Sipa1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sipa1l1
Entrez Gene ID	246212
Full Name	signal-induced proliferation-associated 1 like 1
Synonyms	SPAL,Spa-1,Spa1,Spar
General protein information	Preferred Names signal-induced proliferation-associated 1 like 1 Names signal-induced proliferation-associated 1-like protein 1 SIPA1-like protein 1 SPA-1 like protein SPA-1-like protein p1294 spine-associated Rap GTPase-activating protein spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	GTPase-activating protein (GAP) that is specific for Rap1; may be involved in cytoskeletal organization of neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139330.1	NP_647546.1	signal-induced proliferation-associated 1-like protein 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SIPA1L1	XP_002691041.1
Homo sapiens (human)	SIPA1L1	NP_056371.1
	SIPA1L1	XP_001084201.1
Canis lupus familiaris (dog)	SIPA1L1	XP_005623657.1
Xenopus tropicalis (tropical clawed frog)	sipa1l1	XP_004917306.1
Mus musculus (house mouse)	Sipa1l1	NP_766167.2
Rattus norvegicus (Norway rat)	Sipa1l1	NP_647546.1
Pan troglodytes (chimpanzee)	SIPA1L1	XP_510040.2
Gallus gallus (chicken)	SIPA1L1	NP_001186619.1
Danio rerio (zebrafish)	sipa1l1	NP_001025340.1

Gene Ontology
Bibliography

Related articles in PubMed

Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.
Zhi WJ, Peng RY, Li HJ, Zou Y, Yao BW, Wang CZ, Liu ZH, Gao XH, Xu XP, Dong J, Zhao L, Zhou HM, Wang LF, Hu XJ
Brain research1679134-143(2018 Jan)

Prenatal stress increased Snk Polo-like kinase 2, SCF ?-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.
Chutabhakdikul N, Surakul P
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience31(7)560-7(2013 Nov)

Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons.
Chen Y, Yuanxiang P, Kn?pfel T, Thomas U, Behnisch T
Synapse (New York, N.Y.)66(2)142-50(2012 Feb)

Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.
Lee KJ, Lee Y, Rozeboom A, Lee JY, Udagawa N, Hoe HS, Pak DT
Neuron69(5)957-73(2011 Mar)

Role of the SNK-SPAR pathway in the development of Alzheimer's disease.
Gong X, Lu X, Zhan L, Sui H, Qi X, Ji Z, Niu X, Liu L
IUBMB life62(3)214-21(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats
Title: Prenatal stress increased Snk Polo-like kinase 2, SCF ?-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.

Long-term potentiation triggers downregulation of SPAR requiring ubiquitin proteasome system and NMDA receptor activation but not cyclin-dependent kinase (CDK)5.
Title: Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons.

the SNK-SPAR pathway may possibly play a crucial role in Amyloid beta-induced excitotoxic damage in the central nervous system by regulating synaptic stability.
Title: Role of the SNK-SPAR pathway in the development of Alzheimer's disease.

the multiple SPAR functional domains have been expressed in E. coli in quantities suitable for biophysical and biochemical studies, allowing us to investigate the role of the PDZ domain in SPAR function .
Title: Heterologous high-level E. coli expression, purification and biophysical characterization of the spine-associated RapGAP (SPAR) PDZ domain.

postsynaptic RapGAP SPAR is regulated by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
Title: Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.

The following Sipa1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sipa1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02366	NM_139330.1 Latest version!	Rattus norvegicus signal-induced proliferation-associated 1 like 1 (Sipa1l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sipa1l1 ( NM_139330.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_647546.1 Rattus norvegicus signal-induced proliferation-associated 1 like 1 (Sipa1l1), mRNA.

