Psmb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmb8
Entrez Gene ID	24968
Full Name	proteasome subunit beta 8
Synonyms	Lmp7,Ring10
General protein information	Preferred Names proteasome subunit beta 8 Names proteasome subunit beta type-8 large multifunctional protease 7 low molecular mass polypeptide 7 macropain subunit C13 multicatalytic endopeptidase complex subunit C13 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) proteasome (prosome, macropain) subunit, beta type, 8 proteasome component C13 proteasome subunit beta-5i
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	may play a role in antigen processing [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080767.2	NP_542945.2	proteasome subunit beta type-8

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	PRE2	NP_015428.1
Eremothecium gossypii	AGOS_AEL326C	NP_984534.2
Homo sapiens (human)	PSMB8	NP_683720.2
Kluyveromyces lactis	KLLA0F08228g	XP_455453.1
Schizosaccharomyces pombe (fission yeast)	pts1	NP_593825.1
Magnaporthe oryzae (rice blast fungus)	MGG_00170	XP_003718955.1
Xenopus tropicalis (tropical clawed frog)	psmb8	NP_001103512.1
Mus musculus (house mouse)	Psmb8	NP_034854.2
Neurospora crassa	NCU09309	XP_963951.1
Pan troglodytes (chimpanzee)	PSMB8	XP_001167272.1
	LOC717766	XP_001115562.2
Canis lupus familiaris (dog)	PSMB8	NP_001041550.1
Bos taurus (cattle)	PSMB8	NP_001035570.1
Rattus norvegicus (Norway rat)	Psmb8	NP_542945.2
Danio rerio (zebrafish)	psmb8	XP_005159529.1

Gene Ontology
Bibliography

Related articles in PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Rother K, Hildebrand PW, Brogan P, Kr?ger E, Aksentijevich I, Goldbach-Mansky R
The Journal of clinical investigation125(11)4196-211(2015 Nov)

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
Tuncel J, Haag S, Yau AC, Norin U, Baud A, L?nnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, , Stridh P, Jagodic M, Olsson T, Fern?ndez-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R
PLoS genetics10(2)e1004151(2014 Feb)

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.
Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB
Cell153(5)1012-24(2013 May)

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.
Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K
The Journal of clinical investigation121(10)4150-60(2011 Oct)

Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.
Melnikova VI, Sharova NP, Maslova EV, Voronova SN, Zakharova LA
Cellular immunology266(1)83-9(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LMP7 and LMP2 were detected in thymic epithelial and dendritic cells, in CD68 positive cells (macrophages, monocytes), and in CD90 lymphocytes through pre- and postnatal ontogenesis.
Title: Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.

LMP7 mRNA expression and protein content was reduced in alcoholic liver disease.
Title: [An experimental study on the relationship between proteasome LMP7 subunit and alcoholic liver disease].

LMP7 immuno-subunit is induced in renal cells exposed to a long-lasting renal ischemia and inflammation.
Title: Immuno-proteasome subunit LMP7 is up-regulated in the ischemic kidney in an experimental model of renovascular hypertension.

The following Psmb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13177	NM_080767.2 Latest version!	Rattus norvegicus proteasome 20S subunit beta 8 (Psmb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmb8 ( NM_080767.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_542945.2 Rattus norvegicus proteasome 20S subunit beta 8 (Psmb8), mRNA.

Price & Availability↑

CloneID	ORa13177
Clone ID Related Accession (Same CDS sequence)	NM_080767.2
Accession Version	NM_080767.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit beta type-8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX883043.1. On or before Dec 15, 2013 this sequence version replaced XM_006256033.1, XM_003751930.1, NM_080767.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTTAC TGGATCTGTG CGGCGCTCCT CGGGGGCAGC GGCCCGAGTG GGCTGCCGTG 
GATGCAGGAA GCGGGCTTCG CTCGGACCCG GGACACTACA GTTTCTCCGT GCAAGCTCCG 
GAGCTCGCGC TTCCCCGGGG AATGCAGCCC ACTGAATTCC TAAGGTCCTT TGGTGATGAC 
CAGGAAAGGA AGGTTCAGAT TGAAATGGCG CACGGCACAA CCACGCTGGC CTTCAAGTTC 
CAGCATGGAG TCATCGTGGC GGTGGACTCC AGGGCCTCCG CAGGAAGTTA CATTGCTACC 
ATAAGGGTGA ACAAGGTGAT CGAGATTAAC CCTTACCTGC TTGGAACCAT GTCTGGTTGT 
GCAGCCGACT GTCAGTACTG GGAGAGGCTG TTGGCCAAGG AATGCAGGCT ATACTATCTG 
CGGAATGGGG AACGCATCTC CGTGTCTGCA GCCTCCAAGC TACTTTCCAA CATGATGCTG 
CAGTACCGGG GTATGGGCCT CTCCATGGGC AGCATGATCT GCGGCTGGGA CAAGAAGGGA 
CCGGGACTTT ATTACGTAGA TGACAATGGG ACTCGGCTCT CGGGACAGAT GTTCTCCACA 
GGCAGCGGGA ACACCTATGC CTACGGGGTG ATGGACAGTG GGTACCGGCA GGATCTCAGT 
CCTGAGGAGG CCTACGACCT TGCCCGAAGA GCTATTGTTT ATGCTACCCA CAGAGACAGC 
TATTCTGGAG GAGTTGTCAA CATGTACCAC ATGAAGAAAG ACGGTTGGGT GAAAGTGGAG 
AGCACTGACG TCAGTGACCT GCTGCACAAG TACCGAGAGG CCACTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542945.2
CDS	51..881
Translation	MALLDLCGAPRGQRPEWAAVDAGSGLRSDPGHYSFSVQAPELALPRGMQPTEFLRSFGDDQERKVQIEMAHGTTTLAFKFQHGVIVAVDSRASAGSYIATIRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLARRAIVYATHRDSYSGGVVNMYHMKKDGWVKVESTDVSDLLHKYREATL

