Vsnl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vsnl1
Entrez Gene ID	24877
Full Name	visinin-like 1
Synonyms	Nvp1,Ratnvp1
General protein information	Preferred Names visinin-like 1 Names visinin-like protein 1 21 kDa CABP NVL-1 NVP-1 VILIP neural visinin-like protein 1 neurocalcin alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q15
Summary	binds calcium; plays a role in calcium dependent signalling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012686.2	NP_036818.2	visinin-like protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VSNL1	XP_001135557.1
Bos taurus (cattle)	VSNL1	NP_776915.1
Rattus norvegicus (Norway rat)	Vsnl1	NP_036818.2
Danio rerio (zebrafish)	vsnl1a	NP_001007367.1
Danio rerio (zebrafish)	vsnl1b	XP_005158647.1
Xenopus tropicalis (tropical clawed frog)	vsnl1	NP_001072326.1
Gallus gallus (chicken)	VSNL1	NP_990586.1
Homo sapiens (human)	VSNL1	NP_003376.2
Mus musculus (house mouse)	Vsnl1	NP_036168.1

Gene Ontology
Bibliography

Related articles in PubMed

Visinin-like peptide 1 in adrenal gland of the rat. Gene expression and its hormonal control.
Trejter M, Hochol A, Tyczewska M, Ziolkowska A, Jopek K, Szyszka M, Malendowicz LK, Rucinski M
Peptides6322-9(2015 Jan)

Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.
Liu M, Yang H, Fang D, Yang JJ, Cai J, Wan Y, Chui DH, Han JS, Xing GG
Pain154(9)1551-68(2013 Sep)

Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology.
Braunewell KH, Dwary AD, Richter F, Trappe K, Zhao C, Giegling I, Sch?nrath K, Rujescu D
Translational psychiatry1e22(2011 Jul)

Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.
Buttgereit J, Qadri F, Monti J, Langenickel TH, Dietz R, Braunewell KH, Bader M
Regulatory peptides161(1-3)51-7(2010 Apr)

Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors.
Zhao C, Anand R, Braunewell KH
Cellular and molecular neurobiology29(2)273-86(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of Vsnl1 in the rat adrenal gland or adrenocortical cells was acutely down regulated by ACTH, while chronic administration of corticotrophin or dexamethasone did not change Vsnl1 mRNA levels.
Title: Visinin-like peptide 1 in adrenal gland of the rat. Gene expression and its hormonal control.

This study demonistrated that Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.
Title: Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.

In dissociated rat hippocampal neurons, VILIP-1 small interfering RNA knockdown decreases cyclic AMP levels and reduces dendrite branching, compared with control-transfected cells. In contrast, VILIP-1 overexpression has the opposite effect.
Title: Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology.

Results show that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B.
Title: Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.

VILIP-1 might provide a novel functional crosstalk between alpha4- and alpha7-containing nAChRs.
Title: Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors.

The following Vsnl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vsnl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12512	NM_012686.2 Latest version!	Rattus norvegicus visinin-like 1 (Vsnl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vsnl1 ( NM_012686.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036818.2 Rattus norvegicus visinin-like 1 (Vsnl1), mRNA.

Price & Availability↑

CloneID	ORa12512
Clone ID Related Accession (Same CDS sequence)	NM_012686.2
Accession Version	NM_012686.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	visinin-like protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092197.1. On Apr 11, 2005 this sequence version replaced NM_012686.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092197.1, D10666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAAAC AGAATAGCAA ACTGGCCCCA GAAGTCATGG AGGACCTGGT GAAGAGCACC 
GAGTTCAATG AGCATGAGCT CAAGCAGTGG TACAAGGGCT TCCTCAAGGA CTGTCCGAGC 
GGGAGGCTGA ATCTCGAAGA GTTCCAGCAG CTCTATGTGA AGTTCTTCCC CTATGGAGAT 
GCCTCCAAGT TCGCTCAGCA CGCCTTCCGC ACCTTCGACA AGAATGGTGA TGGCACCATC 
GACTTCCGAG AGTTCATCTG TGCTCTGTCC ATCACCTCCA GAGGCAGCTT TGAGCAGAAA 
CTGAACTGGG TTTTCAACAT GTATGATCTG GATGGTGACG GCAAGATCAC CAGGGTGGAG 
ATGCTGGAGA TTATCGAGGC TATCTACAAG ATGGTGGGCA CTGTGATCAT GATGAAAATG 
AATGAGGATG GCCTCACGCC AGAACAGCGA GTGGACAAGA TTTTCAGCAA GATGGATAAG 
AACAAAGATG ACCAGATTAC ATTGGATGAA TTCAAAGAAG CTGCAAAAAG CGACCCTTCC 
ATTGTATTAC TCCTGCAGTG CGACATTCAG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036818.2
CDS	232..807
Translation	MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWVFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDPSIVLLLQCDIQK

Target ORF information:

RefSeq Version	NM_012686.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus visinin-like 1 (Vsnl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012686.2

ORF Insert Sequence:

ATGGGGAAAC AGAATAGCAA ACTGGCCCCA GAAGTCATGG AGGACCTGGT GAAGAGCACC 
GAGTTCAATG AGCATGAGCT CAAGCAGTGG TACAAGGGCT TCCTCAAGGA CTGTCCGAGC 
GGGAGGCTGA ATCTCGAAGA GTTCCAGCAG CTCTATGTGA AGTTCTTCCC CTATGGAGAT 
GCCTCCAAGT TCGCTCAGCA CGCCTTCCGC ACCTTCGACA AGAATGGTGA TGGCACCATC 
GACTTCCGAG AGTTCATCTG TGCTCTGTCC ATCACCTCCA GAGGCAGCTT TGAGCAGAAA 
CTGAACTGGG TTTTCAACAT GTATGATCTG GATGGTGACG GCAAGATCAC CAGGGTGGAG 
ATGCTGGAGA TTATCGAGGC TATCTACAAG ATGGTGGGCA CTGTGATCAT GATGAAAATG 
AATGAGGATG GCCTCACGCC AGAACAGCGA GTGGACAAGA TTTTCAGCAA GATGGATAAG 
AACAAAGATG ACCAGATTAC ATTGGATGAA TTCAAAGAAG CTGCAAAAAG CGACCCTTCC 
ATTGTATTAC TCCTGCAGTG CGACATTCAG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Visinin-like peptide 1 in adrenal gland of the rat. Gene expression and its hormonal control.
Peptides6322-9(2015 Jan)
Trejter M,Hochol A,Tyczewska M,Ziolkowska A,Jopek K,Szyszka M,Malendowicz LK,Rucinski M

Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.
Pain154(9)1551-68(2013 Sep)
Liu M,Yang H,Fang D,Yang JJ,Cai J,Wan Y,Chui DH,Han JS,Xing GG

Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology.
Translational psychiatry1e22(2011 Jul)
Braunewell KH,Dwary AD,Richter F,Trappe K,Zhao C,Giegling I,Sch?nrath K,Rujescu D

Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.
Regulatory peptides161(1-3)51-7(2010 Apr)
Buttgereit J,Qadri F,Monti J,Langenickel TH,Dietz R,Braunewell KH,Bader M

Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors.
Cellular and molecular neurobiology29(2)273-86(2009 Mar)
Zhao C,Anand R,Braunewell KH

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Vsnl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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