGTTACTGGT ATTGGAACTG GTCCTGGCAC CGGCCTTGTA 
CCTGGTGATC TTGGAGGAGC AGGGACACCA GCTGCTGCCA AATCTGCTGC TAAGGCGGCT 
GCCAAAGCCC AGTACAGGGC TGCTGCTGGG CTTGGGGCCG GTGTCCCTGG ACTTGGGGTT 
GGTGCTGGTG TCCCCGGATT TGGGGCTGGT GCTGGTGGAT TTGGGGCTGG TGCTGGTGTC 
CCTGGATTTG GAGCTGGAGC AGTTCCTGGA TCCCTGGCTG CATCCAAAGC TGCTAAATAC 
GGAGCAGCAG GTGGCCTTGG AGGGCCTGGA GGACTTGGTG GGCCTGGAGG ACTTGGTGGG 
CCCGGAGGAC TTGGTGGGCC TGGAGGACTC GGTGGGCCTG GAGGACTCGG TGGTGTTCCT 
GGTGGAGTAG CAGGAGGTGC ACCTGCTGCT GCTGCTGCTG CCAAAGCTGC CGCTAAGGCT 
GCCCAGTACG GTCTTGGTGG AGCTGGAGGA CTCGGGGCCG GTGGACTGGG AGCCGGAGGA 
CTGGGGGCCG GTGGACTGGG AGCCGGAGGA CTGGGAGCTG GTGGACTGGG GGCTGGGGGA 
GTGATCCCTG GTGCTGTAGG CCTTGGAGGT GTGTCCCCTG CTGCAGCTGC TAAGGCTGCC 
AAATATGGTG CTGCTGGCCT TGGAGGTGTC CTAGGAGCCA GGCCATTCCC AGGCGGAGGA 
GTGGCAGCAA GACCTGGGTT TGGACTTTCT CCTATCTACC CAGGTGGTGG TGCTGGGGGC 
CTGGGAGTTG GTGGAAAACC CCCGAAGCCC TATGGAGGAG CCCTTGGAGC CCTGGGATAT 
CAAGGTGGGG GCTGCTTTGG GAAATCTTGT GGCCGGAAGA GAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human umbilical cord-derived mesenchymal stem cells protect from hyperoxic lung injury by ameliorating aberrant elastin remodeling in the lung of O
Biochemical and biophysical research communications495(2)1972-1979(2018 Jan)
Hou C,Peng D,Gao L,Tian D,Dai J,Luo Z,Liu E,Chen H,Zou L,Fu Z

Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix.
PloS one12(3)e0171711(2017)
Seidl SE,Pessolano LG Jr,Bishop CA,Best M,Rich CB,Stone PJ,Schreiber BM

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin.
British journal of pharmacology172(17)4406-18(2015 Sep)
Gil-Ortega M,Garc?a-Prieto CF,Ruiz-Hurtado G,Steireif C,Gonz?lez MC,Schulz A,Kreutz R,Fern?ndez-Alfonso MS,Arribas S,Somoza B

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Eln cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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