Slc2a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc2a1
Entrez Gene ID	24778
Full Name	solute carrier family 2 member 1
Synonyms	GLUTB,GTG1,Glut1,Gtg3,RATGTG1
General protein information	Preferred Names solute carrier family 2 member 1 Names solute carrier family 2, facilitated glucose transporter member 1 GLUT-1 Solute carrier family 2 a 1 (facilitated glucose transporter) brain glucose transporter type 1, erythrocyte/brain solute carrier family 2 (facilitated glucose transporter), member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	transporter for glucose and other hexoses; may be involved in response to osmotic and metabolic stress [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138827.1	NP_620182.1	solute carrier family 2, facilitated glucose transporter member 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slc2a1	NP_035530.2
Gallus gallus (chicken)	SLC2A1	NP_990540.1
	SLC2A1	XP_001090868.1
Canis lupus familiaris (dog)	SLC2A1	NP_001152798.1
Bos taurus (cattle)	SLC2A1	NP_777027.1
Rattus norvegicus (Norway rat)	Slc2a1	NP_620182.1
Danio rerio (zebrafish)	slc2a1a	NP_001034897.1
Danio rerio (zebrafish)	slc2a1b	XP_002662574.1
Eremothecium gossypii	AGOS_AFL034W	NP_985514.2
Homo sapiens (human)	SLC2A1	NP_006507.2
Pan troglodytes (chimpanzee)	SLC2A1	XP_003308077.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
N?sken E, Gellhaus A, K?hnel E, Swoboda I, Wohlfarth M, Vohlen C, Schneider H, D?tsch J, N?sken KD
Journal of cellular biochemistry117(7)1594-603(2016 07)

Suberoylanilide hydroxamic acid prevents downregulation of spinal glutamate transporter-1 and attenuates spinal nerve ligation-induced neuropathic pain behavior.
Cui SS, Lu R, Zhang H, Wang W, Ke JJ
Neuroreport27(6)427-34(2016 Apr)

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, M?ller T, Siebeneicher H, Stroud RM
Proceedings of the National Academy of Sciences of the United States of America113(17)4711-6(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming
Title: Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.

The data of this study provided evidence that histone deacetylation may contribute toward the loss of GLT-1
Title: Suberoylanilide hydroxamic acid prevents downregulation of spinal glutamate transporter-1 and attenuates spinal nerve ligation-induced neuropathic pain behavior.

Increased GLUT1 expression was observed together with overproduction of NO and pronounced liver injury in severely hyperglycaemic rats. GLUT1 overexpression might be implicated in the toxic effects of glucose in the liver.
Title: Changes in glucose transporter expression and nitric oxide production are associated with liver injury in diabetes.

Ascorbic acid markedly upregulated the basal expression of GLUT1 in endothelial cells of nondiabetic and diabetic cortex, which did not affect total ascorbic acid levels in the cortex.
Title: Orally administrated ascorbic acid suppresses neuronal damage and modifies expression of SVCT2 and GLUT1 in the brain of diabetic rats with cerebral ischemia-reperfusion.

The GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS.
Title: Role of GLUT1 in regulation of reactive oxygen species.

The following Slc2a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc2a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01643	NM_138827.1 Latest version!	Rattus norvegicus solute carrier family 2 member 1 (Slc2a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc2a1 ( NM_138827.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620182.1 Rattus norvegicus solute carrier family 2 member 1 (Slc2a1), mRNA.

