Slc9a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc9a3
Entrez Gene ID	24784
Full Name	solute carrier family 9 member A3
Synonyms	Nhe3
General protein information	Preferred Names solute carrier family 9 member A3 Names sodium/hydrogen exchanger 3 NHE-3 Na(+)/H(+) exchanger 3 Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive) plasma membrane ion transport protein solute carrier family 9 (sodium/hydrogen exchanger), member 3 solute carrier family 9 member 3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p11
Summary	displays Na+/H+ exchanger transport activity; mediates sodium ion transport across the renal proximal tubule [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008758677.2	XP_008756899.1	sodium/hydrogen exchanger 3 isoform X1
NM_012654.1	NP_036786.1	sodium/hydrogen exchanger 3 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Slc9a3	NP_036786.1
Gallus gallus (chicken)	SLC9A3	XP_004935132.1
Pan troglodytes (chimpanzee)	SLC9A3	XP_003954578.1
Homo sapiens (human)	SLC9A3	NP_004165.2
Danio rerio (zebrafish)	slc9a3.2	NP_001106951.1
Danio rerio (zebrafish)	slc9a3.1	NP_001106944.1
Xenopus tropicalis (tropical clawed frog)	LOC100492870	XP_004915375.1
Bos taurus (cattle)	SLC9A3	NP_001179083.1
Mus musculus (house mouse)	Slc9a3	NP_001074529.1

Gene Ontology
Bibliography

Related articles in PubMed

The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca
Castelo-Branco RC, Leite-Dellova DCA, Fernandes FB, Malnic G, de Mello-Aires M
American journal of physiology. Renal physiology313(2)F450-F460(2017 Aug)

Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata.
Nishi EE, Martins BS, Milanez MI, Lopes NR, de Melo JF Jr, Pontes RB, Girardi AC, Campos RR, Bergamaschi CT
Autonomic neuroscience : basic & clinical20448-56(2017 May)

Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats.
Linz B, Hohl M, Reil JC, B?hm M, Linz D
Journal of cardiovascular pharmacology67(3)225-31(2016 Mar)

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.
Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, M?ller T
Human molecular genetics24(23)6614-23(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In spontaneously hypertensive rats, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated the hypertension caused by the high plasma level of ANG II.
Title: The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca

Results show that renal afferents leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. When renorenal reflex is induced, NHE3 exchanger activity appears to be decreased, resulting in decreased sodium and water reabsorption in the contralateral kidney.
Title: Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata.

Reduction of intestinal sodium absorption by selective NHE3 inhibition in the gut lowered high blood pressure and reduced LV remodeling without deteriorating renal functional and structural parameters in obese spontaneously hypertensive rats.
Title: Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats.

Increased pendrin in pregnant rats may compensate for the decreased NCC and aid in the renal sodium chloride reabsorption of pregnancy.
Title: The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat.

These findings indicate that biased signaling of the beta-arrestin pathway through the AT1 receptor inhibits NHE3 activity in the proximal tubule at least in part due to changes in NHE3 subcellular localization.
Title: Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.

The following Slc9a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc9a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00544	NM_012654.1 Latest version!	Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa42956	XM_008758677.2 Latest version!	Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc9a3 ( NM_012654.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036786.1 Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA.

Price & Availability↑

CloneID	ORa00544
Clone ID Related Accession (Same CDS sequence)	NM_012654.1
Accession Version	NM_012654.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2496bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	sodium/hydrogen exchanger 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M85300.1. On Dec 17, 2003 this sequence version replaced XM_346529.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M85300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642745 [ECO:0000348] ##Evidence-Data-END##

