Tbxa2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tbxa2r
Entrez Gene ID	24816
Full Name	thromboxane A2 receptor
General protein information	Preferred Names thromboxane A2 receptor Names thromboxane A2 receptor TXA2-R TXR2 Thromboxane receptor prostanoid TP receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11
Summary	binds thromboxane and induces an increase in cytosolic Ca2+ levels; may play a role renal electrolyte metabolism; may mediate vascular smooth muscle cell contraction and proliferation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017054.1	NP_058750.1	thromboxane A2 receptor
XM_006240846.2	XP_006240908.1	thromboxane A2 receptor isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TBXA2R	XP_542174.1
Gallus gallus (chicken)	TBXA2R	XP_003642889.2
Homo sapiens (human)	TBXA2R	NP_963998.2
Pan troglodytes (chimpanzee)	TBXA2R	XP_524054.1
Mus musculus (house mouse)	Tbxa2r	NP_033351.1
Bos taurus (cattle)	TBXA2R	NP_001161391.1
	LOC721732	XP_001117938.2
Xenopus tropicalis (tropical clawed frog)	tbxa2r	NP_001120295.1
Rattus norvegicus (Norway rat)	Tbxa2r	NP_058750.1

Gene Ontology
Bibliography

Related articles in PubMed

Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells.
Zhao Z, Hu J, Gao X, Liang H, Yu H, Liu S, Liu Z
Oncotarget8(18)30030-30038(2017 May)

Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.
Gariepy H, Zhao J, Levy D
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism37(3)1060-1068(2017 Mar)

Mechanisms Involved in Thromboxane A
Grann M, Comerma-Steffensen S, Arcanjo DD, Simonsen U
Basic & clinical pharmacology & toxicology119 Suppl 386-95(2016 Oct)

?1 -Adrenoceptor activation of PKC-? causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
Zhao Y, Vanhoutte PM, Leung SW
British journal of pharmacology172(14)3687-701(2015 Jul)

Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.
Wang HW, Huang TS, Lo HH, Huang PH, Lin CC, Chang SJ, Liao KH, Tsai CH, Chan CH, Tsai CF, Cheng YC, Chiu YL, Tsai TN, Cheng CC, Cheng SM
Arteriosclerosis, thrombosis, and vascular biology34(4)857-69(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the long-lasting oligemia following cortical spreading depression consists of at least two distinct temporal phases, mediated by preferential actions of COX-1- and COX-2-derived prostanoids: an initial phase mediated by COX-1 that involves TXA2 followed by a later phase, mediated by COX-2 and PGF2alpha.
Title: Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.

Data suggest that thromboxane A2/Tbxa2r-mediated vasoconstriction of intracavernous small penile arteries depends on Ca2+ influx through L-type calcium channels and TRP (transient receptor potential) channels, and ROCK- (Rho kinase)-dependent mechanisms in vascular smooth muscle.
Title: Mechanisms Involved in Thromboxane A

The experiments suggest that in the SHR but not the WKY aorta, alpha1 -adrenoceptor activation desensitizes TP receptors through activation of PKC-epsilon.
Title: ?1 -Adrenoceptor activation of PKC-? causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.

Low-dose TP stimulation constricts the ductus arteriosus with minimal adverse effects at least in rat neonates.
Title: Low-dose thromboxane A2 receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects.

analysis of hypersensitivity to the thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats
Title: Hypersensitivity to thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats.

The following Tbxa2r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbxa2r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02635	NM_017054.1 Latest version!	Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa29806	XM_006240846.2 Latest version!	Rattus norvegicus thromboxane A2 receptor (Tbxa2r), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tbxa2r ( NM_017054.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058750.1 Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA.