Target ORF information:

RefSeq Version	NM_080767.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome 20S subunit beta 8 (Psmb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080767.2

ORF Insert Sequence:

ATGGCGTTAC TGGATCTGTG CGGCGCTCCT CGGGGGCAGC GGCCCGAGTG GGCTGCCGTG 
GATGCAGGAA GCGGGCTTCG CTCGGACCCG GGACACTACA GTTTCTCCGT GCAAGCTCCG 
GAGCTCGCGC TTCCCCGGGG AATGCAGCCC ACTGAATTCC TAAGGTCCTT TGGTGATGAC 
CAGGAAAGGA AGGTTCAGAT TGAAATGGCG CACGGCACAA CCACGCTGGC CTTCAAGTTC 
CAGCATGGAG TCATCGTGGC GGTGGACTCC AGGGCCTCCG CAGGAAGTTA CATTGCTACC 
ATAAGGGTGA ACAAGGTGAT CGAGATTAAC CCTTACCTGC TTGGAACCAT GTCTGGTTGT 
GCAGCCGACT GTCAGTACTG GGAGAGGCTG TTGGCCAAGG AATGCAGGCT ATACTATCTG 
CGGAATGGGG AACGCATCTC CGTGTCTGCA GCCTCCAAGC TACTTTCCAA CATGATGCTG 
CAGTACCGGG GTATGGGCCT CTCCATGGGC AGCATGATCT GCGGCTGGGA CAAGAAGGGA 
CCGGGACTTT ATTACGTAGA TGACAATGGG ACTCGGCTCT CGGGACAGAT GTTCTCCACA 
GGCAGCGGGA ACACCTATGC CTACGGGGTG ATGGACAGTG GGTACCGGCA GGATCTCAGT 
CCTGAGGAGG CCTACGACCT TGCCCGAAGA GCTATTGTTT ATGCTACCCA CAGAGACAGC 
TATTCTGGAG GAGTTGTCAA CATGTACCAC ATGAAGAAAG ACGGTTGGGT GAAAGTGGAG 
AGCACTGACG TCAGTGACCT GCTGCACAAG TACCGAGAGG CCACTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
The Journal of clinical investigation125(11)4196-211(2015 Nov)
Brehm A,Liu Y,Sheikh A,Marrero B,Omoyinmi E,Zhou Q,Montealegre G,Biancotto A,Reinhardt A,Almeida de Jesus A,Pelletier M,Tsai WL,Remmers EF,Kardava L,Hill S,Kim H,Lachmann HJ,Megarbane A,Chae JJ,Brady J,Castillo RD,Brown D,Casano AV,Gao L,Chapelle D,Huang Y,Stone D,Chen Y,Sotzny F,Lee CC,Kastner DL,Torrelo A,Zlotogorski A,Moir S,Gadina M,McCoy P,Wesley R,Rother KI,Rother K,Hildebrand PW,Brogan P,Kr?ger E,Aksentijevich I,Goldbach-Mansky R

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
PLoS genetics10(2)e1004151(2014 Feb)
Tuncel J,Haag S,Yau AC,Norin U,Baud A,L?nnblom E,Maratou K,Ytterberg AJ,Ekman D,Thordardottir S,Johannesson M,Gillett A,,Stridh P,Jagodic M,Olsson T,Fern?ndez-Teruel A,Zubarev RA,Mott R,Aitman TJ,Flint J,Holmdahl R

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.
Cell153(5)1012-24(2013 May)
Qian MX,Pang Y,Liu CH,Haratake K,Du BY,Ji DY,Wang GF,Zhu QQ,Song W,Yu Y,Zhang XX,Huang HT,Miao S,Chen LB,Zhang ZH,Liang YN,Liu S,Cha H,Yang D,Zhai Y,Komatsu T,Tsuruta F,Li H,Cao C,Li W,Li GH,Cheng Y,Chiba T,Wang L,Goldberg AL,Shen Y,Qiu XB

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.
The Journal of clinical investigation121(10)4150-60(2011 Oct)
Kitamura A,Maekawa Y,Uehara H,Izumi K,Kawachi I,Nishizawa M,Toyoshima Y,Takahashi H,Standley DM,Tanaka K,Hamazaki J,Murata S,Obara K,Toyoshima I,Yasutomo K

Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.
Cellular immunology266(1)83-9(2010)
Melnikova VI,Sharova NP,Maslova EV,Voronova SN,Zakharova LA

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Psmb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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