ATGTGGCACC CGGCTCTGGG ACCAGGGTGG AAGCCGCTGC TGGCGCTGGC CGTGGCCGTG 
ACCAGCCTGC GAGGCGTGAG GGGCATTGAG GAGGAACCGA ACAGTGGTGG GAGCTTCCAG 
ATAGTCACCT TCAAATGGCA CCACGTCCAG GATCCATACA TCATCGCACT CTGGATCCTC 
GTGGCCAGCT TGGCCAAAAT CGTCTTCCAT CTGTCCCACA AGGTCACCAG TGTTGTCCCG 
GAGAGTGCTC TGCTCATCGT TCTGGGCCTG GTGCTGGGCG GCATCGTCTG GGCAGCTGAC 
CACATCGCCT CCTTCACACT CACACCCACA CTCTTCTTCT TCTACCTGCT GCCCCCTATT 
GTGTTGGATG CTGGGTACTT CATGCCCAAT CGACTCTTCT TTGGCAACCT GGGCACCATC 
CTGCTATATG CTGTCATTGG CACTATATGG AACGCAGCTA CCACAGGATT GTCCCTCTAT 
GGTGTCTTCC TCAGTGGCCT GATGGGCGAA CTGAAGATCG GCCTCCTGGA TTTCCTGCTA 
TTTGGCAGCC TCATTGCAGC TGTGGACCCG GTGGCTGTGC TGGCTGTGTT TGAGGAAGTC 
CATGTCAATG AAGTCCTGTT CATCATTGTT TTTGGGGAGT CACTGCTTAA TGACGCGGTG 
ACTGTGGTCT TGTACAATGT GTTTGAGTCT TTCGTGACGC TGGGTGGTGA TGCAGTGACT 
GGCGTGGACT GTGTGAAAGG CATAGTGTCC TTCTTCGTGG TGAGCCTGGG GGGCACTCTG 
GTGGGTGTCA TCTTCGCCTT CCTGCTGTCC TTGGTGACTC GTTTCACCAA GCATGTGCGT 
ATCATCGAGC CTGGCTTCGT CTTTGTCATT TCCTACCTGT CCTATCTGAC CTCCGAGATG 
CTGTCCTTGT CAGCCATCCT GGCCATCACC TTTTGTGGCA TCTGCTGTCA GAAGTACGTG 
AAGGCCAACA TCTCAGAGCA GTCGGCCACC ACCGTGCGCT ACACTATGAA GATGCTGGCA 
AGTGGAGCAG AGACCATTAT CTTCATGTTC CTGGGCATCT CGGCTGTGGA CCCCGTCATC 
TGGACATGGA ACACAGCTTT TGTGTTGCTG ACACTGGTCT TCATTTCTGT ATACCGAGCC 
ATTGGTGTTG TTCTGCAGAC CTGGATCCTG AATCGCTACC GCATGGTGCA GCTAGAGACC 
ATTGACCAGG TGGTCATGTC CTACGGTGGC CTGCGTGGGG CAGTGGCCTA TGCCTTGGTG 
GTACTTCTGG ATGAGAAAAA AGTCAAGGAG AAAAACCTGT TTGTCAGCAC CACTCTCATT 
GTGGTCTTCT TCACAGTCAT CTTTCAGGGC CTGACCATTA AGCCCCTGGT GCAGTGGCTG 
AAGGTGAAGA GGAGCGAGCA GCGTGAGCCG AAGCTCAACG AGAAGCTGCA TGGCCGGGCT 
TTCGACCACA TCCTCTCAGC CATTGAGGAC ATCTCAGGAC AAATTGGACA CAATTACCTC 
AGAGATAAGT GGTCCAATTT TGATAGGAAG TTCCTCAGCA AAGTCCTCAT GAGAAGATCT 
GCTCAAAAAT CTCGAGATCG GATCCTGAAT GTTTTCCATG AGCTGAATTT GAAGGATGCC 
ATTAGCTATG TGGCCGAGGG AGAGCGCCGT GGGTCCCTGG CCTTCATTCG CTCCCCAAGT 
ACGGACAATA TGGTCAATGT GGACTTCAGC ACACCCCGCC CATCTACAGT GGAGGCATCC 
GTCTCCTATT TCTTGAGGGA AAATGTCAGT GCTGTATGCC TGGACATGCA GTCCTTGGAA 
CAGAGGCGGA GGAGCATCCG TGACACCGAG GACATGGTCA CCCACCACAC GTTGCAGCAG 
TACCTCTACA AGCCTCGGCA GGAGTACAAG CATCTCTACA GTCGGCACGA GCTCACACCC 
AATGAGGATG AGAAGCAGGA CAAGGAGATC TTCCACAGGA CCATGCGGAA GCGCCTGGAG 
TCCTTTAAGT CGGCTAAGCT GGGCATCAAC CAGAACAAGA AGGCAGCCAA GCTATATAAG 
AGGGAGCGCG CACAGAAGCG GAGGAATAGC AGCATTCCTA ATGGGAAGCT GCCTATGGAG 
AATCTGGCAC ACAACTTCAC CATCAAGGAG AAAGATTTGG AACTTTCAGA GCCTGAGGAG 
GCCACCAACT ATGAAGAGAT CAGTGGAGGC ATTGAATTTC TGGCCAGCGT CACCAAAGAT 
GTAGCCTCTG ACTCTGGGGC AGGAATTGAT AATCCTGTGT TCTCCCCTGA CGAGGATCTG 
GACCCAAGCA TCCTATCCAG GGTGCCACCC TGGCTGTCCC CTGGGGAGAC TGTGGTGCCC 
TCCCAGAGGG CCCGTGTCCA GATTCCCAAC TCTCCCAGCA ACTTCCGCCG CCTGACTCCA 
TTCCGCCTCA GCAACAAATC AGTGGATTCC TTCCTGCAGG CTGATGGCCC CGAGGAACAG 
CTCCAACCCG CTTCCCCTGA GTCCACACAC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036786.1
CDS	89..2584
Translation	MWHPALGPGWKPLLALAVAVTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM

Target ORF information:

RefSeq Version	NM_012654.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012654.1

ORF Insert Sequence:

ATGTGGCACC CGGCTCTGGG ACCAGGGTGG AAGCCGCTGC TGGCGCTGGC CGTGGCCGTG 
ACCAGCCTGC GAGGCGTGAG GGGCATTGAG GAGGAACCGA ACAGTGGTGG GAGCTTCCAG 
ATAGTCACCT TCAAATGGCA CCACGTCCAG GATCCATACA TCATCGCACT CTGGATCCTC 
GTGGCCAGCT TGGCCAAAAT CGTCTTCCAT CTGTCCCACA AGGTCACCAG TGTTGTCCCG 
GAGAGTGCTC TGCTCATCGT TCTGGGCCTG GTGCTGGGCG GCATCGTCTG GGCAGCTGAC 
CACATCGCCT CCTTCACACT CACACCCACA CTCTTCTTCT TCTACCTGCT GCCCCCTATT 
GTGTTGGATG CTGGGTACTT CATGCCCAAT CGACTCTTCT TTGGCAACCT GGGCACCATC 
CTGCTATATG CTGTCATTGG CACTATATGG AACGCAGCTA CCACAGGATT GTCCCTCTAT 
GGTGTCTTCC TCAGTGGCCT GATGGGCGAA CTGAAGATCG GCCTCCTGGA TTTCCTGCTA 
TTTGGCAGCC TCATTGCAGC TGTGGACCCG GTGGCTGTGC TGGCTGTGTT TGAGGAAGTC 
CATGTCAATG AAGTCCTGTT CATCATTGTT TTTGGGGAGT CACTGCTTAA TGACGCGGTG 
ACTGTGGTCT TGTACAATGT GTTTGAGTCT TTCGTGACGC TGGGTGGTGA TGCAGTGACT 
GGCGTGGACT GTGTGAAAGG CATAGTGTCC TTCTTCGTGG TGAGCCTGGG GGGCACTCTG 
GTGGGTGTCA TCTTCGCCTT CCTGCTGTCC TTGGTGACTC GTTTCACCAA GCATGTGCGT 
ATCATCGAGC CTGGCTTCGT CTTTGTCATT TCCTACCTGT CCTATCTGAC CTCCGAGATG 
CTGTCCTTGT CAGCCATCCT GGCCATCACC TTTTGTGGCA TCTGCTGTCA GAAGTACGTG 
AAGGCCAACA TCTCAGAGCA GTCGGCCACC ACCGTGCGCT ACACTATGAA GATGCTGGCA 
AGTGGAGCAG AGACCATTAT CTTCATGTTC CTGGGCATCT CGGCTGTGGA CCCCGTCATC 
TGGACATGGA ACACAGCTTT TGTGTTGCTG ACACTGGTCT TCATTTCTGT ATACCGAGCC 
ATTGGTGTTG TTCTGCAGAC CTGGATCCTG AATCGCTACC GCATGGTGCA GCTAGAGACC 
ATTGACCAGG TGGTCATGTC CTACGGTGGC CTGCGTGGGG CAGTGGCCTA TGCCTTGGTG 
GTACTTCTGG ATGAGAAAAA AGTCAAGGAG AAAAACCTGT TTGTCAGCAC CACTCTCATT 
GTGGTCTTCT TCACAGTCAT CTTTCAGGGC CTGACCATTA AGCCCCTGGT GCAGTGGCTG 
AAGGTGAAGA GGAGCGAGCA GCGTGAGCCG AAGCTCAACG AGAAGCTGCA TGGCCGGGCT 
TTCGACCACA TCCTCTCAGC CATTGAGGAC ATCTCAGGAC AAATTGGACA CAATTACCTC 
AGAGATAAGT GGTCCAATTT TGATAGGAAG TTCCTCAGCA AAGTCCTCAT GAGAAGATCT 
GCTCAAAAAT CTCGAGATCG GATCCTGAAT GTTTTCCATG AGCTGAATTT GAAGGATGCC 
ATTAGCTATG TGGCCGAGGG AGAGCGCCGT GGGTCCCTGG CCTTCATTCG CTCCCCAAGT 
ACGGACAATA TGGTCAATGT GGACTTCAGC ACACCCCGCC CATCTACAGT GGAGGCATCC 
GTCTCCTATT TCTTGAGGGA AAATGTCAGT GCTGTATGCC TGGACATGCA GTCCTTGGAA 
