Ppp2ca cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp2ca
Entrez Gene ID	24672
Full Name	protein phosphatase 2, catalytic subunit, alpha isozyme
Synonyms	Pp2a1
General protein information	Preferred Names protein phosphatase 2, catalytic subunit, alpha isozyme Names serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PP2A-alpha protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform protein phosphatase 2, catalytic subunit, alpha isoform protein phosphatase 2a, catalytic subunit, alpha isoform protein phosphatase-2A-alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	catalyzes the removal of serine- and threonine- bound phosphate groups [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597004.1	XP_017452493.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1
NM_017039.2	NP_058735.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	mts	NP_476805.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010172	XP_319345.3
Arabidopsis thaliana (thale cress)	PP2A	NP_177154.1
Oryza sativa (rice)	Os06g0574500	NP_001057926.1
Homo sapiens (human)	PPP2CA	NP_002706.1
Canis lupus familiaris (dog)	PPP2CA	NP_001003063.1
Arabidopsis thaliana (thale cress)	PP2A-1	NP_176192.1
Oryza sativa (rice)	Os02g0217600	NP_001046300.1
Pan troglodytes (chimpanzee)	PPP2CA	XP_003954119.1
Bos taurus (cattle)	PPP2CA	NP_851374.1
Mus musculus (house mouse)	Ppp2ca	NP_062284.1
Schizosaccharomyces pombe (fission yeast)	ppa1	NP_593842.1
Arabidopsis thaliana (thale cress)	PP2A-2	NP_172514.1
Xenopus tropicalis (tropical clawed frog)	ppp2ca	NP_989274.1
Rattus norvegicus (Norway rat)	Ppp2ca	NP_058735.1
Gallus gallus (chicken)	PPP2CA	NP_001006152.1
Danio rerio (zebrafish)	zgc:56064	NP_957205.1
Caenorhabditis elegans (roundworm)	let-92	NP_502247.1

Gene Ontology
Bibliography

Related articles in PubMed

Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
Lin L, Lo LH, Lyu Q, Lai KO
The Journal of biological chemistry292(23)9451-9464(2017 06)

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model.
Liu J, Chen M, Wang X, Wang Y, Duan C, Gao G, Lu L, Wu X, Wang X, Yang H
Oncotarget7(38)60823-60843(2016 Sep)

Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.
Liu CD, Wang Q, Zong DK, Pei SC, Yan Y, Yan ML, Sun LL, Hao YY, Mao M, Xing WJ, Ren H, Ai J
Neurobiology of aging4576-87(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

STRN4 is preferentially expressed in mushroom spines, and STRN4 specifically maintains mushroom spines but not thin spines and filopodia through interaction with the phosphatase PP2A
Title: Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.

Reduction of protein phosphatase-2A (PP2A) activity is a common clinical feature of Alzheimer's disease and vascular dementia.
Title: Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.

Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons.
Title: Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.

We discovered that PP-2A was capable of regulating the Abeta level by regulating APP phosphorylation level and beta and gamma-secretase activity
Title: Mechanism of protein phosphatase-2Aregulating phosphorylation of amyloid precursor proteosome and A? generation.

that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
Title: GBA deficiency promotes SNCA/?-synuclein accumulation through autophagic inhibition by inactivated PPP2A.

The following Ppp2ca gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp2ca cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13075	NM_017039.2 Latest version!	Rattus norvegicus protein phosphatase 2 catalytic subunit alpha (Ppp2ca), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa56281	XM_017597004.1 Latest version!	Rattus norvegicus protein phosphatase 2, catalytic subunit, alpha isozyme (Ppp2ca), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp2ca ( NM_017039.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058735.1 Rattus norvegicus protein phosphatase 2 catalytic subunit alpha (Ppp2ca), mRNA.

