Fgl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgl1
Entrez Gene ID	246186
Full Name	fibrinogen-like 1
Synonyms	Frep1,Lfire1
General protein information	Preferred Names fibrinogen-like 1 Names fibrinogen-like protein 1 fibrinogen-related protein 1 fibronigen-like protein 1 liver fibrinogen-related protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.1
Summary	member of the fibrinogen family; appears to lack the platelet-binding and thrombin-sensitive sites, and cross-linking region, which are necessary for fibrin clot formation; protein may be liver-specific [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172010.1	NP_742007.1	fibrinogen-like protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FGL1	NP_004458.3
Bos taurus (cattle)	FGL1	NP_001029485.1
Rattus norvegicus (Norway rat)	Fgl1	NP_742007.1
Pan troglodytes (chimpanzee)	FGL1	XP_001141969.1
Canis lupus familiaris (dog)	FGL1	XP_532831.3
Gallus gallus (chicken)	FGL1	NP_001264748.1
Danio rerio (zebrafish)	LOC100003029	XP_001923586.1
Xenopus tropicalis (tropical clawed frog)	fgl1	XP_002940496.1
Mus musculus (house mouse)	Fgl1	NP_663569.2

Gene Ontology
Bibliography

Related articles in PubMed

Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3.
Zou Z, Cai Y, Chen Y, Chen S, Liu L, Shen Z, Zhang S, Xu L, Chen Y
Molecular medicine reports12(2)2089-97(2015 Aug)

Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization.
Demchev V, Malana G, Vangala D, Stoll J, Desai A, Kang HW, Li Y, Nayeb-Hashemi H, Niepel M, Cohen DE, Ukomadu C
PloS one8(3)e58084(2013)

Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure.
Li CY, Cao CZ, Xu WX, Cao MM, Yang F, Dong L, Yu M, Zhan YQ, Gao YB, Li W, Wang ZD, Ge CH, Wang QM, Peng RY, Yang XM
Gut59(6)817-26(2010 Jun)

Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA
Nature444(7117)337-42(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of FGL1 and p-STAT3 were elevated concurrently with the improvement of liver function.
Title: Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3.

The following Fgl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02350	NM_172010.1 Latest version!	Rattus norvegicus fibrinogen-like 1 (Fgl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgl1 ( NM_172010.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_742007.1 Rattus norvegicus fibrinogen-like 1 (Fgl1), mRNA.

Price & Availability↑

CloneID	ORa02350
Clone ID Related Accession (Same CDS sequence)	NM_172010.1
Accession Version	NM_172010.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	fibrinogen-like protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF508020.1. ##Evidence-Data-START## Transcript exon combination :: AF508020.1, BC088107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAGA TTCGCAGCTT TGTCCTCATC ACTGTTGCTC TGATTCTGGG CAAGGAGAGC 
TGGGTCCTCG GAGATGAGAA CTGTTTGCAG GAGCAGGTGA GGCTCAGGGC TCAGGTGCGC 
CAGCTTGAGA CCCGGGTCAA ACAACAACAG GTGGTGATTG CACAGCTCTT GCACGAGAAG 
GAGGTCCAGT TCCTGGATAG AGGACAGGAG GACAGCTTCA TTGACCTTGG AGGCAAGAGG 
CATTACGCAG ATTGTTCAGA GATTTACAAT GATGGATTTA AACATAGTGG GTTTTACAAA 
ATCAAACCTC TTCAGAGTCT GGCAGAATTC TCTGTTTATT GTGATATGTC TGATGGAGGA 
GGATGGACTG TAATTCAGAG ACGATCTGAC GGCAGTGAGA ACTTTAACAG GGGTTGGAAC 
GACTATGAAA ATGGCTTTGG AAACTTTGTC CAAAGCAATG GTGAATACTG GCTGGGTAAC 
AAAAACATTA ACTTGCTGAC TATGCAAGGA GACTACACTT TAAAAATCGA CCTGACAGAC 
TTTGAGAAAA ACAGCCGCTT CGCACAATAC GAAAAATTTA AAGTTGGCGA TGAAAAGTCT 
TTTTACGAAC TGAATATTGG AGAATATTCT GGCACCGCCG GAGACTCCCT GTCGGGAACA 
TTTCACCCTG AAGTGCAGTG GTGGGCTAGT CACCAAACAA TGAAGTTCAG CACACGCGAC 
AGAGACAACG ACAACTACAA CGGGAACTGT GCTGAGGAGG AACAGTCTGG CTGGTGGTTA 
ACAGGTGTCA CTCTGCAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742007.1
CDS	100..903
Translation	MGEIRSFVLITVALILGKESWVLGDENCLQEQVRLRAQVRQLETRVKQQQVVIAQLLHEKEVQFLDRGQEDSFIDLGGKRHYADCSEIYNDGFKHSGFYKIKPLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQSNGEYWLGNKNINLLTMQGDYTLKIDLTDFEKNSRFAQYEKFKVGDEKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQTMKFSTRDRDNDNYNGNCAEEEQSGWWLTGVTLQT