CAGAGGCGGA GGAGCATCCG TGACACCGAG GACATGGTCA CCCACCACAC GTTGCAGCAG 
TACCTCTACA AGCCTCGGCA GGAGTACAAG CATCTCTACA GTCGGCACGA GCTCACACCC 
AATGAGGATG AGAAGCAGGA CAAGGAGATC TTCCACAGGA CCATGCGGAA GCGCCTGGAG 
TCCTTTAAGT CGGCTAAGCT GGGCATCAAC CAGAACAAGA AGGCAGCCAA GCTATATAAG 
AGGGAGCGCG CACAGAAGCG GAGGAATAGC AGCATTCCTA ATGGGAAGCT GCCTATGGAG 
AATCTGGCAC ACAACTTCAC CATCAAGGAG AAAGATTTGG AACTTTCAGA GCCTGAGGAG 
GCCACCAACT ATGAAGAGAT CAGTGGAGGC ATTGAATTTC TGGCCAGCGT CACCAAAGAT 
GTAGCCTCTG ACTCTGGGGC AGGAATTGAT AATCCTGTGT TCTCCCCTGA CGAGGATCTG 
GACCCAAGCA TCCTATCCAG GGTGCCACCC TGGCTGTCCC CTGGGGAGAC TGTGGTGCCC 
TCCCAGAGGG CCCGTGTCCA GATTCCCAAC TCTCCCAGCA ACTTCCGCCG CCTGACTCCA 
TTCCGCCTCA GCAACAAATC AGTGGATTCC TTCCTGCAGG CTGATGGCCC CGAGGAACAG 
CTCCAACCCG CTTCCCCTGA GTCCACACAC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc9a3 ( XM_008758677.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008756899.1 Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa42956
Clone ID Related Accession (Same CDS sequence)	XM_008758677.2
Accession Version	XM_008758677.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2496bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium/hydrogen exchanger 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008758677.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCACC CGGCTCTGGG ACCAGGGTGG AAGCCGCTGC TGGCGCTGGC GCTGGCGCTG 
ACCAGCCTGC GAGGCGTGAG GGGCATTGAG GAGGAACCGA ACAGTGGTGG GAGCTTCCAG 
ATAGTCACCT TCAAATGGCA CCACGTCCAG GATCCATACA TCATCGCACT CTGGATCCTC 
GTGGCCAGCT TGGCCAAAAT CGTCTTCCAT CTGTCCCACA AGGTCACCAG TGTTGTCCCG 
GAGAGTGCTC TGCTCATCGT TCTGGGCCTG GTGCTGGGCG GCATCGTCTG GGCAGCTGAC 
CACATCGCCT CCTTCACACT CACACCCACA CTCTTCTTCT TCTACCTGCT GCCCCCTATT 
GTGTTGGATG CTGGGTACTT CATGCCCAAT CGACTCTTCT TTGGCAACCT GGGCACCATC 
CTGCTATATG CTGTCATTGG CACTATATGG AACGCAGCTA CCACAGGATT GTCCCTCTAT 
GGTGTCTTCC TCAGTGGCCT GATGGGCGAA CTGAAGATCG GCCTCCTGGA TTTCCTGCTA 
TTTGGCAGCC TCATTGCAGC TGTGGACCCG GTGGCTGTGC TGGCTGTGTT TGAGGAAGTC 
CATGTCAATG AAGTCCTGTT CATCATTGTT TTTGGGGAGT CACTGCTTAA TGACGCGGTG 
ACTGTGGTCT TGTACAATGT GTTTGAGTCT TTCGTGACGC TGGGTGGTGA TGCAGTGACT 