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CloneID	ORa02366
Clone ID Related Accession (Same CDS sequence)	NM_139330.1
Accession Version	NM_139330.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	signal-induced proliferation-associated 1-like protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF026504.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF026504.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGACCAGCT TGAAGAGGTC GCAGACCGAA AGGCCTGTCA CTGCTGACAG AGCCTCTGTT 
GTCAGCACAG ATGGCACCCC CAAAGTTCAC ACTGATGATT TCTACATGCG TCGCTTCCGG 
TCCCAAAATG GCAGCTTAGG ATCATCAGTC ATGGCTGCAG TAGGGCCCCC TCGAAGTGAA 
GGTCCTCACC ATATAACCTC AACCCCCGGA GTCCCCAAGA TGGGGGTTAG GGCAAGAATT 
GCAGATTGGC CTCCAAGAAA GGAAAATGTA AAAGAATCTA GCCGTTCAAG CCAGGAAATA 
GAAACCTCAA GTTGCCTTGA GAGCCTGTCC TCCAAAGGCA GTCCTGTGAG TCAGGGGAGT 
TCTGTTAGCC TCAATTCCAA TGACTCAGCC ATGCTGAAGA GCATCCAGAA CACCCTGAAG 
AACAAGACGG GGCCAGCGGA GAGCATGGAC TCGAGATTCC TCATGCCTGA AGCCTACCCC 
AGCTCCCCCA GGAAAGCCCT TCGCCGAATC CGTCAGCGTA GCAACAGTGA TATCACCATA 
AGTGAGCTTG ATGTGGATAG TTTTGATGAA TGTATCTCCC CAACCTACAA GTCGGGGCCA 
TCATTGCACA GGGAATATGG TAGCACATCT TCAATCGACA AGCAGGGGAC ATCCGGAGAA 
AGCTTCTTCG GTTTGTTAAA GGGCTATAAA GACGACAGAG CTGACCGAGG TCCAACTCCA 
ACCAAACTCA GTGACTTCCT CATCACTGGT GGGGGCAAGG GTTCTGGTTT CTCCTTGGAT 
GTGATCGATG GACCCATTTC ACAGAGAGAG AACCTCAGGC TATTCAAGGA AAGGGAAAAA 
CCACTCAAGC GACGTTCTAA GTCTGAAACT GGAGACTCAT CCATTTTTCG TAAATTACGC 
AATGCCAAAG GTGAAGAACT CGGGAAGTCA TCAGACCTTG AAGACAACAG ATCAGAGGAT 
TCTGTGAGGC CCTGGACATG TCCAAAGTGC TTTGCCCACT ATGATGTCCA GAGCATATTG 
TTTGACTTGA ATGAAGCCAT TATGAACAGG CATAATGTGA TTAAGAGGAG AAACACCACA 
ACGGGAGCTT CTGCAGCCGC TGTGGCGTCC TTAGTCTCGG GACCTTTGTC TCACTCAACC 
AGCTTCAGCT CTCCTATGGG CAGCACAGAG GACTTCAATT CCAAAGGAAG CCTCGGCATG 
GACCAGGGAG ATGACAAGAG CAATGAACTC GTCATGAGCT GTCCGTACTT TCGGAATGAG 
ATTGGGGGAG AAGGTGAGAG GAAAATCAGC CTGTCCAAGT CCAATTCTGG CTCATTCAGT 
GGGTGTGAGA GCACGTCCTT TGAGTCTGCC CTCAGCTCTC ACTGCACAAA CGCAGGAGTG 
GCGGTTCTCG AAGTGCCCAA GGAGAGCTTG ATGCTGCATC TAGACAGAGT GAGACGGTAC 
ACTGTGGAGC ACGTGGATCT TGGAGCATAC TATTACAGGA AGTGCTTCTA CCAAAAGGAA 
CACTGGAACT ATTTTGGGGC TGATGAAAAC CTCGGTCCAG TGGCTGTGAG CATTCGAAGG 
GAAAAACCAG AAGACATGAA GGAAAATGGA TCTCCCTACA ACTACCGAAT AATTTTTAGA 
ACTAGTGAGC TCATGACACT GAGAGGGTCT GTCCTGGAGG ATGCCATTCC CTCCACAGCC 
AAGCACTCGA CAGCCAGAGG ATTGCCGCTG AAAGAGGTGC TGGAACATGT GATCCCAGAG 
CTCAACGTGC AGTGCCTGCG TTTGGCCTTC AACACGCCCA AAGTCACCGA GCAGCTTATG 
AAACTGGACG AGCAAGGGCT GAACTATCAG CAGAAAGTAG GCATCATGTA CTGCAAAGCA 
