Lamp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lamp2
Entrez Gene ID	24944
Full Name	lysosomal-associated membrane protein 2
General protein information	Preferred Names lysosomal-associated membrane protein 2 Names lysosome-associated membrane glycoprotein 2 CD107 antigen-like family member B LAMP-2 LGP-110 LGP-96 LGP-B lysosomal membrane glycoprotein 2 lysosomal membrane glycoprotein type B lysosome-associated membrane protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq35
Summary	intrinsic lysosomal membrane protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006257486.3	XP_006257548.1	lysosome-associated membrane glycoprotein 2 isoform X1
NM_017068.2	NP_058764.2	lysosome-associated membrane glycoprotein 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LAMP2	XP_003317709.1
Rattus norvegicus (Norway rat)	Lamp2	NP_058764.2
Canis lupus familiaris (dog)	LAMP2	XP_005641822.1
Bos taurus (cattle)	LAMP2	NP_001029742.1
Homo sapiens (human)	LAMP2	NP_002285.1
Mus musculus (house mouse)	Lamp2	NP_034815.2
Gallus gallus (chicken)	LAMP2	NP_001001749.1
	LAMP2	XP_001084005.2
Xenopus tropicalis (tropical clawed frog)	lamp2	NP_001116192.2

Gene Ontology
Bibliography

Related articles in PubMed

The lysosomal protein cathepsin L is a progranulin protease.
Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L
Molecular neurodegeneration12(1)55(2017 07)

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.
Yin Y, Li E, Sun G, Yan HQ, Foley LM, Andrzejczuk LA, Attarwala IY, Hitchens TK, Kiselyov K, Dixon CE, Sun D
Molecular neurobiology(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In rat spermatogenic cells AGO2 colocalizes with the lysosomal membrane protein LAMP2 in small vesicles that contact and surround chromatoid bodies.
Title: Argonaute2 Protein in Rat Spermatogenic Cells Is Localized to Nuage Structures and LAMP2-Positive Vesicles Surrounding Chromatoid Bodies.

On prolonged exposure to indomethacin (6-24 h), there was a decrease of LAMP-2 expression in enterocytes coupled with accumulation of ALPs and LDs with fewer autolysosomes in addition to an elevation of lipoapoptosis.
Title: Indomethacin suppresses LAMP-2 expression and induces lipophagy and lipoapoptosis in rat enterocytes via the ER stress pathway.

Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis.
Title: Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis.

Chaperone-mediated autophagy is increased in rats with pilocarpine-induced status epilepticus through upregulation of de novo synthesis of lysosome-associated membrane protein 2a.
Title: Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.

Results show that LAMP-2A organizes at the lysosomal membrane into protein complexes of different sizes.
Title: The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.

The following Lamp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lamp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02695	NM_017068.2 Latest version!	Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa40210	XM_006257486.3 Latest version!	Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lamp2 ( NM_017068.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058764.2 Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), mRNA.

