Pdgfrb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdgfrb
Entrez Gene ID	24629
Full Name	platelet derived growth factor receptor beta
Synonyms	PDGFR-1
General protein information	Preferred Names platelet derived growth factor receptor beta Names platelet-derived growth factor receptor beta CD140 antigen-like family member B PDGF-R-beta PDGFR-beta Platelet-derived growth factor receptor, beta beta platelet-derived growth factor receptor beta-type platelet-derived growth factor receptor platelet derived growth factor receptor, beta polypeptide platelet-derived growth factor receptor 1 platelet-derived growth factor receptor beta variant 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	binds platelet derived growth factor BB homodimer [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254789.3	XP_006254851.1	platelet-derived growth factor receptor beta isoform X1
NM_031525.1	NP_113713.1	platelet-derived growth factor receptor beta precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PDGFRB	NP_002600.1
Mus musculus (house mouse)	Pdgfrb	NP_001139740.1
Pan troglodytes (chimpanzee)	PDGFRB	XP_518034.3
Bos taurus (cattle)	PDGFRB	NP_001069364.2
Rattus norvegicus (Norway rat)	Pdgfrb	NP_113713.1
Canis lupus familiaris (dog)	PDGFRB	NP_001003382.1
Xenopus tropicalis (tropical clawed frog)	pdgfrb	XP_002940133.2
	PDGFRB	XP_001107595.1
Gallus gallus (chicken)	PDGFRB	XP_001233830.1
Danio rerio (zebrafish)	pdgfrb	NP_001177862.1

Gene Ontology
Bibliography

Related articles in PubMed

mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Ivanovska J, Shah S, Wong MJ, Kantores C, Jain A, Post M, Yeganeh B, Jankov RP
Pediatric pulmonology52(11)1443-1454(2017 Nov)

Expansion of the phenotype of Kosaki overgrowth syndrome.
Minatogawa M, Takenouchi T, Tsuyusaki Y, Iwasaki F, Uehara T, Kurosawa K, Kosaki K, Curry CJ
American journal of medical genetics. Part A173(9)2422-2427(2017 Sep)

Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFR?.
K?r?a M, O?uz N, ?etin A, Uzuner F, Ye?ilkaya A
Journal of receptor and signal transduction research37(2)167-173(2017 Apr)

MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFR? signaling.
Dong N, Wang W, Tian J, Xie Z, Lv B, Dai J, Jiang R, Huang D, Fang S, Tian J, Li H, Yu B
International journal of molecular medicine39(4)791-798(2017 Apr)

Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor ? in the rat brain.
Bor A, Nishijo M, Nishimaru H, Nakamura T, Tran NN, Van Le Q, Takamura Y, Matsumoto J, Nishino Y, Nishijo H
Journal of integrative neuroscience16(4)453-470(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid.
Title: Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFR?.

These data suggest that miR182 may be a novel smooth muscle cell phenotypic marker and a modulator that may be used to prevent smooth muscle cell dedifferentiation via FGF9/PDGFRbeta signaling.
Title: MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFR? signaling.

Data suggest that expression of microRNA-9 (Mir9) in cardiac fibroblasts is involved in regulation of expression of Pdgfr-beta (platelet-derived growth factor beta receptor) and in prevention of cardiac fibrosis; here, overexpression of Mir9 inhibits cardiac fibrosis in primary cardiac fibroblasts by targeting Pdgfr-beta.
Title: MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-? in rats.

dihydroartemisinin protects the liver from injury and fibrogenesis via disruption of the PDGF-betaR/ERK pathway
Title: Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-?R/ERK signaling pathway.

Data indicate transforming growth factor beta (TGFbeta) involvement in early activation of platelet-derived growth factor receptor beta (PDGFRbeta)+ pericytes in aristolochic acid induced acute kidney injury.
Title: Blocking TGF-? Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFR?+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.

The following Pdgfrb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdgfrb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12535	NM_031525.1 Latest version!	Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa38424	XM_006254789.3 Latest version!	Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdgfrb ( NM_031525.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113713.1 Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), mRNA.

