Tf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tf
Entrez Gene ID	24825
Full Name	transferrin
Synonyms	Tfn,Trf
General protein information	Preferred Names transferrin Names serotransferrin beta-1 metal-binding globulin liver regeneration-related protein LRRG03 siderophilin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	plays a role iin iron transport and homeostasis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013110.1	NP_001013128.1	serotransferrin precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	tf	NP_001027487.1
Bos taurus (cattle)	TF	NP_803450.2
Rattus norvegicus (Norway rat)	Tf	NP_001013128.1
Mus musculus (house mouse)	Trf	NP_598738.1
Homo sapiens (human)	TF	NP_001054.1
Canis lupus familiaris (dog)	TF	XP_534268.3
Gallus gallus (chicken)	TF	NP_990635.1
Pan troglodytes (chimpanzee)	TF	NP_001138307.1
Danio rerio (zebrafish)	tfa	NP_001015057.1

Gene Ontology
Bibliography

Related articles in PubMed

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
DeGregorio-Rocasolano N, Mart?-Sistac O, Ponce J, Castell?-Ruiz M, Mill?n M, Guirao V, Garc?a-Y?benes I, Salom JB, Ramos-Cabrer P, Alborch E, Lizasoain I, Castillo J, D?valos A, Gasull T
Redox biology15143-158(2017 Dec)

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.
Ji C, Kosman DJ
Journal of neurochemistry133(5)668-83(2015 Jun)

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

Transferrin and thyroid hormone converge in the control of myelinogenesis.
Marziali LN, Garcia CI, Pasquini JM
Experimental neurology265129-41(2015 Mar)

Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.
Ouyang Q, Lizarraga SB, Schmidt M, Yang U, Gong J, Ellisor D, Kauer JA, Morrow EM
Neuron80(1)97-112(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In brain interstitial fluid, transferrin-bound iron and non-transferrin-bound iron (NTBI) exist as potential iron sources
Title: Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.

Transferrin and thyroid hormone converge to regulate oligodendrocyte maturation and myelinogenesis.
Title: Transferrin and thyroid hormone converge in the control of myelinogenesis.

This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment.
Title: ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.

synthesis and secretion of transferrin in rat parotid acinar cells
Title: Transferrin secretory pathways in rat parotid acinar cells.

we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention.
Title: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.

The following Tf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03420	NM_001013110.1 Latest version!	Rattus norvegicus transferrin (Tf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tf ( NM_001013110.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013128.1 Rattus norvegicus transferrin (Tf), mRNA.