GGCCAGAGCA CCGAGGAGGA GATGTACAAC ACGCCCAAAG TCACGGAGCA GTTTATGAAA 
CTGGACGAGC AAGGGCTGAA TTATCAGCAG AAAGTAGGCA TCATGTACTG CAAAGCAGGC 
CAGAGCACCG AGGAGGAGAT GTACAATAAT GAGTCCGCTG GCCCGGCCTT TGAGGAATTT 
CTTCAGCTAC TGGGAGAGCG AGTTCGCCTA AAAGGATTTG AAAAGTATCG TGCGCAGCTC 
GACACCAAAA CTGACTCCAC TGGAACCCAC TCTCTGTACA CAACCTACAA AGACTATGAG 
ATAATGTTCC ACGTCTCCAC CATGCTGCCC TACACACCTA ACAACAAGCA ACAGCTCCTG 
AGGAAGCGGC ACATTGGGAA TGACATTGTG ACAATAGTTT TCCAGGAGCC TGGAGCACAA 
CCATTTAGCC CGAAAAACAT CCGATCTCAC TTTCAGCATG TTTTTGTCAT TGTCCGGGCT 
CACAACCCCT GCACTGAGAG TGTCTGTTAC AGTGTGGCAG TCACCAGGTC CAGAGATGTG 
CCTTCTTTTG GACCTCCCAT CCCTAAAGGG GTCACCTTCC CCAAGTCAAA CGTGTTCAGG 
GACTTCCTTT TGGCCAAAGT GATTAATGCA GAAAACGCTG CTCATAAATC AGAGAAGTTC 
AGGGCCATGG CAACAAGGAC CCGCCAGGAA TACCTGAAAG ATCTGGCAGA AAAGAATGTC 
ACCAACACAC CTATTGACCC TTCTGGCAAG TTTCCATTTA TTTCTCTGGC TTCTAAGAAG 
AAGGAAAAGT CTAAGCCTTA CCCAGGAGCT GAGCTCAGTA GCATGGGGGC CATTGTGTGG 
GCAGTCCGGG CCAAAGACTA CAACAAGGCC ATGGAATTCG ACTGCCTCCT TGGAATCTCC 
AATGAGTTCA TCGTCCTCAT TGAGCAGGAA ACAAAGAGCG TGGTTTTCAA TTGCTCCTGC 
AGAGATGTGA TAGGGTGGAC TTCCAGCGAC AGCAGCCTTA AGATCTTCTA TGAGCGTGGA 
GAATGCATTT CTGTGGAGAG CTTCATGAGC AGTGAAGATA TCAAAGAAAT TGTCAAAAGG 
CTGCAGTTTG TTTCAAAAGG TTGTGAATCA GTGGAGATGA CGCTGCGAAG AAATGGGCTA 
GGCCAGCTTG GCTTCCATGT CAACTATGAG GGCATCGTGG CGGATGTAGA ACCCTATGGC 
TATGCATGGC AAGCAGGTTT GAAGCAGGGC AGCCGCCTGG TGGAGATCTG CAAGGTGGCA 
GTGGCCACCC TGAGCCATGA ACAGATGATC GATCTCTTGA GAACGTCAGT CACAGTGAAA 
GTTGTCATTA TCCCTCCCCA TGATGACTGC ACCCCTCGGA GGAGTTGCTC AGAAACCTAC 
CGCATGCCAG TGATGGAGTA CAAGATGAAT GAAGGCGTTT CCTATGAGTA CAAGTTTCCC 
TTCCGGAGTA ACAACAAATG GCAGCGTAAT GCCGGCAAGG GTGCCCATTC GCCCCAGGTT 
CCATTGCAGC TGCAGAGCCC CATGATTTCA CGGGTGAATG CTGGGAAGGG AGATGGAAAG 
ATGCCCCTTC CAGAAAGAGC CGCCAACATC CCTCGAAGCA TCTCCAGTGA TGGGCGCCCA 
CTGGAAAGGA GGCTGTCTCC TGGTTCGGAC ATCTATGTGA CAGTCTCATC CATGGCTTTG 
GCGAGATCCC AGTGCCGTAA CTCCCCCAGC AACTTGTCAT CGTCCAGCGA GACTGGCTCT 
GGGGGTGGCA CTTACAGACA AAAATCCATG CCTGAAGGGT TTGGAGTGAG CCGAAGATCC 
CCAGCTTCCA TCGACAGGCA AAACACCCAG TCGGATATTG GTGGCAGTGG AAAATCCACA 
CCCAGCTGGC AGAGAAGTGA GGACAGCCTT GCCGACCAGA TGGAGCCTAC ATGCCATCTC 
CCAGCAGTAT CTAAGGTACT GCCTGCTTTC CGAGAGAGCC CCAGTGGGAG GTTGATGCGG 
CAGGATCCCG TGGTTCACTT GTCTCCAAAC AAGCAAGGCC ATTCTGACAG CCACTACTCC 
AGCCACTCCA GCAGCAACAC TCTGTCCAGC AACGCCTCGA GTGCCCACAG TGACGAGAAG 
TGGTACGATG GAGACCGCAC CGAGTCCGAC CTCAACAGCT ATAACTACCT ACAGGGCACA 
TCTGCTGACA GCGGCATCGA CACCGCCTCA TACGGCCTCA GCCATGGCAG CACGGCCTCC 
CTGGGAGCCT CCACATCCTC ACCTCGTTCA GGGCCAGGCA AAGAGAAGGT GGCACCCCTG 
