Abcb1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb1b
Entrez Gene ID	24646
Full Name	ATP-binding cassette, subfamily B (MDR/TAP), member 1B
Synonyms	Abcb1,Mdr1,Pgy1,mdr1b
General protein information	Preferred Names ATP-binding cassette, subfamily B (MDR/TAP), member 1B Names multidrug resistance protein 1 ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) ATP-binding cassette sub-family B member 1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) ATP-binding cassette, sub-family B (MDR/TAP), member 1B ATP-binding cassette, subfamily B, member 1B P-glycoprotein 1 P-glycoprotein/multidrug resistance 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q12
Summary	member of the ATP-binding cassette (ABC) protein superfamily; may play a role in drug disposition [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012623.2	NP_036755.2	ATP-dependent translocase ABCB1
XM_017592469.1	XP_017447958.1	multidrug resistance protein 1 isoform X1
XM_008762689.2	XP_008760911.1	multidrug resistance protein 1 isoform X2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Abcb1b	NP_035205.1
Oryza sativa (rice)	Os02g0693700	NP_001047803.1
Arabidopsis thaliana (thale cress)	PGP10	NP_172538.1
Rattus norvegicus (Norway rat)	Abcb1b	NP_036755.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005639	XP_315658.3
Caenorhabditis elegans (roundworm)	pgp-2	NP_491707.2
Drosophila melanogaster (fruit fly)	Mdr49	NP_523724.2
Arabidopsis thaliana (thale cress)	PGP2	NP_194326.2

Gene Ontology
Bibliography

Related articles in PubMed

Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
Su L, Cheng YC, Lee WM, Zhang M, Yang F, Zhao B, Han D, Liu Y, Hu D
Cell death & disease8(9)e3038(2017 Sep)

Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Yu N, Zhang YF, Zhang K, Cheng YF, Ma HY, Di Q
Neurochemical research42(8)2167-2177(2017 Aug)

Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.
Mesev EV, Miller DS, Cannon RE
Molecular pharmacology91(4)373-382(2017 Apr)

The absorption enhancement of norisoboldine in the duodenum of adjuvant-induced arthritis rats involves the impairment of P-glycoprotein.
Duan C, Guo JM, Dai Y, Xia YF
Biopharmaceutics & drug disposition38(1)75-83(2017 Jan)

Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.
Aryal M, Fischer K, Gentile C, Gitto S, Zhang YZ, McDannold N
PloS one12(1)e0166061(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX-2 and prostaglandin E2 are required for C1P-mediated increases in P-glycoprotein activity independent of transporter protein expression.
Title: Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.

The impairment of P-gp function positively correlated with the severity of adjuvant-induced arthritis rats .
Title: The absorption enhancement of norisoboldine in the duodenum of adjuvant-induced arthritis rats involves the impairment of P-glycoprotein.

focused ultrasound-induced blood-brain barrier disruption can temporarily suppress P-Glycoprotein expression in brain blood vessels
Title: Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.

conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.
Title: Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents.

Study demonstrates that P-GP expression and function may be altered in cerebral cortex, hippocampus, liver and kidney of rats under the vitamin A deficiency condition.
Title: The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo.

The following Abcb1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12675	NM_012623.2 Latest version!	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$937.30 $1339.00
ORa26967	XM_017592469.1 Latest version!	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
ORa42940	XM_008762689.2 Latest version!	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb1b ( NM_012623.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036755.2 Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), mRNA.