Price & Availability↑

CloneID	ORa03420
Clone ID Related Accession (Same CDS sequence)	NM_001013110.1
Accession Version	NM_001013110.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	serotransferrin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087021.1. On Mar 25, 2005 this sequence version replaced NM_017055.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087021.1, D38380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGAGGTTCG CTGTGGGTGC CCTGCTGGCT TGTGCCGCCC TGGGACTGTG TCTGGCTGTC 
CCTGACAAAA CGGTCAAATG GTGCGCAGTG TCTGAGCATG AGAACACCAA GTGTATCAGT 
TTCCGTGACC ACATGAAAAC CGTCCTTCCA GCTGATGGCC CCCGGCTTGC CTGTGTGAAG 
AAAACCTCCT ATCAAGATTG CATCAAGGCC ATTTCTGGAG GTGAAGCTGA TGCCATTACC 
TTGGATGGGG GTTGGGTGTA CGATGCAGGC CTGACTCCCA ACAACCTGAA GCCTGTGGCA 
GCAGAGTTTT ATGGATCACT TGAACATCCA CAGACCCACT ACTTGGCTGT GGCCGTGGTG 
AAGAAGGGAA CAGACTTCCA GCTGAACCAG CTCCAGGGCA AGAAGTCCTG CCACACTGGC 
CTGGGCAGGT CTGCAGGCTG GATTATCCCC ATTGGCTTAC TTTTCTGTAA CTTGCCAGAG 
CCCCGCAAGC CTCTTGAGAA AGCTGTGGCC AGTTTCTTCT CGGGCAGTTG TGTCCCCTGT 
GCAGATCCAG TGGCCTTCCC CCAGCTGTGT CAACTGTGTC CAGGCTGTGG CTGCTCCCCG 
ACTCAACCGT TCTTTGGCTA CGTAGGCGCC TTCAAGTGTC TGAGAGATGG AGGTGGAGAT 
GTGGCCTTTG TCAAGCATAC AACCATATTT GAGGTCTTGC CACAGAAGGC TGACAGGGAT 
CAATATGAGC TGCTCTGCCT TGACAATACC CGCAAGCCAG TGGATCAGTA TGAGGACTGC 
TACCTAGCCC GGATCCCTTC TCATGCTGTT GTGGCTCGAA ATGGAGATGG CAAAGAGGAC 
TTGATCTGGG AGATCCTCAA AGTGGCTCAG GAACACTTTG GCAAAGGCAA ATCAAAAGAC 
TTCCAACTGT TCGGCTCTCC TCTTGGGAAA GACCTGCTGT TTAAGGATTC TGCCTTTGGG 
CTGTTACGGG TGCCCCCAAG GATGGACTAC AGGCTGTACC TCGGCCACAG CTATGTCACT 
GCCATTCGAA ATCAGCGGGA AGGCGTGTGC CCGGAGGGCT CCATCGACAG CGCGCCAGTG 
AAATGGTGTG CACTGAGTCA CCAAGAGAGA GCCAAGTGTG ATGAGTGGAG CGTCAGCAGC 
AATGGGCAGA TAGAGTGTGA GTCAGCAGAG AGCACTGAGG ACTGCATTGA CAAGATTGTG 