Price & Availability↑

CloneID	ORa12535
Clone ID Related Accession (Same CDS sequence)	NM_031525.1
Accession Version	NM_031525.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	platelet-derived growth factor receptor beta precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY090783.1. On Jan 12, 2005 this sequence version replaced XM_214560.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY090783.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCTTC CAGAGGTGAT GCCAGCTTCA GTCCTCAGAG GCCAATTGTT GCTGTTCGTG 
CTATTGCTCC TGGGACCACA GATCTCCCAA GGCCTAGTCA TCACGCCCCC TGGGCCAGAG 
TTCGTCCTCA ACATTTCGAG CACCTTTGTT CTGACATGCT CAAGTTCAGC TCCAGTGATG 
TGGGAACAGA TGTCCCAGGT GCCCTGGCAA GAAGCAGCCA TGAACCAGGA TGGCACCTTC 
TCCAGTGTGC TGACACTGAC TAATGTCACT GGGGGAGACA CCGGAGAATA CTTTTGTGTC 
TACAACAACT CACTGGGGCC AGAGCTCAGT GAGCGGAAGC GCATCTATAT CTTTGTGCCA 
GATCCCACCA TGGGCTTCCT CCCGATGGAC TCTGAGGACC TATTCATTTT TGTCACGGAT 
GTCACTGAGA CGACGATTCC ATGCCGAGTG ACAGACCCCC AGCTGGAGGT GACGCTGCAT 
GAGAAGAAAG TGGATATCCC CCTACATGTA CCCTATGACC ACCAGCGAGG TTTCATTGGT 
ACTTTTGAGG ACAAGACTTA CATTTGCAAA ACCACCATTG GGGACAGGGA AGTGGACTCC 
GATACTTACT ATGTCTACAG CCTGCAGGTG TCATCCATCA ATGTCTCTGT GAATGCAGTG 
CAGACTGTGG TCCGCCAGGG CGAGAGCATC ACCATCAGGT GCATCGTGAT GGGCAATGAT 
GTGGTCAACT TCCAGTGGAC GTACCCCCGC ATGAAGAGTG GGCGGCTGGT GGAGCCGGTG 
ACAGATTACC TCTTCGGAGT GCCCTCCCGC ATTGGCTCCA TTCTTCATAT CCCCACCGCT 
GAGCTGAGTG ACTCTGGCAC CTATACTTGC AACGTGTCAG TGAGTGTGAA TGACCACGGC 
GATGAGAAAG CCATCAACGT TACTGTGATC GAAAATGGCT ATGTGCGGCT GCTGGAAACA 
CTGGAAGACG TACAAATTGC TGAGCTGCAC CGGAGCCGGA CGTTGCAGGT GGTGTTTGAG 
GCTTATCCGA CGCCCTCTGT CCTGTGGTTC AAGGACAACC GTACCTTGGG TGACTCCAGC 
GCTGGCGAGT TGGTTCTGTC CACTCGCAAC GTGTCTGAGA CCCGGTATGT GTCAGAACTG 
ACCTTGGTAC GTGTGAAGGT GTCAGAAGCG GGCTACTATA CCATGCGGGC CTTCCATGCG 
GACGACCAGG TCCAGCTCTC ATTCAAGCTG CAGGTCAATG TCCCTGTCCG TGTACTGGAG 
CTGAGTGAGA GTCATCCTGC CAATGGGGAG CAGATACTCC GCTGTCGGGG CCGGGGCATG 
CCTCAGCCAA ATGTCACCTG GTCTACCTGC AGAGACCTCA AAAGGTGTCC GCGAAAACTG 
TCACCCACAC CCTTGGGGAA TAGTTCCAAG GAGGAGAGCC AGCTAGAAAC GAACGTGACT 
TTCTGGGAGG AAGATCAGGA ATATGAGGTG GTGAGCACGC TGCGCCTGCG TCACGTGGAC 
CAGCCACTGT CAGTGCGCTG TATGCTGCAG AACTCGATGG GCAGAGATTC ACAAGAGGTC 
ACCGTGGTAC CACACTCCTT GCCTTTCAAA GTGGTGGTGA TCTCAGCCAT CTTGGCCTTG 
GTGGTCCTTA CTGTCATCTC TCTCATCATC CTCATCATGC TGTGGCAGAG GAAACCACGC 
TATGAGATCC GATGGAAGGT CATTGAGTCT GTGAGCTCTG ACGGCCATGA GTACATCTAT 
GTGGATCCTG TGCAGTTGCC TTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTTGTT 