Price & Availability↑

CloneID	ORa12675
Clone ID Related Accession (Same CDS sequence)	NM_012623.2
Accession Version	NM_012623.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-dependent translocase ABCB1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY082609.1. On Nov 26, 2002 this sequence version replaced NM_012623.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY082609.1, M81855.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTTTG AAGAGGGCCT TAACGGAACA GCAGACAAGA ACTTCTCAAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGGA GAAGAAACCT GCTGTTGGCA TATTCGGGAT GTTTCGCTAT 
GCAGATTGGC TTGACAAGCT GTGCATGGCT CTGGGAACTC TCGCTGCTAT CATCCACGGA 
ACCCTGCTTC CCCTCCTGAT GCTGGTGTTC GGATACATGA CAGATAGTTT TACCCAAGCA 
GAGACCCGCA TTCTGCCGAG CGTTACTAAT CAAAGTGAAA TCAACAGTAC ACAGACCGTC 
AGCGACAGCA GTCTGGAGGA GGACATGGCC ATGTACGCCT ACTATTACAC GGGCATTGGT 
GCCGGTGTGC TCATCGTTGC CTACATCCAG GTTTCACTTT GGTGCCTGGC AGCTGGGAGA 
CAAATACACA AGATTAGGCA GAAGTTTTTC CATGCCATCA TGAATCAGGA GATAGGCTGG 
TTTGACGTGA ATGACGCTGG GGAGCTCAAC ACCCGGCTCA CAGATGACGT CTCCAAAATT 
AATGACGGAA TTGGTGACAA ACTTGGAATG TTCTTTCAGT CCATAACGAC ATTTTCAGCC 
GGTTTTATAA TAGGATTTAT AAGTGGTTGG AAGCTAACCC TTGTAATTTT GGCCGTCAGC 
CCTCTTATTG GGTTGTCATC TGCCATGTGG GCAAAGGTAC TGACTTCATT TACTAATAAG 
GAACTCCAGG CTTATGCGAA AGCTGGAGCA GTTGCCGAAG AAGTCTTAGC AGCCATCAGA 
ACTGTGATTG CATTTGGAGG ACAAAAGAAG GAACTTGAAA GGTACAATAA AAATTTAGAA 
GAAGCTAAAA GAGTTGGCAT AAAGAAAGCC ATCACGGCCA ACATTTCCAT AGGTATTGCC 
TACCTGTTGG TCTATGCGTC TTATGCACTG GCATTCTGGT ATGGGACCTC CTTGGTCCTC 
TCAAATGAAT ATTCTATTGG ACAAGTGCTT ACCGTCTTCT TCTCTATTTT ATTGGGGACT 
TTCAGTATTG GACATTTAGC CCCAAACATA GAAGCCTTTG CAAATGCAAG AGGGGCAGCC 
TATGAAATCT TCAAGATAAT TGATAATGAG CCAAGCATTG ACAGCTTCTC AACCAAGGGA 
CACAAACCAG ACAGTATAAT GGGAAATTTG GAATTTAAAA ATGTTTACTT CAACTACCCA 
TCACGAAGTG AAGTTAAGAT CTTGAAGGGC CTCAACCTGA AGGTGAAGAG CGGGCAGACG 
GTAGCCCTGG TTGGCAACAG TGGCTGTGGG AAAAGCACAA CTGTCCAGCT GCTGCAGAGG 
CTCTACGACC CCATAGAGGG CGAGGTCAGT ATCGACGGAC AGGACATCAG GACCATCAAT 
GTGAGGTATC TGCGGGAAAT CATTGGGGTG GTGAGTCAGG AACCCGTGCT GTTTGCCACC 
ACGATTGCCG AAAACATTCG CTATGGCCGA GAAAACGTCA CCATGGATGA GATAGAGAAA 
GCTGTCAAGG AAGCCAATGC CTATGACTTC ATCATGAAAC TGCCCCACAA ATTTAACACC 
CTGGTTGGTG AGAGAGGGGC GCAGCTGAGT GGGGGACAGA AACAGAGGAT CGCCATTGCC 
CGGGCCCTGG TCCGCAACCC CAAGATCCTT TTGTTGGATG AGGCCACGTC AGCCTTGGAC 
ACAGAAAGCG AAGCCGTGGT TCAGGCCGCT CTGGATAAGG CTAGAGAAGG CCGGACCACC 
ATTGTGATAG CTCACCGCTT GTCTACAGTG CGCAATGCTG ACGTCATTGC TGGTTTTGAT 
GGTGGTGTCA TTGTGGAGCA AGGAAATCAT GAAGAGCTCA TGAAAGAGAA GGGCATTTAC 
TTCAAACTTG TCATGACACA GACTAGAGGA AATGAAATTG AACCAGGAAA TAATGCTTAT 
GAATCCCAAA GTGACACTGG TGCCTCTGAG TTGACTTCAG AAAAATCAAA ATCTCCTTTA 
ATAAGGAGAT CAATTCGCAG AAGTATCCAC AGAAGACAAG ACCAGGAGAG AAGACTTAGT 
TCGAAAGAGG ATGTGGATGA AGATGTGCCT ATGGTTTCCT TTTGGCAGAT CCTAAAGCTA 
AATATTAGTG AATGGCCCTA TTTAGTTGTG GGTGTACTTT GTGCTGTTAT AAATGGGTGC 
ATACAACCAG TGTTTGCCAT AGTGTTTTCA AAGATTGTAG GGGTTTTTTC AAGAGACGAC 
GACCATGAAA CCAAACAACG GAATTGTAAC TTGTTTTCCC TTCTCTTTCT GGTCATGGGA 
ATGATTTCTT TTGTTACGTA CTTCTTTCAA GGCTTCGCAT TTGGCAAAGC TGGAGAGATC 
CTCACCAAGC GACTCCGATA CATGGTCTTC AAATCCATGC TGCGACAGGA TATAAGCTGG 
TTTGATGACC ATAAAAACAC CACTGGCTCG CTGACTACCA GGCTCGCTAG TGACGCTTCT 
AATGTTAAAG GGGCTATGGG CTCCAGGCTT GCTGTAGTTA CCCAGAATGT AGCAAACCTT 
GGCACAGGAA TTATCTTATC CTTAGTCTAT GGCTGGCAGC TTACACTTTT ACTTGTAGTA 
ATTATACCAC TCATTGTCTT GGGTGGAATT ATTGAAATGA AACTGTTGTC TGGTCAAGCC 
TTGAAGGACA AGAAAGAGCT AGAGATCTCT GGGAAGATCG CTACAGAAGC AATTGAAAAC 
TTCCGCACTG TTGTCTCTTT GACTCGGGAG CAGAAGTTTG AAACTATGTA TGCCCAGAGC 
TTGCAGATAC CATACAGAAA TGCTTTGAAG AAAGCACACG TCTTTGGGAT CACCTTCGCC 
TTCACCCAGG CCATGATTTA TTTCTCCTAT GCTGCTTGTT TCCGGTTCGG TGCCTACTTG 
GTGGCACGAG AACTCATGAC ATTTGAAAAT GTTATGTTGG TATTTTCTGC TGTTGTCTTT 
GGTGCCATGG CAGCAGGGAA TACCAGTTCA TTCGCTCCTG ACTACGCGAA GGCCAAAGTC 
TCAGCATCCC ACATCATCAG GATCATTGAG AAAATCCCCG AGATTGACAG CTACAGCACG 
GAGGGCTTGA AGCCTAATTG GTTAGAAGGA AATGTGAAAT TTAATGGAGT CATGTTCAAC 
TATCCCACCC GACCCAACAT CCCAGTGCTT CAGGGACTGA GCTTCGAGGT GAAGAAGGGG 
CAGACGCTCG CCCTGGTGGG CAGCAGTGGC TGCGGGAAGA GCACGGTGGT CCAGCTGCTC 
GAGCGCTTCT ACAACCCCAT GGCTGGAACA GTGTTTCTAG ATGGCAAAGA AATAAAACAA 
CTCAACGTCC AGTGGCTCCG CGCCCACCTG GGCATTGTGT CCCAGGAGCC CATCCTGTTT 
GACTGCAGCA TCACCGAGAA CATCGCCTAC GGAGACAACA GCCGTGTCGT GTCTCATGAG 
GAGATCGTGA GGGCCGCCAG GGAGGCCAAC ATCCACCAGT TCATCGACTC ACTGCCTGAG 
AAATACAACA CCAGAGTGGG AGACAAAGGG ACTCAGCTGT CGGGCGGGCA GAAGCAGCGC 
ATCGCCATCG CGCGCGCCCT CGTCAGACAG CCTCACATCT TACTTCTGGA TGAAGCGACA 
TCAGCTCTGG ATACGGAGAG TGAAAAGGTC GTCCAGGAAG CGCTGGACAA AGCCAGGGAA 
GGCCGCACCT GCATTGTGAT CGCGCACCGC CTGTCCACCA TCCAGAACGC AGACTTGATC 
GTGGTGATTC AGAACGGCCA GGTCAAGGAG CACGGCACCC ACCAGCAGCT GCTGGCCCAG 
AAAGGCATCT ATTTCTCGAT GGTTCAGGCT GGAGCAAAGC GCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036755.2
CDS	36..3863
Translation	MEFEEGLNGTADKNFSKMGKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQSEINSTQTVSDSSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQAGAKRS

Target ORF information:

RefSeq Version	NM_012623.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012623.2

ORF Insert Sequence:

ATGGAGTTTG AAGAGGGCCT TAACGGAACA GCAGACAAGA ACTTCTCAAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGGA GAAGAAACCT GCTGTTGGCA TATTCGGGAT GTTTCGCTAT 
GCAGATTGGC TTGACAAGCT GTGCATGGCT CTGGGAACTC TCGCTGCTAT CATCCACGGA 
ACCCTGCTTC CCCTCCTGAT GCTGGTGTTC GGATACATGA CAGATAGTTT TACCCAAGCA 
GAGACCCGCA TTCTGCCGAG CGTTACTAAT CAAAGTGAAA TCAACAGTAC ACAGACCGTC 
AGCGACAGCA GTCTGGAGGA GGACATGGCC ATGTACGCCT ACTATTACAC GGGCATTGGT 
GCCGGTGTGC TCATCGTTGC CTACATCCAG GTTTCACTTT GGTGCCTGGC AGCTGGGAGA 
CAAATACACA AGATTAGGCA GAAGTTTTTC CATGCCATCA TGAATCAGGA GATAGGCTGG 
TTTGACGTGA ATGACGCTGG GGAGCTCAAC ACCCGGCTCA CAGATGACGT CTCCAAAATT 
AATGACGGAA TTGGTGACAA ACTTGGAATG TTCTTTCAGT CCATAACGAC ATTTTCAGCC 
GGTTTTATAA TAGGATTTAT AAGTGGTTGG AAGCTAACCC TTGTAATTTT GGCCGTCAGC 
CCTCTTATTG GGTTGTCATC TGCCATGTGG GCAAAGGTAC TGACTTCATT TACTAATAAG 
GAACTCCAGG CTTATGCGAA AGCTGGAGCA GTTGCCGAAG AAGTCTTAGC AGCCATCAGA 
ACTGTGATTG CATTTGGAGG ACAAAAGAAG GAACTTGAAA GGTACAATAA AAATTTAGAA 
GAAGCTAAAA GAGTTGGCAT AAAGAAAGCC ATCACGGCCA ACATTTCCAT AGGTATTGCC 
TACCTGTTGG TCTATGCGTC TTATGCACTG GCATTCTGGT ATGGGACCTC CTTGGTCCTC 
TCAAATGAAT ATTCTATTGG ACAAGTGCTT ACCGTCTTCT TCTCTATTTT ATTGGGGACT 
TTCAGTATTG GACATTTAGC CCCAAACATA GAAGCCTTTG CAAATGCAAG AGGGGCAGCC 
TATGAAATCT TCAAGATAAT TGATAATGAG CCAAGCATTG ACAGCTTCTC AACCAAGGGA 
CACAAACCAG ACAGTATAAT GGGAAATTTG GAATTTAAAA ATGTTTACTT CAACTACCCA 
TCACGAAGTG AAGTTAAGAT CTTGAAGGGC CTCAACCTGA AGGTGAAGAG CGGGCAGACG 
GTAGCCCTGG TTGGCAACAG TGGCTGTGGG AAAAGCACAA CTGTCCAGCT GCTGCAGAGG 
CTCTACGACC CCATAGAGGG CGAGGTCAGT ATCGACGGAC AGGACATCAG GACCATCAAT 
GTGAGGTATC TGCGGGAAAT CATTGGGGTG GTGAGTCAGG AACCCGTGCT GTTTGCCACC 
ACGATTGCCG AAAACATTCG CTATGGCCGA GAAAACGTCA CCATGGATGA GATAGAGAAA 
GCTGTCAAGG AAGCCAATGC CTATGACTTC ATCATGAAAC TGCCCCACAA ATTTAACACC 
CTGGTTGGTG AGAGAGGGGC GCAGCTGAGT GGGGGACAGA AACAGAGGAT CGCCATTGCC 
CGGGCCCTGG TCCGCAACCC CAAGATCCTT TTGTTGGATG AGGCCACGTC AGCCTTGGAC 
ACAGAAAGCG AAGCCGTGGT TCAGGCCGCT CTGGATAAGG CTAGAGAAGG CCGGACCACC 
ATTGTGATAG CTCACCGCTT GTCTACAGTG CGCAATGCTG ACGTCATTGC TGGTTTTGAT 
GGTGGTGTCA TTGTGGAGCA AGGAAATCAT GAAGAGCTCA TGAAAGAGAA GGGCATTTAC 
TTCAAACTTG TCATGACACA GACTAGAGGA AATGAAATTG AACCAGGAAA TAATGCTTAT 
GAATCCCAAA GTGACACTGG TGCCTCTGAG TTGACTTCAG AAAAATCAAA ATCTCCTTTA 
ATAAGGAGAT CAATTCGCAG AAGTATCCAC AGAAGACAAG ACCAGGAGAG AAGACTTAGT 
TCGAAAGAGG ATGTGGATGA AGATGTGCCT ATGGTTTCCT TTTGGCAGAT CCTAAAGCTA 
AATATTAGTG AATGGCCCTA TTTAGTTGTG GGTGTACTTT GTGCTGTTAT AAATGGGTGC 
ATACAACCAG TGTTTGCCAT AGTGTTTTCA AAGATTGTAG GGGTTTTTTC AAGAGACGAC 
GACCATGAAA CCAAACAACG GAATTGTAAC TTGTTTTCCC TTCTCTTTCT GGTCATGGGA 
ATGATTTCTT TTGTTACGTA CTTCTTTCAA GGCTTCGCAT TTGGCAAAGC TGGAGAGATC 
CTCACCAAGC GACTCCGATA CATGGTCTTC AAATCCATGC TGCGACAGGA TATAAGCTGG 
TTTGATGACC ATAAAAACAC CACTGGCTCG CTGACTACCA GGCTCGCTAG TGACGCTTCT 
AATGTTAAAG GGGCTATGGG CTCCAGGCTT GCTGTAGTTA CCCAGAATGT AGCAAACCTT 
GGCACAGGAA TTATCTTATC CTTAGTCTAT GGCTGGCAGC TTACACTTTT ACTTGTAGTA 
ATTATACCAC TCATTGTCTT GGGTGGAATT ATTGAAATGA AACTGTTGTC TGGTCAAGCC 