AATGGAGAAG CAGATGCCAT GAGCTTGGAT GGAGGTCATG CCTACATAGC AGGCCAGTGT 
GGACTAGTGC CCGTCATGGC AGAGAACTAT GATATCTCTT CGTGTACAAA CCCACAATCA 
GATGTCTTTC CTAAAGGGTA TTATGCCGTG GCTGTGGTGA AGGCATCAGA CTCCAGCATC 
AACTGGAACA ACCTGAAAGG CAAGAAGTCC TGCCATACTG GAGTAGACAG AACCGCCGGC 
TGGAACATCC CTATGGGCCT GCTGTTCAGC AGGATCAACC ACTGCAAGTT CGATGAATTT 
TTCAGTCAAG GCTGTGCTCC TGGCTATAAG AAGAATTCCA CCCTCTGTGA CCTGTGTATT 
GGCCCAGCAA AATGTGCTCC GAACAACAGA GAGGGATATA ATGGTTATAC AGGGGCTTTC 
CAGTGCCTCG TTGAGAAGGG AGACGTAGCC TTTGTGAAGC ACCAGACTGT CCTGGAAAAC 
ACGAACGGAA AGAACACTGC TGCATGGGCT AAGGATCTGA AGCAGGAAGA CTTCCAGCTG 
CTGTGCCCTG ATGGTACCAA GAAGCCTGTA ACCGAGTTCG CCACCTGCCA CCTGGCCCAA 
GCTCCAAACC ATGTTGTGGT CTCACGAAAA GAGAAGGCAG CCCGGGTTAG CACTGTGCTG 
ACTGCCCAGA AGGATTTATT TTGGAAAGGT GACAAGGACT GCACTGGCAA TTTCTGTTTG 
TTCCGGTCTT CCACCAAGGA CCTTCTGTTC AGAGATGACA CCAAGTGTTT GACTAAACTT 
CCAGAAGGTA CCACATATGA AGAGTACTTA GGAGCAGAGT ACTTGCAAGC TGTTGGAAAC 
ATAAGGAAGT GTTCAACCTC ACGACTCCTA GAAGCCTGCA CTTTCCACAA AAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013128.1
CDS	32..2128
Translation	MRFAVGALLACAALGLCLAVPDKTVKWCAVSEHENTKCISFRDHMKTVLPADGPRLACVKKTSYQDCIKAISGGEADAITLDGGWVYDAGLTPNNLKPVAAEFYGSLEHPQTHYLAVAVVKKGTDFQLNQLQGKKSCHTGLGRSAGWIIPIGLLFCNLPEPRKPLEKAVASFFSGSCVPCADPVAFPQLCQLCPGCGCSPTQPFFGYVGAFKCLRDGGGDVAFVKHTTIFEVLPQKADRDQYELLCLDNTRKPVDQYEDCYLARIPSHAVVARNGDGKEDLIWEILKVAQEHFGKGKSKDFQLFGSPLGKDLLFKDSAFGLLRVPPRMDYRLYLGHSYVTAIRNQREGVCPEGSIDSAPVKWCALSHQERAKCDEWSVSSNGQIECESAESTEDCIDKIVNGEADAMSLDGGHAYIAGQCGLVPVMAENYDISSCTNPQSDVFPKGYYAVAVVKASDSSINWNNLKGKKSCHTGVDRTAGWNIPMGLLFSRINHCKFDEFFSQGCAPGYKKNSTLCDLCIGPAKCAPNNREGYNGYTGAFQCLVEKGDVAFVKHQTVLENTNGKNTAAWAKDLKQEDFQLLCPDGTKKPVTEFATCHLAQAPNHVVVSRKEKAARVSTVLTAQKDLFWKGDKDCTGNFCLFRSSTKDLLFRDDTKCLTKLPEGTTYEEYLGAEYLQAVGNIRKCSTSRLLEACTFHKS

