Vhl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vhl
Entrez Gene ID	24874
Full Name	von Hippel-Lindau tumor suppressor
Synonyms	Vhlh
General protein information	Preferred Names von Hippel-Lindau tumor suppressor Names von Hippel-Lindau disease tumor suppressor pVHL von Hippel-Lindau protein von Hippel-Lindau syndrome homolog von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	may act as a tumor suppressor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_052801.1	NP_434688.1	von Hippel-Lindau disease tumor suppressor

Pathways from BioSystems

Homologies

	LOC701870	XP_001090152.2
Bos taurus (cattle)	VHL	NP_001103489.1
Mus musculus (house mouse)	Vhl	NP_033533.1
Xenopus tropicalis (tropical clawed frog)	vhl	NP_001016367.1
Gallus gallus (chicken)	VHL	XP_414447.3
Homo sapiens (human)	VHL	NP_000542.1
Canis lupus familiaris (dog)	VHL	NP_001008552.1
Rattus norvegicus (Norway rat)	Vhl	NP_434688.1
Danio rerio (zebrafish)	vhl	NP_001074153.1

Gene Ontology
Bibliography

Related articles in PubMed

The Expression of VHL (Von Hippel-Lindau) After Traumatic Spinal Cord Injury and Its Role in Neuronal Apoptosis.
Hao J, Chen X, Fu T, Liu J, Yu M, Han W, He S, Qian R, Zhang F
Neurochemical research41(9)2391-400(2016 Sep)

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.
Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesqui?re B, Giugliano M, Ruiz de Almodovar C, Dewerchin M, Carmeliet P
Cell reports14(11)2653-67(2016 Mar)

Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1? in hypoxic cardiomyocytes.
Jiang X, Zhang D, Zhang H, Huang Y, Teng M
Scientific reports59193(2015 Mar)

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B
Diabetologia57(11)2348-56(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that the change of VHL protein expression was related to neuronal apoptosis after spinal cord injury
Title: The Expression of VHL (Von Hippel-Lindau) After Traumatic Spinal Cord Injury and Its Role in Neuronal Apoptosis.

we observed that microtubule network stabilization downregulated Ran-mediated pVHL nuclear accumulation, which in turn led to the upregulation of HIF-1alpha protein
Title: Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1? in hypoxic cardiomyocytes.

The protein levels of HIF-1alpha were down-regulated through overexpression of pVHL and were up-regulated through knockdown of pVHL in hypoxic cardiomyocytes.
Title: Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.

VHL peptide-delivered MSCs differentiated into neuron-like cells, and that engrafted VHL peptide-delivered marrow stromal cells (MSCs) more recovered the behaviors of the rats than that of nondelivered MSCs.
Title: Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats.

Von Hippel-Lindau protein (VHL) pre-induction by thrombin aggravates glomerulonephritis (GN), and the increase in VHL expression due to Habu snake venom might be involved in accelerating onset of GN.
Title: Modification in the von Hippel-Lindau protein is involved in the progression of experimentally induced rat glomerulonephritis.

The following Vhl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vhl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09147	NM_052801.1 Latest version!	Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vhl ( NM_052801.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_434688.1 Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl), mRNA.

Price & Availability↑

CloneID	ORa09147
Clone ID Related Accession (Same CDS sequence)	NM_052801.1
Accession Version	NM_052801.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	von Hippel-Lindau disease tumor suppressor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U14746.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14746.1, FQ138719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCGGA AGGCAGCTAG TCCAGAGGAG GCAGAAAGGA TGCCGGGCTC TGAAGAGATA 
GAGGCTGGGC GGCCGCGGCC GGTTTTACGC TCTGTGAACT CGCGCGAACC CTCTCAGGTC 
ATCTTCTGCA ACCGCAGCCC GCGCGTCGTG CTGCCTTTGT GGCTCAACTT TGATGGTGAG 
CCTCAGCCCT ACCCGACCTT ACCACCGGGC ACCGGCCGCC GCATCCACAG CTACCGAGGT 
CACCTTTGGC TCTTCAGGGA TGCGGGGACC CATGATGGAC TTCTGGTTAA CCAAACGGAA 
CTGTTTGTGC CATCCCTCAA TGTTGATGGA CAGCCTATTT TTGCCAACAT CACATTGCCA 
GTGTATACCC TGAAAGAGCG GTGCCTTCAG GTTGTACGGA GCCTGGTCAA GCCTGAGAAC 
TACAGGAGGC TGGACATCGT CAGGTCGCTC TATGAAGACT TGGAAGACCA CCCAAATGTG 
CGGAAAGACA TACAGCGGCT GACCCAAGAG CACCTCGAGA ATCAGGCCCT GGGAGAGGAG 
CCTGAAGGAG TCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_434688.1
CDS	120..677
Translation	MPRKAASPEEAERMPGSEEIEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVRKDIQRLTQEHLENQALGEEPEGVH

Target ORF information:

RefSeq Version	NM_052801.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052801.1

ORF Insert Sequence:

ATGCCCCGGA AGGCAGCTAG TCCAGAGGAG GCAGAAAGGA TGCCGGGCTC TGAAGAGATA 
GAGGCTGGGC GGCCGCGGCC GGTTTTACGC TCTGTGAACT CGCGCGAACC CTCTCAGGTC 
ATCTTCTGCA ACCGCAGCCC GCGCGTCGTG CTGCCTTTGT GGCTCAACTT TGATGGTGAG 
CCTCAGCCCT ACCCGACCTT ACCACCGGGC ACCGGCCGCC GCATCCACAG CTACCGAGGT 
CACCTTTGGC TCTTCAGGGA TGCGGGGACC CATGATGGAC TTCTGGTTAA CCAAACGGAA 
CTGTTTGTGC CATCCCTCAA TGTTGATGGA CAGCCTATTT TTGCCAACAT CACATTGCCA 
GTGTATACCC TGAAAGAGCG GTGCCTTCAG GTTGTACGGA GCCTGGTCAA GCCTGAGAAC 
TACAGGAGGC TGGACATCGT CAGGTCGCTC TATGAAGACT TGGAAGACCA CCCAAATGTG 
CGGAAAGACA TACAGCGGCT GACCCAAGAG CACCTCGAGA ATCAGGCCCT GGGAGAGGAG 
CCTGAAGGAG TCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Expression of VHL (Von Hippel-Lindau) After Traumatic Spinal Cord Injury and Its Role in Neuronal Apoptosis.
Neurochemical research41(9)2391-400(2016 Sep)
Hao J,Chen X,Fu T,Liu J,Yu M,Han W,He S,Qian R,Zhang F

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.
Cell reports14(11)2653-67(2016 Mar)
Segura I,Lange C,Knevels E,Moskalyuk A,Pulizzi R,Eelen G,Chaze T,Tudor C,Boulegue C,Holt M,Daelemans D,Matondo M,Ghesqui?re B,Giugliano M,Ruiz de Almodovar C,Dewerchin M,Carmeliet P

Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1? in hypoxic cardiomyocytes.
Scientific reports59193(2015 Mar)
Jiang X,Zhang D,Zhang H,Huang Y,Teng M

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Diabetologia57(11)2348-56(2014 Nov)
Soggia A,Ramond C,Akiyama H,Scharfmann R,Duvillie B

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Vhl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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