GGCGTGGACT GTGTGAAAGG CATAGTGTCC TTCTTCGTGG TGAGCCTGGG GGGCACTCTG 
GTGGGTGTCA TCTTCGCCTT CCTGCTGTCC TTGGTGACTC GTTTCACCAA GCATGTGCGT 
ATCATCGAGC CTGGCTTCGT CTTTGTCATT TCCTACCTGT CCTATCTGAC CTCCGAGATG 
CTGTCCTTGT CAGCCATCCT GGCCATCACC TTTTGTGGCA TCTGCTGTCA GAAGTACGTG 
AAGGCCAACA TCTCAGAGCA GTCGGCCACC ACCGTGCGCT ACACTATGAA GATGCTGGCA 
AGTGGAGCAG AGACCATTAT CTTCATGTTC CTGGGCATCT CGGCTGTGGA CCCCGTCATC 
TGGACATGGA ACACAGCTTT TGTGTTGCTG ACACTGGTCT TCATTTCTGT ATACCGAGCC 
ATTGGTGTTG TTCTGCAGAC CTGGATCCTG AATCGCTACC GCATGGTGCA GCTAGAGACC 
ATTGACCAGG TGGTCATGTC CTACGGTGGC CTGCGTGGGG CAGTGGCCTA TGCCTTGGTG 
GTACTTCTGG ATGAGAAAAA AGTCAAGGAG AAAAACCTGT TTGTCAGCAC CACTCTCATT 
GTGGTCTTCT TCACAGTCAT CTTTCAGGGC CTGACCATTA AGCCCCTGGT GCAGTGGCTG 
AAGGTGAAGA GGAGCGAGCA GCGTGAGCCG AAGCTCAACG AGAAGCTGCA TGGCCGGGCT 
TTCGACCACA TCCTCTCAGC CATTGAGGAC ATCTCAGGAC AAATTGGACA CAATTACCTC 
AGAGATAAGT GGTCCAATTT TGATAGGAAG TTCCTCAGCA AAGTCCTCAT GAGAAGATCT 
GCTCAAAAAT CTCGAGATCG GATCCTGAAT GTTTTCCATG AGCTGAATTT GAAGGATGCC 
ATTAGCTATG TGGCCGAGGG AGAGCGCCGT GGGTCCCTGG CCTTCATTCG CTCCCCAAGT 
ACGGACAATA TGGTCAATGT GGACTTCAGC ACACCCCGCC CATCTACAGT GGAGGCATCC 
GTCTCCTATT TCTTGAGGGA AAATGTCAGT GCTGTATGCC TGGACATGCA GTCCTTGGAA 
CAGAGGCGGA GGAGCATCCG TGACACCGAG GACATGGTCA CCCACCACAC GTTGCAGCAG 
TACCTCTACA AGCCTCGGCA GGAGTACAAG CATCTCTACA GTCGGCACGA GCTCACACCC 
AATGAGGATG AGAAGCAGGA CAAGGAGATC TTCCACAGGA CCATGCGGAA GCGCCTGGAG 
TCCTTTAAGT CGGCTAAGCT GGGCATCAAC CAGAACAAGA AGGCAGCCAA GCTATATAAG 
AGGGAGCGCG CACAGAAGCG GAGGAATAGC AGCATTCCTA ATGGGAAGCT GCCTATGGAG 
AATCTGGCAC ACAACTTCAC CATCAAGGAG AAAGATTTGG AACTTTCAGA GCCTGAGGAG 
GCCACCAACT ATGAAGAGAT CAGTGGAGGC ATTGAATTTC TGGCCAGCGT CACCAAAGAT 
GTAGCCTCTG ACTCTGGGGC AGGAATTGAT AATCCTGTGT TCTCCCCTGA CGAGGATCTG 
GACCCAAGCA TCCTATCCAG GGTGCCACCC TGGCTGTCCC CTGGGGAGAC TGTGGTGCCC 
TCCCAGAGGG CCCGTGTCCA GATTCCCAAC TCTCCCAGCA ACTTCCGCCG CCTGACTCCA 
TTCCGCCTCA GCAACAAATC AGTGGATTCC TTCCTGCAGG CTGATGGCCC CGAGGAACAG 
CTCCAACCCG CTTCCCCTGA GTCCACACAC ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008756899.1
CDS	163..2658
Translation	MWHPALGPGWKPLLALALALTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM

Target ORF information:

RefSeq Version	XM_008758677.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008758677.2

ORF Insert Sequence:

ATGTGGCACC CGGCTCTGGG ACCAGGGTGG AAGCCGCTGC TGGCGCTGGC GCTGGCGCTG 
ACCAGCCTGC GAGGCGTGAG GGGCATTGAG GAGGAACCGA ACAGTGGTGG GAGCTTCCAG 
ATAGTCACCT TCAAATGGCA CCACGTCCAG GATCCATACA TCATCGCACT CTGGATCCTC 
GTGGCCAGCT TGGCCAAAAT CGTCTTCCAT CTGTCCCACA AGGTCACCAG TGTTGTCCCG 
GAGAGTGCTC TGCTCATCGT TCTGGGCCTG GTGCTGGGCG GCATCGTCTG GGCAGCTGAC 
CACATCGCCT CCTTCACACT CACACCCACA CTCTTCTTCT TCTACCTGCT GCCCCCTATT 
GTGTTGGATG CTGGGTACTT CATGCCCAAT CGACTCTTCT TTGGCAACCT GGGCACCATC 
CTGCTATATG CTGTCATTGG CACTATATGG AACGCAGCTA CCACAGGATT GTCCCTCTAT 
GGTGTCTTCC TCAGTGGCCT GATGGGCGAA CTGAAGATCG GCCTCCTGGA TTTCCTGCTA 
TTTGGCAGCC TCATTGCAGC TGTGGACCCG GTGGCTGTGC TGGCTGTGTT TGAGGAAGTC 
CATGTCAATG AAGTCCTGTT CATCATTGTT TTTGGGGAGT CACTGCTTAA TGACGCGGTG 
ACTGTGGTCT TGTACAATGT GTTTGAGTCT TTCGTGACGC TGGGTGGTGA TGCAGTGACT 
GGCGTGGACT GTGTGAAAGG CATAGTGTCC TTCTTCGTGG TGAGCCTGGG GGGCACTCTG 
GTGGGTGTCA TCTTCGCCTT CCTGCTGTCC TTGGTGACTC GTTTCACCAA GCATGTGCGT 
ATCATCGAGC CTGGCTTCGT CTTTGTCATT TCCTACCTGT CCTATCTGAC CTCCGAGATG 
CTGTCCTTGT CAGCCATCCT GGCCATCACC TTTTGTGGCA TCTGCTGTCA GAAGTACGTG 
AAGGCCAACA TCTCAGAGCA GTCGGCCACC ACCGTGCGCT ACACTATGAA GATGCTGGCA 
AGTGGAGCAG AGACCATTAT CTTCATGTTC CTGGGCATCT CGGCTGTGGA CCCCGTCATC 
TGGACATGGA ACACAGCTTT TGTGTTGCTG ACACTGGTCT TCATTTCTGT ATACCGAGCC 
ATTGGTGTTG TTCTGCAGAC CTGGATCCTG AATCGCTACC GCATGGTGCA GCTAGAGACC 
ATTGACCAGG TGGTCATGTC CTACGGTGGC CTGCGTGGGG CAGTGGCCTA TGCCTTGGTG 
GTACTTCTGG ATGAGAAAAA AGTCAAGGAG AAAAACCTGT TTGTCAGCAC CACTCTCATT 
GTGGTCTTCT TCACAGTCAT CTTTCAGGGC CTGACCATTA AGCCCCTGGT GCAGTGGCTG 
AAGGTGAAGA GGAGCGAGCA GCGTGAGCCG AAGCTCAACG AGAAGCTGCA TGGCCGGGCT 
TTCGACCACA TCCTCTCAGC CATTGAGGAC ATCTCAGGAC AAATTGGACA CAATTACCTC 
AGAGATAAGT GGTCCAATTT TGATAGGAAG TTCCTCAGCA AAGTCCTCAT GAGAAGATCT 
GCTCAAAAAT CTCGAGATCG GATCCTGAAT GTTTTCCATG AGCTGAATTT GAAGGATGCC 
ATTAGCTATG TGGCCGAGGG AGAGCGCCGT GGGTCCCTGG CCTTCATTCG CTCCCCAAGT 