Price & Availability↑

CloneID	ORa01643
Clone ID Related Accession (Same CDS sequence)	NM_138827.1
Accession Version	NM_138827.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 2, facilitated glucose transporter member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M13979.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M13979.1, BC061873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA GCAGCAAGAA GGTGACGGGC CGCCTTATGT TGGCCGTGGG AGGGGCAGTG 
CTCGGATCCC TGCAGTTCGG CTATAACACC GGTGTCATCA ACGCCCCCCA GAAGGTAATT 
GAGGAGTTCT ACAATCAAAC ATGGAACCAC CGCTATGGAG AGTCCATCCC ATCCACCACA 
CTCACCACAC TCTGGTCTCT CTCCGTGGCC ATCTTCTCTG TCGGGGGCAT GATTGGTTCC 
TTCTCTGTGG GCCTCTTTGT TAATCGCTTT GGCAGGCGGA ACTCCATGCT GATGATGAAC 
CTGTTGGCCT TTGTGTCTGC CGTGCTTATG GGTTTCTCCA AACTGGGCAA GTCCTTTGAG 
ATGCTGATCC TGGGCCGCTT CATCATTGGA GTGTACTGTG GCCTGACCAC CGGCTTTGTG 
CCCATGTATG TGGGGGAGGT GTCACCCACA GCTCTTCGTG GAGCCCTGGG CACCCTGCAC 
CAGCTGGGCA TCGTCGTTGG GATCCTTATT GCCCAGGTGT TCGGCTTAGA CTCCATCATG 
GGCAATGCAG ACTTGTGGCC TCTACTGCTC AGTGTCATCT TCATCCCAGC CCTGCTACAG 
TGTATCCTGT TGCCCTTCTG CCCTGAGAGC CCCCGCTTCC TGCTCATCAA TCGTAACGAG 
GAGAACCGGG CCAAGAGTGT GCTGAAAAAG CTTCGAGGGA CAGCCGATGT GACCCGAGAC 
CTGCAGGAGA TGAAAGAAGA GGGTCGGCAG ATGATGCGGG AGAAGAAGGT CACCATCTTG 
GAGCTGTTCC GCTCACCCGC CTACCGCCAG CCCATCCTCA TCGCCGTGGT GCTGCAGCTG 
TCCCAGCAGC TGTCGGGCAT CAATGCTGTG TTCTACTACT CAACGAGCAT CTTCGAGAAG 
GCAGGTGTGC AGCAGCCTGT GTATGCCACC ATCGGCTCGG GTATCGTCAA CACGGCCTTC 
ACTGTGGTGT CGCTGTTCGT CGTGGAGCGA GCTGGCCGTC GGACCCTGCA TCTCATTGGT 
CTGGCTGGCA TGGCGGGCTG TGCTGTGCTC ATGACCATCG CCCTGGCCCT GCTGGAGCAG 
CTGCCCTGGA TGTCCTATCT GAGTATCGTG GCCATCTTTG GCTTTGTGGC CTTCTTTGAA 
GTAGGCCCTG GTCCTATTCC ATGGTTCATT GTGGCCGAGC TGTTCAGCCA GGGGCCCCGA 
CCTGCTGCTG TTGCTGTGGC TGGCTTCTCT AACTGGACCT CAAACTTCAT CGTGGGCATG 
TGCTTCCAAT ATGTGGAGCA ACTGTGTGGC CCCTACGTCT TCATCATCTT CACGGTGCTG 
CTGGTACTCT TCTTCATCTT CACCTACTTC AAAGTTCCTG AGACCAAAGG CCGGACCTTC 
GATGAGATCG CTTCCGGCTT CCGGCAGGGG GGTGCCAGCC AGAGCGACAA GACACCTGAG 
GAGCTCTTCC ACCCTCTGGG GGCTGACTCC CAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620182.1
CDS	209..1687
Translation	MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV

Target ORF information:

RefSeq Version	NM_138827.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 2 member 1 (Slc2a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138827.1

ORF Insert Sequence:

ATGGAGCCCA GCAGCAAGAA GGTGACGGGC CGCCTTATGT TGGCCGTGGG AGGGGCAGTG 
CTCGGATCCC TGCAGTTCGG CTATAACACC GGTGTCATCA ACGCCCCCCA GAAGGTAATT 
GAGGAGTTCT ACAATCAAAC ATGGAACCAC CGCTATGGAG AGTCCATCCC ATCCACCACA 
CTCACCACAC TCTGGTCTCT CTCCGTGGCC ATCTTCTCTG TCGGGGGCAT GATTGGTTCC 
TTCTCTGTGG GCCTCTTTGT TAATCGCTTT GGCAGGCGGA ACTCCATGCT GATGATGAAC 
CTGTTGGCCT TTGTGTCTGC CGTGCTTATG GGTTTCTCCA AACTGGGCAA GTCCTTTGAG 
ATGCTGATCC TGGGCCGCTT CATCATTGGA GTGTACTGTG GCCTGACCAC CGGCTTTGTG 
CCCATGTATG TGGGGGAGGT GTCACCCACA GCTCTTCGTG GAGCCCTGGG CACCCTGCAC 
CAGCTGGGCA TCGTCGTTGG GATCCTTATT GCCCAGGTGT TCGGCTTAGA CTCCATCATG 
GGCAATGCAG ACTTGTGGCC TCTACTGCTC AGTGTCATCT TCATCCCAGC CCTGCTACAG 
TGTATCCTGT TGCCCTTCTG CCCTGAGAGC CCCCGCTTCC TGCTCATCAA TCGTAACGAG 
GAGAACCGGG CCAAGAGTGT GCTGAAAAAG CTTCGAGGGA CAGCCGATGT GACCCGAGAC 
CTGCAGGAGA TGAAAGAAGA GGGTCGGCAG ATGATGCGGG AGAAGAAGGT CACCATCTTG 
GAGCTGTTCC GCTCACCCGC CTACCGCCAG CCCATCCTCA TCGCCGTGGT GCTGCAGCTG 
TCCCAGCAGC TGTCGGGCAT CAATGCTGTG TTCTACTACT CAACGAGCAT CTTCGAGAAG 
GCAGGTGTGC AGCAGCCTGT GTATGCCACC ATCGGCTCGG GTATCGTCAA CACGGCCTTC 
ACTGTGGTGT CGCTGTTCGT CGTGGAGCGA GCTGGCCGTC GGACCCTGCA TCTCATTGGT 
CTGGCTGGCA TGGCGGGCTG TGCTGTGCTC ATGACCATCG CCCTGGCCCT GCTGGAGCAG 
CTGCCCTGGA TGTCCTATCT GAGTATCGTG GCCATCTTTG GCTTTGTGGC CTTCTTTGAA 
GTAGGCCCTG GTCCTATTCC ATGGTTCATT GTGGCCGAGC TGTTCAGCCA GGGGCCCCGA 
CCTGCTGCTG TTGCTGTGGC TGGCTTCTCT AACTGGACCT CAAACTTCAT CGTGGGCATG 
TGCTTCCAAT ATGTGGAGCA ACTGTGTGGC CCCTACGTCT TCATCATCTT CACGGTGCTG 
CTGGTACTCT TCTTCATCTT CACCTACTTC AAAGTTCCTG AGACCAAAGG CCGGACCTTC 
GATGAGATCG CTTCCGGCTT CCGGCAGGGG GGTGCCAGCC AGAGCGACAA GACACCTGAG 
GAGCTCTTCC ACCCTCTGGG GGCTGACTCC CAAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
Journal of cellular biochemistry117(7)1594-603(2016 07)
N?sken E,Gellhaus A,K?hnel E,Swoboda I,Wohlfarth M,Vohlen C,Schneider H,D?tsch J,N?sken KD

Suberoylanilide hydroxamic acid prevents downregulation of spinal glutamate transporter-1 and attenuates spinal nerve ligation-induced neuropathic pain behavior.
Neuroreport27(6)427-34(2016 Apr)
Cui SS,Lu R,Zhang H,Wang W,Ke JJ

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proceedings of the National Academy of Sciences of the United States of America113(17)4711-6(2016 Apr)
Kapoor K,Finer-Moore JS,Pedersen BP,Caboni L,Waight A,Hillig RC,Bringmann P,Heisler I,M?ller T,Siebeneicher H,Stroud RM

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Slc2a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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