Price & Availability↑

CloneID	ORa02695
Clone ID Related Accession (Same CDS sequence)	NM_017068.2
Accession Version	NM_017068.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	lysosome-associated membrane glycoprotein 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061990.1. On Dec 20, 2003 this sequence version replaced NM_017068.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061990.1, FQ211284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGCGCCTCC TCTCTCCGGT TACGGGCTCG AAGCTCGTCC TGCTCTTTCT GTTCCTGGGA 
GCAGTTCGGT CCGATGCATT GAAACTTAAT TTGACAGATT CAAAGGGTAC TTGCCTTTAT 
GCAGAATGGG AGATGAATTT CACAATAACA TATGAAGCTC TAAAAGTCAA TGAAACTGTA 
ACCATTACAG TGCCTGACAA GGTGACATAC AATGGAAGCA GTTGTGGCGA TGATAAGAAT 
GGTGCCAAAA TAATGATACA ATATGGATCC ACTCTCTCTT GGGCTGTGAA TTTCACCAAG 
GAAGCATCTC AGTATTTTAT TAACAACATC ACGCTTTCTT ACAACACTAA TGATACCAAA 
ACATTTCCTG GTGCTGTACC TAAAGGAATC CTTACTGTTA TCATTCCTGT GGGATCCCAG 
CTTCCATTGG GTGTCATCTT TAAGTGCAGT AGTGTTTTAA CTTTCAACCT GAGTCCTGTT 
GTTCAGCACT ATTGGGGCAT TCACCTGCAA GCTTTTGTCC AAAATGGTAC AGTGAGTAAA 
CATGAACAAG TGTGTAAGGA GGACAAAACT GCTACCACTG TAGCACCCAT CATTCACACC 
ACCGTGCCAT CGCCTACTAC GACACTCACT CCAACTTCAA TACCCGTTCC AACTCCAACG 
GTTGGAAACT ACACCATTTC TAATGGCAAT GCTACCTGTC TGCTGGCTAC CATGGGGCTG 
CAGCTGAACA TCACCGAGGA GAAGGTGCCT TTCATTTTTA ACATCAACCC TGCCACAACC 
AACTTCACCG GCAGCTGTCA GCCCCAAACA GCTCAACTTA GGCTGAACAA CAGCCAAATT 
AAGTATCTCG ACTTTATCTT TGCTGTGAAA AATGAAAAAC GGTTCTATCT GAAGGAAGTG 
AATGTCAACA TGTATTTGGC TAATGGCTCA GCTTTCCATG TTTCAAATAA CAACCTTAGC 
TTCTGGGATG CTCCTCTGGG AAGTTCTTAT ATGTGCAACA AAGAGCAGGT GGTTTCCGTG 
TCTCGAACAT TTCAGATAAA TACCTTTAAC CTGAAGGTGC AACCTTTTAA TGTGACGAAA 
GGAGAGTATT CTACAGCTCA AGACTGCAGT GCAGATGAAG ACAACTTCCT TGTGCCCATA 
GCGGTGGGAG CAGCCCTGGG AGGAGTACTT ATTCTAGTGT TGCTGGCTTA TTTTATTGGT 
CTCAAGCGCC ATCATACTGG ATATGAGCAA TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058764.2
CDS	109..1344
Translation	MRLLSPVTGSKLVLLFLFLGAVRSDALKLNLTDSKGTCLYAEWEMNFTITYEALKVNETVTITVPDKVTYNGSSCGDDKNGAKIMIQYGSTLSWAVNFTKEASQYFINNITLSYNTNDTKTFPGAVPKGILTVIIPVGSQLPLGVIFKCSSVLTFNLSPVVQHYWGIHLQAFVQNGTVSKHEQVCKEDKTATTVAPIIHTTVPSPTTTLTPTSIPVPTPTVGNYTISNGNATCLLATMGLQLNITEEKVPFIFNINPATTNFTGSCQPQTAQLRLNNSQIKYLDFIFAVKNEKRFYLKEVNVNMYLANGSAFHVSNNNLSFWDAPLGSSYMCNKEQVVSVSRTFQINTFNLKVQPFNVTKGEYSTAQDCSADEDNFLVPIAVGAALGGVLILVLLAYFIGLKRHHTGYEQF

Target ORF information:

RefSeq Version	NM_017068.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017068.2

ORF Insert Sequence:

ATGCGCCTCC TCTCTCCGGT TACGGGCTCG AAGCTCGTCC TGCTCTTTCT GTTCCTGGGA 
GCAGTTCGGT CCGATGCATT GAAACTTAAT TTGACAGATT CAAAGGGTAC TTGCCTTTAT 
GCAGAATGGG AGATGAATTT CACAATAACA TATGAAGCTC TAAAAGTCAA TGAAACTGTA 
ACCATTACAG TGCCTGACAA GGTGACATAC AATGGAAGCA GTTGTGGCGA TGATAAGAAT 
GGTGCCAAAA TAATGATACA ATATGGATCC ACTCTCTCTT GGGCTGTGAA TTTCACCAAG 
GAAGCATCTC AGTATTTTAT TAACAACATC ACGCTTTCTT ACAACACTAA TGATACCAAA 
ACATTTCCTG GTGCTGTACC TAAAGGAATC CTTACTGTTA TCATTCCTGT GGGATCCCAG 
CTTCCATTGG GTGTCATCTT TAAGTGCAGT AGTGTTTTAA CTTTCAACCT GAGTCCTGTT 
GTTCAGCACT ATTGGGGCAT TCACCTGCAA GCTTTTGTCC AAAATGGTAC AGTGAGTAAA 
CATGAACAAG TGTGTAAGGA GGACAAAACT GCTACCACTG TAGCACCCAT CATTCACACC 
ACCGTGCCAT CGCCTACTAC GACACTCACT CCAACTTCAA TACCCGTTCC AACTCCAACG 
GTTGGAAACT ACACCATTTC TAATGGCAAT GCTACCTGTC TGCTGGCTAC CATGGGGCTG 
CAGCTGAACA TCACCGAGGA GAAGGTGCCT TTCATTTTTA ACATCAACCC TGCCACAACC 
AACTTCACCG GCAGCTGTCA GCCCCAAACA GCTCAACTTA GGCTGAACAA CAGCCAAATT 
AAGTATCTCG ACTTTATCTT TGCTGTGAAA AATGAAAAAC GGTTCTATCT GAAGGAAGTG 
AATGTCAACA TGTATTTGGC TAATGGCTCA GCTTTCCATG TTTCAAATAA CAACCTTAGC 
TTCTGGGATG CTCCTCTGGG AAGTTCTTAT ATGTGCAACA AAGAGCAGGT GGTTTCCGTG 
TCTCGAACAT TTCAGATAAA TACCTTTAAC CTGAAGGTGC AACCTTTTAA TGTGACGAAA 
GGAGAGTATT CTACAGCTCA AGACTGCAGT GCAGATGAAG ACAACTTCCT TGTGCCCATA 
GCGGTGGGAG CAGCCCTGGG AGGAGTACTT ATTCTAGTGT TGCTGGCTTA TTTTATTGGT 
CTCAAGCGCC ATCATACTGG ATATGAGCAA TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lamp2 ( XM_006257486.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257548.1 Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa40210
Clone ID Related Accession (Same CDS sequence)	XM_006257486.3
Accession Version	XM_006257486.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	lysosome-associated membrane glycoprotein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006257486.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCCTCC TCTCTCCGGT TACGGGCTCG AAGCTCGTCC TGCTCTTTCT GTTCCTGGGA 
GCAGTTCGGT CCGATGCATT GAAACTTAAT TTGACAGATT CAAAGGGTAC TTGCCTTTAT 
GCAGAATGGG AGATGAATTT CACAATAACA TATGAAGCTC TAAAAGTCAA TGAAACTGTA 
ACCATTACAG TGCCTGACAA GGTGACATAC AATGGAAGCA GTTGTGGCGA TGATAAGAAT 
GGTGCCAAAA TAATGATACA ATATGGATCC ACTCTCTCTT GGGCTGTGAA TTTCACCAAG 
GAAGCATCTC AGTATTTTAT TAACAACATC ACGCTTTCTT ACAACACTAA TGATACCAAA 
ACATTTCCTG GTGCTGTACC TAAAGGAATC CTTACTGTTA TCATTCCTGT GGGATCCCAG 
CTTCCATTGG GTGTCATCTT TAAGTGCAGT AGTGTTTTAA CTTTCAACCT GAGTCCTGTT 
GTTCAGCACT ATTGGGGCAT TCACCTGCAA GCTTTTGTCC AAAATGGTAC AGTGAGTAAA 
CATGAACAAG TGTGTAAGGA GGACAAAACT GCTACCACTG TAGCACCCAT CATTCACACC 
ACCGTGCCAT CGCCTACTAC GACACTCACT CCAACTTCAA TACCCGTTCC AACTCCAACG 
GTTGGAAACT ACACCATTTC TAATGGCAAT GCTACCTGTC TGCTGGCTAC CATGGGGCTG 
CAGCTGAACA TCACCGAGGA GAAGGTGCCT TTCATTTTTA ACATCAACCC TGCCATAACC 
AACTTCACCG GCAGCTGTCA GCCCCAAACA GCTCAACTTA GGCTGAACAA CAGCCAAATT 
AAGTATCTCG ACTTTATCTT TGCTGTGAAA AATGAAAAAC GGTTCTATCT GAAGGAAGTG 
AATGTCAACA TGTATTTGGC TAATGGCTCA GCTTTCCATG TTTCAAATAA CAACCTTAGC 
TTCTGGGATG CTCCTCTGGG AAGTTCTTAT ATGTGCAACA AAGAGCAGGT GGTTTCCGTG 
TCTCGAACAT TTCAGATAAA TACCTTTAAC CTGAAGGTGC AACCTTTTAA TGTGACGAAA 
GGAGAGTATT CTACAGCCCA GGAGTGTTCG CTGGATGATG ACACCATTCT AATACCAATT 
ATAGTTGGTG CTGGTCTTTC AGGCTTGATT ATCGTTATAG TGATTGCTTA CCTAATTGGC 
AGAAGAAAGA CTTATGCTGG ATATCAGACT CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257548.1
CDS	144..1379
Translation	MRLLSPVTGSKLVLLFLFLGAVRSDALKLNLTDSKGTCLYAEWEMNFTITYEALKVNETVTITVPDKVTYNGSSCGDDKNGAKIMIQYGSTLSWAVNFTKEASQYFINNITLSYNTNDTKTFPGAVPKGILTVIIPVGSQLPLGVIFKCSSVLTFNLSPVVQHYWGIHLQAFVQNGTVSKHEQVCKEDKTATTVAPIIHTTVPSPTTTLTPTSIPVPTPTVGNYTISNGNATCLLATMGLQLNITEEKVPFIFNINPAITNFTGSCQPQTAQLRLNNSQIKYLDFIFAVKNEKRFYLKEVNVNMYLANGSAFHVSNNNLSFWDAPLGSSYMCNKEQVVSVSRTFQINTFNLKVQPFNVTKGEYSTAQECSLDDDTILIPIIVGAGLSGLIIVIVIAYLIGRRKTYAGYQTL

