Tacr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tacr2
Entrez Gene ID	25007
Full Name	tachykinin receptor 2
Synonyms	Tac2r
General protein information	Preferred Names tachykinin receptor 2 Names substance-K receptor NK-2 receptor NK-2R SKR Tachykinin 2 (substance K) receptor neurokinin A receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q11
Summary	G-protein coupled receptor for tachykinin K (neurokinin A); coupled to the phosphatidylinositol-calcium second messenger system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080768.1	NP_542946.1	substance-K receptor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TACR2	XP_507831.2
Rattus norvegicus (Norway rat)	Tacr2	NP_542946.1
Drosophila melanogaster (fruit fly)	Takr86C	NP_524304.2
Gallus gallus (chicken)	TACR2	XP_004942063.1
Anopheles gambiae (African malaria mosquito)	GPRTAK1	XP_312088.4
Homo sapiens (human)	TACR2	NP_001048.2
Canis lupus familiaris (dog)	TACR2	NP_001012635.1
Bos taurus (cattle)	TACR2	NP_776894.1
Mus musculus (house mouse)	Tacr2	NP_033340.3
	TACR2	XP_001110044.1
Danio rerio (zebrafish)	tacr2	XP_001341981.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.
Sch?ble S, Huston JP, Silva MA
Hippocampus22(5)1058-67(2012 May)

Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity.
Sch?ble S, Huston JP, Brandao ML, Dere E, de Souza Silva MA
Peptides31(1)108-15(2010 Jan)

Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment.
Ye YM, Lee HY, Kim SH, Jee YK, Lee SK, Lee SH, Park HS
Journal of clinical pharmacy and therapeutics34(6)693-701(2009 Dec)

The effect of the tachykinin NK(2) receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics.
Schelfhout V, Van De Velde V, Maggi C, Pauwels R, Joos G
Therapeutic advances in respiratory disease3(5)219-26(2009 Oct)

Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough.
Kim TB, Oh SY, Park HK, Jeon SG, Chang YS, Lee KY, Cho YS, Chae IH, Kim YK, Cho SH, Moon HB, Min KU, Kim YY
Journal of clinical pharmacy and therapeutics34(4)457-64(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that medial septal NK(2)-R have an important role in mediating acetylcholine release, for one, via the septal-hippocampal cholinergic projection and, secondly, via direct or indirect route to the amygdala, but not frontal cortex.
Title: Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.

Data show that injection of vehicle alone into the medial septum impaired memory for temporal order and spatial location, while the NK(2) receptor antagonist partially reversed this deficit by reinstating memory for temporal order.
Title: Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity.

Results suggest that the changes in tachykinin and receptor localization during colitis emphasize their role in both acute and repair phases.
Title: Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats.

activation of NK2 autoreceptors by NKs released from the peripheral afferent terminals or by mast cells during inflammatory responses may be a mechanism that sensitizes TRPV1 channels and enhances afferent excitability
Title: Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.

role for tachykinin NK-1 (and possibly for NK-2) receptors in tachykinin-mediated stimulation of vasopressin secretion from the rat hypothalamo hypophyseal system in vitro.
Title: Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.

The following Tacr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tacr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00146	NM_080768.1 Latest version!	Rattus norvegicus tachykinin receptor 2 (Tacr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tacr2 ( NM_080768.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_542946.1 Rattus norvegicus tachykinin receptor 2 (Tacr2), mRNA.

Price & Availability↑

CloneID	ORa00146
Clone ID Related Accession (Same CDS sequence)	NM_080768.1
Accession Version	NM_080768.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	substance-K receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M31838.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M31838.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642595 [ECO:0000348] ##Evidence-Data-END##

ATGGGGACCC GTGCCATTGT TTCTGACGCC AACATCTTGT CTGGCCTCGA GAGCAATGCC 
ACGGGTGTTA CAGCCTTCTC CATGCCTGGC TGGCAGCTGG CGTTATGGGC CACAGCCTAC 
CTGGCCCTGG TGCTGGTGGC TGTGACAGGC AATGCCACAG TCATCTGGAT CATTCTGGCC 
CACGAGAGGA TGCGCACAGT CACCAACTAT TTCATCATCA ACCTGGCCTT GGCGGACCTC 
TGCATGGCAG CCTTCAACGC GACCTTCAAC TTCATCTACG CCAGTCACAA CATCTGGTAC 
TTCGGCCGTG CCTTCTGCTA TTTCCAGAAC CTCTTTCCCA TCACAGCCAT GTTCGTCAGC 
ATCTACTCCA TGACCGCCAT TGCTGCTGAC AGGTACATGG CCATCGTTCA CCCCTTCCAG 
CCACGGCTCT CGGCCCCCAG CACCAAGGCG ATTATCGCTG GCATCTGGCT GGTAGCCCTG 
GCTCTCGCCT CCCCGCAATG CTTCTACTCC ACCATCACTG TGGACGAGGG GGCCACCAAG 
TGTGTGGTGG CCTGGCCCAA TGACAACGGA GGCAAGATGC TCCTACTGTA TCATCTGGTC 
GTGTTTGTCC TCATCTACTT CCTGCCTCTC CTGGTGATGT TCGGGGCTTA CAGTGTCATC 
GGCCTCACAC TGTGGAAGCG CGCGGTACCC AGACACCAGG CTCACGGAGC CAACTTACGC 
CATCTACAGG CCAAGAAGAA GTTTGTGAAG GCCATGGTAC TGGTGGTGCT GACATTTGCC 
ATCTGCTGGC TGCCCTACCA CCTCTACTTC ATCCTGGGGA CCTTCCAAGA GGACATCTAC 
TACCACAAGT TTATCCAGCA GGTCTACCTG GCGCTCTTCT GGCTGGCCAT GAGCTCCACA 
ATGTACAACC CTATCATTTA TTGCTGCCTT AACCACAGGT TTCGCTCTGG ATTCCGGCTT 
GCTTTCCGGT GCTGCCCCTG GGTGACACCA ACTGAGGAAG ACAGGCTGGA GCTGACTCAC 
ACGCCATCCC TCTCCAGGAG AGTCAACCGG TGTCATACCA AGGAGACTTT GTTCATGACG 
GGGGACATGA CCCACTCTGA GGCTACCAAT GGACAGGTTG GGAGTCCCCA GGATGGGGAG 
CCTGCTGGAC CCATCTGCAA GGCCCAGGCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542946.1
CDS	449..1621
Translation	MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA

Target ORF information:

RefSeq Version	NM_080768.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin receptor 2 (Tacr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080768.1

ORF Insert Sequence:

ATGGGGACCC GTGCCATTGT TTCTGACGCC AACATCTTGT CTGGCCTCGA GAGCAATGCC 
ACGGGTGTTA CAGCCTTCTC CATGCCTGGC TGGCAGCTGG CGTTATGGGC CACAGCCTAC 
CTGGCCCTGG TGCTGGTGGC TGTGACAGGC AATGCCACAG TCATCTGGAT CATTCTGGCC 
CACGAGAGGA TGCGCACAGT CACCAACTAT TTCATCATCA ACCTGGCCTT GGCGGACCTC 
TGCATGGCAG CCTTCAACGC GACCTTCAAC TTCATCTACG CCAGTCACAA CATCTGGTAC 
TTCGGCCGTG CCTTCTGCTA TTTCCAGAAC CTCTTTCCCA TCACAGCCAT GTTCGTCAGC 
ATCTACTCCA TGACCGCCAT TGCTGCTGAC AGGTACATGG CCATCGTTCA CCCCTTCCAG 
CCACGGCTCT CGGCCCCCAG CACCAAGGCG ATTATCGCTG GCATCTGGCT GGTAGCCCTG 
GCTCTCGCCT CCCCGCAATG CTTCTACTCC ACCATCACTG TGGACGAGGG GGCCACCAAG 
TGTGTGGTGG CCTGGCCCAA TGACAACGGA GGCAAGATGC TCCTACTGTA TCATCTGGTC 
GTGTTTGTCC TCATCTACTT CCTGCCTCTC CTGGTGATGT TCGGGGCTTA CAGTGTCATC 
GGCCTCACAC TGTGGAAGCG CGCGGTACCC AGACACCAGG CTCACGGAGC CAACTTACGC 
CATCTACAGG CCAAGAAGAA GTTTGTGAAG GCCATGGTAC TGGTGGTGCT GACATTTGCC 
ATCTGCTGGC TGCCCTACCA CCTCTACTTC ATCCTGGGGA CCTTCCAAGA GGACATCTAC 
TACCACAAGT TTATCCAGCA GGTCTACCTG GCGCTCTTCT GGCTGGCCAT GAGCTCCACA 
ATGTACAACC CTATCATTTA TTGCTGCCTT AACCACAGGT TTCGCTCTGG ATTCCGGCTT 
GCTTTCCGGT GCTGCCCCTG GGTGACACCA ACTGAGGAAG ACAGGCTGGA GCTGACTCAC 
ACGCCATCCC TCTCCAGGAG AGTCAACCGG TGTCATACCA AGGAGACTTT GTTCATGACG 
GGGGACATGA CCCACTCTGA GGCTACCAAT GGACAGGTTG GGAGTCCCCA GGATGGGGAG 
CCTGCTGGAC CCATCTGCAA GGCCCAGGCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.
Hippocampus22(5)1058-67(2012 May)
Sch?ble S,Huston JP,Silva MA

Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity.
Peptides31(1)108-15(2010 Jan)
Sch?ble S,Huston JP,Brandao ML,Dere E,de Souza Silva MA

Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment.
Journal of clinical pharmacy and therapeutics34(6)693-701(2009 Dec)
Ye YM,Lee HY,Kim SH,Jee YK,Lee SK,Lee SH,Park HS

The effect of the tachykinin NK(2) receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics.
Therapeutic advances in respiratory disease3(5)219-26(2009 Oct)
Schelfhout V,Van De Velde V,Maggi C,Pauwels R,Joos G

Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough.
Journal of clinical pharmacy and therapeutics34(4)457-64(2009 Aug)
Kim TB,Oh SY,Park HK,Jeon SG,Chang YS,Lee KY,Cho YS,Chae IH,Kim YK,Cho SH,Moon HB,Min KU,Kim YY

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Tacr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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