CTGGGACGCA CTCTTGGCTC TGGGGCTTTC GGACAGGTGG TGGAGGCCAC CGCTCATGGT 
CTGAGCCACT CACAAGCCAC CATGAAAGTG GCTGTCAAGA TGCTGAAATC TACAGCCAGA 
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG TTGAAGATCA TGAGTCATCT CGGACCCCAC 
CTGAACGTGG TCAACCTGCT GGGGGCCTGT ACCAAAGGAG GGCCCATCTA CATTATCACG 
GAATACTGCC GTTATGGTGA CCTGGTGGAC TACCTGCACC GAAACAAACA CACCTTCCTG 
CAACGACACT CCAACAAGCA TTGTCCACCC AGCACTGAGC TCTACAGCAA CGCCCTGCCG 
GTGGGGCTCT CCCTACCCAG CCACTTGAAC CTGACTGGGG AGAGCGACGG TGGTTACATG 
GACATGAGCA AGGATGAATC TGTAGATTAC GTGCCCATGT TGGACATGAA AGGACACATC 
AAATACGCGG ACATCGAGTC CTCCAGCTAC ATGGCCCCTT ACGATAACTA TGTCCCATCT 
GCCCCTGAAA GGACCTATCG TGCTACCTTA ATCAACGACT CACCAGTGCT CAGCTACACA 
GACCTCGTGG GCTTCAGTTA CCAAGTGGCC AATGGCATGG AATTCTTGGC CTCTAAGAAC 
TGTGTTCACC GAGACCTGGC GGCCAGGAAT GTGCTCATCT GTGAGGGCAA GTTGGTCAAG 
ATCTGTGACT TTGGCCTGGC TCGAGACATC ATGCGGGACT CAAACTACAT CTCCAAAGGC 
AGTACTTTCC TGCCTCTGAA GTGGATGGCC CCAGAGAGCA TCTTCAACAG CCTCTACACC 
ACCTTGAGTG ATGTGTGGTC CTTTGGAATC CTACTCTGGG AAATCTTCAC ACTGGGTGGC 
ACCCCTTACC CAGAGCTGCC CATGAACGAC CAGTTCTACA ATGCCATCAA GAGGGGCTAC 
CGCATGGCCC AACCTGCTCA TGCCTCCGAC GAGATCTATG AGATCATGCA GAAATGCTGG 
GAAGAAAAGT TTGAGACTCG GCCCCCCTTC TCTCAGCTGG TGCTGCTCCT GGAGAGGCTT 
CTGGGTGAAG GCTATAAAAA GAAGTACCAG CAGGTGGATG AGGAGTTTCT GAGGAGTGAC 
CATCCAGCCA TCCTGAGGTC CCAAGCCCGC TTGCCGGGTC TCCACAGCCT CCGATCCCCT 
CTGGATACCA GCTCTGTCCT CTACACTGCT GTGCAGCCTA ATGAGACTGA CAATGACTAC 
ATCATCCCCT TGCCTGACCC CAAGCCTGAT GCTGCTGATG AGGGCCTCCT AGAGGGTTCC 
CCCAGCCTTG CCAGCTCCAC CTTGAATGAA GTCAACACTT CTTCCACCAT CTCCTGCGAC 
AGCCCCCTGG AGCTCCAAGA AGAGCCGCAA GCAGAGCCTG AGGCACAGCT GGAGCAGCCA 
CAGGATTCAG GCTGCCCAGG ACCTCTGGCT GAGGCAGAGG ACAGCTTCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113713.1
CDS	367..3660
Translation	MGLPEVMPASVLRGQLLLFVLLLLGPQISQGLVITPPGPEFVLNISSTFVLTCSSSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFIGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETLEDVQIAELHRSRTLQVVFEAYPTPSVLWFKDNRTLGDSSAGELVLSTRNVSETRYVSELTLVRVKVSEAGYYTMRAFHADDQVQLSFKLQVNVPVRVLELSESHPANGEQILRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGRDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQRKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHLNLTGESDGGYMDMSKDESVDYVPMLDMKGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGLHSLRSPLDTSSVLYTAVQPNETDNDYIIPLPDPKPDAADEGLLEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQAEPEAQLEQPQDSGCPGPLAEAEDSFL