TTGAAGGACA AGAAAGAGCT AGAGATCTCT GGGAAGATCG CTACAGAAGC AATTGAAAAC 
TTCCGCACTG TTGTCTCTTT GACTCGGGAG CAGAAGTTTG AAACTATGTA TGCCCAGAGC 
TTGCAGATAC CATACAGAAA TGCTTTGAAG AAAGCACACG TCTTTGGGAT CACCTTCGCC 
TTCACCCAGG CCATGATTTA TTTCTCCTAT GCTGCTTGTT TCCGGTTCGG TGCCTACTTG 
GTGGCACGAG AACTCATGAC ATTTGAAAAT GTTATGTTGG TATTTTCTGC TGTTGTCTTT 
GGTGCCATGG CAGCAGGGAA TACCAGTTCA TTCGCTCCTG ACTACGCGAA GGCCAAAGTC 
TCAGCATCCC ACATCATCAG GATCATTGAG AAAATCCCCG AGATTGACAG CTACAGCACG 
GAGGGCTTGA AGCCTAATTG GTTAGAAGGA AATGTGAAAT TTAATGGAGT CATGTTCAAC 
TATCCCACCC GACCCAACAT CCCAGTGCTT CAGGGACTGA GCTTCGAGGT GAAGAAGGGG 
CAGACGCTCG CCCTGGTGGG CAGCAGTGGC TGCGGGAAGA GCACGGTGGT CCAGCTGCTC 
GAGCGCTTCT ACAACCCCAT GGCTGGAACA GTGTTTCTAG ATGGCAAAGA AATAAAACAA 
CTCAACGTCC AGTGGCTCCG CGCCCACCTG GGCATTGTGT CCCAGGAGCC CATCCTGTTT 
GACTGCAGCA TCACCGAGAA CATCGCCTAC GGAGACAACA GCCGTGTCGT GTCTCATGAG 
GAGATCGTGA GGGCCGCCAG GGAGGCCAAC ATCCACCAGT TCATCGACTC ACTGCCTGAG 
AAATACAACA CCAGAGTGGG AGACAAAGGG ACTCAGCTGT CGGGCGGGCA GAAGCAGCGC 
ATCGCCATCG CGCGCGCCCT CGTCAGACAG CCTCACATCT TACTTCTGGA TGAAGCGACA 
TCAGCTCTGG ATACGGAGAG TGAAAAGGTC GTCCAGGAAG CGCTGGACAA AGCCAGGGAA 
GGCCGCACCT GCATTGTGAT CGCGCACCGC CTGTCCACCA TCCAGAACGC AGACTTGATC 
GTGGTGATTC AGAACGGCCA GGTCAAGGAG CACGGCACCC ACCAGCAGCT GCTGGCCCAG 
AAAGGCATCT ATTTCTCGAT GGTTCAGGCT GGAGCAAAGC GCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb1b ( XM_017592469.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447958.1 Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26967
Clone ID Related Accession (Same CDS sequence)	XM_017592469.1
Accession Version	XM_017592469.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	multidrug resistance protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTTTG AAGAGGGCCT TAACGGAACA GCAGACAAGA ACTTCTCAAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGGA GAAGAAACCT GCTGTTGGCA TATTCGGGAT GTTTCGCTAT 
GCAGATTGGC TTGACAAGCT GTGCATGGCT CTGGGAACTC TCGCTGCTAT CATCCACGGA 
ACCCTGCTTC CCCTCCTGAT GCTGGTGTTC GGATACATGA CAGATAGTTT TACCCAAGCA 
GAGACCCGCA TTCTGCCGAG CGTTACTAAT CAAAGTGAAA TCAACAGTAC ACAGACCGTC 
AGCGACAGCA GTCTGGAGGA GGACATGGCC ATGTACGCCT ACTATTACAC GGGCATTGGT 
GCCGGTGTGC TCATCGTTGC CTACATCCAG GTTTCACTTT GGTGCCTGGC AGCTGGGAGA 
CAAATACACA AGATTAGGCA GAAGTTTTTC CATGCCATCA TGAATCAGGA GATAGGCTGG 
TTTGACGTGA ATGACGCTGG GGAGCTCAAC ACCCGGCTCA CAGATGACGT CTCCAAAATT 
AATGACGGAA TTGGTGACAA ACTTGGAATG TTCTTTCAGT CCATAACGAC ATTTTCAGCC 
GGTTTTATAA TAGGATTTAT AAGTGGTTGG AAGCTAACCC TTGTAATTTT GGCCGTCAGC 
CCTCTTATTG GGTTGTCATC TGCCATGTGG GCAAAGGTAC TGACTTCATT TACTAATAAG 
GAACTCCAGG CTTATGCGAA AGCTGGAGCA GTTGCCGAAG AAGTCTTAGC AGCCATCAGA 
ACTGTGATTG CATTTGGAGG ACAAAAGAAG GAACTTGAAA GGTACAATAA AAATTTAGAA 
GAAGCTAAAA GAGTTGGCAT AAAGAAAGCC ATCACGGCCA ACATTTCCAT AGGTATTGCC 
TACCTGTTGG TCTATGCGTC TTATGCACTG GCATTCTGGT ATGGGACCTC CTTGGTCCTC 
TCAAATGAAT ATTCTATTGG ACAAGTGCTT ACCGTCTTCT TCTCTATTTT ATTGGGGACT 
TTCAGTATTG GACATTTAGC CCCAAACATA GAAGCCTTTG CAAATGCAAG AGGGGCAGCC 
TATGAAATCT TCAAGATAAT TGATAATGAG CCAAGCATTG ACAGCTTCTC AACCAAGGGA 
