Adm cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adm
Entrez Gene ID	25026
Full Name	adrenomedullin
Synonyms	Ap,H39316,RATAP
General protein information	Preferred Names adrenomedullin Names ADM
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q33
Summary	involved in the regulation of adrenal development; plays a role in inhibition of apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008759687.2	XP_008757909.1	ADM isoform X1
NM_012715.1	NP_036847.1	ADM precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ADM	NP_001003183.1
Rattus norvegicus (Norway rat)	Adm	NP_036847.1
	ADM	XP_001100827.1
Pan troglodytes (chimpanzee)	ADM	XP_001169702.1
Mus musculus (house mouse)	Adm	NP_033757.1
Bos taurus (cattle)	ADM	NP_776313.1
Homo sapiens (human)	ADM	NP_001115.1
Xenopus tropicalis (tropical clawed frog)	adm	XP_002936787.1

Gene Ontology
Bibliography

Related articles in PubMed

Adrenomedullin mediates tumor necrosis factor-?-induced responses in dorsal root ganglia in rats.
Chen Y, Zhang Y, Huo Y, Wang D, Hong Y
Brain research1644183-91(2016 08)

Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.
Li W, Guo A, Wang L, Kong Q, Wang R, Han L, Zhao C
Congenital anomalies56(1)28-34(2016 Jan)

Role of cerebellar adrenomedullin in blood pressure regulation.
Figueira L, Israel A
Neuropeptides5459-66(2015 Dec)

An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora.
Allaker RP, Zihni C, Kapas S
FEMS immunology and medical microbiology23(4)289-93(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study suggests that the increased adrenomedullin receptor signaling mediated the many, but not all, tumor necrosis factor-alpha-induced activities, contributing to peripheral sensitization in neuropathic pain.
Title: Adrenomedullin mediates tumor necrosis factor-?-induced responses in dorsal root ganglia in rats.

Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP.
Title: Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.

Levels of adrenomedullin peptide fragments respond to pulmonary remodeling in pulmonary hypertension.
Title: Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.

Findings demonstrate a dysregulation of cerebellar adrenomedullin-system during hypertension, and suggest that cerebellar drenomedullin plays an important role in the regulation of blood pressure.
Title: Role of cerebellar adrenomedullin in blood pressure regulation.

AM/AMBP-1 accelerated wound healing by promoting angiogenesis, collagen deposition and remodeling
Title: Combination of adrenomedullin with its binding protein accelerates cutaneous wound healing.

The following Adm gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adm cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13478	NM_012715.1 Latest version!	Rattus norvegicus adrenomedullin (Adm), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa13478	XM_008759687.2 Latest version!	Rattus norvegicus adrenomedullin (Adm), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adm ( NM_012715.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036847.1 Rattus norvegicus adrenomedullin (Adm), mRNA.

Price & Availability↑

CloneID	ORa13478
Clone ID Related Accession (Same CDS sequence)	XM_008759687.2 , NM_012715.1
Accession Version	NM_012715.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	ADM precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U15419.1. On Mar 7, 2003 this sequence version replaced NM_173716.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U15419.1, BC061775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTGG TTTCCATCGC CCTGATGTTA TTGGGTTCGC TCGCCGTTCT CGGCGCGGAC 
ACCGCACGGC TCGACACTTC CTCGCAGTTC CGAAAGAAGT GGAATAAGTG GGCGCTAAGT 
CGTGGGAAGA GGGAACTACA AGCGTCCAGC AGCTACCCTA CGGGGCTCGT TGATGAGAAG 
ACAGTCCCGA CCCAGACTCT TGGGCTCCAG GACAAGCAGA GCACGTCTAG CACCCCACAA 
GCCAGCACTC AGAGCACAGC CCACATTCGA GTCAAACGCT ACCGCCAGAG CATGAACCAG 
GGGTCCCGCA GCACTGGATG CCGCTTTGGG ACCTGCACAA TGCAGAAACT GGCTCACCAG 
ATCTACCAGT TTACAGACAA AGACAAGGAC GGCATGGCCC CCAGAAACAA GATCAGCCCT 
CAAGGCTATG GCCGCCGGCG CCGGCGTTCC CTGCCAGAGG TCCTCCGAGC CCGGACTGTG 
GAGTCCTCCC AGGAGCAGAC ACACTCAGCT CCAGCCTCCC CGGCGCACCA AGACATCTCC 
AGAGTCTCTA GGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036847.1
CDS	172..729
Translation	MKLVSIALMLLGSLAVLGADTARLDTSSQFRKKWNKWALSRGKRELQASSSYPTGLVDEKTVPTQTLGLQDKQSTSSTPQASTQSTAHIRVKRYRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGYGRRRRRSLPEVLRARTVESSQEQTHSAPASPAHQDISRVSRL

Target ORF information:

RefSeq Version	NM_012715.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adrenomedullin (Adm), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012715.1

ORF Insert Sequence:

ATGAAGCTGG TTTCCATCGC CCTGATGTTA TTGGGTTCGC TCGCCGTTCT CGGCGCGGAC 
ACCGCACGGC TCGACACTTC CTCGCAGTTC CGAAAGAAGT GGAATAAGTG GGCGCTAAGT 
CGTGGGAAGA GGGAACTACA AGCGTCCAGC AGCTACCCTA CGGGGCTCGT TGATGAGAAG 
ACAGTCCCGA CCCAGACTCT TGGGCTCCAG GACAAGCAGA GCACGTCTAG CACCCCACAA 
GCCAGCACTC AGAGCACAGC CCACATTCGA GTCAAACGCT ACCGCCAGAG CATGAACCAG 
GGGTCCCGCA GCACTGGATG CCGCTTTGGG ACCTGCACAA TGCAGAAACT GGCTCACCAG 
ATCTACCAGT TTACAGACAA AGACAAGGAC GGCATGGCCC CCAGAAACAA GATCAGCCCT 
CAAGGCTATG GCCGCCGGCG CCGGCGTTCC CTGCCAGAGG TCCTCCGAGC CCGGACTGTG 
GAGTCCTCCC AGGAGCAGAC ACACTCAGCT CCAGCCTCCC CGGCGCACCA AGACATCTCC 
AGAGTCTCTA GGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Adm ( XM_008759687.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757909.1 Rattus norvegicus adrenomedullin (Adm), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13478
Clone ID Related Accession (Same CDS sequence)	XM_008759687.2 , NM_012715.1
Accession Version	XM_008759687.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	ADM isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759687.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTGG TTTCCATCGC CCTGATGTTA TTGGGTTCGC TCGCCGTTCT CGGCGCGGAC 
ACCGCACGGC TCGACACTTC CTCGCAGTTC CGAAAGAAGT GGAATAAGTG GGCGCTAAGT 
CGTGGGAAGA GGGAACTACA AGCGTCCAGC AGCTACCCTA CGGGGCTCGT TGATGAGAAG 
ACAGTCCCGA CCCAGACTCT TGGGCTCCAG GACAAGCAGA GCACGTCTAG CACCCCACAA 
GCCAGCACTC AGAGCACAGC CCACATTCGA GTCAAACGCT ACCGCCAGAG CATGAACCAG 
GGGTCCCGCA GCACTGGATG CCGCTTTGGG ACCTGCACAA TGCAGAAACT GGCTCACCAG 
ATCTACCAGT TTACAGACAA AGACAAGGAC GGCATGGCCC CCAGAAACAA GATCAGCCCT 
CAAGGCTATG GCCGCCGGCG CCGGCGTTCC CTGCCAGAGG TCCTCCGAGC CCGGACTGTG 
GAGTCCTCCC AGGAGCAGAC ACACTCAGCT CCAGCCTCCC CGGCGCACCA AGACATCTCC 
AGAGTCTCTA GGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757909.1
CDS	1698..2255
Translation	MKLVSIALMLLGSLAVLGADTARLDTSSQFRKKWNKWALSRGKRELQASSSYPTGLVDEKTVPTQTLGLQDKQSTSSTPQASTQSTAHIRVKRYRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGYGRRRRRSLPEVLRARTVESSQEQTHSAPASPAHQDISRVSRL

Target ORF information:

RefSeq Version	XM_008759687.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adrenomedullin (Adm), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759687.2

ORF Insert Sequence:

ATGAAGCTGG TTTCCATCGC CCTGATGTTA TTGGGTTCGC TCGCCGTTCT CGGCGCGGAC 
ACCGCACGGC TCGACACTTC CTCGCAGTTC CGAAAGAAGT GGAATAAGTG GGCGCTAAGT 
CGTGGGAAGA GGGAACTACA AGCGTCCAGC AGCTACCCTA CGGGGCTCGT TGATGAGAAG 
ACAGTCCCGA CCCAGACTCT TGGGCTCCAG GACAAGCAGA GCACGTCTAG CACCCCACAA 
GCCAGCACTC AGAGCACAGC CCACATTCGA GTCAAACGCT ACCGCCAGAG CATGAACCAG 
GGGTCCCGCA GCACTGGATG CCGCTTTGGG ACCTGCACAA TGCAGAAACT GGCTCACCAG 
ATCTACCAGT TTACAGACAA AGACAAGGAC GGCATGGCCC CCAGAAACAA GATCAGCCCT 
CAAGGCTATG GCCGCCGGCG CCGGCGTTCC CTGCCAGAGG TCCTCCGAGC CCGGACTGTG 
GAGTCCTCCC AGGAGCAGAC ACACTCAGCT CCAGCCTCCC CGGCGCACCA AGACATCTCC 
AGAGTCTCTA GGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adrenomedullin mediates tumor necrosis factor-?-induced responses in dorsal root ganglia in rats.
Brain research1644183-91(2016 08)
Chen Y,Zhang Y,Huo Y,Wang D,Hong Y

Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.
Congenital anomalies56(1)28-34(2016 Jan)
Li W,Guo A,Wang L,Kong Q,Wang R,Han L,Zhao C

Role of cerebellar adrenomedullin in blood pressure regulation.
Neuropeptides5459-66(2015 Dec)
Figueira L,Israel A

An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora.
FEMS immunology and medical microbiology23(4)289-93(1999 Apr)
Allaker RP,Zihni C,Kapas S