Target ORF information:

RefSeq Version	NM_031525.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031525.1

ORF Insert Sequence:

ATGGGGCTTC CAGAGGTGAT GCCAGCTTCA GTCCTCAGAG GCCAATTGTT GCTGTTCGTG 
CTATTGCTCC TGGGACCACA GATCTCCCAA GGCCTAGTCA TCACGCCCCC TGGGCCAGAG 
TTCGTCCTCA ACATTTCGAG CACCTTTGTT CTGACATGCT CAAGTTCAGC TCCAGTGATG 
TGGGAACAGA TGTCCCAGGT GCCCTGGCAA GAAGCAGCCA TGAACCAGGA TGGCACCTTC 
TCCAGTGTGC TGACACTGAC TAATGTCACT GGGGGAGACA CCGGAGAATA CTTTTGTGTC 
TACAACAACT CACTGGGGCC AGAGCTCAGT GAGCGGAAGC GCATCTATAT CTTTGTGCCA 
GATCCCACCA TGGGCTTCCT CCCGATGGAC TCTGAGGACC TATTCATTTT TGTCACGGAT 
GTCACTGAGA CGACGATTCC ATGCCGAGTG ACAGACCCCC AGCTGGAGGT GACGCTGCAT 
GAGAAGAAAG TGGATATCCC CCTACATGTA CCCTATGACC ACCAGCGAGG TTTCATTGGT 
ACTTTTGAGG ACAAGACTTA CATTTGCAAA ACCACCATTG GGGACAGGGA AGTGGACTCC 
GATACTTACT ATGTCTACAG CCTGCAGGTG TCATCCATCA ATGTCTCTGT GAATGCAGTG 
CAGACTGTGG TCCGCCAGGG CGAGAGCATC ACCATCAGGT GCATCGTGAT GGGCAATGAT 
GTGGTCAACT TCCAGTGGAC GTACCCCCGC ATGAAGAGTG GGCGGCTGGT GGAGCCGGTG 
ACAGATTACC TCTTCGGAGT GCCCTCCCGC ATTGGCTCCA TTCTTCATAT CCCCACCGCT 
GAGCTGAGTG ACTCTGGCAC CTATACTTGC AACGTGTCAG TGAGTGTGAA TGACCACGGC 
GATGAGAAAG CCATCAACGT TACTGTGATC GAAAATGGCT ATGTGCGGCT GCTGGAAACA 
CTGGAAGACG TACAAATTGC TGAGCTGCAC CGGAGCCGGA CGTTGCAGGT GGTGTTTGAG 
GCTTATCCGA CGCCCTCTGT CCTGTGGTTC AAGGACAACC GTACCTTGGG TGACTCCAGC 
GCTGGCGAGT TGGTTCTGTC CACTCGCAAC GTGTCTGAGA CCCGGTATGT GTCAGAACTG 
ACCTTGGTAC GTGTGAAGGT GTCAGAAGCG GGCTACTATA CCATGCGGGC CTTCCATGCG 
GACGACCAGG TCCAGCTCTC ATTCAAGCTG CAGGTCAATG TCCCTGTCCG TGTACTGGAG 
CTGAGTGAGA GTCATCCTGC CAATGGGGAG CAGATACTCC GCTGTCGGGG CCGGGGCATG 
CCTCAGCCAA ATGTCACCTG GTCTACCTGC AGAGACCTCA AAAGGTGTCC GCGAAAACTG 
TCACCCACAC CCTTGGGGAA TAGTTCCAAG GAGGAGAGCC AGCTAGAAAC GAACGTGACT 
TTCTGGGAGG AAGATCAGGA ATATGAGGTG GTGAGCACGC TGCGCCTGCG TCACGTGGAC 
CAGCCACTGT CAGTGCGCTG TATGCTGCAG AACTCGATGG GCAGAGATTC ACAAGAGGTC 
ACCGTGGTAC CACACTCCTT GCCTTTCAAA GTGGTGGTGA TCTCAGCCAT CTTGGCCTTG 
GTGGTCCTTA CTGTCATCTC TCTCATCATC CTCATCATGC TGTGGCAGAG GAAACCACGC 
TATGAGATCC GATGGAAGGT CATTGAGTCT GTGAGCTCTG ACGGCCATGA GTACATCTAT 
GTGGATCCTG TGCAGTTGCC TTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTTGTT 
CTGGGACGCA CTCTTGGCTC TGGGGCTTTC GGACAGGTGG TGGAGGCCAC CGCTCATGGT 
CTGAGCCACT CACAAGCCAC CATGAAAGTG GCTGTCAAGA TGCTGAAATC TACAGCCAGA 
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG TTGAAGATCA TGAGTCATCT CGGACCCCAC 
CTGAACGTGG TCAACCTGCT GGGGGCCTGT ACCAAAGGAG GGCCCATCTA CATTATCACG 
GAATACTGCC GTTATGGTGA CCTGGTGGAC TACCTGCACC GAAACAAACA CACCTTCCTG 
CAACGACACT CCAACAAGCA TTGTCCACCC AGCACTGAGC TCTACAGCAA CGCCCTGCCG 
GTGGGGCTCT CCCTACCCAG CCACTTGAAC CTGACTGGGG AGAGCGACGG TGGTTACATG 
GACATGAGCA AGGATGAATC TGTAGATTAC GTGCCCATGT TGGACATGAA AGGACACATC 
AAATACGCGG ACATCGAGTC CTCCAGCTAC ATGGCCCCTT ACGATAACTA TGTCCCATCT 
GCCCCTGAAA GGACCTATCG TGCTACCTTA ATCAACGACT CACCAGTGCT CAGCTACACA 
GACCTCGTGG GCTTCAGTTA CCAAGTGGCC AATGGCATGG AATTCTTGGC CTCTAAGAAC 