ACGGACAATA TGGTCAATGT GGACTTCAGC ACACCCCGCC CATCTACAGT GGAGGCATCC 
GTCTCCTATT TCTTGAGGGA AAATGTCAGT GCTGTATGCC TGGACATGCA GTCCTTGGAA 
CAGAGGCGGA GGAGCATCCG TGACACCGAG GACATGGTCA CCCACCACAC GTTGCAGCAG 
TACCTCTACA AGCCTCGGCA GGAGTACAAG CATCTCTACA GTCGGCACGA GCTCACACCC 
AATGAGGATG AGAAGCAGGA CAAGGAGATC TTCCACAGGA CCATGCGGAA GCGCCTGGAG 
TCCTTTAAGT CGGCTAAGCT GGGCATCAAC CAGAACAAGA AGGCAGCCAA GCTATATAAG 
AGGGAGCGCG CACAGAAGCG GAGGAATAGC AGCATTCCTA ATGGGAAGCT GCCTATGGAG 
AATCTGGCAC ACAACTTCAC CATCAAGGAG AAAGATTTGG AACTTTCAGA GCCTGAGGAG 
GCCACCAACT ATGAAGAGAT CAGTGGAGGC ATTGAATTTC TGGCCAGCGT CACCAAAGAT 
GTAGCCTCTG ACTCTGGGGC AGGAATTGAT AATCCTGTGT TCTCCCCTGA CGAGGATCTG 
GACCCAAGCA TCCTATCCAG GGTGCCACCC TGGCTGTCCC CTGGGGAGAC TGTGGTGCCC 
TCCCAGAGGG CCCGTGTCCA GATTCCCAAC TCTCCCAGCA ACTTCCGCCG CCTGACTCCA 
TTCCGCCTCA GCAACAAATC AGTGGATTCC TTCCTGCAGG CTGATGGCCC CGAGGAACAG 
CTCCAACCCG CTTCCCCTGA GTCCACACAC ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca
American journal of physiology. Renal physiology313(2)F450-F460(2017 Aug)
Castelo-Branco RC,Leite-Dellova DCA,Fernandes FB,Malnic G,de Mello-Aires M

Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata.
Autonomic neuroscience : basic & clinical20448-56(2017 May)
Nishi EE,Martins BS,Milanez MI,Lopes NR,de Melo JF Jr,Pontes RB,Girardi AC,Campos RR,Bergamaschi CT

Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats.
Journal of cardiovascular pharmacology67(3)225-31(2016 Mar)
Linz B,Hohl M,Reil JC,B?hm M,Linz D

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.
Human molecular genetics24(23)6614-23(2015 Dec)
Janecke AR,Heinz-Erian P,Yin J,Petersen BS,Franke A,Lechner S,Fuchs I,Melancon S,Uhlig HH,Travis S,Marinier E,Perisic V,Ristic N,Gerner P,Booth IW,Wedenoja S,Baumgartner N,Vodopiutz J,Frechette-Duval MC,De Lafollie J,Persad R,Warner N,Tse CM,Sud K,Zachos NC,Sarker R,Zhu X,Muise AM,Zimmer KP,Witt H,Zoller H,Donowitz M,M?ller T

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Slc9a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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