Psmb9 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmb9
Entrez Gene ID	24967
Full Name	proteasome subunit beta 9
Synonyms	Lmp2
General protein information	Preferred Names proteasome subunit beta 9 Names proteasome subunit beta type-9 RING12 protein large multifunctional protease 2 low molecular mass polypeptide 2 low molecular mass protein 2 macropain chain 7 multicatalytic endopeptidase complex chain 7 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) proteasome (prosome, macropain) subunit, beta type, 9 proteasome chain 7 proteasome subunit beta-1i proteosome (prosome, macropain) subunit, beta type 9 really interesting new gene 12 protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	subunit of the proteasome complex, which may play a role in protein catabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012708.2	NP_036840.2	proteasome subunit beta type-9

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSMB9	XP_001167429.1
Bos taurus (cattle)	PSMB9	NP_001029560.1
Rattus norvegicus (Norway rat)	Psmb9	NP_036840.2
Xenopus tropicalis (tropical clawed frog)	psmb9	NP_001003660.1
Homo sapiens (human)	PSMB9	NP_002791.1
	PSMB9	XP_001108087.2
Canis lupus familiaris (dog)	PSMB9	NP_001041551.1
Mus musculus (house mouse)	Psmb9	NP_038613.1
Danio rerio (zebrafish)	psmb9a	NP_571466.1

Gene Ontology
Bibliography

Related articles in PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Rother K, Hildebrand PW, Brogan P, Kr?ger E, Aksentijevich I, Goldbach-Mansky R
The Journal of clinical investigation125(11)4196-211(2015 Nov)

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
Tuncel J, Haag S, Yau AC, Norin U, Baud A, L?nnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, , Stridh P, Jagodic M, Olsson T, Fern?ndez-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R
PLoS genetics10(2)e1004151(2014 Feb)

Effects of sterigmatocystin on esophageal epithelium and experimental reflux esophagitis in rats.
Tong PZ, Zhang GJ, Zhang XH, Yan X, Wang JL
Molecular medicine reports8(4)1043-8(2013 Oct)

[Immune proteasomes in the development of rat immune system].
Karpova IaD, Lyupina IuV, Astakhova TM, Stepanova AA, Erokhov PA, Abramova EB, Sharova NP
Bioorganicheskaia khimiia39(4)400-10(2013 Jul-Aug)

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.
Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB
Cell153(5)1012-24(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1.
Title: Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.

LMP7 and LMP2 were detected in thymic epithelial and dendritic cells, in CD68 positive cells (macrophages, monocytes), and in CD90 lymphocytes through pre- and postnatal ontogenesis.
Title: Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.

Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1
Title: Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1.

The following Psmb9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00698	NM_012708.2 Latest version!	Rattus norvegicus proteasome 20S subunit beta 9 (Psmb9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmb9 ( NM_012708.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036840.2 Rattus norvegicus proteasome 20S subunit beta 9 (Psmb9), mRNA.

Price & Availability↑

CloneID	ORa00698
Clone ID Related Accession (Same CDS sequence)	NM_012708.2
Accession Version	NM_012708.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit beta type-9
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP500440.1, BC091161.1 and D10757.1. On Sep 17, 2009 this sequence version replaced NM_012708.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP500440.1, BC091161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCAAG CCGGAGCACC TACCGCCGGC TCTTTCCGGA CGGGAGAAGT CCACACCGGG 
ACAACCATCA TGGCTGTGGA ATTTGACGGG GGTGTCGTGG TGGGCTCTGA TTCCCGAGTG 
TCAGCGGGAG CAGCCGTAGT GAACCGCGTG TTTGACAAGC TCTCCCCTCT GCACCAGCGC 
ATCTACTGTG CCCTCTCGGG TTCCGCTGCT GATGCCCAAG CCATAGCGGA CATGGCCGCC 
TACCAGCTGG AGCTGCACGG GTTGGAACTG GAGGAGCCGC CCCTTGTTCT GGCTGCTGCA 
AACATAGTGA AGAACATCTC CTACAAGTAC CGCGAGGACT TGTTAGCGCA TCTCATGGTA 
GCTGGTTGGG ACCAACGTGA GGGGGGCCAG GTGTATGGAA CCATGGGAGG GATGCTAATT 
CGACAGCCCT TTGCAATCGG TGGTTCCGGA AGCACCTATA TTTACGGTTA TGTGGACGCA 
GCTTATAAAC CAGGCATGAC CCCCGAGGAG TGCCGGCGTT TCACCACAGA CGCCATCACT 
CTGGCCATGA ACCGAGATGG CTCCAGTGGG GGTGTCATCT ACCTGGTCAC CATTACAGCT 
GATGGTGTGG ACCATCGCGT CATCCTGGGA GACGAGCTGC CAAAATTCTA CGATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036840.2
CDS	52..711
Translation	MLQAGAPTAGSFRTGEVHTGTTIMAVEFDGGVVVGSDSRVSAGAAVVNRVFDKLSPLHQRIYCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANIVKNISYKYREDLLAHLMVAGWDQREGGQVYGTMGGMLIRQPFAIGGSGSTYIYGYVDAAYKPGMTPEECRRFTTDAITLAMNRDGSSGGVIYLVTITADGVDHRVILGDELPKFYDE