TGTGTTCACC GAGACCTGGC GGCCAGGAAT GTGCTCATCT GTGAGGGCAA GTTGGTCAAG 
ATCTGTGACT TTGGCCTGGC TCGAGACATC ATGCGGGACT CAAACTACAT CTCCAAAGGC 
AGTACTTTCC TGCCTCTGAA GTGGATGGCC CCAGAGAGCA TCTTCAACAG CCTCTACACC 
ACCTTGAGTG ATGTGTGGTC CTTTGGAATC CTACTCTGGG AAATCTTCAC ACTGGGTGGC 
ACCCCTTACC CAGAGCTGCC CATGAACGAC CAGTTCTACA ATGCCATCAA GAGGGGCTAC 
CGCATGGCCC AACCTGCTCA TGCCTCCGAC GAGATCTATG AGATCATGCA GAAATGCTGG 
GAAGAAAAGT TTGAGACTCG GCCCCCCTTC TCTCAGCTGG TGCTGCTCCT GGAGAGGCTT 
CTGGGTGAAG GCTATAAAAA GAAGTACCAG CAGGTGGATG AGGAGTTTCT GAGGAGTGAC 
CATCCAGCCA TCCTGAGGTC CCAAGCCCGC TTGCCGGGTC TCCACAGCCT CCGATCCCCT 
CTGGATACCA GCTCTGTCCT CTACACTGCT GTGCAGCCTA ATGAGACTGA CAATGACTAC 
ATCATCCCCT TGCCTGACCC CAAGCCTGAT GCTGCTGATG AGGGCCTCCT AGAGGGTTCC 
CCCAGCCTTG CCAGCTCCAC CTTGAATGAA GTCAACACTT CTTCCACCAT CTCCTGCGAC 
AGCCCCCTGG AGCTCCAAGA AGAGCCGCAA GCAGAGCCTG AGGCACAGCT GGAGCAGCCA 
CAGGATTCAG GCTGCCCAGG ACCTCTGGCT GAGGCAGAGG ACAGCTTCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pdgfrb ( XM_006254789.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254851.1 Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38424
Clone ID Related Accession (Same CDS sequence)	XM_006254789.3
Accession Version	XM_006254789.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	platelet-derived growth factor receptor beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254789.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCTTC CAGAGGTGAT GCCAGCTTCA GTCCTCAGAG GCCAATTGTT GCTGTTCGTG 
CTATTGCTCC TGGGACCACA GATCTCCCAA GGCCTAGTCA TCACGCCCCC TGGGCCAGAG 
TTCGTCCTCA ACATTTCGAG CACCTTTGTT CTGACATGCT CAAGTTCAGC TCCAGTGATG 
TGGGAACAGA TGTCCCAGGT GCCCTGGCAA GAAGCAGCCA TGAACCAGGA TGGCACCTTC 
TCCAGTGTGC TGACACTGAC TAATGTCACT GGGGGAGACA CCGGAGAATA CTTTTGTGTC 
TACAACAACT CACTGGGGCC AGAGCTCAGT GAGCGGAAGC GCATCTATAT CTTTGTGCCA 
GATCCCACCA TGGGCTTCCT CCCGATGGAC TCTGAGGACC TATTCATTTT TGTCACGGAT 
GTCACTGAGA CGACGATTCC ATGCCGAGTG ACAGACCCCC AGCTGGAGGT GACGCTGCAT 
GAGAAGAAAG TGGATATCCC CCTACATGTA CCCTATGACC ACCAGCGAGG TTTCATTGGT 
ACTTTTGAGG ACAAGACTTA CATTTGCAAA ACCACCATTG GGGACAGGGA AGTGGACTCC 
GATACTTACT ATGTCTACAG CCTGCAGGTG TCATCCATCA ATGTCTCTGT GAATGCAGTG 
CAGACTGTGG TCCGCCAGGG CGAGAGCATC ACCATCAGGT GCATCGTGAT GGGCAATGAT 
GTGGTCAACT TCCAGTGGAC GTACCCCCGC ATGAAGAGTG GGCGGCTGGT GGAGCCGGTG 
ACAGATTACC TCTTCGGAGT GCCCTCCCGC ATTGGCTCCA TTCTTCATAT CCCCACCGCT 
GAGCTGAGTG ACTCTGGCAC CTATACTTGC AACGTGTCAG TGAGTGTGAA TGACCACGGC 
GATGAGAAAG CCATCAACGT TACTGTGATC GAAAATGGCT ATGTGCGGCT GCTGGAAACA 
CTGGAAGACG TACAAATTGC TGAGCTGCAC CGGAGCCGGA CGTTGCAGGT GGTGTTTGAG 
GCTTATCCGA CGCCCTCTGT CCTGTGGTTC AAGGACAACC GTACCTTGGG TGACTCCAGC 
GCTGGCGAGT TGGTTCTGTC CACTCGCAAC GTGTCTGAGA CCCGGTATGT GTCAGAACTG 
ACCTTGGTAC GTGTGAAGGT GTCAGAAGCG GGCTACTATA CCATGCGGGC CTTCCATGCG 
GACGACCAGG TCCAGCTCTC ATTCAAGCTG CAGGTCAATG TCCCTGTCCG TGTACTGGAG 
CTGAGTGAGA GTCATCCTGC CAATGGGGAG CAGATACTCC GCTGTCGGGG CCGGGGCATG 
CCTCAGCCAA ATGTCACCTG GTCTACCTGC AGAGACCTCA AAAGGTGTCC GCGAAAACTG 
