Klrk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klrk1
Entrez Gene ID	24934
Full Name	killer cell lectin like receptor K1
Synonyms	NKG2D,Nkrp2
General protein information	Preferred Names killer cell lectin like receptor K1 Names NKG2-D type II integral membrane protein NK cell receptor D NK lectin-like receptor NKG2-D-activating NK receptor NKLLR NKR-P2, ortholog of human NKG2D killer cell lectin-like receptor subfamily K, member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237075.3	XP_006237137.1	NKG2-D type II integral membrane protein isoform X2
XM_006237073.2	XP_006237135.1	NKG2-D type II integral membrane protein isoform X1
XM_006237074.3	XP_006237136.1	NKG2-D type II integral membrane protein isoform X2
XM_006237076.3	XP_006237138.1	NKG2-D type II integral membrane protein isoform X2
XM_006237077.3	XP_006237139.1	NKG2-D type II integral membrane protein isoform X3
NM_133512.2	NP_598196.1	NKG2-D type II integral membrane protein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Klrk1	NP_598196.1
	NKG2D	NP_001028061.1
Bos taurus (cattle)	KLRK1	NP_001068607.1
Mus musculus (house mouse)	Klrk1	NP_149069.1
Pan troglodytes (chimpanzee)	KLRK1	NP_001009059.1
Canis lupus familiaris (dog)	KLRK1	XP_005637217.1

Gene Ontology
Bibliography

Related articles in PubMed

NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model.
Shen B, Li J, Yang B
Transplantation proceedings45(6)2513-6(2013 Jul-Aug)

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, Jiang M, Wu Y, Xu T, Cao X
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Serrano-Pertierra E, Cernuda-Moroll?n E, L?pez-Larrea C
European journal of immunology42(8)2142-51(2012 Aug)

Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
Wai LE, Garcia JA, Martinez OM, Krams SM
Journal of immunology (Baltimore, Md. : 1950)186(1)222-9(2011 Jan)

Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
Zhuo M, Fujiki M, Wang M, Piard-Ruster K, Wai LE, Wei L, Martinez OM, Krams SM
European journal of immunology40(6)1748-57(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Blockade of NKG2D significantly attenuated ischemia-reperfusion injury in a cardiac transplantation model.
Title: NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model.

Natural killer (NK) cell-activating receptor NKG2D is important for NK-mediated killing of hepatoma McA tumor cells; NK cell cytotoxicity against McA-RH7777 is mediated by both NKp30 and NKG2D.
Title: Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.

the splice forms of NKG2D arise from alternative promoters and that the NKG2D-L promoter is derived from a B1 retrotransposon.
Title: Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion.

In vitro cytotoxic assays reveal that a subset of rat monocytes/macrophages expressing both CD4 and CD8 antigens can kill certain tumor cells in a cell-cell contact-dependent manner through recognition of NKG2D ligands.
Title: Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.

A novel role of Irp94 as a ligand for NKR-P2 on DCs, which in turn executes both innate and adaptive immunity, was demonstrated.
Title: The ischemia-responsive protein 94 (Irp94) activates dendritic cells through NK cell receptor protein-2/NK group 2 member D (NKR-P2/NKG2D) leading to their maturation.

The following Klrk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klrk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13224	NM_133512.2 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13224	XM_006237077.3 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa27590	XM_006237073.2 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa27591	XM_006237076.3 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa27591	XM_006237075.3 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa27591	XM_006237074.3 Latest version!	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klrk1 ( NM_133512.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598196.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), mRNA.

