Svs4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Svs4
Entrez Gene ID	24802
Full Name	seminal vesicle secretory protein 4
Synonyms	ADP,RNSVSP4U,SVS IV,SVSIV1,Svp4
General protein information	Preferred Names seminal vesicle secretory protein 4 Names seminal vesicle secretory protein 4 SVS protein S Seminal vesicle protein-4 androgen-dependent protein seminal vesicle protein 2 seminal vesicle protein 4 seminal vesicle secretory protein IV
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42
Summary	potent immunomodulatory and anti-inflammatory secretory protein which promotes nitric oxide production [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012662.3	NP_036794.1	seminal vesicle secretory protein 4 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC100909594	XP_006235568.1
Rattus norvegicus (Norway rat)	Svs4	NP_036794.1

Gene Ontology
Bibliography

Related articles in PubMed

Antiapoptotic seminal vesicle protein IV induces histamine release from human FcepsilonRI+ cells.
Prevete N, Rossi FW, Triggiani M, Marone G, de Paulis A, Metafora V, De Maria S, Carten? M, Ragone R, Ravagnan G, Metafora S
International archives of allergy and immunology151(4)318-30(2010)

In vitro stimulatory effect of anti-apoptotic seminal vesicle protein 4 on purified peroxidase enzymes.
Metafora V, Stiuso P, Ferranti P, Giannattasio A, Dicitore A, Ravagnan G, De Maria S, Pontoni G, Carten? M, Metafora S
The FEBS journal275(15)3870-83(2008 Aug)

Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.
Fuggetta MP, Lanzilli G, Cottarelli A, Ravagnan G, Carten? M, De Maria S, Metafora BM, Metafora V, Metafora S
Journal of reproductive immunology78(2)85-93(2008 Jul)

Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle.
Vilasi S, Ragone R
The FEBS journal275(4)763-74(2008 Feb)

The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo.
Morelli F, Peluso G, Petillo O, Giannattasio A, Filosa S, Motta CM, Tammaro S, Zatterale A, Calzone R, Budillon A, Carten? M, de Maria S, Costanza MR, Nigro A, Petrazzuolo M, Buommino E, Rizzo M, Capasso G, Baiano S, Moscatiello F, Ravagnan G, Fuggetta MP, Tajana G, Stiuso P, Metafora BM, Metafora V, Metafora S
Journal of cellular physiology212(3)610-25(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

induces histamine release from human FcepsilonRI+ cells
Title: Antiapoptotic seminal vesicle protein IV induces histamine release from human FcepsilonRI+ cells.

native seminal vesicle protein 4 was shown by spectrophotometric and electrospray-MS analysis to interact with NADPH, an electron donor substrate of the selenium-dependent glutathione peroxidase/glutathione reductase redox system
Title: In vitro stimulatory effect of anti-apoptotic seminal vesicle protein 4 on purified peroxidase enzymes.

findings indicate that seminal vesicle protein IV has a marked in vitro inhibitory effect on natural killer cell, lymphokine-activated killer cell and cytotoxic T lymphocyte cytotoxicity
Title: Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.

Data strongly suggest that SV-IV needs large plasticity to efficiently interact with the different targets that characterize its multifaceted biological function, and should therefore be better classified as an intrinsically disordered protein.
Title: Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle.

Seminal vesicle protein 4 act as a cell survival factor, preventing apoptosis but not cell cycle arrest. May be involved in survival of implanting embryos.
Title: The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo.

The following Svs4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Svs4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa26642	NM_012662.3 Latest version!	Rattus norvegicus seminal vesicle secretory protein 4 (Svs4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Svs4 ( NM_012662.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036794.1 Rattus norvegicus seminal vesicle secretory protein 4 (Svs4), mRNA.