TCACCCACAC CCTTGGGGAA TAGTTCCAAG GAGGAGAGCC AGCTAGAAAC GAACGTGACT 
TTCTGGGAGG AAGATCAGGA ATATGAGGTG GTGAGCACGC TGCGCCTGCG TCACGTGGAC 
CAGCCACTGT CAGTGCGCTG TATGCTGCAG AACTCGATGG GCAGAGATTC ACAAGAGGTC 
ACCGTGGTAC CACACTCCTT GCCTTTCAAA GTGGTGGTGA TCTCAGCCAT CTTGGCCTTG 
GTGGTCCTTA CTGTCATCTC TCTCATCATC CTCATCATGC TGTGGCAGAG GAAACCACGC 
TATGAGATCC GATGGAAGGT CATTGAGTCT GTGAGCTCTG ACGGCCATGA GTACATCTAT 
GTGGATCCTG TGCAGTTGCC TTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTTGTT 
CTGGGACGCA CTCTTGGCTC TGGGGCTTTC GGACAGGTGG TGGAGGCCAC GGCTCATGGT 
CTGAGCCACT CACAGGCCAC CATGAAAGTG GCTGTCAAGA TGCTGAAATC TACAGCCAGA 
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG CTGAAGATCA TGAGTCATCT CGGACCCCAC 
CTGAACGTGG TCAACCTGCT GGGGGCCTGT ACCAAAGGAG GGCCCATCTA CATTATCACG 
GAATACTGCC GTTATGGTGA CCTGGTGGAC TACCTGCACC GAAACAAACA CACCTTCCTG 
CAACGACACT CCAACAAGCA TTGTCCACCC AGCACTGAGC TCTACAGCAA CGCCCTGCCG 
GTGGGGCTCT CCCTACCCAG CCACTTGAAC CTGACTGGGG AGAGCGACGG TGGTTACATG 
GACATGAGCA AGGATGAATC TGTAGATTAC GTGCCCATGT TGGACATGAA AGGACACATC 
AAATACGCGG ACATCGAGTC CTCCAGCTAC ATGGCCCCTT ACGATAACTA TGTCCCATCT 
GCCCCTGAAA GGACCTATCG TGCTACCTTA ATCAACGACT CACCAGTGCT CAGCTACACG 
GACCTCGTGG GCTTCAGTTA CCAAGTGGCC AATGGCATGG AATTCTTGGC CTCTAAGAAC 
TGTGTTCACC GAGACCTGGC GGCCAGGAAT GTGCTCATCT GTGAGGGCAA GTTGGTCAAG 
ATCTGTGACT TTGGCCTGGC TCGAGACATC ATGCGGGACT CAAACTACAT CTCCAAAGGC 
AGTACTTTCC TGCCTCTGAA GTGGATGGCC CCAGAGAGCA TCTTCAACAG CCTCTACACC 
ACCTTGAGTG ATGTGTGGTC CTTTGGAATC CTACTCTGGG AAATCTTCAC ACTGGGTGGC 
ACCCCTTACC CAGAGCTGCC CATGAACGAC CAGTTCTACA ATGCCATCAA GAGGGGCTAC 
CGCATGGCCC AACCTGCTCA TGCCTCCGAC GAGATCTATG AGATCATGCA GAAATGCTGG 
GAAGAAAAGT TTGAGACTCG GCCCCCCTTC TCTCAGCTGG TGCTGCTCCT GGAGAGGCTT 
CTGGGTGAAG GCTATAAAAA GAAGTACCAG CAGGTGGATG AGGAGTTTCT GAGGAGTGAC 
CATCCAGCCA TCCTGAGGTC CCAAGCCCGC TTGCCGGGTC TCCACAGCCT CCGATCCCCT 
CTGGATACCA GCTCTGTCCT CTACACTGCT GTGCAGCCTA ATGAGACTGA CAATGACTAC 
ATCATCCCCT TGCCTGACCC CAAGCCTGAT GCTGCTGATG AGGGCCTCCT AGAGGGTTCC 
CCCAGCCTTG CCAGCTCCAC CTTGAATGAA GTCAACACTT CTTCCACCAT CTCCTGCGAC 
AGCCCCCTGG AGCTCCAAGA AGAGCCGCAA GCAGAGCCTG AGGCACAGCT GGAGCAGCCA 
CAGGATTCAG GCTGCCCAGG ACCTCTGGCT GAGGCAGAGG ACAGCTTCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254851.1
CDS	458..3751
Translation	MGLPEVMPASVLRGQLLLFVLLLLGPQISQGLVITPPGPEFVLNISSTFVLTCSSSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFIGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETLEDVQIAELHRSRTLQVVFEAYPTPSVLWFKDNRTLGDSSAGELVLSTRNVSETRYVSELTLVRVKVSEAGYYTMRAFHADDQVQLSFKLQVNVPVRVLELSESHPANGEQILRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGRDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQRKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHLNLTGESDGGYMDMSKDESVDYVPMLDMKGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGLHSLRSPLDTSSVLYTAVQPNETDNDYIIPLPDPKPDAADEGLLEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQAEPEAQLEQPQDSGCPGPLAEAEDSFL