Target ORF information:

RefSeq Version	NM_172010.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibrinogen-like 1 (Fgl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172010.1

ORF Insert Sequence:

ATGGGGGAGA TTCGCAGCTT TGTCCTCATC ACTGTTGCTC TGATTCTGGG CAAGGAGAGC 
TGGGTCCTCG GAGATGAGAA CTGTTTGCAG GAGCAGGTGA GGCTCAGGGC TCAGGTGCGC 
CAGCTTGAGA CCCGGGTCAA ACAACAACAG GTGGTGATTG CACAGCTCTT GCACGAGAAG 
GAGGTCCAGT TCCTGGATAG AGGACAGGAG GACAGCTTCA TTGACCTTGG AGGCAAGAGG 
CATTACGCAG ATTGTTCAGA GATTTACAAT GATGGATTTA AACATAGTGG GTTTTACAAA 
ATCAAACCTC TTCAGAGTCT GGCAGAATTC TCTGTTTATT GTGATATGTC TGATGGAGGA 
GGATGGACTG TAATTCAGAG ACGATCTGAC GGCAGTGAGA ACTTTAACAG GGGTTGGAAC 
GACTATGAAA ATGGCTTTGG AAACTTTGTC CAAAGCAATG GTGAATACTG GCTGGGTAAC 
AAAAACATTA ACTTGCTGAC TATGCAAGGA GACTACACTT TAAAAATCGA CCTGACAGAC 
TTTGAGAAAA ACAGCCGCTT CGCACAATAC GAAAAATTTA AAGTTGGCGA TGAAAAGTCT 
TTTTACGAAC TGAATATTGG AGAATATTCT GGCACCGCCG GAGACTCCCT GTCGGGAACA 
TTTCACCCTG AAGTGCAGTG GTGGGCTAGT CACCAAACAA TGAAGTTCAG CACACGCGAC 
AGAGACAACG ACAACTACAA CGGGAACTGT GCTGAGGAGG AACAGTCTGG CTGGTGGTTA 
ACAGGTGTCA CTCTGCAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3.
Molecular medicine reports12(2)2089-97(2015 Aug)
Zou Z,Cai Y,Chen Y,Chen S,Liu L,Shen Z,Zhang S,Xu L,Chen Y

Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization.
PloS one8(3)e58084(2013)
Demchev V,Malana G,Vangala D,Stoll J,Desai A,Kang HW,Li Y,Nayeb-Hashemi H,Niepel M,Cohen DE,Ukomadu C

Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure.
Gut59(6)817-26(2010 Jun)
Li CY,Cao CZ,Xu WX,Cao MM,Yang F,Dong L,Yu M,Zhan YQ,Gao YB,Li W,Wang ZD,Ge CH,Wang QM,Peng RY,Yang XM

Resveratrol improves health and survival of mice on a high-calorie diet.
Nature444(7117)337-42(2006 Nov)
Baur JA,Pearson KJ,Price NL,Jamieson HA,Lerin C,Kalra A,Prabhu VV,Allard JS,Lopez-Lluch G,Lewis K,Pistell PJ,Poosala S,Becker KG,Boss O,Gwinn D,Wang M,Ramaswamy S,Fishbein KW,Spencer RG,Lakatta EG,Le Couteur D,Shaw RJ,Navas P,Puigserver P,Ingram DK,de Cabo R,Sinclair DA

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Fgl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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