CACAAACCAG ACAGTATAAT GGGAAATTTG GAATTTAAAA ATGTTTACTT CAACTACCCA 
TCACGAAGTG AAGTTAAGAT CTTGAAGGGC CTCAACCTGA AGGTGAAGAG CGGGCAGACG 
GTAGCCCTGG TTGGCAACAG TGGCTGTGGG AAAAGCACAA CTGTCCAGCT GCTGCAGAGG 
CTCTACGACC CCATAGAGGG CGAGGTCAGT ATCGACGGAC AGGACATCAG GACCATCAAT 
GTGAGGTATC TGCGGGAAAT CATTGGGGTG GTGAGTCAGG AACCCGTGCT GTTTGCCACC 
ACGATTGCCG AAAACATTCG CTATGGCCGA GAAAACGTCA CCATGGATGA GATAGAGAAA 
GCTGTCAAGG AAGCCAATGC CTATGACTTC ATCATGAAAC TGCCCCACAA ATTTAACACC 
CTGGTTGGTG AGAGAGGGGC GCAGCTGAGT GGGGGACAGA AACAGAGGAT CGCCATTGCC 
CGGGCCCTGG TCCGCAACCC CAAGATCCTT TTGTTGGATG AGGCCACGTC AGCCTTGGAC 
ACAGAAAGCG AAGCCGTGGT TCAGGCCGCT CTGGATAAGG CTAGAGAAGG CCGGACCACC 
ATTGTGATAG CTCACCGCTT GTCTACAGTG CGCAATGCTG ACGTCATTGC TGGTTTTGAT 
GGTGGTGTCA TTGTGGAGCA AGGAAATCAT GAAGAGCTCA TGAAAGAGAA GGGCATTTAC 
TTCAAACTTG TCATGACACA GACTAGAGGA AATGAAATTG AACCAGGAAA TAATGCTTAT 
GAATCCCAAA GTGACACTGG TGCCTCTGAG TTGACTTCAG AAAAATCAAA ATCTCCTTTA 
ATAAGGAGAT CAATTCGCAG AAGTATCCAC AGAAGACAAG ACCAGGAGAG AAGACTTAGT 
TCGAAAGAGG ATGTGGATGA AGATGTGCCT ATGGTTTCCT TTTGGCAGAT CCTAAAGCTA 
AATATTAGTG AATGGCCCTA TTTAGTTGTG GGTGTACTTT GTGCTGTTAT AAATGGGTGC 
ATACAACCAG TGTTTGCCAT AGTGTTTTCA AAGATTGTAG GGGTTTTTTC AAGAGACGAC 
GACCATGAAA CCAAACAACG GAATTGTAAC TTGTTTTCCC TTCTCTTTCT GGTCATGGGA 
ATGATTTCTT TTGTTACGTA CTTCTTTCAA GGCTTCACAT TTGGCAAAGC TGGAGAGATC 
CTCACCAAGC GACTCCGATA CATGGTCTTC AAATCCATGC TGCGACAGGA TATAAGCTGG 
TTTGATGACC ATAAAAACAC CACTGGCTCG CTGACTACCA GGCTCGCTAG TGACGCTTCT 
AATGTTAAAG GGATCGCTAC AGAAGCAATT GAAAACTTCC GCACTGTTGT CTCTTTGACT 
CGGGAGCAGA AGTTTGAAAC TATGTATGCC CAGAGCTTGC AGATACCATA CAGAAATGCT 
TTGAAGAAAG CACACGTCTT TGGGATCACC TTCGCCTTCA CCCAGGCCAT GATTTATTTC 
TCCTATGCTG CTTGTTTCCG GTTCGGTGCC TACTTGGTGG CACGAGAACT CATGACATTT 
GAAAATGTTA TGTTGGTATT TTCTGCTGTT GTCTTTGGTG CCATGGCAGC AGGGAATACC 
AGTTCATTCG CTCCTGACTA CGCGAAGGCC AAAGTCTCAG CATCCCACAT CATCAGGATC 
ATTGAGAAAA TCCCCGAGAT TGACAGCTAC AGCACGGAGG GCTTGAAGCC TAATTGGTTA 
GAAGGAAATG TGAAATTTAA TGGAGTCATG TTCAACTATC CCACCCGACC CAACATCCCA 
GTGCTTCAGG GACTGAGCTT CGAGGTGAAG AAGGGGCAGA CGCTCGCCCT GGTGGGCAGC 
AGTGGCTGCG GGAAGAGCAC GGTGGTCCAG CTGCTCGAGC GCTTCTACAA CCCCATGGCT 
GGAACAGTGT TTCTAGATGG CAAAGAAATA AAACAACTCA ACGTCCAGTG GCTCCGCGCC 
CACCTGGGCA TTGTGTCCCA GGAGCCCATC CTGTTTGACT GCAGCATCAC CGAGAACATC 
GCCTACGGAG ACAACAGCCG TGTCGTGTCT CATGAGGAGA TCGTGAGGGC CGCCAGGGAG 
GCCAACATCC ACCAGTTCAT CGACTCACTG CCTGAGAAAT ACAACACCAG AGTGGGAGAC 
AAAGGGACTC AGCTGTCGGG CGGGCAGAAG CAGCGCATCG CCATCGCGCG CGCCCTCGTC 
AGACAGCCTC ACATCTTACT TCTGGATGAA GCGACATCAG CTCTGGATAC GGAGAGTGAA 
AAGGTCGTCC AGGAAGCGCT GGACAAAGCC AGGGAAGGCC GCACCTGCAT TGTGATCGCG 
CACCGCCTGT CCACCATCCA GAACGCAGAC TTGATCGTGG TGATTCAGAA CGGCCAGGTC 
AAGGAGCACG GCACCCACCA GCAGCTGCTG GCCCAGAAAG GCATCTATTT CTCGATGGTT 
CAGGCTGGAG CAAAGCGCTC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447958.1
CDS	161..3784
Translation	MEFEEGLNGTADKNFSKMGKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQSEINSTQTVSDSSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQAGAKRS

Target ORF information:

RefSeq Version	XM_017592469.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592469.1

ORF Insert Sequence:

ATGGAGTTTG AAGAGGGCCT TAACGGAACA GCAGACAAGA ACTTCTCAAA GATGGGCAAA 
AAGAGTAAAA AGGAGAAGGA GAAGAAACCT GCTGTTGGCA TATTCGGGAT GTTTCGCTAT 
GCAGATTGGC TTGACAAGCT GTGCATGGCT CTGGGAACTC TCGCTGCTAT CATCCACGGA 
ACCCTGCTTC CCCTCCTGAT GCTGGTGTTC GGATACATGA CAGATAGTTT TACCCAAGCA 
GAGACCCGCA TTCTGCCGAG CGTTACTAAT CAAAGTGAAA TCAACAGTAC ACAGACCGTC 
AGCGACAGCA GTCTGGAGGA GGACATGGCC ATGTACGCCT ACTATTACAC GGGCATTGGT 
GCCGGTGTGC TCATCGTTGC CTACATCCAG GTTTCACTTT GGTGCCTGGC AGCTGGGAGA 
CAAATACACA AGATTAGGCA GAAGTTTTTC CATGCCATCA TGAATCAGGA GATAGGCTGG 
TTTGACGTGA ATGACGCTGG GGAGCTCAAC ACCCGGCTCA CAGATGACGT CTCCAAAATT 
AATGACGGAA TTGGTGACAA ACTTGGAATG TTCTTTCAGT CCATAACGAC ATTTTCAGCC 
GGTTTTATAA TAGGATTTAT AAGTGGTTGG AAGCTAACCC TTGTAATTTT GGCCGTCAGC 
CCTCTTATTG GGTTGTCATC TGCCATGTGG GCAAAGGTAC TGACTTCATT TACTAATAAG 
GAACTCCAGG CTTATGCGAA AGCTGGAGCA GTTGCCGAAG AAGTCTTAGC AGCCATCAGA 
ACTGTGATTG CATTTGGAGG ACAAAAGAAG GAACTTGAAA GGTACAATAA AAATTTAGAA 
GAAGCTAAAA GAGTTGGCAT AAAGAAAGCC ATCACGGCCA ACATTTCCAT AGGTATTGCC 
TACCTGTTGG TCTATGCGTC TTATGCACTG GCATTCTGGT ATGGGACCTC CTTGGTCCTC 
TCAAATGAAT ATTCTATTGG ACAAGTGCTT ACCGTCTTCT TCTCTATTTT ATTGGGGACT 
TTCAGTATTG GACATTTAGC CCCAAACATA GAAGCCTTTG CAAATGCAAG AGGGGCAGCC 
TATGAAATCT TCAAGATAAT TGATAATGAG CCAAGCATTG ACAGCTTCTC AACCAAGGGA 
CACAAACCAG ACAGTATAAT GGGAAATTTG GAATTTAAAA ATGTTTACTT CAACTACCCA 
TCACGAAGTG AAGTTAAGAT CTTGAAGGGC CTCAACCTGA AGGTGAAGAG CGGGCAGACG 
GTAGCCCTGG TTGGCAACAG TGGCTGTGGG AAAAGCACAA CTGTCCAGCT GCTGCAGAGG 
CTCTACGACC CCATAGAGGG CGAGGTCAGT ATCGACGGAC AGGACATCAG GACCATCAAT 
GTGAGGTATC TGCGGGAAAT CATTGGGGTG GTGAGTCAGG AACCCGTGCT GTTTGCCACC 
ACGATTGCCG AAAACATTCG CTATGGCCGA GAAAACGTCA CCATGGATGA GATAGAGAAA 
GCTGTCAAGG AAGCCAATGC CTATGACTTC ATCATGAAAC TGCCCCACAA ATTTAACACC 
CTGGTTGGTG AGAGAGGGGC GCAGCTGAGT GGGGGACAGA AACAGAGGAT CGCCATTGCC 
CGGGCCCTGG TCCGCAACCC CAAGATCCTT TTGTTGGATG AGGCCACGTC AGCCTTGGAC 
ACAGAAAGCG AAGCCGTGGT TCAGGCCGCT CTGGATAAGG CTAGAGAAGG CCGGACCACC 
ATTGTGATAG CTCACCGCTT GTCTACAGTG CGCAATGCTG ACGTCATTGC TGGTTTTGAT 
GGTGGTGTCA TTGTGGAGCA AGGAAATCAT GAAGAGCTCA TGAAAGAGAA GGGCATTTAC 
TTCAAACTTG TCATGACACA GACTAGAGGA AATGAAATTG AACCAGGAAA TAATGCTTAT 
GAATCCCAAA GTGACACTGG TGCCTCTGAG TTGACTTCAG AAAAATCAAA ATCTCCTTTA 
ATAAGGAGAT CAATTCGCAG AAGTATCCAC AGAAGACAAG ACCAGGAGAG AAGACTTAGT 
TCGAAAGAGG ATGTGGATGA AGATGTGCCT ATGGTTTCCT TTTGGCAGAT CCTAAAGCTA 
AATATTAGTG AATGGCCCTA TTTAGTTGTG GGTGTACTTT GTGCTGTTAT AAATGGGTGC 
ATACAACCAG TGTTTGCCAT AGTGTTTTCA AAGATTGTAG GGGTTTTTTC AAGAGACGAC 
GACCATGAAA CCAAACAACG GAATTGTAAC TTGTTTTCCC TTCTCTTTCT GGTCATGGGA 
ATGATTTCTT TTGTTACGTA CTTCTTTCAA GGCTTCACAT TTGGCAAAGC TGGAGAGATC 
CTCACCAAGC GACTCCGATA CATGGTCTTC AAATCCATGC TGCGACAGGA TATAAGCTGG 
TTTGATGACC ATAAAAACAC CACTGGCTCG CTGACTACCA GGCTCGCTAG TGACGCTTCT 
AATGTTAAAG GGATCGCTAC AGAAGCAATT GAAAACTTCC GCACTGTTGT CTCTTTGACT 
CGGGAGCAGA AGTTTGAAAC TATGTATGCC CAGAGCTTGC AGATACCATA CAGAAATGCT 
TTGAAGAAAG CACACGTCTT TGGGATCACC TTCGCCTTCA CCCAGGCCAT GATTTATTTC 
TCCTATGCTG CTTGTTTCCG GTTCGGTGCC TACTTGGTGG CACGAGAACT CATGACATTT 
GAAAATGTTA TGTTGGTATT TTCTGCTGTT GTCTTTGGTG CCATGGCAGC AGGGAATACC 
AGTTCATTCG CTCCTGACTA CGCGAAGGCC AAAGTCTCAG CATCCCACAT CATCAGGATC 
ATTGAGAAAA TCCCCGAGAT TGACAGCTAC AGCACGGAGG GCTTGAAGCC TAATTGGTTA 
GAAGGAAATG TGAAATTTAA TGGAGTCATG TTCAACTATC CCACCCGACC CAACATCCCA 
GTGCTTCAGG GACTGAGCTT CGAGGTGAAG AAGGGGCAGA CGCTCGCCCT GGTGGGCAGC 
AGTGGCTGCG GGAAGAGCAC GGTGGTCCAG CTGCTCGAGC GCTTCTACAA CCCCATGGCT 
GGAACAGTGT TTCTAGATGG CAAAGAAATA AAACAACTCA ACGTCCAGTG GCTCCGCGCC 
CACCTGGGCA TTGTGTCCCA GGAGCCCATC CTGTTTGACT GCAGCATCAC CGAGAACATC 
GCCTACGGAG ACAACAGCCG TGTCGTGTCT CATGAGGAGA TCGTGAGGGC CGCCAGGGAG 
GCCAACATCC ACCAGTTCAT CGACTCACTG CCTGAGAAAT ACAACACCAG AGTGGGAGAC 
AAAGGGACTC AGCTGTCGGG CGGGCAGAAG CAGCGCATCG CCATCGCGCG CGCCCTCGTC 
AGACAGCCTC ACATCTTACT TCTGGATGAA GCGACATCAG CTCTGGATAC GGAGAGTGAA 
AAGGTCGTCC AGGAAGCGCT GGACAAAGCC AGGGAAGGCC GCACCTGCAT TGTGATCGCG 
CACCGCCTGT CCACCATCCA GAACGCAGAC TTGATCGTGG TGATTCAGAA CGGCCAGGTC 
AAGGAGCACG GCACCCACCA GCAGCTGCTG GCCCAGAAAG GCATCTATTT CTCGATGGTT 
CAGGCTGGAG CAAAGCGCTC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb1b ( XM_008762689.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760911.1 Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X2, mRNA.