TGGCACAGCT CCAGTGAGGT GCTCTCCCTG GCAGATCGGA CCTTAGAGAC TGAGGGCCAT 
GGCATGGACA GGAAAACAGA GTCCTCCCTG AGCCTGGACA TCCACAGCAA GAGCCAAGGC 
GGTTCAAGCC CGCTGACAAG GGAGAACAGC ACCTTCAGCA TAAATGATGC CACATCTCAC 
ACCAGTACCA TGAGCTCCCG ACACTCTGCC AGCCCAGTGG TGTTCTCCAG TGCCAGAAGT 
TCACCCAAAG AAGAGCTTCA CCCCACCACG TCCTCCCAGC TCGCACCTTC CTTCTCTTCC 
TCTTCCTCAT CTTCCTCTGG ACCTAGGACT TTCTATCCCC GCCAGGGCGC CACTAGCAAA 
TACCTGATTG GATGGAAAAA GCCAGAAGGA ACCATTAACT CCGTGGGATT TATGGATACA 
AGAAAGCGAC ATCAGAGTGA TGGTAATGAG ATAGCCCACA CTAGGCTTCG AGCCTCAACC 
AGGGACCTTC GGGCATCCCC AAAGCCAACT TCCAAGTCCA CCATTGAGGA GGATCTAAAG 
AAACTCATCG ACCTTGAGAG CCCAACTCCT GAATCACAGA AAAACTTCAA GTTCCATGGA 
CTGTCCTCCC CACAGTCCCC GTTCCCCAGC ACCCCTACCT CCCGGCGGGC CCTGCACAGG 
ACTCTGTCTG ATGAGAGCAT TTACAGCAGC CAGAGGGAGC ATTTCTTCAC CTCCAGGGCC 
TCACTTCTAG ACCAAGCCCT GCCCAATGAT GTCTTTTTCA GCAGCACTTA CCCATCTCTC 
CCCAAGTCGC TTCCACTGAG GAGGCCATCT TACACATTGG GAATGAAGTC GCTGCATGGA 
GAGTTCTTTG CTTCCGACAG CTCCCTTACC GACATCCAGG AGACCCGGAG GCAGCCTATT 
CCTGACCCTG GCCTGATGCC CCTGCCTGAC ACTGCTTCGG ACTTGGACTG GTCCAACCTA 
GTAGATGCCG CCAAAGCCTA TGAGGTCCAG AGAGCCTCAT TTTTTGCTGC TAGTGATGAA 
AACCATCGCC CCTTGAGTGC GGCCTCCAAC AGCGACCAGC TAGAGGAGCA GGCCCTGGTC 
CAGATGAAGT CGTACAGCAG CAGTAAGGAC TCCTCTCCCA CTCTGGCTTC TAAAGTGGAC 
CAGTTGGAAG GTATGCTGAA AATGCTTCGA GAAGATTTGA AGAAGGAAAA GGAAGACAAG 
GCCCACCTGC AGGCAGAGGT TGAGCACTTG CGGGAGGACA ACCTGAGGCT GCAGGAGGAG 
TCCCAGAATG CCTCGGACAA GCTGAAGAAG TTCACAGAGT GGGTCTTCAA CACCATAGAC 
ATGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647546.1
CDS	734..6202
Translation	MTSLKRSQTERPVTADRASVVSTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGESFFGLLKGYKDDRADRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSTSFSSPMGSTEDFNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVRRYTVEHVDLGAYYYRKCFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNTPKVTEQFMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSSDSSLKIFYERGECISVESFMSSEDIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLKQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEYKFPFRSNNKWQRNAGKGAHSPQVPLQLQSPMISRVNAGKGDGKMPLPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGLSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKTESSLSLDIHSKSQGGSSPLTRENSTFSINDATSHTSTMSSRHSASPVVFSSARSSPKEELHPTTSSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHGLSSPQSPFPSTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVFFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFFASDSSLTDIQETRRQPIPDPGLMPLPDTASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS

Target ORF information:

RefSeq Version	NM_139330.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal-induced proliferation-associated 1 like 1 (Sipa1l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139330.1

ORF Insert Sequence:

ATGACCAGCT TGAAGAGGTC GCAGACCGAA AGGCCTGTCA CTGCTGACAG AGCCTCTGTT 
GTCAGCACAG ATGGCACCCC CAAAGTTCAC ACTGATGATT TCTACATGCG TCGCTTCCGG 
TCCCAAAATG GCAGCTTAGG ATCATCAGTC ATGGCTGCAG TAGGGCCCCC TCGAAGTGAA 
GGTCCTCACC ATATAACCTC AACCCCCGGA GTCCCCAAGA TGGGGGTTAG GGCAAGAATT 
GCAGATTGGC CTCCAAGAAA GGAAAATGTA AAAGAATCTA GCCGTTCAAG CCAGGAAATA 
GAAACCTCAA GTTGCCTTGA GAGCCTGTCC TCCAAAGGCA GTCCTGTGAG TCAGGGGAGT 
TCTGTTAGCC TCAATTCCAA TGACTCAGCC ATGCTGAAGA GCATCCAGAA CACCCTGAAG 
AACAAGACGG GGCCAGCGGA GAGCATGGAC TCGAGATTCC TCATGCCTGA AGCCTACCCC 
AGCTCCCCCA GGAAAGCCCT TCGCCGAATC CGTCAGCGTA GCAACAGTGA TATCACCATA 
AGTGAGCTTG ATGTGGATAG TTTTGATGAA TGTATCTCCC CAACCTACAA GTCGGGGCCA 
TCATTGCACA GGGAATATGG TAGCACATCT TCAATCGACA AGCAGGGGAC ATCCGGAGAA 
AGCTTCTTCG GTTTGTTAAA GGGCTATAAA GACGACAGAG CTGACCGAGG TCCAACTCCA 
ACCAAACTCA GTGACTTCCT CATCACTGGT GGGGGCAAGG GTTCTGGTTT CTCCTTGGAT 
GTGATCGATG GACCCATTTC ACAGAGAGAG AACCTCAGGC TATTCAAGGA AAGGGAAAAA 
CCACTCAAGC GACGTTCTAA GTCTGAAACT GGAGACTCAT CCATTTTTCG TAAATTACGC 
AATGCCAAAG GTGAAGAACT CGGGAAGTCA TCAGACCTTG AAGACAACAG ATCAGAGGAT 
TCTGTGAGGC CCTGGACATG TCCAAAGTGC TTTGCCCACT ATGATGTCCA GAGCATATTG 
TTTGACTTGA ATGAAGCCAT TATGAACAGG CATAATGTGA TTAAGAGGAG AAACACCACA 
ACGGGAGCTT CTGCAGCCGC TGTGGCGTCC TTAGTCTCGG GACCTTTGTC TCACTCAACC 
AGCTTCAGCT CTCCTATGGG CAGCACAGAG GACTTCAATT CCAAAGGAAG CCTCGGCATG 
GACCAGGGAG ATGACAAGAG CAATGAACTC GTCATGAGCT GTCCGTACTT TCGGAATGAG 
ATTGGGGGAG AAGGTGAGAG GAAAATCAGC CTGTCCAAGT CCAATTCTGG CTCATTCAGT 
GGGTGTGAGA GCACGTCCTT TGAGTCTGCC CTCAGCTCTC ACTGCACAAA CGCAGGAGTG 
GCGGTTCTCG AAGTGCCCAA GGAGAGCTTG ATGCTGCATC TAGACAGAGT GAGACGGTAC 
