Pdgfb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdgfb
Entrez Gene ID	24628
Full Name	platelet derived growth factor subunit B
Synonyms	SIS,c-sis
General protein information	Preferred Names platelet derived growth factor subunit B Names platelet-derived growth factor subunit B PDGF subunit B PDGF-2 Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis) pdgf protein platelet derived growth factor, B polypeptide platelet derived growth factor-bb platelet-derived growth factor B chain platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	may play a role in carotid artery smooth muscle cell proliferation and neointimal formation in response to balloon catheter injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031524.1	NP_113712.1	platelet-derived growth factor subunit B precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDGFB	NP_001003383.1
Pan troglodytes (chimpanzee)	PDGFB	XP_515140.2
	PDGFB	XP_001097395.1
Gallus gallus (chicken)	PDGFB	NP_989601.2
Danio rerio (zebrafish)	LOC796490	XP_005171670.1
Bos taurus (cattle)	PDGFB	NP_001017953.2
Mus musculus (house mouse)	Pdgfb	NP_035187.2
Xenopus tropicalis (tropical clawed frog)	pdgfb	XP_002933796.1
Homo sapiens (human)	PDGFB	NP_002599.1
Rattus norvegicus (Norway rat)	Pdgfb	NP_113712.1

Gene Ontology
Bibliography

Related articles in PubMed

Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
Zhang M, Ahn W, Kim S, Hong HS, Quan C, Son Y
Microcirculation (New York, N.Y. : 1994)24(8)(2017 Nov)

PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1? Signaling Pathway.
Xiao Y, Peng H, Hong C, Chen Z, Deng X, Wang A, Yang F, Yang L, Chen C, Qin X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1603-1613(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Warburg effect plays a critical role in PDGF-induced pulmonary arterial smooth muscle cells proliferation and is mediated by activation of the PI3K signaling pathway and HIF-1alpha.
Title: PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1? Signaling Pathway.

Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation.
Title: Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.

These effects of digoxin were shown to be mediated, at least in part, through an increase in ILK/Akt signaling and a decrease in GSK-3beta signaling in PDGFBB-stimulated VSMCs
Title: Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury.

expression altered in experimental Necrotizing enterocolitis
Title: Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis.

Endogenous PDGF-BB exerts a crucial protective effect to cultured cardiomyocytes exposed to hypoxia.
Title: Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia.

The following Pdgfb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdgfb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13492	NM_031524.1 Latest version!	Rattus norvegicus platelet derived growth factor subunit B (Pdgfb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdgfb ( NM_031524.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113712.1 Rattus norvegicus platelet derived growth factor subunit B (Pdgfb), mRNA.

Price & Availability↑

CloneID	ORa13492
Clone ID Related Accession (Same CDS sequence)	NM_031524.1
Accession Version	NM_031524.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	platelet-derived growth factor subunit B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB580369.1, Z14117.1, CB783426.1 and BQ782530.1. On or before Oct 11, 2007 this sequence version replaced XM_343293.3, XM_001075973.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAATCGCT GCTGGGCGCT CTTCCTGCCT CTCTGCTGCT ACCTGCGTCT GGTCAGCGCT 
GAGGGGGATC CCATTCCTGA GGAACTCTAT GAAATGCTGA GTGACCACTC CATCCGCTCC 
TTTGATGACC TTCAGCGCCT GCTGCACAGA GACTCCGTAG ACGAAGATGG GGCTGAGCTG 
GACTTGAACA TGACCCGAGC ACATTCTGGA GTCGAGTCGG AAAGCTCATC TCGAGGGAGG 
AGGAGCCTAG GGTCTCTGGC TGCAGCAGAG CCTGCCGTAA TCGCCGAGTG CAAGACGCGT 
ACAGAGGTGT TCCAGATCTC GCGGAACCTC ATCGATCGCA CCAATGCCAA CTTCCTGGTG 
TGGCCGCCCT GCGTGGAGGT GCAGCGCTGC TCGGGCTGCT GCAATAACCG CAATGTGCAG 
TGCCGGGCCT CGCAGGTGCA GATGCGGCCG GTGCAGGTGA GAAAGATCGA AATTGTGAGA 
AAGAAGCCAG TCTTCAAGAA GGCCACAGTG ACCCTGGAGG ACCATCTGGC CTGCAAGTGT 
GAGACAGTAG TGACCCCTCG GCCCGTGACT CGAAGTCCTG GGACATCCAG GGAGCATCGA 
GCCAAGACAC CTCAAACTCG GGTGACCGTT CGGACGGTGC GAATCCGCCG GCCCCCCAAA 
GGGAAGCACC GAAAGTTTAA GCACACCCAT GACAAGAAGG CACTGAAGGA GATCCTTGGA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113712.1
CDS	396..1121
Translation	MNRCWALFLPLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHRDSVDEDGAELDLNMTRAHSGVESESSSRGRRSLGSLAAAEPAVIAECKTRTEVFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKKATVTLEDHLACKCETVVTPRPVTRSPGTSREHRAKTPQTRVTVRTVRIRRPPKGKHRKFKHTHDKKALKEILGA

Target ORF information:

RefSeq Version	NM_031524.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus platelet derived growth factor subunit B (Pdgfb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031524.1

ORF Insert Sequence:

ATGAATCGCT GCTGGGCGCT CTTCCTGCCT CTCTGCTGCT ACCTGCGTCT GGTCAGCGCT 
GAGGGGGATC CCATTCCTGA GGAACTCTAT GAAATGCTGA GTGACCACTC CATCCGCTCC 
TTTGATGACC TTCAGCGCCT GCTGCACAGA GACTCCGTAG ACGAAGATGG GGCTGAGCTG 
GACTTGAACA TGACCCGAGC ACATTCTGGA GTCGAGTCGG AAAGCTCATC TCGAGGGAGG 
AGGAGCCTAG GGTCTCTGGC TGCAGCAGAG CCTGCCGTAA TCGCCGAGTG CAAGACGCGT 
ACAGAGGTGT TCCAGATCTC GCGGAACCTC ATCGATCGCA CCAATGCCAA CTTCCTGGTG 
TGGCCGCCCT GCGTGGAGGT GCAGCGCTGC TCGGGCTGCT GCAATAACCG CAATGTGCAG 
TGCCGGGCCT CGCAGGTGCA GATGCGGCCG GTGCAGGTGA GAAAGATCGA AATTGTGAGA 
AAGAAGCCAG TCTTCAAGAA GGCCACAGTG ACCCTGGAGG ACCATCTGGC CTGCAAGTGT 
GAGACAGTAG TGACCCCTCG GCCCGTGACT CGAAGTCCTG GGACATCCAG GGAGCATCGA 
GCCAAGACAC CTCAAACTCG GGTGACCGTT CGGACGGTGC GAATCCGCCG GCCCCCCAAA 
GGGAAGCACC GAAAGTTTAA GCACACCCAT GACAAGAAGG CACTGAAGGA GATCCTTGGA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
Microcirculation (New York, N.Y. : 1994)24(8)(2017 Nov)
Zhang M,Ahn W,Kim S,Hong HS,Quan C,Son Y

PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1? Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1603-1613(2017)
Xiao Y,Peng H,Hong C,Chen Z,Deng X,Wang A,Yang F,Yang L,Chen C,Qin X

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Pdgfb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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