Serpina3n cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina3n
Entrez Gene ID	24795
Full Name	serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms	CPi-26,SPI3,Spi-2.2,Spin2c,Spin3
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A, member 3N Names serine protease inhibitor A3N SPI-3 contrapsin-like protease inhibitor 6 serine protease inhibitor 2c serine protease inhibitor 3 serpin A3N serpina3n-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	secreted acidic glycoprotein that may act as a serine protease inhibitor; expression is transiently induced during inflammation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031531.1	NP_113719.1	serine protease inhibitor A3N

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SERPINA3-7	NP_001012283.2
Bos taurus (cattle)	LOC784932	XP_002696874.1
Bos taurus (cattle)	SERPINA3	XP_005222351.1
Mus musculus (house mouse)	Serpina3n	NP_033278.2
Homo sapiens (human)	SERPINA3	NP_001076.2
Bos taurus (cattle)	SERPINA3-1	NP_777193.2
Bos taurus (cattle)	SERPINA3-3	NP_001033293.1
Mus musculus (house mouse)	Serpina3c	NP_032484.1
Pan troglodytes (chimpanzee)	SERPINA3	XP_510145.2
Mus musculus (house mouse)	Serpina3k	NP_035588.2
Mus musculus (house mouse)	Serpina3m	NP_033279.2
Rattus norvegicus (Norway rat)	Serpina3n	NP_113719.1
	SERPINA3	XP_001096947.2
Canis lupus familiaris (dog)	SERPINA3	XP_005623829.1
Bos taurus (cattle)	SERPINA3-8	NP_001075181.1

Gene Ontology
Bibliography

Related articles in PubMed

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicu?a L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R
Nature medicine21(5)518-23(2015 May)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration.
Wang GP, Zhang XS, Li YH, Zheng JL, Tang CZ, Zhang WX
Genetics and molecular research : GMR11(3)3175-85(2012 Sep)

Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-?-stimulated HT-29 cells.
Yanaka N, Ohata T, Toya K, Kanda M, Hirata A, Kato N
Molecular nutrition & food research55(4)635-43(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

The sequence of HM448398 was highly homologous to that of rat Serpina3n, suggesting that it may be a homolog of Serpina3n.
Title: Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration.

SPI-3 may be involved during early events of modulating the activities of serine proteases following nerve injury.
Title: Peripheral nerve injury induced expression of mRNA for serine protease inhibitor 3 in the rat facial and hypoglossal nuclei but not in the spinal cord.

The following Serpina3n gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina3n cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08003	NM_031531.1 Latest version!	Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade A, member 3N (Serpina3n), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina3n ( NM_031531.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113719.1 Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade A, member 3N (Serpina3n), mRNA.

Price & Availability↑

CloneID	ORa08003
Clone ID Related Accession (Same CDS sequence)	NM_031531.1
Accession Version	NM_031531.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	serine protease inhibitor A3N
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X16359.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16359.1, FQ209856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGGATGGGA TCGGCTCTGC TCTCCTCTCC TTCCCAGATT GCATACTGGG AGAGGACACT 
CTATTCCATG AAGACCAAGA CAAGGGGACA CAACTGGACA GTCTCACATT GGCCTCCATC 
AATACTGACT TTGCCTTCAG CCTCTACAAG AAGCTGGCTT TGAGGAATCC ACATAAAAAT 
GTTGTCTTCT CCCCACTTAG CATCTCAGCC GCCTTGGCCG TCGTGTCCCT GGGAGCAAAG 
GGCAGCAGCA TGGAAGAGAT TCTAGAAGGT CTCAAGTTCA ATCTCACAGA GACCCCTGAG 
ACAGAAATCC ACCGGGGCTT TGGACACCTC CTCCAGAGGC TCAGCCAGCC AAGGGACGAG 
ATACAGATCA GTACAGGCAA TGCCCTGTTT ATTGAAAAAC GCCTTCAGGT CCTGGCAGAG 
TTCCAGGAGA AGGCAAAGGC TCTGTACCAA GCTGAGGCCT TCACAGCTGA TTTCCAGCAG 
TCTCGTGAGG CCAAAAAGCT CATCAATGAC TATGTGAGTA AACAGACCCA GGGGAAGATC 
CAGGGACTGA TCACAAACCT AGCTAAGAAG ACATCCATGG TACTGGTGAA TTACATCTAC 
TTTAAAGGCA AATGGAAGGT GCCTTTTGAC CCTCGGGACA CATTCCAGTC TGAGTTCTAC 
TCTGGCAAAA GGAGGTCTGT GAAAGTGCCC ATGATGAAGC TTGAGGACCT GACCACACCC 
TACGTCCGGG ATGAGGAGCT GAACTGCACT GTTGTGGAGC TGAAGTACAC AGGAAATGCC 
AGCGCCCTGT TTATCCTCCC TGACCAGGGC AAGATGCAGC AGGTGGAAGC CAGCTTGCAA 
CCAGAGACCC TGAGGAGATG GAAGGACTCT CTCAGGCCCA GCATGATAGA TGAGCTCTAC 
CTGCCCAAGT TCTCCATCTC TGCTGACTAC AACCTGGAGG ACGTCCTTCC AGAGCTGGGC 
ATCAAAGAAG TCTTCTCCAC ACAGGCTGAC CTGTCTGGGA TCACAGGGGA TAAGGACCTG 
ATGGTCTTTC AGGTGGTCCA CAAGGCTGTT CTGGATGTGG CTGAGACAGG CACAGAAGCA 
GCCGCTGCCA CAGGGGTCAA ATTTGTTCCA ATGTCTGCAA AACTGGACCC TCTGATTATA 
GCTTTCGACC GGCCTTTCCT GATGATTATC TCTGACACAG AAACTGCAAT AGCTCCCTTT 
TTGGCCAAGA TATTTAACCC CAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113719.1
CDS	129..1355
Translation	MDGIGSALLSFPDCILGEDTLFHEDQDKGTQLDSLTLASINTDFAFSLYKKLALRNPHKNVVFSPLSISAALAVVSLGAKGSSMEEILEGLKFNLTETPETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQAEAFTADFQQSREAKKLINDYVSKQTQGKIQGLITNLAKKTSMVLVNYIYFKGKWKVPFDPRDTFQSEFYSGKRRSVKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFILPDQGKMQQVEASLQPETLRRWKDSLRPSMIDELYLPKFSISADYNLEDVLPELGIKEVFSTQADLSGITGDKDLMVFQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLDPLIIAFDRPFLMIISDTETAIAPFLAKIFNPK