Price & Availability↑

CloneID	ORa13224
Clone ID Related Accession (Same CDS sequence)	XM_006237077.3 , NM_133512.2
Accession Version	NM_133512.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FQ241294.1 and AF009511.1. On Jul 25, 2012 this sequence version replaced NM_133512.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ241294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642639 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGAGCAAAT GCCATAATTA TGACCTCAAG CCAGCAAAGT GGGATACTTC TCAAGAGCAT 
CAGAAACAAA GATCTGCACT CCCTACCAGC CGACCTGGAG AGAATGGTAT CATAAGACGA 
AGGTCTTCTA TAGAAGAACT CAAAATATCT CCACTGTTCG TTGTTCGAGT CCTTGTTGCA 
GCCATGACCA TTCGCTTCAC CGTTATCACA TTGACATGGC TTGCTGTTTT CATAACTTTG 
TTATGCAACA AGGAAGTTTC AGTTTCCTCA AGAGAGGGCT ACTGTGGCCC ATGCCCTAAC 
GACTGGATAT GTCACAGAAA CAACTGTTAC CAATTTTTTA ATGAGAACAA AGCCTGGAAC 
CAGAGCCAAG CTTCCTGTTT GTCTCAAAAT TCCAGCCTGC TGAAGATATA CAGTAAAGAA 
GAACAGGATT TCTTAAAGCT GGTTAAGTCC TATCACTGGA TGGGACTAGT CCAGAGCCCA 
GCAAATGGCT CCTGGCAGTG GGAAGATGGC TCCTCTCTAT CACCCAACGA GTTAACACTG 
GTGAAAACAC CAAGCGGAAC CTGTGCTGTC TATGGCTCAA GCTTTAAGGC CTACACAGAA 
GACTGTTCAA ATCCAAACAC ATACATCTGT ATGAAAAGGG CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598196.1
CDS	94..741
Translation	MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	NM_133512.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133512.2

ORF Insert Sequence:

ATGAGCAAAT GCCATAATTA TGACCTCAAG CCAGCAAAGT GGGATACTTC TCAAGAGCAT 
CAGAAACAAA GATCTGCACT CCCTACCAGC CGACCTGGAG AGAATGGTAT CATAAGACGA 
AGGTCTTCTA TAGAAGAACT CAAAATATCT CCACTGTTCG TTGTTCGAGT CCTTGTTGCA 
GCCATGACCA TTCGCTTCAC CGTTATCACA TTGACATGGC TTGCTGTTTT CATAACTTTG 
TTATGCAACA AGGAAGTTTC AGTTTCCTCA AGAGAGGGCT ACTGTGGCCC ATGCCCTAAC 
GACTGGATAT GTCACAGAAA CAACTGTTAC CAATTTTTTA ATGAGAACAA AGCCTGGAAC 
CAGAGCCAAG CTTCCTGTTT GTCTCAAAAT TCCAGCCTGC TGAAGATATA CAGTAAAGAA 
GAACAGGATT TCTTAAAGCT GGTTAAGTCC TATCACTGGA TGGGACTAGT CCAGAGCCCA 
GCAAATGGCT CCTGGCAGTG GGAAGATGGC TCCTCTCTAT CACCCAACGA GTTAACACTG 
GTGAAAACAC CAAGCGGAAC CTGTGCTGTC TATGGCTCAA GCTTTAAGGC CTACACAGAA 
GACTGTTCAA ATCCAAACAC ATACATCTGT ATGAAAAGGG CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrk1 ( XM_006237077.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237139.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X5, mRNA.

Price & Availability↑

CloneID	ORa13224
Clone ID Related Accession (Same CDS sequence)	XM_006237077.3 , NM_133512.2
Accession Version	XM_006237077.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237077.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAT GCCATAATTA TGACCTCAAG CCAGCAAAGT GGGATACTTC TCAAGAGCAT 
CAGAAACAAA GATCTGCACT CCCTACCAGC CGACCTGGAG AGAATGGTAT CATAAGACGA 
AGGTCTTCTA TAGAAGAACT CAAAATATCT CCACTGTTCG TTGTTCGAGT CCTTGTTGCA 
GCCATGACCA TTCGCTTCAC CGTTATCACA TTGACATGGC TTGCTGTTTT CATAACTTTG 
TTATGCAACA AGGAAGTTTC AGTTTCCTCA AGAGAGGGCT ACTGTGGCCC ATGCCCTAAC 
GACTGGATAT GTCACAGAAA CAACTGTTAC CAATTTTTTA ATGAGAACAA AGCCTGGAAC 
CAGAGCCAAG CTTCCTGTTT GTCTCAAAAT TCCAGCCTGC TGAAGATATA CAGTAAAGAA 
GAACAGGATT TCTTAAAGCT GGTTAAGTCC TATCACTGGA TGGGACTAGT CCAGAGCCCA 
GCAAATGGCT CCTGGCAGTG GGAAGATGGC TCCTCTCTAT CACCCAACGA GTTAACACTG 
GTGAAAACAC CAAGCGGAAC CTGTGCTGTC TATGGCTCAA GCTTTAAGGC CTACACAGAA 
GACTGTTCAA ATCCAAACAC ATACATCTGT ATGAAAAGGG CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237139.1
CDS	135..782
Translation	MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	XM_006237077.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237077.3