Target ORF information:

RefSeq Version	XM_006254789.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus platelet derived growth factor receptor beta (Pdgfrb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254789.3

ORF Insert Sequence:

ATGGGGCTTC CAGAGGTGAT GCCAGCTTCA GTCCTCAGAG GCCAATTGTT GCTGTTCGTG 
CTATTGCTCC TGGGACCACA GATCTCCCAA GGCCTAGTCA TCACGCCCCC TGGGCCAGAG 
TTCGTCCTCA ACATTTCGAG CACCTTTGTT CTGACATGCT CAAGTTCAGC TCCAGTGATG 
TGGGAACAGA TGTCCCAGGT GCCCTGGCAA GAAGCAGCCA TGAACCAGGA TGGCACCTTC 
TCCAGTGTGC TGACACTGAC TAATGTCACT GGGGGAGACA CCGGAGAATA CTTTTGTGTC 
TACAACAACT CACTGGGGCC AGAGCTCAGT GAGCGGAAGC GCATCTATAT CTTTGTGCCA 
GATCCCACCA TGGGCTTCCT CCCGATGGAC TCTGAGGACC TATTCATTTT TGTCACGGAT 
GTCACTGAGA CGACGATTCC ATGCCGAGTG ACAGACCCCC AGCTGGAGGT GACGCTGCAT 
GAGAAGAAAG TGGATATCCC CCTACATGTA CCCTATGACC ACCAGCGAGG TTTCATTGGT 
ACTTTTGAGG ACAAGACTTA CATTTGCAAA ACCACCATTG GGGACAGGGA AGTGGACTCC 
GATACTTACT ATGTCTACAG CCTGCAGGTG TCATCCATCA ATGTCTCTGT GAATGCAGTG 
CAGACTGTGG TCCGCCAGGG CGAGAGCATC ACCATCAGGT GCATCGTGAT GGGCAATGAT 
GTGGTCAACT TCCAGTGGAC GTACCCCCGC ATGAAGAGTG GGCGGCTGGT GGAGCCGGTG 
ACAGATTACC TCTTCGGAGT GCCCTCCCGC ATTGGCTCCA TTCTTCATAT CCCCACCGCT 
GAGCTGAGTG ACTCTGGCAC CTATACTTGC AACGTGTCAG TGAGTGTGAA TGACCACGGC 
GATGAGAAAG CCATCAACGT TACTGTGATC GAAAATGGCT ATGTGCGGCT GCTGGAAACA 
CTGGAAGACG TACAAATTGC TGAGCTGCAC CGGAGCCGGA CGTTGCAGGT GGTGTTTGAG 
GCTTATCCGA CGCCCTCTGT CCTGTGGTTC AAGGACAACC GTACCTTGGG TGACTCCAGC 
GCTGGCGAGT TGGTTCTGTC CACTCGCAAC GTGTCTGAGA CCCGGTATGT GTCAGAACTG 
ACCTTGGTAC GTGTGAAGGT GTCAGAAGCG GGCTACTATA CCATGCGGGC CTTCCATGCG 
GACGACCAGG TCCAGCTCTC ATTCAAGCTG CAGGTCAATG TCCCTGTCCG TGTACTGGAG 
CTGAGTGAGA GTCATCCTGC CAATGGGGAG CAGATACTCC GCTGTCGGGG CCGGGGCATG 
CCTCAGCCAA ATGTCACCTG GTCTACCTGC AGAGACCTCA AAAGGTGTCC GCGAAAACTG 
TCACCCACAC CCTTGGGGAA TAGTTCCAAG GAGGAGAGCC AGCTAGAAAC GAACGTGACT 
TTCTGGGAGG AAGATCAGGA ATATGAGGTG GTGAGCACGC TGCGCCTGCG TCACGTGGAC 
CAGCCACTGT CAGTGCGCTG TATGCTGCAG AACTCGATGG GCAGAGATTC ACAAGAGGTC 
ACCGTGGTAC CACACTCCTT GCCTTTCAAA GTGGTGGTGA TCTCAGCCAT CTTGGCCTTG 
GTGGTCCTTA CTGTCATCTC TCTCATCATC CTCATCATGC TGTGGCAGAG GAAACCACGC 
TATGAGATCC GATGGAAGGT CATTGAGTCT GTGAGCTCTG ACGGCCATGA GTACATCTAT 
GTGGATCCTG TGCAGTTGCC TTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTTGTT 
CTGGGACGCA CTCTTGGCTC TGGGGCTTTC GGACAGGTGG TGGAGGCCAC GGCTCATGGT 
CTGAGCCACT CACAGGCCAC CATGAAAGTG GCTGTCAAGA TGCTGAAATC TACAGCCAGA 
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG CTGAAGATCA TGAGTCATCT CGGACCCCAC 
CTGAACGTGG TCAACCTGCT GGGGGCCTGT ACCAAAGGAG GGCCCATCTA CATTATCACG 
