Sod1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sod1
Entrez Gene ID	24786
Full Name	superoxide dismutase 1
Synonyms	CuZnSOD
General protein information	Preferred Names superoxide dismutase 1 Names superoxide dismutase [Cu-Zn] superoxide dismutase 1, soluble
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen; involved in response to oxidative stress [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017050.1	NP_058746.1	superoxide dismutase [Cu-Zn]

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SOD1	NP_001003035.1
Gallus gallus (chicken)	SOD1	NP_990395.1
Anopheles gambiae (African malaria mosquito)	CUSOD3	XP_311594.2
Mus musculus (house mouse)	Sod1	NP_035564.1
Caenorhabditis elegans (roundworm)	sod-5	NP_494779.1
Schizosaccharomyces pombe (fission yeast)	sod1	NP_593163.1
Homo sapiens (human)	SOD1	NP_000445.1
Pan troglodytes (chimpanzee)	SOD1	NP_001009025.1
	SOD1	NP_001027976.1
Rattus norvegicus (Norway rat)	Sod1	NP_058746.1
Caenorhabditis elegans (roundworm)	sod-1	NP_001021956.1
Xenopus tropicalis (tropical clawed frog)	sod1	NP_001016252.1
Bos taurus (cattle)	SOD1	NP_777040.1
Saccharomyces cerevisiae (baker's yeast)	SOD1	NP_012638.1
Kluyveromyces lactis	KLLA0E05567g	XP_454197.1
Magnaporthe oryzae (rice blast fungus)	MGG_02625	XP_003721165.1
Arabidopsis thaliana (thale cress)	CSD1	NP_001077494.1
Danio rerio (zebrafish)	sod1	NP_571369.1
Drosophila melanogaster (fruit fly)	Sod	NP_001261700.1
Eremothecium gossypii	AGOS_AGL321W	NP_986346.2
Neurospora crassa	NCU02133	XP_964291.2
Oryza sativa (rice)	Os03g0351500	NP_001050118.1
Oryza sativa (rice)	Os07g0665200	NP_001060564.1

Gene Ontology
Bibliography

Related articles in PubMed

Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1
Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A
Neurochemical research(2018 Jan)

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ
Human molecular genetics26(23)4668-4679(2017 Dec)

Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice.
Cowley PM, Nair DR, DeRuisseau LR, Keslacy S, Atalay M, DeRuisseau KC
Redox biology13421-425(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.

SOD1 and zinc have roles in methotrexate-induced germ cell toxicity
Title: Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms.

Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA, and Bcl-2 expressions whereas increased COX-2, NF-kappaB, MT, IL-6, and p-ERK levels. SOD1 and GPX5 were decreased in the epididymis of diabetic rat, whereas Zn supplementation attenuated these changes.
Title: Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5.

A motility defect in SOD1-G93A was highly correlated with mitochondrial movement.
Title: Impairment of SOD1-G93A motility is linked to mitochondrial movement in axons of hippocampal neurons.

These results suggest that the superoxide anion may be the cause of the observed oxidative damage to SOD1(G93A) rat neural tissues and that the iron-sulfur clusters may be the source of poorly liganded redox active iron implicated in ALS pathogenesis. Low temperature EPR spectroscopy appears to be a valuable tool in assessing the role of metals in neurodegenerative diseases
Title: Iron-sulfur cluster damage by the superoxide radical in neural tissues of the SOD1(G93A) ALS rat model.

The following Sod1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sod1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12626	NM_017050.1 Latest version!	Rattus norvegicus superoxide dismutase 1 (Sod1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sod1 ( NM_017050.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058746.1 Rattus norvegicus superoxide dismutase 1 (Sod1), mRNA.

Price & Availability↑

CloneID	ORa12626
Clone ID Related Accession (Same CDS sequence)	NM_017050.1
Accession Version	NM_017050.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	superoxide dismutase [Cu-Zn]
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y00404.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y00404.1, CA339871.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATGA AGGCCGTGTG CGTGCTGAAG GGCGACGGTC CGGTGCAGGG CGTCATTCAC 
TTCGAGCAGA AGGCAAGCGG TGAACCAGTT GTGGTGTCAG GACAGATTAC AGGATTAACT 
GAAGGCGAGC ATGGGTTCCA TGTCCATCAA TATGGGGACA ATACACAAGG CTGTACCACT 
GCAGGACCTC ATTTTAATCC TCACTCTAAG AAACATGGCG GTCCAGCGGA TGAAGAGAGG 
CATGTTGGAG ACCTGGGCAA TGTGGCTGCT GGAAAGGACG GTGTGGCCAA TGTGTCCATT 
GAAGATCGTG TGATCTCACT CTCAGGAGAG CATTCCATCA TTGGCCGTAC TATGGTGGTC 
CACGAGAAAC AAGATGACTT GGGCAAAGGT GGAAATGAAG AAAGTACAAA GACTGGAAAT 
GCTGGAAGCC GCTTGGCTTG TGGTGTGATT GGGATTGCCC AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058746.1
CDS	94..558
Translation	MAMKAVCVLKGDGPVQGVIHFEQKASGEPVVVSGQITGLTEGEHGFHVHQYGDNTQGCTTAGPHFNPHSKKHGGPADEERHVGDLGNVAAGKDGVANVSIEDRVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ

Target ORF information:

RefSeq Version	NM_017050.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus superoxide dismutase 1 (Sod1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017050.1

ORF Insert Sequence:

ATGGCGATGA AGGCCGTGTG CGTGCTGAAG GGCGACGGTC CGGTGCAGGG CGTCATTCAC 
TTCGAGCAGA AGGCAAGCGG TGAACCAGTT GTGGTGTCAG GACAGATTAC AGGATTAACT 
GAAGGCGAGC ATGGGTTCCA TGTCCATCAA TATGGGGACA ATACACAAGG CTGTACCACT 
GCAGGACCTC ATTTTAATCC TCACTCTAAG AAACATGGCG GTCCAGCGGA TGAAGAGAGG 
CATGTTGGAG ACCTGGGCAA TGTGGCTGCT GGAAAGGACG GTGTGGCCAA TGTGTCCATT 
GAAGATCGTG TGATCTCACT CTCAGGAGAG CATTCCATCA TTGGCCGTAC TATGGTGGTC 
CACGAGAAAC AAGATGACTT GGGCAAAGGT GGAAATGAAG AAAGTACAAA GACTGGAAAT 
GCTGGAAGCC GCTTGGCTTG TGGTGTGATT GGGATTGCCC AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1
Neurochemical research(2018 Jan)
Kim JM,Billington E,Reyes A,Notarianni T,Sage J,Agbas E,Taylor M,Monast I,Stanford JA,Agbas A

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Human molecular genetics26(23)4668-4679(2017 Dec)
Moller A,Bauer CS,Cohen RN,Webster CP,De Vos KJ

Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice.
Redox biology13421-425(2017 Oct)
Cowley PM,Nair DR,DeRuisseau LR,Keslacy S,Atalay M,DeRuisseau KC

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Sod1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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