ORF Insert Sequence:

ATGAGCAAAT GCCATAATTA TGACCTCAAG CCAGCAAAGT GGGATACTTC TCAAGAGCAT 
CAGAAACAAA GATCTGCACT CCCTACCAGC CGACCTGGAG AGAATGGTAT CATAAGACGA 
AGGTCTTCTA TAGAAGAACT CAAAATATCT CCACTGTTCG TTGTTCGAGT CCTTGTTGCA 
GCCATGACCA TTCGCTTCAC CGTTATCACA TTGACATGGC TTGCTGTTTT CATAACTTTG 
TTATGCAACA AGGAAGTTTC AGTTTCCTCA AGAGAGGGCT ACTGTGGCCC ATGCCCTAAC 
GACTGGATAT GTCACAGAAA CAACTGTTAC CAATTTTTTA ATGAGAACAA AGCCTGGAAC 
CAGAGCCAAG CTTCCTGTTT GTCTCAAAAT TCCAGCCTGC TGAAGATATA CAGTAAAGAA 
GAACAGGATT TCTTAAAGCT GGTTAAGTCC TATCACTGGA TGGGACTAGT CCAGAGCCCA 
GCAAATGGCT CCTGGCAGTG GGAAGATGGC TCCTCTCTAT CACCCAACGA GTTAACACTG 
GTGAAAACAC CAAGCGGAAC CTGTGCTGTC TATGGCTCAA GCTTTAAGGC CTACACAGAA 
GACTGTTCAA ATCCAAACAC ATACATCTGT ATGAAAAGGG CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrk1 ( XM_006237073.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237135.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27590
Clone ID Related Accession (Same CDS sequence)	XM_006237073.2
Accession Version	XM_006237073.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006237073.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGGCAT GGGTTCGTGA TCGAAAGTCT CATCACCCAG AGATGAGCAA ATGCCATAAT 
TATGACCTCA AGCCAGCAAA GTGGGATACT TCTCAAGAGC ATCAGAAACA AAGATCTGCA 
CTCCCTACCA GCCGACCTGG AGAGAATGGT ATCATAAGAC GAAGGTCTTC TATAGAAGAA 
CTCAAAATAT CTCCACTGTT CGTTGTTCGA GTCCTTGTTG CAGCCATGAC CATTCGCTTC 
ACCGTTATCA CATTGACATG GCTTGCTGTT TTCATAACTT TGTTATGCAA CAAGGAAGTT 
TCAGTTTCCT CAAGAGAGGG CTACTGTGGC CCATGCCCTA ACGACTGGAT ATGTCACAGA 
AACAACTGTT ACCAATTTTT TAATGAGAAC AAAGCCTGGA ACCAGAGCCA AGCTTCCTGT 
TTGTCTCAAA ATTCCAGCCT GCTGAAGATA TACAGTAAAG AAGAACAGGA TTTCTTAAAG 
CTGGTTAAGT CCTATCACTG GATGGGACTA GTCCAGAGCC CAGCAAATGG CTCCTGGCAG 
TGGGAAGATG GCTCCTCTCT ATCACCCAAC GAGTTAACAC TGGTGAAAAC ACCAAGCGGA 
ACCTGTGCTG TCTATGGCTC AAGCTTTAAG GCCTACACAG AAGACTGTTC AAATCCAAAC 
ACATACATCT GTATGAAAAG GGCAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237135.1
CDS	1234..1923
Translation	MMAWVRDRKSHHPEMSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	XM_006237073.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237073.2

ORF Insert Sequence:

ATGATGGCAT GGGTTCGTGA TCGAAAGTCT CATCACCCAG AGATGAGCAA ATGCCATAAT 
TATGACCTCA AGCCAGCAAA GTGGGATACT TCTCAAGAGC ATCAGAAACA AAGATCTGCA 
CTCCCTACCA GCCGACCTGG AGAGAATGGT ATCATAAGAC GAAGGTCTTC TATAGAAGAA 
CTCAAAATAT CTCCACTGTT CGTTGTTCGA GTCCTTGTTG CAGCCATGAC CATTCGCTTC 
ACCGTTATCA CATTGACATG GCTTGCTGTT TTCATAACTT TGTTATGCAA CAAGGAAGTT 
TCAGTTTCCT CAAGAGAGGG CTACTGTGGC CCATGCCCTA ACGACTGGAT ATGTCACAGA 
AACAACTGTT ACCAATTTTT TAATGAGAAC AAAGCCTGGA ACCAGAGCCA AGCTTCCTGT 
TTGTCTCAAA ATTCCAGCCT GCTGAAGATA TACAGTAAAG AAGAACAGGA TTTCTTAAAG 
CTGGTTAAGT CCTATCACTG GATGGGACTA GTCCAGAGCC CAGCAAATGG CTCCTGGCAG 
TGGGAAGATG GCTCCTCTCT ATCACCCAAC GAGTTAACAC TGGTGAAAAC ACCAAGCGGA 
ACCTGTGCTG TCTATGGCTC AAGCTTTAAG GCCTACACAG AAGACTGTTC AAATCCAAAC 
ACATACATCT GTATGAAAAG GGCAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrk1 ( XM_006237075.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237137.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa27591
Clone ID Related Accession (Same CDS sequence)	XM_006237075.3 , XM_006237074.3 , XM_006237076.3
Accession Version	XM_006237075.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237075.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237137.1
CDS	211..894
Translation	MDLCQLELLPPEMSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	XM_006237075.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237075.3

ORF Insert Sequence:

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrk1 ( XM_006237074.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237136.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa27591
Clone ID Related Accession (Same CDS sequence)	XM_006237075.3 , XM_006237074.3 , XM_006237076.3
Accession Version	XM_006237074.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237074.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237136.1
CDS	1352..2035
Translation	MDLCQLELLPPEMSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	XM_006237074.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237074.3

ORF Insert Sequence:

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrk1 ( XM_006237076.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237138.1 Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa27591
Clone ID Related Accession (Same CDS sequence)	XM_006237075.3 , XM_006237074.3 , XM_006237076.3
Accession Version	XM_006237076.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	NKG2-D type II integral membrane protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237076.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237138.1
CDS	1281..1964
Translation	MDLCQLELLPPEMSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV

Target ORF information:

RefSeq Version	XM_006237076.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor K1 (Klrk1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237076.3

ORF Insert Sequence:

ATGGACTTGT GTCAACTTGA ATTGCTTCCT CCAGAGATGA GCAAATGCCA TAATTATGAC 
CTCAAGCCAG CAAAGTGGGA TACTTCTCAA GAGCATCAGA AACAAAGATC TGCACTCCCT 
ACCAGCCGAC CTGGAGAGAA TGGTATCATA AGACGAAGGT CTTCTATAGA AGAACTCAAA 
ATATCTCCAC TGTTCGTTGT TCGAGTCCTT GTTGCAGCCA TGACCATTCG CTTCACCGTT 
ATCACATTGA CATGGCTTGC TGTTTTCATA ACTTTGTTAT GCAACAAGGA AGTTTCAGTT 
TCCTCAAGAG AGGGCTACTG TGGCCCATGC CCTAACGACT GGATATGTCA CAGAAACAAC 
TGTTACCAAT TTTTTAATGA GAACAAAGCC TGGAACCAGA GCCAAGCTTC CTGTTTGTCT 
CAAAATTCCA GCCTGCTGAA GATATACAGT AAAGAAGAAC AGGATTTCTT AAAGCTGGTT 
AAGTCCTATC ACTGGATGGG ACTAGTCCAG AGCCCAGCAA ATGGCTCCTG GCAGTGGGAA 
GATGGCTCCT CTCTATCACC CAACGAGTTA ACACTGGTGA AAACACCAAG CGGAACCTGT 
GCTGTCTATG GCTCAAGCTT TAAGGCCTAC ACAGAAGACT GTTCAAATCC AAACACATAC 
ATCTGTATGA AAAGGGCAGT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model.
Transplantation proceedings45(6)2513-6(2013 Jul-Aug)
Shen B,Li J,Yang B

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)
Liu J,Liu S,Xia M,Xu S,Wang C,Bao Y,Jiang M,Wu Y,Xu T,Cao X

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
European journal of immunology42(8)2142-51(2012 Aug)
Serrano-Pertierra E,Cernuda-Moroll?n E,L?pez-Larrea C

Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
Journal of immunology (Baltimore, Md. : 1950)186(1)222-9(2011 Jan)
Wai LE,Garcia JA,Martinez OM,Krams SM

Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
European journal of immunology40(6)1748-57(2010 Jun)
Zhuo M,Fujiki M,Wang M,Piard-Ruster K,Wai LE,Wei L,Martinez OM,Krams SM

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Klrk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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