Tac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tac1
Entrez Gene ID	24806
Full Name	tachykinin, precursor 1
Synonyms	PPTA3,Ppt5fl,RATPPTA3,TAC
General protein information	Preferred Names tachykinin, precursor 1 Names protachykinin-1 PPT Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma) tachykinin 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q21
Summary	encodes neuropeptides substance P, neurokinin A, neuropeptide K, and neuropeptide gamma [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001124770.1	NP_001118242.1	protachykinin-1 isoform d precursor
NM_001124769.1	NP_001118241.1	protachykinin-1 isoform c precursor
NM_012666.2	NP_036798.1	protachykinin-1 isoform a precursor
NM_001124768.1	NP_001118240.1	protachykinin-1 isoform b precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TAC1	XP_005628590.1
Bos taurus (cattle)	TAC1	NP_776618.1
Gallus gallus (chicken)	TAC1	XP_418674.2
	TAC1	XP_001089871.1
Rattus norvegicus (Norway rat)	Tac1	NP_036798.1
Danio rerio (zebrafish)	tac1	NP_001243320.1
Pan troglodytes (chimpanzee)	TAC1	XP_001171112.1
Homo sapiens (human)	TAC1	NP_003173.1
Mus musculus (house mouse)	Tac1	NP_033337.1
Xenopus tropicalis (tropical clawed frog)	tac1	NP_001165757.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells.
Mu?oz M, Mu?oz MF, Ayala A
Journal of cellular biochemistry118(12)4686-4696(2017 Dec)

Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
Zhang M, Ahn W, Kim S, Hong HS, Quan C, Son Y
Microcirculation (New York, N.Y. : 1994)24(8)(2017 Nov)

Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation.
Da Silva JT, Evangelista BG, Venega RAG, Oliveira ME, Chacur M
Journal of biological regulators and homeostatic agents31(2)309-319(2017 Apr-Jun)

Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes.
Frara N, Fisher PW, Zhao Y, Tarr JT, Amin M, Popoff SN, Barbe MF
Connective tissue research1-15(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats
Title: Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation.

Inferior alveolar nerve injury did not change the expression of GluA1, GluA2 and CGRP, but increased the expression of TRPV1 and substance P.
Title: Neurochemical effects of photobiostimulation in the trigeminal ganglion after inferior alveolar nerve injury.

the present molecular and immunocytochemistry studies showed that there existed intrinsic substance P (SP) expression in the neurons of intrapancreatic ganglia, which constituted around half of SP origins in the pancreas suggesting that intrapancreatic ganglia might play an important role on mechanisms involving SP.
Title: Substance P expresses in intrapancreatic ganglia of the rats.

The expression and distribution of SP and NK1R along the brain-gut axis in neonatal maternal separation rat.
Title: Expression and distribution of SP and its NK1 receptor in the brain-gut axis in neonatal maternally separated rat model with visceral hypersensitivity.

The findings of this study suggested that there is an increased mobilization of SubP within processes in the RVM shortly after injury accompanied by an increased synthesis of SubP in neurons that project to the RVM.
Title: Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.

The following Tac1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tac1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13561	NM_001124768.1 Latest version!	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa13564	NM_001124770.1 Latest version!	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa13566	NM_012666.2 Latest version!	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa13567	NM_001124769.1 Latest version!	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tac1 ( NM_001124768.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001118240.1 Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa13561
Clone ID Related Accession (Same CDS sequence)	NM_001124768.1
Accession Version	NM_001124768.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	protachykinin-1 isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M34184.1, M14312.1 and AA818532.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M34183.1, CB315982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG GGCATGGTCA GATCTCTCAC 
AAAAGGCATA AAACAGATTC CTTTGTTGGA CTAATGGGCA AAAGAGCTTT AAATTCTGTG 
GCTTATGAAA GAAGCGCAAT GCAGAACTAC GAAAGAAGGC GTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001118240.1
CDS	98..445
Translation	MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK

Target ORF information:

RefSeq Version	NM_001124768.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001124768.1

ORF Insert Sequence:

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG GGCATGGTCA GATCTCTCAC 
AAAAGGCATA AAACAGATTC CTTTGTTGGA CTAATGGGCA AAAGAGCTTT AAATTCTGTG 
GCTTATGAAA GAAGCGCAAT GCAGAACTAC GAAAGAAGGC GTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tac1 ( NM_001124770.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001118242.1 Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	ORa13564
Clone ID Related Accession (Same CDS sequence)	NM_001124770.1
Accession Version	NM_001124770.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	protachykinin-1 isoform d precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M34184.1 and AA818532.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M34184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG ATTCCTCAAT TGAAAAACAA 
GTGGCCCTGT TAAAGGCTCT TTATGGGCAT GGTCAGATCT CTCACAAAAT GGCTTATGAA 
AGAAGCGCAA TGCAGAACTA CGAAAGAAGG CGTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001118242.1
CDS	98..436
Translation	MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKMAYERSAMQNYERRRK

Target ORF information:

RefSeq Version	NM_001124770.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001124770.1

ORF Insert Sequence:

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG ATTCCTCAAT TGAAAAACAA 
GTGGCCCTGT TAAAGGCTCT TTATGGGCAT GGTCAGATCT CTCACAAAAT GGCTTATGAA 
AGAAGCGCAA TGCAGAACTA CGAAAGAAGG CGTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tac1 ( NM_012666.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036798.1 Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa13566
Clone ID Related Accession (Same CDS sequence)	NM_012666.2
Accession Version	NM_012666.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	protachykinin-1 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M15191.1, M34184.1 and AA818532.1. On Apr 30, 2008 this sequence version replaced NM_012666.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M15191.1, CB743638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG ATTCCTCAAT TGAAAAACAA 
GTGGCCCTGT TAAAGGCTCT TTATGGGCAT GGTCAGATCT CTCACAAAAG GCATAAAACA 
GATTCCTTTG TTGGACTAAT GGGCAAAAGA GCTTTAAATT CTGTGGCTTA TGAAAGAAGC 
GCAATGCAGA ACTACGAAAG AAGGCGTAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036798.1
CDS	98..490
Translation	MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK

Target ORF information:

RefSeq Version	NM_012666.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012666.2

ORF Insert Sequence:

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG ATTCCTCAAT TGAAAAACAA 
GTGGCCCTGT TAAAGGCTCT TTATGGGCAT GGTCAGATCT CTCACAAAAG GCATAAAACA 
GATTCCTTTG TTGGACTAAT GGGCAAAAGA GCTTTAAATT CTGTGGCTTA TGAAAGAAGC 
GCAATGCAGA ACTACGAAAG AAGGCGTAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tac1 ( NM_001124769.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001118241.1 Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa13567
Clone ID Related Accession (Same CDS sequence)	NM_001124769.1
Accession Version	NM_001124769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	protachykinin-1 isoform c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M34184.1, X56306.1 and AA818532.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV719350.1, BG671061.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG GGCATGGTCA GATCTCTCAC 
AAAATGGCTT ATGAAAGAAG CGCAATGCAG AACTACGAAA GAAGGCGTAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001118241.1
CDS	98..391
Translation	MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKMAYERSAMQNYERRRK

Target ORF information:

RefSeq Version	NM_001124769.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001124769.1

ORF Insert Sequence:

ATGAAAATCC TCGTGGCGGT GGCGGTCTTT TTTCTCGTTT CCACTCAACT GTTTGCAGAG 
GAAATCGGTG CCAACGATGA TCTAAATTAT TGGTCCGACT GGTCCGACAG TGACCAAATC 
AAGGAGGCAA TGCCGGAGCC CTTTGAGCAT CTTCTTCAGA GAATCGCCCG AAGACCCAAG 
CCTCAGCAGT TCTTTGGATT AATGGGCAAA CGGGATGCTG GGCATGGTCA GATCTCTCAC 
AAAATGGCTT ATGAAAGAAG CGCAATGCAG AACTACGAAA GAAGGCGTAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells.
Journal of cellular biochemistry118(12)4686-4696(2017 Dec)
Mu?oz M,Mu?oz MF,Ayala A

Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
Microcirculation (New York, N.Y. : 1994)24(8)(2017 Nov)
Zhang M,Ahn W,Kim S,Hong HS,Quan C,Son Y

Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation.
Journal of biological regulators and homeostatic agents31(2)309-319(2017 Apr-Jun)
Da Silva JT,Evangelista BG,Venega RAG,Oliveira ME,Chacur M

Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes.
Connective tissue research1-15(2017 Mar)
Frara N,Fisher PW,Zhao Y,Tarr JT,Amin M,Popoff SN,Barbe MF

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Tac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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