Target ORF information:

RefSeq Version	NM_001013110.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transferrin (Tf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013110.1

ORF Insert Sequence:

ATGAGGTTCG CTGTGGGTGC CCTGCTGGCT TGTGCCGCCC TGGGACTGTG TCTGGCTGTC 
CCTGACAAAA CGGTCAAATG GTGCGCAGTG TCTGAGCATG AGAACACCAA GTGTATCAGT 
TTCCGTGACC ACATGAAAAC CGTCCTTCCA GCTGATGGCC CCCGGCTTGC CTGTGTGAAG 
AAAACCTCCT ATCAAGATTG CATCAAGGCC ATTTCTGGAG GTGAAGCTGA TGCCATTACC 
TTGGATGGGG GTTGGGTGTA CGATGCAGGC CTGACTCCCA ACAACCTGAA GCCTGTGGCA 
GCAGAGTTTT ATGGATCACT TGAACATCCA CAGACCCACT ACTTGGCTGT GGCCGTGGTG 
AAGAAGGGAA CAGACTTCCA GCTGAACCAG CTCCAGGGCA AGAAGTCCTG CCACACTGGC 
CTGGGCAGGT CTGCAGGCTG GATTATCCCC ATTGGCTTAC TTTTCTGTAA CTTGCCAGAG 
CCCCGCAAGC CTCTTGAGAA AGCTGTGGCC AGTTTCTTCT CGGGCAGTTG TGTCCCCTGT 
GCAGATCCAG TGGCCTTCCC CCAGCTGTGT CAACTGTGTC CAGGCTGTGG CTGCTCCCCG 
ACTCAACCGT TCTTTGGCTA CGTAGGCGCC TTCAAGTGTC TGAGAGATGG AGGTGGAGAT 
GTGGCCTTTG TCAAGCATAC AACCATATTT GAGGTCTTGC CACAGAAGGC TGACAGGGAT 
CAATATGAGC TGCTCTGCCT TGACAATACC CGCAAGCCAG TGGATCAGTA TGAGGACTGC 
TACCTAGCCC GGATCCCTTC TCATGCTGTT GTGGCTCGAA ATGGAGATGG CAAAGAGGAC 
TTGATCTGGG AGATCCTCAA AGTGGCTCAG GAACACTTTG GCAAAGGCAA ATCAAAAGAC 
TTCCAACTGT TCGGCTCTCC TCTTGGGAAA GACCTGCTGT TTAAGGATTC TGCCTTTGGG 
CTGTTACGGG TGCCCCCAAG GATGGACTAC AGGCTGTACC TCGGCCACAG CTATGTCACT 
GCCATTCGAA ATCAGCGGGA AGGCGTGTGC CCGGAGGGCT CCATCGACAG CGCGCCAGTG 
AAATGGTGTG CACTGAGTCA CCAAGAGAGA GCCAAGTGTG ATGAGTGGAG CGTCAGCAGC 
AATGGGCAGA TAGAGTGTGA GTCAGCAGAG AGCACTGAGG ACTGCATTGA CAAGATTGTG 
AATGGAGAAG CAGATGCCAT GAGCTTGGAT GGAGGTCATG CCTACATAGC AGGCCAGTGT 
GGACTAGTGC CCGTCATGGC AGAGAACTAT GATATCTCTT CGTGTACAAA CCCACAATCA 
GATGTCTTTC CTAAAGGGTA TTATGCCGTG GCTGTGGTGA AGGCATCAGA CTCCAGCATC 
AACTGGAACA ACCTGAAAGG CAAGAAGTCC TGCCATACTG GAGTAGACAG AACCGCCGGC 
TGGAACATCC CTATGGGCCT GCTGTTCAGC AGGATCAACC ACTGCAAGTT CGATGAATTT 
TTCAGTCAAG GCTGTGCTCC TGGCTATAAG AAGAATTCCA CCCTCTGTGA CCTGTGTATT 
GGCCCAGCAA AATGTGCTCC GAACAACAGA GAGGGATATA ATGGTTATAC AGGGGCTTTC 
CAGTGCCTCG TTGAGAAGGG AGACGTAGCC TTTGTGAAGC ACCAGACTGT CCTGGAAAAC 
ACGAACGGAA AGAACACTGC TGCATGGGCT AAGGATCTGA AGCAGGAAGA CTTCCAGCTG 
CTGTGCCCTG ATGGTACCAA GAAGCCTGTA ACCGAGTTCG CCACCTGCCA CCTGGCCCAA 
GCTCCAAACC ATGTTGTGGT CTCACGAAAA GAGAAGGCAG CCCGGGTTAG CACTGTGCTG 
ACTGCCCAGA AGGATTTATT TTGGAAAGGT GACAAGGACT GCACTGGCAA TTTCTGTTTG 
TTCCGGTCTT CCACCAAGGA CCTTCTGTTC AGAGATGACA CCAAGTGTTT GACTAAACTT 
CCAGAAGGTA CCACATATGA AGAGTACTTA GGAGCAGAGT ACTTGCAAGC TGTTGGAAAC 
ATAAGGAAGT GTTCAACCTC ACGACTCCTA GAAGCCTGCA CTTTCCACAA AAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
Redox biology15143-158(2017 Dec)
DeGregorio-Rocasolano N,Mart?-Sistac O,Ponce J,Castell?-Ruiz M,Mill?n M,Guirao V,Garc?a-Y?benes I,Salom JB,Ramos-Cabrer P,Alborch E,Lizasoain I,Castillo J,D?valos A,Gasull T

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.
Journal of neurochemistry133(5)668-83(2015 Jun)
Ji C,Kosman DJ

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

Transferrin and thyroid hormone converge in the control of myelinogenesis.
Experimental neurology265129-41(2015 Mar)
Marziali LN,Garcia CI,Pasquini JM

Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.
Neuron80(1)97-112(2013 Oct)
Ouyang Q,Lizarraga SB,Schmidt M,Yang U,Gong J,Ellisor D,Kauer JA,Morrow EM

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Tf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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