Price & Availability↑

CloneID	ORa13075
Clone ID Related Accession (Same CDS sequence)	NM_017039.2
Accession Version	NM_017039.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC072531.1. On Jun 13, 2004 this sequence version replaced NM_017039.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072531.1, M33114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 
AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 
AAAGAATCTA ATGTTCAGGA GGTTCGATGT CCAGTCACTG TGTGTGGAGA TGTGCATGGG 
CAATTTCATG ACCTCATGGA ACTCTTTAGA ATTGGTGGTA AATCACCAGA TACAAATTAC 
TTGTTTATGG GAGACTATGT GGACAGAGGA TATTACTCAG TTGAAACAGT TACACTGCTT 
GTAGCTCTTA AGGTTCGTTA CCGAGAGCGT ATCACCATAC TCCGAGGGAA TCACGAGAGC 
AGACAGATCA CACAAGTTTA TGGTTTCTAC GATGAGTGTT TAAGGAAATA CGGAAATGCA 
AATGTTTGGA AATACTTCAC AGACCTTTTT GACTACCTTC CTCTCACTGC CTTGGTGGAT 
GGGCAGATCT TCTGTCTACA TGGTGGTCTT TCACCATCCA TAGACACACT GGATCACATC 
CGAGCACTTG ATCGCCTACA AGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGG ATATCTCCTC GGGGAGCTGG TTATACCTTT 
GGCCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCCAGAGCT 
CACCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACAATTTTC 
AGTGCTCCAA ACTATTGCTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAC 
ACTCTTAAGT ATTCTTTCTT GCAGTTCGAT CCAGCACCTC GTAGAGGCGA GCCACATGTC 
ACTCGTCGTA CCCCAGACTA CTTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058735.1
CDS	198..1127
Translation	MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Target ORF information:

RefSeq Version	NM_017039.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 2 catalytic subunit alpha (Ppp2ca), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017039.2

ORF Insert Sequence:

ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 
AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 
AAAGAATCTA ATGTTCAGGA GGTTCGATGT CCAGTCACTG TGTGTGGAGA TGTGCATGGG 
CAATTTCATG ACCTCATGGA ACTCTTTAGA ATTGGTGGTA AATCACCAGA TACAAATTAC 
TTGTTTATGG GAGACTATGT GGACAGAGGA TATTACTCAG TTGAAACAGT TACACTGCTT 
GTAGCTCTTA AGGTTCGTTA CCGAGAGCGT ATCACCATAC TCCGAGGGAA TCACGAGAGC 
AGACAGATCA CACAAGTTTA TGGTTTCTAC GATGAGTGTT TAAGGAAATA CGGAAATGCA 
AATGTTTGGA AATACTTCAC AGACCTTTTT GACTACCTTC CTCTCACTGC CTTGGTGGAT 
GGGCAGATCT TCTGTCTACA TGGTGGTCTT TCACCATCCA TAGACACACT GGATCACATC 
CGAGCACTTG ATCGCCTACA AGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGG ATATCTCCTC GGGGAGCTGG TTATACCTTT 
GGCCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCCAGAGCT 
CACCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACAATTTTC 
AGTGCTCCAA ACTATTGCTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAC 
ACTCTTAAGT ATTCTTTCTT GCAGTTCGAT CCAGCACCTC GTAGAGGCGA GCCACATGTC 
ACTCGTCGTA CCCCAGACTA CTTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp2ca ( XM_017597004.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452493.1 Rattus norvegicus protein phosphatase 2, catalytic subunit, alpha isozyme (Ppp2ca), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56281
Clone ID Related Accession (Same CDS sequence)	XM_017597004.1
Accession Version	XM_017597004.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCGTT TGGCACACCA GTGTCTAGCA CGGGGTGGAA TCACTCAGAT GGCTAAAGAA 
ATCCTGACAA AAGAATCTAA TGTTCAGGAG GTTCGATGTC CAGTCACTGT GTGTGGAGAT 
GTGCATGGGC AATTTCATGA CCTCATGGAA CTCTTTAGAA TTGGTGGTAA ATCACCAGAT 
ACAAATTACT TGTTTATGGG AGACTATGTG GACAGAGGAT ATTACTCAGT TGAAACAGTT 
ACACTGCTTG TAGCTCTTAA GGTTCGTTAC CGAGAGCGTA TCACCATACT CCGAGGGAAT 
CACGAGAGCA GACAGATCAC ACAAGTTTAT GGTTTCTACG ATGAGTGTTT AAGGAAATAC 
GGAAATGCAA ATGTTTGGAA ATACTTCACA GACCTTTTTG ACTACCTTCC TCTCACTGCC 
TTGGTGGATG GGCAGATCTT CTGTCTACAT GGTGGTCTTT CACCATCCAT AGACACACTG 
GATCACATCC GAGCACTTGA TCGCCTACAA GAAGTTCCTC ATGAGGGTCC AATGTGTGAC 
TTGCTGTGGT CAGATCCAGA TGACCGTGGT GGCTGGGGGA TATCTCCTCG GGGAGCTGGT 
TATACCTTTG GCCAAGATAT TTCTGAGACA TTTAATCATG CCAATGGCCT CACGTTGGTG 
TCCAGAGCTC ACCAGCTGGT GATGGAGGGA TATAACTGGT GCCATGACCG GAATGTAGTA 
ACAATTTTCA GTGCTCCAAA CTATTGCTAT CGTTGTGGTA ACCAAGCTGC AATCATGGAA 
CTTGATGACA CTCTTAAGTA TTCTTTCTTG CAGTTCGATC CAGCACCTCG TAGAGGCGAG 
CCACATGTCA CTCGTCGTAC CCCAGACTAC TTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452493.1
CDS	108..986
Translation	MTRLAHQCLARGGITQMAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Target ORF information:

RefSeq Version	XM_017597004.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 2, catalytic subunit, alpha isozyme (Ppp2ca), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597004.1

ORF Insert Sequence:

ATGACCCGTT TGGCACACCA GTGTCTAGCA CGGGGTGGAA TCACTCAGAT GGCTAAAGAA 
ATCCTGACAA AAGAATCTAA TGTTCAGGAG GTTCGATGTC CAGTCACTGT GTGTGGAGAT 
GTGCATGGGC AATTTCATGA CCTCATGGAA CTCTTTAGAA TTGGTGGTAA ATCACCAGAT 
ACAAATTACT TGTTTATGGG AGACTATGTG GACAGAGGAT ATTACTCAGT TGAAACAGTT 
ACACTGCTTG TAGCTCTTAA GGTTCGTTAC CGAGAGCGTA TCACCATACT CCGAGGGAAT 
CACGAGAGCA GACAGATCAC ACAAGTTTAT GGTTTCTACG ATGAGTGTTT AAGGAAATAC 
GGAAATGCAA ATGTTTGGAA ATACTTCACA GACCTTTTTG ACTACCTTCC TCTCACTGCC 
TTGGTGGATG GGCAGATCTT CTGTCTACAT GGTGGTCTTT CACCATCCAT AGACACACTG 
GATCACATCC GAGCACTTGA TCGCCTACAA GAAGTTCCTC ATGAGGGTCC AATGTGTGAC 
TTGCTGTGGT CAGATCCAGA TGACCGTGGT GGCTGGGGGA TATCTCCTCG GGGAGCTGGT 
TATACCTTTG GCCAAGATAT TTCTGAGACA TTTAATCATG CCAATGGCCT CACGTTGGTG 
TCCAGAGCTC ACCAGCTGGT GATGGAGGGA TATAACTGGT GCCATGACCG GAATGTAGTA 
ACAATTTTCA GTGCTCCAAA CTATTGCTAT CGTTGTGGTA ACCAAGCTGC AATCATGGAA 
CTTGATGACA CTCTTAAGTA TTCTTTCTTG CAGTTCGATC CAGCACCTCG TAGAGGCGAG 
CCACATGTCA CTCGTCGTAC CCCAGACTAC TTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
The Journal of biological chemistry292(23)9451-9464(2017 06)
Lin L,Lo LH,Lyu Q,Lai KO

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model.
Oncotarget7(38)60823-60843(2016 Sep)
Liu J,Chen M,Wang X,Wang Y,Duan C,Gao G,Lu L,Wu X,Wang X,Yang H

Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.
Neurobiology of aging4576-87(2016 09)
Liu CD,Wang Q,Zong DK,Pei SC,Yan Y,Yan ML,Sun LL,Hao YY,Mao M,Xing WJ,Ren H,Ai J

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Ppp2ca cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報