Target ORF information:

RefSeq Version	NM_031531.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade A, member 3N (Serpina3n), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031531.1

ORF Insert Sequence:

ATGGATGGGA TCGGCTCTGC TCTCCTCTCC TTCCCAGATT GCATACTGGG AGAGGACACT 
CTATTCCATG AAGACCAAGA CAAGGGGACA CAACTGGACA GTCTCACATT GGCCTCCATC 
AATACTGACT TTGCCTTCAG CCTCTACAAG AAGCTGGCTT TGAGGAATCC ACATAAAAAT 
GTTGTCTTCT CCCCACTTAG CATCTCAGCC GCCTTGGCCG TCGTGTCCCT GGGAGCAAAG 
GGCAGCAGCA TGGAAGAGAT TCTAGAAGGT CTCAAGTTCA ATCTCACAGA GACCCCTGAG 
ACAGAAATCC ACCGGGGCTT TGGACACCTC CTCCAGAGGC TCAGCCAGCC AAGGGACGAG 
ATACAGATCA GTACAGGCAA TGCCCTGTTT ATTGAAAAAC GCCTTCAGGT CCTGGCAGAG 
TTCCAGGAGA AGGCAAAGGC TCTGTACCAA GCTGAGGCCT TCACAGCTGA TTTCCAGCAG 
TCTCGTGAGG CCAAAAAGCT CATCAATGAC TATGTGAGTA AACAGACCCA GGGGAAGATC 
CAGGGACTGA TCACAAACCT AGCTAAGAAG ACATCCATGG TACTGGTGAA TTACATCTAC 
TTTAAAGGCA AATGGAAGGT GCCTTTTGAC CCTCGGGACA CATTCCAGTC TGAGTTCTAC 
TCTGGCAAAA GGAGGTCTGT GAAAGTGCCC ATGATGAAGC TTGAGGACCT GACCACACCC 
TACGTCCGGG ATGAGGAGCT GAACTGCACT GTTGTGGAGC TGAAGTACAC AGGAAATGCC 
AGCGCCCTGT TTATCCTCCC TGACCAGGGC AAGATGCAGC AGGTGGAAGC CAGCTTGCAA 
CCAGAGACCC TGAGGAGATG GAAGGACTCT CTCAGGCCCA GCATGATAGA TGAGCTCTAC 
CTGCCCAAGT TCTCCATCTC TGCTGACTAC AACCTGGAGG ACGTCCTTCC AGAGCTGGGC 
ATCAAAGAAG TCTTCTCCAC ACAGGCTGAC CTGTCTGGGA TCACAGGGGA TAAGGACCTG 
ATGGTCTTTC AGGTGGTCCA CAAGGCTGTT CTGGATGTGG CTGAGACAGG CACAGAAGCA 
GCCGCTGCCA CAGGGGTCAA ATTTGTTCCA ATGTCTGCAA AACTGGACCC TCTGATTATA 
GCTTTCGACC GGCCTTTCCT GATGATTATC TCTGACACAG AAACTGCAAT AGCTCCCTTT 
TTGGCCAAGA TATTTAACCC CAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Nature medicine21(5)518-23(2015 May)
Vicu?a L,Strochlic DE,Latremoliere A,Bali KK,Simonetti M,Husainie D,Prokosch S,Riva P,Griffin RS,Njoo C,Gehrig S,Mall MA,Arnold B,Devor M,Woolf CJ,Liberles SD,Costigan M,Kuner R

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration.
Genetics and molecular research : GMR11(3)3175-85(2012 Sep)
Wang GP,Zhang XS,Li YH,Zheng JL,Tang CZ,Zhang WX

Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-?-stimulated HT-29 cells.
Molecular nutrition & food research55(4)635-43(2011 Apr)
Yanaka N,Ohata T,Toya K,Kanda M,Hirata A,Kato N

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Serpina3n cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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