Target ORF information:

RefSeq Version	XM_006257486.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006257486.3

ORF Insert Sequence:

ATGCGCCTCC TCTCTCCGGT TACGGGCTCG AAGCTCGTCC TGCTCTTTCT GTTCCTGGGA 
GCAGTTCGGT CCGATGCATT GAAACTTAAT TTGACAGATT CAAAGGGTAC TTGCCTTTAT 
GCAGAATGGG AGATGAATTT CACAATAACA TATGAAGCTC TAAAAGTCAA TGAAACTGTA 
ACCATTACAG TGCCTGACAA GGTGACATAC AATGGAAGCA GTTGTGGCGA TGATAAGAAT 
GGTGCCAAAA TAATGATACA ATATGGATCC ACTCTCTCTT GGGCTGTGAA TTTCACCAAG 
GAAGCATCTC AGTATTTTAT TAACAACATC ACGCTTTCTT ACAACACTAA TGATACCAAA 
ACATTTCCTG GTGCTGTACC TAAAGGAATC CTTACTGTTA TCATTCCTGT GGGATCCCAG 
CTTCCATTGG GTGTCATCTT TAAGTGCAGT AGTGTTTTAA CTTTCAACCT GAGTCCTGTT 
GTTCAGCACT ATTGGGGCAT TCACCTGCAA GCTTTTGTCC AAAATGGTAC AGTGAGTAAA 
CATGAACAAG TGTGTAAGGA GGACAAAACT GCTACCACTG TAGCACCCAT CATTCACACC 
ACCGTGCCAT CGCCTACTAC GACACTCACT CCAACTTCAA TACCCGTTCC AACTCCAACG 
GTTGGAAACT ACACCATTTC TAATGGCAAT GCTACCTGTC TGCTGGCTAC CATGGGGCTG 
CAGCTGAACA TCACCGAGGA GAAGGTGCCT TTCATTTTTA ACATCAACCC TGCCATAACC 
AACTTCACCG GCAGCTGTCA GCCCCAAACA GCTCAACTTA GGCTGAACAA CAGCCAAATT 
AAGTATCTCG ACTTTATCTT TGCTGTGAAA AATGAAAAAC GGTTCTATCT GAAGGAAGTG 
AATGTCAACA TGTATTTGGC TAATGGCTCA GCTTTCCATG TTTCAAATAA CAACCTTAGC 
TTCTGGGATG CTCCTCTGGG AAGTTCTTAT ATGTGCAACA AAGAGCAGGT GGTTTCCGTG 
TCTCGAACAT TTCAGATAAA TACCTTTAAC CTGAAGGTGC AACCTTTTAA TGTGACGAAA 
GGAGAGTATT CTACAGCCCA GGAGTGTTCG CTGGATGATG ACACCATTCT AATACCAATT 
ATAGTTGGTG CTGGTCTTTC AGGCTTGATT ATCGTTATAG TGATTGCTTA CCTAATTGGC 
AGAAGAAAGA CTTATGCTGG ATATCAGACT CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The lysosomal protein cathepsin L is a progranulin protease.
Molecular neurodegeneration12(1)55(2017 07)
Lee CW,Stankowski JN,Chew J,Cook CN,Lam YW,Almeida S,Carlomagno Y,Lau KF,Prudencio M,Gao FB,Bogyo M,Dickson DW,Petrucelli L

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.
Molecular neurobiology(2017 Apr)
Yin Y,Li E,Sun G,Yan HQ,Foley LM,Andrzejczuk LA,Attarwala IY,Hitchens TK,Kiselyov K,Dixon CE,Sun D

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Lamp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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