ACTGTGGAGC ACGTGGATCT TGGAGCATAC TATTACAGGA AGTGCTTCTA CCAAAAGGAA 
CACTGGAACT ATTTTGGGGC TGATGAAAAC CTCGGTCCAG TGGCTGTGAG CATTCGAAGG 
GAAAAACCAG AAGACATGAA GGAAAATGGA TCTCCCTACA ACTACCGAAT AATTTTTAGA 
ACTAGTGAGC TCATGACACT GAGAGGGTCT GTCCTGGAGG ATGCCATTCC CTCCACAGCC 
AAGCACTCGA CAGCCAGAGG ATTGCCGCTG AAAGAGGTGC TGGAACATGT GATCCCAGAG 
CTCAACGTGC AGTGCCTGCG TTTGGCCTTC AACACGCCCA AAGTCACCGA GCAGCTTATG 
AAACTGGACG AGCAAGGGCT GAACTATCAG CAGAAAGTAG GCATCATGTA CTGCAAAGCA 
GGCCAGAGCA CCGAGGAGGA GATGTACAAC ACGCCCAAAG TCACGGAGCA GTTTATGAAA 
CTGGACGAGC AAGGGCTGAA TTATCAGCAG AAAGTAGGCA TCATGTACTG CAAAGCAGGC 
CAGAGCACCG AGGAGGAGAT GTACAATAAT GAGTCCGCTG GCCCGGCCTT TGAGGAATTT 
CTTCAGCTAC TGGGAGAGCG AGTTCGCCTA AAAGGATTTG AAAAGTATCG TGCGCAGCTC 
GACACCAAAA CTGACTCCAC TGGAACCCAC TCTCTGTACA CAACCTACAA AGACTATGAG 
ATAATGTTCC ACGTCTCCAC CATGCTGCCC TACACACCTA ACAACAAGCA ACAGCTCCTG 
AGGAAGCGGC ACATTGGGAA TGACATTGTG ACAATAGTTT TCCAGGAGCC TGGAGCACAA 
CCATTTAGCC CGAAAAACAT CCGATCTCAC TTTCAGCATG TTTTTGTCAT TGTCCGGGCT 
CACAACCCCT GCACTGAGAG TGTCTGTTAC AGTGTGGCAG TCACCAGGTC CAGAGATGTG 
CCTTCTTTTG GACCTCCCAT CCCTAAAGGG GTCACCTTCC CCAAGTCAAA CGTGTTCAGG 
GACTTCCTTT TGGCCAAAGT GATTAATGCA GAAAACGCTG CTCATAAATC AGAGAAGTTC 
AGGGCCATGG CAACAAGGAC CCGCCAGGAA TACCTGAAAG ATCTGGCAGA AAAGAATGTC 
ACCAACACAC CTATTGACCC TTCTGGCAAG TTTCCATTTA TTTCTCTGGC TTCTAAGAAG 
AAGGAAAAGT CTAAGCCTTA CCCAGGAGCT GAGCTCAGTA GCATGGGGGC CATTGTGTGG 
GCAGTCCGGG CCAAAGACTA CAACAAGGCC ATGGAATTCG ACTGCCTCCT TGGAATCTCC 
AATGAGTTCA TCGTCCTCAT TGAGCAGGAA ACAAAGAGCG TGGTTTTCAA TTGCTCCTGC 
AGAGATGTGA TAGGGTGGAC TTCCAGCGAC AGCAGCCTTA AGATCTTCTA TGAGCGTGGA 
GAATGCATTT CTGTGGAGAG CTTCATGAGC AGTGAAGATA TCAAAGAAAT TGTCAAAAGG 
CTGCAGTTTG TTTCAAAAGG TTGTGAATCA GTGGAGATGA CGCTGCGAAG AAATGGGCTA 
GGCCAGCTTG GCTTCCATGT CAACTATGAG GGCATCGTGG CGGATGTAGA ACCCTATGGC 