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CloneID	ORa42940
Clone ID Related Accession (Same CDS sequence)	XM_008762689.2
Accession Version	XM_008762689.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	multidrug resistance protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762689.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTTTC AGTCCATAAC GACATTTTCA GCCGGTTTTA TAATAGGATT TATAAGTGGT 
TGGAAGCTAA CCCTTGTAAT TTTGGCCGTC AGCCCTCTTA TTGGGTTGTC ATCTGCCATG 
TGGGCAAAGG TACTGACTTC ATTTACTAAT AAGGAACTCC AGGCTTATGC GAAAGCTGGA 
GCAGTTGCCG AAGAAGTCTT AGCAGCCATC AGAACTGTGA TTGCATTTGG AGGACAAAAG 
AAGGAACTTG AAAGGTACAA TAAAAATTTA GAAGAAGCTA AAAGAGTTGG CATAAAGAAA 
GCCATCACGG CCAACATTTC CATAGGTATT GCCTACCTGT TGGTCTATGC GTCTTATGCA 
CTGGCATTCT GGTATGGGAC CTCCTTGGTC CTCTCAAATG AATATTCTAT TGGACAAGTG 
CTTACCGTCT TCTTCTCTAT TTTATTGGGG ACTTTCAGTA TTGGACATTT AGCCCCAAAC 
ATAGAAGCCT TTGCAAATGC AAGAGGGGCA GCCTATGAAA TCTTCAAGAT AATTGATAAT 
GAGCCAAGCA TTGACAGCTT CTCAACCAAG GGACACAAAC CAGACAGTAT AATGGGAAAT 
TTGGAATTTA AAAATGTTTA CTTCAACTAC CCATCACGAA GTGAAGTTAA GATCTTGAAG 
GGCCTCAACC TGAAGGTGAA GAGCGGGCAG ACGGTAGCCC TGGTTGGCAA CAGTGGCTGT 
GGGAAAAGCA CAACTGTCCA GCTGCTGCAG AGGCTCTACG ACCCCATAGA GGGCGAGGTC 
AGTATCGACG GACAGGACAT CAGGACCATC AATGTGAGGT ATCTGCGGGA AATCATTGGG 
GTGGTGAGTC AGGAACCCGT GCTGTTTGCC ACCACGATTG CCGAAAACAT TCGCTATGGC 
CGAGAAAACG TCACCATGGA TGAGATAGAG AAAGCTGTCA AGGAAGCCAA TGCCTATGAC 
TTCATCATGA AACTGCCCCA CAAATTTAAC ACCCTGGTTG GTGAGAGAGG GGCGCAGCTG 
AGTGGGGGAC AGAAACAGAG GATCGCCATT GCCCGGGCCC TGGTCCGCAA CCCCAAGATC 
CTTTTGTTGG ATGAGGCCAC GTCAGCCTTG GACACAGAAA GCGAAGCCGT GGTTCAGGCC 
GCTCTGGATA AGGCTAGAGA AGGCCGGACC ACCATTGTGA TAGCTCACCG CTTGTCTACA 
GTGCGCAATG CTGACGTCAT TGCTGGTTTT GATGGTGGTG TCATTGTGGA GCAAGGAAAT 
CATGAAGAGC TCATGAAAGA GAAGGGCATT TACTTCAAAC TTGTCATGAC ACAGACTAGA 
GGAAATGAAA TTGAACCAGG AAATAATGCT TATGAATCCC AAAGTGACAC TGGTGCCTCT 
GAGTTGACTT CAGAAAAATC AAAATCTCCT TTAATAAGGA GATCAATTCG CAGAAGTATC 
CACAGAAGAC AAGACCAGGA GAGAAGACTT AGTTCGAAAG AGGATGTGGA TGAAGATGTG 
CCTATGGTTT CCTTTTGGCA GATCCTAAAG CTAAATATTA GTGAATGGCC CTATTTAGTT 
GTGGGTGTAC TTTGTGCTGT TATAAATGGG TGCATACAAC CAGTGTTTGC CATAGTGTTT 
TCAAAGATTG TAGGGGTTTT TTCAAGAGAC GACGACCATG AAACCAAACA ACGGAATTGT 
AACTTGTTTT CCCTTCTCTT TCTGGTCATG GGAATGATTT CTTTTGTTAC GTACTTCTTT 
CAAGGCTTCA CATTTGGCAA AGCTGGAGAG ATCCTCACCA AGCGACTCCG ATACATGGTC 
TTCAAATCCA TGCTGCGACA GGATATAAGC TGGTTTGATG ACCATAAAAA CACCACTGGC 
TCGCTGACTA CCAGGCTCGC TAGTGACGCT TCTAATGTTA AAGGGGCTAT GGGCTCCAGG 
CTTGCTGTAG TTACCCAGAA TGTAGCAAAC CTTGGCACAG GAATTATCTT ATCCTTAGTC 
TATGGCTGGC AGCTTACACT TTTACTTGTA GTAATTATAC CACTCATTGT CTTGGGTGGA 
ATTATTGAAA TGAAACTGTT GTCTGGTCAA GCCTTGAAGG ACAAGAAAGA GCTAGAGATC 
TCTGGGAAGA TCGCTACAGA AGCAATTGAA AACTTCCGCA CTGTTGTCTC TTTGACTCGG 
GAGCAGAAGT TTGAAACTAT GTATGCCCAG AGCTTGCAGA TACCATACAG AAATGCTTTG 
AAGAAAGCAC ACGTCTTTGG GATCACCTTC GCCTTCACCC AGGCCATGAT TTATTTCTCC 
TATGCTGCTT GTTTCCGGTT CGGTGCCTAC TTGGTGGCAC GAGAACTCAT GACATTTGAA 
AATGTTATGT TGGTATTTTC TGCTGTTGTC TTTGGTGCCA TGGCAGCAGG GAATACCAGT 
TCATTCGCTC CTGACTACGC GAAGGCCAAA GTCTCAGCAT CCCACATCAT CAGGATCATT 
GAGAAAATCC CCGAGATTGA CAGCTACAGC ACGGAGGGCT TGAAGCCTAA TTGGTTAGAA 
GGAAATGTGA AATTTAATGG AGTCATGTTC AACTATCCCA CCCGACCCAA CATCCCAGTG 
CTTCAGGGAC TGAGCTTCGA GGTGAAGAAG GGGCAGACGC TCGCCCTGGT GGGCAGCAGT 
GGCTGCGGGA AGAGCACGGT GGTCCAGCTG CTCGAGCGCT TCTACAACCC CATGGCTGGA 
ACAGTGTTTC TAGATGGCAA AGAAATAAAA CAACTCAACG TCCAGTGGCT CCGCGCCCAC 
CTGGGCATTG TGTCCCAGGA GCCCATCCTG TTTGACTGCA GCATCACCGA GAACATCGCC 
TACGGAGACA ACAGCCGTGT CGTGTCTCAT GAGGAGATCG TGAGGGCCGC CAGGGAGGCC 
AACATCCACC AGTTCATCGA CTCACTGCCT GAGAAATACA ACACCAGAGT GGGAGACAAA 
GGGACTCAGC TGTCGGGCGG GCAGAAGCAG CGCATCGCCA TCGCGCGCGC CCTCGTCAGA 
CAGCCTCACA TCTTACTTCT GGATGAAGCG ACATCAGCTC TGGATACGGA GAGTGAAAAG 
GTCGTCCAGG AAGCGCTGGA CAAAGCCAGG GAAGGCCGCA CCTGCATTGT GATCGCGCAC 
CGCCTGTCCA CCATCCAGAA CGCAGACTTG ATCGTGGTGA TTCAGAACGG CCAGGTCAAG 
GAGCACGGCA CCCACCAGCA GCTGCTGGCC CAGAAAGGCA TCTATTTCTC GATGGTTCAG 
GCTGGAGCAA AGCGCTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760911.1
CDS	388..3648
Translation	MFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQAGAKRS

Target ORF information:

RefSeq Version	XM_008762689.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762689.2

ORF Insert Sequence:

ATGTTCTTTC AGTCCATAAC GACATTTTCA GCCGGTTTTA TAATAGGATT TATAAGTGGT 
TGGAAGCTAA CCCTTGTAAT TTTGGCCGTC AGCCCTCTTA TTGGGTTGTC ATCTGCCATG 
TGGGCAAAGG TACTGACTTC ATTTACTAAT AAGGAACTCC AGGCTTATGC GAAAGCTGGA 
GCAGTTGCCG AAGAAGTCTT AGCAGCCATC AGAACTGTGA TTGCATTTGG AGGACAAAAG 
AAGGAACTTG AAAGGTACAA TAAAAATTTA GAAGAAGCTA AAAGAGTTGG CATAAAGAAA 
GCCATCACGG CCAACATTTC CATAGGTATT GCCTACCTGT TGGTCTATGC GTCTTATGCA 
CTGGCATTCT GGTATGGGAC CTCCTTGGTC CTCTCAAATG AATATTCTAT TGGACAAGTG 
CTTACCGTCT TCTTCTCTAT TTTATTGGGG ACTTTCAGTA TTGGACATTT AGCCCCAAAC 
ATAGAAGCCT TTGCAAATGC AAGAGGGGCA GCCTATGAAA TCTTCAAGAT AATTGATAAT 
GAGCCAAGCA TTGACAGCTT CTCAACCAAG GGACACAAAC CAGACAGTAT AATGGGAAAT 
TTGGAATTTA AAAATGTTTA CTTCAACTAC CCATCACGAA GTGAAGTTAA GATCTTGAAG 
GGCCTCAACC TGAAGGTGAA GAGCGGGCAG ACGGTAGCCC TGGTTGGCAA CAGTGGCTGT 
GGGAAAAGCA CAACTGTCCA GCTGCTGCAG AGGCTCTACG ACCCCATAGA GGGCGAGGTC 
AGTATCGACG GACAGGACAT CAGGACCATC AATGTGAGGT ATCTGCGGGA AATCATTGGG 
GTGGTGAGTC AGGAACCCGT GCTGTTTGCC ACCACGATTG CCGAAAACAT TCGCTATGGC 
CGAGAAAACG TCACCATGGA TGAGATAGAG AAAGCTGTCA AGGAAGCCAA TGCCTATGAC 
TTCATCATGA AACTGCCCCA CAAATTTAAC ACCCTGGTTG GTGAGAGAGG GGCGCAGCTG 
AGTGGGGGAC AGAAACAGAG GATCGCCATT GCCCGGGCCC TGGTCCGCAA CCCCAAGATC 
CTTTTGTTGG ATGAGGCCAC GTCAGCCTTG GACACAGAAA GCGAAGCCGT GGTTCAGGCC 
GCTCTGGATA AGGCTAGAGA AGGCCGGACC ACCATTGTGA TAGCTCACCG CTTGTCTACA 
GTGCGCAATG CTGACGTCAT TGCTGGTTTT GATGGTGGTG TCATTGTGGA GCAAGGAAAT 
CATGAAGAGC TCATGAAAGA GAAGGGCATT TACTTCAAAC TTGTCATGAC ACAGACTAGA 
GGAAATGAAA TTGAACCAGG AAATAATGCT TATGAATCCC AAAGTGACAC TGGTGCCTCT 
GAGTTGACTT CAGAAAAATC AAAATCTCCT TTAATAAGGA GATCAATTCG CAGAAGTATC 
CACAGAAGAC AAGACCAGGA GAGAAGACTT AGTTCGAAAG AGGATGTGGA TGAAGATGTG 
CCTATGGTTT CCTTTTGGCA GATCCTAAAG CTAAATATTA GTGAATGGCC CTATTTAGTT 
GTGGGTGTAC TTTGTGCTGT TATAAATGGG TGCATACAAC CAGTGTTTGC CATAGTGTTT 
TCAAAGATTG TAGGGGTTTT TTCAAGAGAC GACGACCATG AAACCAAACA ACGGAATTGT 
AACTTGTTTT CCCTTCTCTT TCTGGTCATG GGAATGATTT CTTTTGTTAC GTACTTCTTT 
CAAGGCTTCA CATTTGGCAA AGCTGGAGAG ATCCTCACCA AGCGACTCCG ATACATGGTC 
TTCAAATCCA TGCTGCGACA GGATATAAGC TGGTTTGATG ACCATAAAAA CACCACTGGC 
TCGCTGACTA CCAGGCTCGC TAGTGACGCT TCTAATGTTA AAGGGGCTAT GGGCTCCAGG 
CTTGCTGTAG TTACCCAGAA TGTAGCAAAC CTTGGCACAG GAATTATCTT ATCCTTAGTC 
TATGGCTGGC AGCTTACACT TTTACTTGTA GTAATTATAC CACTCATTGT CTTGGGTGGA 
ATTATTGAAA TGAAACTGTT GTCTGGTCAA GCCTTGAAGG ACAAGAAAGA GCTAGAGATC 
TCTGGGAAGA TCGCTACAGA AGCAATTGAA AACTTCCGCA CTGTTGTCTC TTTGACTCGG 
GAGCAGAAGT TTGAAACTAT GTATGCCCAG AGCTTGCAGA TACCATACAG AAATGCTTTG 
AAGAAAGCAC ACGTCTTTGG GATCACCTTC GCCTTCACCC AGGCCATGAT TTATTTCTCC 
TATGCTGCTT GTTTCCGGTT CGGTGCCTAC TTGGTGGCAC GAGAACTCAT GACATTTGAA 
AATGTTATGT TGGTATTTTC TGCTGTTGTC TTTGGTGCCA TGGCAGCAGG GAATACCAGT 
TCATTCGCTC CTGACTACGC GAAGGCCAAA GTCTCAGCAT CCCACATCAT CAGGATCATT 
GAGAAAATCC CCGAGATTGA CAGCTACAGC ACGGAGGGCT TGAAGCCTAA TTGGTTAGAA 
GGAAATGTGA AATTTAATGG AGTCATGTTC AACTATCCCA CCCGACCCAA CATCCCAGTG 
CTTCAGGGAC TGAGCTTCGA GGTGAAGAAG GGGCAGACGC TCGCCCTGGT GGGCAGCAGT 
GGCTGCGGGA AGAGCACGGT GGTCCAGCTG CTCGAGCGCT TCTACAACCC CATGGCTGGA 
ACAGTGTTTC TAGATGGCAA AGAAATAAAA CAACTCAACG TCCAGTGGCT CCGCGCCCAC 
CTGGGCATTG TGTCCCAGGA GCCCATCCTG TTTGACTGCA GCATCACCGA GAACATCGCC 
TACGGAGACA ACAGCCGTGT CGTGTCTCAT GAGGAGATCG TGAGGGCCGC CAGGGAGGCC 
AACATCCACC AGTTCATCGA CTCACTGCCT GAGAAATACA ACACCAGAGT GGGAGACAAA 
GGGACTCAGC TGTCGGGCGG GCAGAAGCAG CGCATCGCCA TCGCGCGCGC CCTCGTCAGA 
CAGCCTCACA TCTTACTTCT GGATGAAGCG ACATCAGCTC TGGATACGGA GAGTGAAAAG 
GTCGTCCAGG AAGCGCTGGA CAAAGCCAGG GAAGGCCGCA CCTGCATTGT GATCGCGCAC 
CGCCTGTCCA CCATCCAGAA CGCAGACTTG ATCGTGGTGA TTCAGAACGG CCAGGTCAAG 
GAGCACGGCA CCCACCAGCA GCTGCTGGCC CAGAAAGGCA TCTATTTCTC GATGGTTCAG 
GCTGGAGCAA AGCGCTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
Cell death & disease8(9)e3038(2017 Sep)
Su L,Cheng YC,Lee WM,Zhang M,Yang F,Zhao B,Han D,Liu Y,Hu D

Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Neurochemical research42(8)2167-2177(2017 Aug)
Yu N,Zhang YF,Zhang K,Cheng YF,Ma HY,Di Q

Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.
Molecular pharmacology91(4)373-382(2017 Apr)
Mesev EV,Miller DS,Cannon RE

The absorption enhancement of norisoboldine in the duodenum of adjuvant-induced arthritis rats involves the impairment of P-glycoprotein.
Biopharmaceutics & drug disposition38(1)75-83(2017 Jan)
Duan C,Guo JM,Dai Y,Xia YF

Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.
PloS one12(1)e0166061(2017)
Aryal M,Fischer K,Gentile C,Gitto S,Zhang YZ,McDannold N

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Abcb1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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