Price & Availability↑

CloneID	ORa02635
Clone ID Related Accession (Same CDS sequence)	NM_017054.1
Accession Version	NM_017054.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	thromboxane A2 receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D32080.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D32080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGGCTCA ACAGCACCTC GCTGGGGGCA TGCTTCCGCC CAGTGAACAT CACGCTGCAG 
GAGCGACGTG CCATCGCGTC GCCATGGTTC GCGGCATCCT TCTGCGCACT GGGCCTGGGG 
TCCAACCTGC TGGCGCTGAG TGTGCTGGCC GGGGCGCGAC CTGGGGCGGG ACCCCGCTCC 
TCCTTCCTCG CTTTGCTGTG CGGCCTCGTC CTCACCGACT TCCTGGGGCT GCTGGTCACC 
GGCGCTGTCG TGGCGTCGCA ACACGCCGCC TTGTTGGACT GGCGTGCCAC TGATCCCGGT 
TGCCGCCTTT GCCACTTCAT GGGCGCGGCC ATGGTGTTCT TCGGGCTGTG TCCCCTGCTC 
CTGGGGGCCG CGATGGCTGC AGAGCGCTTC GTGGGCATCA CACGGCCCTT CTCACGACCC 
GCAGCCACGT CGCGCCGCGC CTGGGCCACT GTGGGGCTGG TGTGGGTGGG GGCCGGGACT 
CTCGGGCTGC TGCCACTGCT GGGGCTCGGC CGCTACAGTG TGCAGTACCC CGGCTCCTGG 
TGCTTCTTGA CTCTTGGGGC GGGACGCGGC GACGTGGCCT TCGGGCTCAT GTTTGCTCTC 
CTGGGCAGCG TGTCCGTGGG GCTGTCCCTC CTGCTCAACA CCGTGAGCGT GGCCACGCTC 
TGCCGCGTCT ACCATGCGCG CGAGGCCACA CAGCGCCCCC GGGACTGTGA GGTGGAGATG 
ATGGTTCAGC TCGTAGGCAT CATGGTGGTG GCCACGGTGT GTTGGATGCC CTTGCTGGTC 
TTCATCCTGC AGACCTTGCT GCAGACGCTA CCTGTCATGA GCCCCTCCGG ACAGCTGTTG 
CGGACCACGG AGCGCCAACT GCTCATCTAC CTACGCGTGG CCACATGGAA CCAGATCTTG 
GACCCCTGGG TCTACATCCT CTTCCGTAGG TCCGTGCTTC GACGCCTGCA TCCAAGGTTC 
ACTTCCCAGC TCCAGGCTGT GTCCTTGCAC TCACCCCCCA CACAGGCCAT GCTCAGTGGA 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058750.1
CDS	385..1410
Translation	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAGRGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP

Target ORF information:

RefSeq Version	NM_017054.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017054.1

ORF Insert Sequence:

ATGTGGCTCA ACAGCACCTC GCTGGGGGCA TGCTTCCGCC CAGTGAACAT CACGCTGCAG 
GAGCGACGTG CCATCGCGTC GCCATGGTTC GCGGCATCCT TCTGCGCACT GGGCCTGGGG 
TCCAACCTGC TGGCGCTGAG TGTGCTGGCC GGGGCGCGAC CTGGGGCGGG ACCCCGCTCC 
TCCTTCCTCG CTTTGCTGTG CGGCCTCGTC CTCACCGACT TCCTGGGGCT GCTGGTCACC 
GGCGCTGTCG TGGCGTCGCA ACACGCCGCC TTGTTGGACT GGCGTGCCAC TGATCCCGGT 
TGCCGCCTTT GCCACTTCAT GGGCGCGGCC ATGGTGTTCT TCGGGCTGTG TCCCCTGCTC 
CTGGGGGCCG CGATGGCTGC AGAGCGCTTC GTGGGCATCA CACGGCCCTT CTCACGACCC 
GCAGCCACGT CGCGCCGCGC CTGGGCCACT GTGGGGCTGG TGTGGGTGGG GGCCGGGACT 
CTCGGGCTGC TGCCACTGCT GGGGCTCGGC CGCTACAGTG TGCAGTACCC CGGCTCCTGG 
TGCTTCTTGA CTCTTGGGGC GGGACGCGGC GACGTGGCCT TCGGGCTCAT GTTTGCTCTC 
CTGGGCAGCG TGTCCGTGGG GCTGTCCCTC CTGCTCAACA CCGTGAGCGT GGCCACGCTC 
TGCCGCGTCT ACCATGCGCG CGAGGCCACA CAGCGCCCCC GGGACTGTGA GGTGGAGATG 
ATGGTTCAGC TCGTAGGCAT CATGGTGGTG GCCACGGTGT GTTGGATGCC CTTGCTGGTC 
TTCATCCTGC AGACCTTGCT GCAGACGCTA CCTGTCATGA GCCCCTCCGG ACAGCTGTTG 
CGGACCACGG AGCGCCAACT GCTCATCTAC CTACGCGTGG CCACATGGAA CCAGATCTTG 
GACCCCTGGG TCTACATCCT CTTCCGTAGG TCCGTGCTTC GACGCCTGCA TCCAAGGTTC 
ACTTCCCAGC TCCAGGCTGT GTCCTTGCAC TCACCCCCCA CACAGGCCAT GCTCAGTGGA 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tbxa2r ( XM_006240846.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240908.1 Rattus norvegicus thromboxane A2 receptor (Tbxa2r), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29806
Clone ID Related Accession (Same CDS sequence)	XM_006240846.2
Accession Version	XM_006240846.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	thromboxane A2 receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240846.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCTCA ACAGCACCTC GCTGGGGGCA TGCTTCCGCC CAGTGAACAT CACGCTGCAG 
GAGCGACGTG CCATCGCGTC GCCATGGTTC GCGGCATCCT TCTGCGCACT GGGCCTGGGG 
TCCAACCTGC TGGCGCTGAG TGTGCTGGCC GGGGCGCGAC CTGGGGCGGG ACCCCGCTCC 
TCCTTCCTCG CTTTGCTGTG CGGCCTCGTC CTCACCGACT TCCTGGGGCT GCTGGTCACC 
GGCGCTGTCG TGGCGTCGCA ACACGCCGCC TTGTTGGACT GGCGTGCCAC TGATCCAGGT 
TGCCGCCTTT GCCACTTCAT GGGCGCGGCC ATGGTGTTCT TCGGGCTGTG TCCCCTGCTC 
CTGGGGGCCG CGATGGCTGC AGAGCGCTTC GTGGGCATCA CACGGCCCTT CTCACGACCC 
GCAGCCACGT CGCGCCGCGC CTGGGCCACT GTGGGGCTGG TGTGGGTGGG GGCCGGGACT 
CTCGGGCTGC TGCCACTGCT GGGGCTCGGC CGCTACAGTG TGCAGTACCC CGGCTCCTGG 
TGCTTCCTGA CTCTTGGGGC GGAGCGCGGC GACGTGGCCT TCGGGCTCAT GTTTGCTCTC 
CTGGGCAGCG TGTCCGTGGG GCTGTCCCTC CTGCTCAACA CCGTGAGCGT GGCCACGCTC 
TGCCGCGTCT ACCATGCGCG CGAGGCCACA CAGCGCCCCC GGGACTGTGA GGTGGAGATG 
ATGGTTCAGC TCGTAGGCAT CATGGTGGTG GCCACGGTGT GTTGGATGCC CTTGCTGGTC 
TTCATCCTGC AGACCTTGCT GCAGACGCTA CCTGTCATGA GCCCCTCCGG ACAGCTGTTG 
CGGACCACGG AGCGCCAACT GCTCATCTAC CTACGCGTGG CCACATGGAA CCAGATCTTG 
GACCCCTGGG TCTACATCCT CTTCCGTAGG TCCGTGCTTC GACGCCTGCA TCCAAGGTTC 
ACTTCCCAGC TCCAGGCTGT GTCCTTGCAC TCACCCCCCA CACAGGCCAT GCTCAGTGGA 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240908.1
CDS	543..1568
Translation	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP

Target ORF information:

RefSeq Version	XM_006240846.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thromboxane A2 receptor (Tbxa2r), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240846.2

ORF Insert Sequence:

ATGTGGCTCA ACAGCACCTC GCTGGGGGCA TGCTTCCGCC CAGTGAACAT CACGCTGCAG 
GAGCGACGTG CCATCGCGTC GCCATGGTTC GCGGCATCCT TCTGCGCACT GGGCCTGGGG 
TCCAACCTGC TGGCGCTGAG TGTGCTGGCC GGGGCGCGAC CTGGGGCGGG ACCCCGCTCC 
TCCTTCCTCG CTTTGCTGTG CGGCCTCGTC CTCACCGACT TCCTGGGGCT GCTGGTCACC 
GGCGCTGTCG TGGCGTCGCA ACACGCCGCC TTGTTGGACT GGCGTGCCAC TGATCCAGGT 
TGCCGCCTTT GCCACTTCAT GGGCGCGGCC ATGGTGTTCT TCGGGCTGTG TCCCCTGCTC 
CTGGGGGCCG CGATGGCTGC AGAGCGCTTC GTGGGCATCA CACGGCCCTT CTCACGACCC 
GCAGCCACGT CGCGCCGCGC CTGGGCCACT GTGGGGCTGG TGTGGGTGGG GGCCGGGACT 
CTCGGGCTGC TGCCACTGCT GGGGCTCGGC CGCTACAGTG TGCAGTACCC CGGCTCCTGG 
TGCTTCCTGA CTCTTGGGGC GGAGCGCGGC GACGTGGCCT TCGGGCTCAT GTTTGCTCTC 
CTGGGCAGCG TGTCCGTGGG GCTGTCCCTC CTGCTCAACA CCGTGAGCGT GGCCACGCTC 
TGCCGCGTCT ACCATGCGCG CGAGGCCACA CAGCGCCCCC GGGACTGTGA GGTGGAGATG 
ATGGTTCAGC TCGTAGGCAT CATGGTGGTG GCCACGGTGT GTTGGATGCC CTTGCTGGTC 
TTCATCCTGC AGACCTTGCT GCAGACGCTA CCTGTCATGA GCCCCTCCGG ACAGCTGTTG 
CGGACCACGG AGCGCCAACT GCTCATCTAC CTACGCGTGG CCACATGGAA CCAGATCTTG 
GACCCCTGGG TCTACATCCT CTTCCGTAGG TCCGTGCTTC GACGCCTGCA TCCAAGGTTC 
ACTTCCCAGC TCCAGGCTGT GTCCTTGCAC TCACCCCCCA CACAGGCCAT GCTCAGTGGA 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells.
Oncotarget8(18)30030-30038(2017 May)
Zhao Z,Hu J,Gao X,Liang H,Yu H,Liu S,Liu Z

Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism37(3)1060-1068(2017 Mar)
Gariepy H,Zhao J,Levy D

Mechanisms Involved in Thromboxane A
Basic & clinical pharmacology & toxicology119 Suppl 386-95(2016 Oct)
Grann M,Comerma-Steffensen S,Arcanjo DD,Simonsen U

?1 -Adrenoceptor activation of PKC-? causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
British journal of pharmacology172(14)3687-701(2015 Jul)
Zhao Y,Vanhoutte PM,Leung SW

Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology34(4)857-69(2014 Apr)
Wang HW,Huang TS,Lo HH,Huang PH,Lin CC,Chang SJ,Liao KH,Tsai CH,Chan CH,Tsai CF,Cheng YC,Chiu YL,Tsai TN,Cheng CC,Cheng SM

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Tbxa2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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