TATGCATGGC AAGCAGGTTT GAAGCAGGGC AGCCGCCTGG TGGAGATCTG CAAGGTGGCA 
GTGGCCACCC TGAGCCATGA ACAGATGATC GATCTCTTGA GAACGTCAGT CACAGTGAAA 
GTTGTCATTA TCCCTCCCCA TGATGACTGC ACCCCTCGGA GGAGTTGCTC AGAAACCTAC 
CGCATGCCAG TGATGGAGTA CAAGATGAAT GAAGGCGTTT CCTATGAGTA CAAGTTTCCC 
TTCCGGAGTA ACAACAAATG GCAGCGTAAT GCCGGCAAGG GTGCCCATTC GCCCCAGGTT 
CCATTGCAGC TGCAGAGCCC CATGATTTCA CGGGTGAATG CTGGGAAGGG AGATGGAAAG 
ATGCCCCTTC CAGAAAGAGC CGCCAACATC CCTCGAAGCA TCTCCAGTGA TGGGCGCCCA 
CTGGAAAGGA GGCTGTCTCC TGGTTCGGAC ATCTATGTGA CAGTCTCATC CATGGCTTTG 
GCGAGATCCC AGTGCCGTAA CTCCCCCAGC AACTTGTCAT CGTCCAGCGA GACTGGCTCT 
GGGGGTGGCA CTTACAGACA AAAATCCATG CCTGAAGGGT TTGGAGTGAG CCGAAGATCC 
CCAGCTTCCA TCGACAGGCA AAACACCCAG TCGGATATTG GTGGCAGTGG AAAATCCACA 
CCCAGCTGGC AGAGAAGTGA GGACAGCCTT GCCGACCAGA TGGAGCCTAC ATGCCATCTC 
CCAGCAGTAT CTAAGGTACT GCCTGCTTTC CGAGAGAGCC CCAGTGGGAG GTTGATGCGG 
CAGGATCCCG TGGTTCACTT GTCTCCAAAC AAGCAAGGCC ATTCTGACAG CCACTACTCC 
AGCCACTCCA GCAGCAACAC TCTGTCCAGC AACGCCTCGA GTGCCCACAG TGACGAGAAG 
TGGTACGATG GAGACCGCAC CGAGTCCGAC CTCAACAGCT ATAACTACCT ACAGGGCACA 
TCTGCTGACA GCGGCATCGA CACCGCCTCA TACGGCCTCA GCCATGGCAG CACGGCCTCC 
CTGGGAGCCT CCACATCCTC ACCTCGTTCA GGGCCAGGCA AAGAGAAGGT GGCACCCCTG 
TGGCACAGCT CCAGTGAGGT GCTCTCCCTG GCAGATCGGA CCTTAGAGAC TGAGGGCCAT 
GGCATGGACA GGAAAACAGA GTCCTCCCTG AGCCTGGACA TCCACAGCAA GAGCCAAGGC 
GGTTCAAGCC CGCTGACAAG GGAGAACAGC ACCTTCAGCA TAAATGATGC CACATCTCAC 
ACCAGTACCA TGAGCTCCCG ACACTCTGCC AGCCCAGTGG TGTTCTCCAG TGCCAGAAGT 
TCACCCAAAG AAGAGCTTCA CCCCACCACG TCCTCCCAGC TCGCACCTTC CTTCTCTTCC 
TCTTCCTCAT CTTCCTCTGG ACCTAGGACT TTCTATCCCC GCCAGGGCGC CACTAGCAAA 
TACCTGATTG GATGGAAAAA GCCAGAAGGA ACCATTAACT CCGTGGGATT TATGGATACA 
AGAAAGCGAC ATCAGAGTGA TGGTAATGAG ATAGCCCACA CTAGGCTTCG AGCCTCAACC 
AGGGACCTTC GGGCATCCCC AAAGCCAACT TCCAAGTCCA CCATTGAGGA GGATCTAAAG 