GAATACTGCC GTTATGGTGA CCTGGTGGAC TACCTGCACC GAAACAAACA CACCTTCCTG 
CAACGACACT CCAACAAGCA TTGTCCACCC AGCACTGAGC TCTACAGCAA CGCCCTGCCG 
GTGGGGCTCT CCCTACCCAG CCACTTGAAC CTGACTGGGG AGAGCGACGG TGGTTACATG 
GACATGAGCA AGGATGAATC TGTAGATTAC GTGCCCATGT TGGACATGAA AGGACACATC 
AAATACGCGG ACATCGAGTC CTCCAGCTAC ATGGCCCCTT ACGATAACTA TGTCCCATCT 
GCCCCTGAAA GGACCTATCG TGCTACCTTA ATCAACGACT CACCAGTGCT CAGCTACACG 
GACCTCGTGG GCTTCAGTTA CCAAGTGGCC AATGGCATGG AATTCTTGGC CTCTAAGAAC 
TGTGTTCACC GAGACCTGGC GGCCAGGAAT GTGCTCATCT GTGAGGGCAA GTTGGTCAAG 
ATCTGTGACT TTGGCCTGGC TCGAGACATC ATGCGGGACT CAAACTACAT CTCCAAAGGC 
AGTACTTTCC TGCCTCTGAA GTGGATGGCC CCAGAGAGCA TCTTCAACAG CCTCTACACC 
ACCTTGAGTG ATGTGTGGTC CTTTGGAATC CTACTCTGGG AAATCTTCAC ACTGGGTGGC 
ACCCCTTACC CAGAGCTGCC CATGAACGAC CAGTTCTACA ATGCCATCAA GAGGGGCTAC 
CGCATGGCCC AACCTGCTCA TGCCTCCGAC GAGATCTATG AGATCATGCA GAAATGCTGG 
GAAGAAAAGT TTGAGACTCG GCCCCCCTTC TCTCAGCTGG TGCTGCTCCT GGAGAGGCTT 
CTGGGTGAAG GCTATAAAAA GAAGTACCAG CAGGTGGATG AGGAGTTTCT GAGGAGTGAC 
CATCCAGCCA TCCTGAGGTC CCAAGCCCGC TTGCCGGGTC TCCACAGCCT CCGATCCCCT 
CTGGATACCA GCTCTGTCCT CTACACTGCT GTGCAGCCTA ATGAGACTGA CAATGACTAC 
ATCATCCCCT TGCCTGACCC CAAGCCTGAT GCTGCTGATG AGGGCCTCCT AGAGGGTTCC 
CCCAGCCTTG CCAGCTCCAC CTTGAATGAA GTCAACACTT CTTCCACCAT CTCCTGCGAC 
AGCCCCCTGG AGCTCCAAGA AGAGCCGCAA GCAGAGCCTG AGGCACAGCT GGAGCAGCCA 
CAGGATTCAG GCTGCCCAGG ACCTCTGGCT GAGGCAGAGG ACAGCTTCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Pediatric pulmonology52(11)1443-1454(2017 Nov)
Ivanovska J,Shah S,Wong MJ,Kantores C,Jain A,Post M,Yeganeh B,Jankov RP

Expansion of the phenotype of Kosaki overgrowth syndrome.
American journal of medical genetics. Part A173(9)2422-2427(2017 Sep)
Minatogawa M,Takenouchi T,Tsuyusaki Y,Iwasaki F,Uehara T,Kurosawa K,Kosaki K,Curry CJ

Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFR?.
Journal of receptor and signal transduction research37(2)167-173(2017 Apr)
K?r?a M,O?uz N,?etin A,Uzuner F,Ye?ilkaya A

MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFR? signaling.
International journal of molecular medicine39(4)791-798(2017 Apr)
Dong N,Wang W,Tian J,Xie Z,Lv B,Dai J,Jiang R,Huang D,Fang S,Tian J,Li H,Yu B

Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor ? in the rat brain.
Journal of integrative neuroscience16(4)453-470(2017)
Bor A,Nishijo M,Nishimaru H,Nakamura T,Tran NN,Van Le Q,Takamura Y,Matsumoto J,Nishino Y,Nishijo H

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Pdgfrb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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