Target ORF information:

RefSeq Version	NM_012708.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome 20S subunit beta 9 (Psmb9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012708.2

ORF Insert Sequence:

ATGCTGCAAG CCGGAGCACC TACCGCCGGC TCTTTCCGGA CGGGAGAAGT CCACACCGGG 
ACAACCATCA TGGCTGTGGA ATTTGACGGG GGTGTCGTGG TGGGCTCTGA TTCCCGAGTG 
TCAGCGGGAG CAGCCGTAGT GAACCGCGTG TTTGACAAGC TCTCCCCTCT GCACCAGCGC 
ATCTACTGTG CCCTCTCGGG TTCCGCTGCT GATGCCCAAG CCATAGCGGA CATGGCCGCC 
TACCAGCTGG AGCTGCACGG GTTGGAACTG GAGGAGCCGC CCCTTGTTCT GGCTGCTGCA 
AACATAGTGA AGAACATCTC CTACAAGTAC CGCGAGGACT TGTTAGCGCA TCTCATGGTA 
GCTGGTTGGG ACCAACGTGA GGGGGGCCAG GTGTATGGAA CCATGGGAGG GATGCTAATT 
CGACAGCCCT TTGCAATCGG TGGTTCCGGA AGCACCTATA TTTACGGTTA TGTGGACGCA 
GCTTATAAAC CAGGCATGAC CCCCGAGGAG TGCCGGCGTT TCACCACAGA CGCCATCACT 
CTGGCCATGA ACCGAGATGG CTCCAGTGGG GGTGTCATCT ACCTGGTCAC CATTACAGCT 
GATGGTGTGG ACCATCGCGT CATCCTGGGA GACGAGCTGC CAAAATTCTA CGATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
The Journal of clinical investigation125(11)4196-211(2015 Nov)
Brehm A,Liu Y,Sheikh A,Marrero B,Omoyinmi E,Zhou Q,Montealegre G,Biancotto A,Reinhardt A,Almeida de Jesus A,Pelletier M,Tsai WL,Remmers EF,Kardava L,Hill S,Kim H,Lachmann HJ,Megarbane A,Chae JJ,Brady J,Castillo RD,Brown D,Casano AV,Gao L,Chapelle D,Huang Y,Stone D,Chen Y,Sotzny F,Lee CC,Kastner DL,Torrelo A,Zlotogorski A,Moir S,Gadina M,McCoy P,Wesley R,Rother KI,Rother K,Hildebrand PW,Brogan P,Kr?ger E,Aksentijevich I,Goldbach-Mansky R

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
PLoS genetics10(2)e1004151(2014 Feb)
Tuncel J,Haag S,Yau AC,Norin U,Baud A,L?nnblom E,Maratou K,Ytterberg AJ,Ekman D,Thordardottir S,Johannesson M,Gillett A,,Stridh P,Jagodic M,Olsson T,Fern?ndez-Teruel A,Zubarev RA,Mott R,Aitman TJ,Flint J,Holmdahl R

Effects of sterigmatocystin on esophageal epithelium and experimental reflux esophagitis in rats.
Molecular medicine reports8(4)1043-8(2013 Oct)
Tong PZ,Zhang GJ,Zhang XH,Yan X,Wang JL

[Immune proteasomes in the development of rat immune system].
Bioorganicheskaia khimiia39(4)400-10(2013 Jul-Aug)
Karpova IaD,Lyupina IuV,Astakhova TM,Stepanova AA,Erokhov PA,Abramova EB,Sharova NP

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.
Cell153(5)1012-24(2013 May)
Qian MX,Pang Y,Liu CH,Haratake K,Du BY,Ji DY,Wang GF,Zhu QQ,Song W,Yu Y,Zhang XX,Huang HT,Miao S,Chen LB,Zhang ZH,Liang YN,Liu S,Cha H,Yang D,Zhai Y,Komatsu T,Tsuruta F,Li H,Cao C,Li W,Li GH,Cheng Y,Chiba T,Wang L,Goldberg AL,Shen Y,Qiu XB

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Psmb9 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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