AAACTCATCG ACCTTGAGAG CCCAACTCCT GAATCACAGA AAAACTTCAA GTTCCATGGA 
CTGTCCTCCC CACAGTCCCC GTTCCCCAGC ACCCCTACCT CCCGGCGGGC CCTGCACAGG 
ACTCTGTCTG ATGAGAGCAT TTACAGCAGC CAGAGGGAGC ATTTCTTCAC CTCCAGGGCC 
TCACTTCTAG ACCAAGCCCT GCCCAATGAT GTCTTTTTCA GCAGCACTTA CCCATCTCTC 
CCCAAGTCGC TTCCACTGAG GAGGCCATCT TACACATTGG GAATGAAGTC GCTGCATGGA 
GAGTTCTTTG CTTCCGACAG CTCCCTTACC GACATCCAGG AGACCCGGAG GCAGCCTATT 
CCTGACCCTG GCCTGATGCC CCTGCCTGAC ACTGCTTCGG ACTTGGACTG GTCCAACCTA 
GTAGATGCCG CCAAAGCCTA TGAGGTCCAG AGAGCCTCAT TTTTTGCTGC TAGTGATGAA 
AACCATCGCC CCTTGAGTGC GGCCTCCAAC AGCGACCAGC TAGAGGAGCA GGCCCTGGTC 
CAGATGAAGT CGTACAGCAG CAGTAAGGAC TCCTCTCCCA CTCTGGCTTC TAAAGTGGAC 
CAGTTGGAAG GTATGCTGAA AATGCTTCGA GAAGATTTGA AGAAGGAAAA GGAAGACAAG 
GCCCACCTGC AGGCAGAGGT TGAGCACTTG CGGGAGGACA ACCTGAGGCT GCAGGAGGAG 
TCCCAGAATG CCTCGGACAA GCTGAAGAAG TTCACAGAGT GGGTCTTCAA CACCATAGAC 
ATGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.
Brain research1679134-143(2018 Jan)
Zhi WJ,Peng RY,Li HJ,Zou Y,Yao BW,Wang CZ,Liu ZH,Gao XH,Xu XP,Dong J,Zhao L,Zhou HM,Wang LF,Hu XJ

Prenatal stress increased Snk Polo-like kinase 2, SCF ?-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience31(7)560-7(2013 Nov)
Chutabhakdikul N,Surakul P

Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons.
Synapse (New York, N.Y.)66(2)142-50(2012 Feb)
Chen Y,Yuanxiang P,Kn?pfel T,Thomas U,Behnisch T

Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.
Neuron69(5)957-73(2011 Mar)
Lee KJ,Lee Y,Rozeboom A,Lee JY,Udagawa N,Hoe HS,Pak DT

Role of the SNK-SPAR pathway in the development of Alzheimer's disease.
IUBMB life62(3)214-21(2010 Mar)
Gong X,Lu X,Zhan L,Sui H,Qi X,Ji Z,Niu X,Liu L

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Sipa1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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