Price & Availability↑

CloneID	ORa26642
Clone ID Related Accession (Same CDS sequence)	NM_012662.3
Accession Version	NM_012662.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	seminal vesicle secretory protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07054533.1. On Dec 2, 2014 this sequence version replaced NM_012662.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA339539.1, CA339495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642699, SAMN02642708 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCTA CCAGCTTGTT CCTCTGTTCT CTGCTCCTCC TTCTAGTGAC AGGAGCCATT 
GGGAGAAAAA CTAAGGAAAA ATACTCACAG TCGGAAGAAG TTGTCAGTGA GAGCTTTGCC 
TCGGGCCCTT CCTCGGGTTC TTCTGATGAA TTAGTGAGAG ACAAGCCATA TGGCCCCAAA 
GTCTCGGGCG GCTCCTTTGG TGAGGAAGCT TCTGAGGAGA TAAGTAGCAG AAGGAGCAAG 
CACATCTCTA GGAGTTCCGG TGGCTCCAAC ATGGAAGGTG AGAGCTCGTA TGCCAAGAAA 
AAGAGGAGCC GGTTTGCCCA AGACGTACTC AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036794.1
CDS	52..387
Translation	MKSTSLFLCSLLLLLVTGAIGRKTKEKYSQSEEVVSESFASGPSSGSSDELVRDKPYGPKVSGGSFGEEASEEISSRRSKHISRSSGGSNMEGESSYAKKKRSRFAQDVLN

Target ORF information:

RefSeq Version	NM_012662.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus seminal vesicle secretory protein 4 (Svs4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012662.3

ORF Insert Sequence:

ATGAAGTCTA CCAGCTTGTT CCTCTGTTCT CTGCTCCTCC TTCTAGTGAC AGGAGCCATT 
GGGAGAAAAA CTAAGGAAAA ATACTCACAG TCGGAAGAAG TTGTCAGTGA GAGCTTTGCC 
TCGGGCCCTT CCTCGGGTTC TTCTGATGAA TTAGTGAGAG ACAAGCCATA TGGCCCCAAA 
GTCTCGGGCG GCTCCTTTGG TGAGGAAGCT TCTGAGGAGA TAAGTAGCAG AAGGAGCAAG 
CACATCTCTA GGAGTTCCGG TGGCTCCAAC ATGGAAGGTG AGAGCTCGTA TGCCAAGAAA 
AAGAGGAGCC GGTTTGCCCA AGACGTACTC AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antiapoptotic seminal vesicle protein IV induces histamine release from human FcepsilonRI+ cells.
International archives of allergy and immunology151(4)318-30(2010)
Prevete N,Rossi FW,Triggiani M,Marone G,de Paulis A,Metafora V,De Maria S,Carten? M,Ragone R,Ravagnan G,Metafora S

In vitro stimulatory effect of anti-apoptotic seminal vesicle protein 4 on purified peroxidase enzymes.
The FEBS journal275(15)3870-83(2008 Aug)
Metafora V,Stiuso P,Ferranti P,Giannattasio A,Dicitore A,Ravagnan G,De Maria S,Pontoni G,Carten? M,Metafora S

Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.
Journal of reproductive immunology78(2)85-93(2008 Jul)
Fuggetta MP,Lanzilli G,Cottarelli A,Ravagnan G,Carten? M,De Maria S,Metafora BM,Metafora V,Metafora S

Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle.
The FEBS journal275(4)763-74(2008 Feb)
Vilasi S,Ragone R

The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo.
Journal of cellular physiology212(3)610-25(2007 Sep)
Morelli F,Peluso G,Petillo O,Giannattasio A,Filosa S,Motta CM,Tammaro S,Zatterale A,Calzone R,Budillon A,Carten? M,de Maria S,Costanza MR,Nigro A,Petrazzuolo M,Buommino E,Rizzo M,Capasso G,Baiano S,Moscatiello F,Ravagnan G,Fuggetta MP,Tajana G,Stiuso P,Metafora BM,Metafora V,Metafora S

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Svs4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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