Wnt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Wnt1
Entrez Gene ID	24881
Full Name	Wnt family member 1
Synonyms	Int1
General protein information	Preferred Names Wnt family member 1 Names proto-oncogene Wnt-1 Wingless-type MMTV integration site 1, homolog wingless-related MMTV integration site 1 wingless-type MMTV integration site family, member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	mouse homolog promotes development of midbrain dopaminergic (DA) neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105714.1	NP_001099184.1	proto-oncogene Wnt-1 precursor

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009734	XP_553580.3
Xenopus tropicalis (tropical clawed frog)	LOC100491444	XP_002935152.1
Homo sapiens (human)	WNT1	NP_005421.1
Bos taurus (cattle)	WNT1	NP_001107663.1
Rattus norvegicus (Norway rat)	Wnt1	NP_001099184.1
Drosophila melanogaster (fruit fly)	wg	NP_523502.1
Pan troglodytes (chimpanzee)	WNT1	XP_001159566.1
	WNT1	XP_001105191.1
Canis lupus familiaris (dog)	WNT1	XP_543686.3
Mus musculus (house mouse)	Wnt1	NP_067254.1
Danio rerio (zebrafish)	wnt1	NP_001188327.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation.
Ma J, Huang C, Ma K, Wu YP, Li BX, Sun Y
Molecular medicine reports16(6)9721-9728(2017 Dec)

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)

Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-? expression and hampering miR-17-5p-activated canonical Wnt-?-catenin signaling.
Hasan HF, Abdel-Rafei MK, Galal SM
Biochemistry and cell biology = Biochimie et biologie cellulaire95(3)400-414(2017 Jun)

Wnt1-overexpressing skeletal myoblasts as an improved cell therapy for cardiac repair following myocardial infarction.
Du GQ, Du WJ, Liu JJ, Wang YS, Nie HG, Zhang MM, Yu B
Panminerva medica57(4)153-66(2015 Dec)

Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth.
Dong L, Hao H, Xia L, Liu J, Ti D, Tong C, Hou Q, Han Q, Zhao Y, Liu H, Fu X, Han W
Scientific reports45432(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low WNT1 expression is associated with hepatic fibrosis.
Title: Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-? expression and hampering miR-17-5p-activated canonical Wnt-?-catenin signaling.

Transplantation of Wnt1 SkMs improves rat myocardial function and enhances anti apoptotic properties of both SkMs and cardiomyocytes and upregulation of tissue Cx43 after infarction via the canonical Wnt/beta-catenin signaling activities
Title: Wnt1-overexpressing skeletal myoblasts as an improved cell therapy for cardiac repair following myocardial infarction.

Data show that bone marrow mesenchymal stem cell (BM-MSC)-generated Wnt1a promotes the dermal papilla's ability to induce hair cycling and regeneration.
Title: Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth.

WNT signaling, which is important in developmental processes of the nervous system, plays a critical role in neuropathic pain after sciatic nerve injury and bone cancer in rodents
Title: WNT signaling underlies the pathogenesis of neuropathic pain in rodents.

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein
Title: Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.

The following Wnt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wnt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11235	NM_001105714.1 Latest version!	Rattus norvegicus Wnt family member 1 (Wnt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Wnt1 ( NM_001105714.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099184.1 Rattus norvegicus Wnt family member 1 (Wnt1), mRNA.

Price & Availability↑

CloneID	ORa11235
Clone ID Related Accession (Same CDS sequence)	NM_001105714.1
Accession Version	NM_001105714.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-21
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene Wnt-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474035.2. On or before Oct 3, 2007 this sequence version replaced XM_235639.3, XM_001062385.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00632250, SAMN02642597 [ECO:0000350] ##Evidence-Data-END##

ATGGGGCTCT GGGCGCTGCT GCCCAGCTGG GTTTCTGCTA CGTTGCTACT GGCACTGACC 
GCTCTGCCCG CAGCCCTGGG CGCCAACAGT AGTGGCCGAT GGTGGGGCAT CGTGAACATA 
GCCTCCTCCA CGAACCTGCT GACAGATTCC AAGAGTCTAC AGCTGGTGCT AGAGCCCAGC 
CTGCAGCTAC TGAGCCGCAA GCAGCGACGA CTGATCCGAC AGAACCCGGG GATCCTGCAC 
AGCGTGAGCG GAGGGCTGCA GAGCGCCGTT CGAGAGTGCA AGTGGCAATT CCGAAACCGC 
CGCTGGAACT GCCCCACTGC TCCCGGGCCC CACCTCTTCG GCAAGATCGT CAACCGAGGC 
TGCCGAGAAA CAGCGTTTAT CTTCGCAATC ACCTCCGCCG GGGTCACACA TTCTGTGGCG 
CGCTCCTGCT CCGAAGGCTC CATCGAATCC TGCACCTGCG ACTACAGGCG GCGCGGTCCT 
GGGGGCCCCG ACTGGCACTG GGGGGGTTGC AGCGACAACA TCGATTTCGG TCGCCTCTTC 
GGCCGAGAGT TCGTGGACTC TGGGGAGAAG GGGCGGGACC TACGCTTCCT CATGAACCTT 
CACAATAACG AGGCAGGGCG CACGACCGTG TTCTCTGAGA TGCGCCAAGA GTGCAAATGC 
CACGGGATGT CCGGTTCCTG CACCGTGCGC ACGTGTTGGA TGCGGCTGCC CACACTGCGC 
GCTGTGGGCG ACGTGCTGCG CGACCGCTTC GACGGCGCCT CCCGCGTCCT TTACGGCAAC 
CGAGGCAACA ACCGCGCTTC GCGGGCGGAG CTGCTGCGCC TGGAGCCCGA AGACCCTGCG 
CACAAGCCGC CCTCCCCTCA CGACCTGGTC TACTTCGAGA AATCGCCCAA CTTCTGCACG 
TACAGTGGAC GCCTGGGCAC AGCTGGCACA GCTGGGCGAG CTTGCAACAG CTCATCTCCA 
GCGCTGGACG GCTGCGAGCT GCTGTGCTGT GGCCGAGGCC ATCGCACGCG CACGCAGCGC 
GTCACCGAGC GCTGCAACTG CACCTTCCAC TGGTGCTGCC ACGTCAGCTG CCGCAACTGC 
ACGCACACGC GCGTACTGCA CGAGTGTCTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099184.1
CDS	334..1446
Translation	MGLWALLPSWVSATLLLALTALPAALGANSSGRWWGIVNIASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL

Target ORF information:

RefSeq Version	NM_001105714.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Wnt family member 1 (Wnt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105714.1

ORF Insert Sequence:

ATGGGGCTCT GGGCGCTGCT GCCCAGCTGG GTTTCTGCTA CGTTGCTACT GGCACTGACC 
GCTCTGCCCG CAGCCCTGGG CGCCAACAGT AGTGGCCGAT GGTGGGGCAT CGTGAACATA 
GCCTCCTCCA CGAACCTGCT GACAGATTCC AAGAGTCTAC AGCTGGTGCT AGAGCCCAGC 
CTGCAGCTAC TGAGCCGCAA GCAGCGACGA CTGATCCGAC AGAACCCGGG GATCCTGCAC 
AGCGTGAGCG GAGGGCTGCA GAGCGCCGTT CGAGAGTGCA AGTGGCAATT CCGAAACCGC 
CGCTGGAACT GCCCCACTGC TCCCGGGCCC CACCTCTTCG GCAAGATCGT CAACCGAGGC 
TGCCGAGAAA CAGCGTTTAT CTTCGCAATC ACCTCCGCCG GGGTCACACA TTCTGTGGCG 
CGCTCCTGCT CCGAAGGCTC CATCGAATCC TGCACCTGCG ACTACAGGCG GCGCGGTCCT 
GGGGGCCCCG ACTGGCACTG GGGGGGTTGC AGCGACAACA TCGATTTCGG TCGCCTCTTC 
GGCCGAGAGT TCGTGGACTC TGGGGAGAAG GGGCGGGACC TACGCTTCCT CATGAACCTT 
CACAATAACG AGGCAGGGCG CACGACCGTG TTCTCTGAGA TGCGCCAAGA GTGCAAATGC 
CACGGGATGT CCGGTTCCTG CACCGTGCGC ACGTGTTGGA TGCGGCTGCC CACACTGCGC 
GCTGTGGGCG ACGTGCTGCG CGACCGCTTC GACGGCGCCT CCCGCGTCCT TTACGGCAAC 
CGAGGCAACA ACCGCGCTTC GCGGGCGGAG CTGCTGCGCC TGGAGCCCGA AGACCCTGCG 
CACAAGCCGC CCTCCCCTCA CGACCTGGTC TACTTCGAGA AATCGCCCAA CTTCTGCACG 
TACAGTGGAC GCCTGGGCAC AGCTGGCACA GCTGGGCGAG CTTGCAACAG CTCATCTCCA 
GCGCTGGACG GCTGCGAGCT GCTGTGCTGT GGCCGAGGCC ATCGCACGCG CACGCAGCGC 
GTCACCGAGC GCTGCAACTG CACCTTCCAC TGGTGCTGCC ACGTCAGCTG CCGCAACTGC 
ACGCACACGC GCGTACTGCA CGAGTGTCTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation.
Molecular medicine reports16(6)9721-9728(2017 Dec)
Ma J,Huang C,Ma K,Wu YP,Li BX,Sun Y

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-? expression and hampering miR-17-5p-activated canonical Wnt-?-catenin signaling.
Biochemistry and cell biology = Biochimie et biologie cellulaire95(3)400-414(2017 Jun)
Hasan HF,Abdel-Rafei MK,Galal SM

Wnt1-overexpressing skeletal myoblasts as an improved cell therapy for cardiac repair following myocardial infarction.
Panminerva medica57(4)153-66(2015 Dec)
Du GQ,Du WJ,Liu JJ,Wang YS,Nie HG,Zhang MM,Yu B

Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth.
Scientific reports45432(2014 Jun)
Dong L,Hao H,Xia L,Liu J,Ti D,Tong C,Hou Q,Han Q,Zhao Y,Liu H,Fu X,Han W

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Wnt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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