Bmf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmf
Entrez Gene ID	246142
Full Name	Bcl2 modifying factor
General protein information	Preferred Names Bcl2 modifying factor Names bcl-2-modifying factor Bcl-2 modifying factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	may be involved in oligodendroglial lineage cell differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139258.1	NP_640351.1	bcl-2-modifying factor
XM_006234723.3	XP_006234785.1	bcl-2-modifying factor isoform X2
XM_008762079.2	XP_008760301.1	bcl-2-modifying factor isoform X1
XM_006234724.3	XP_006234786.1	bcl-2-modifying factor isoform X3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	BMF	NP_001106763.1
Pan troglodytes (chimpanzee)	BMF	XP_003339317.1
	BMF	XP_002804765.1
Canis lupus familiaris (dog)	BMF	XP_005638291.1
Bos taurus (cattle)	BMF	NP_001070953.1
Mus musculus (house mouse)	Bmf	NP_612186.2
Xenopus tropicalis (tropical clawed frog)	bmf	XP_004917347.1
Homo sapiens (human)	BMF	NP_277038.1
Rattus norvegicus (Norway rat)	Bmf	NP_640351.1

Gene Ontology
Bibliography

Related articles in PubMed

Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Wang R, Kang Y, L?hr CV, Fischer KA, Bradford CS, Johnson G, Dashwood WM, Williams DE, Ho E, Dashwood RH
Cancer letters381(2)341-8(2016 10)

Deacetylation of p53 induces autophagy by suppressing Bmf expression.
Contreras AU, Mebratu Y, Delgado M, Montano G, Hu CA, Ryter SW, Choi AM, Lin Y, Xiang J, Chand H, Tesfaigzi Y
The Journal of cell biology201(3)427-37(2013 Apr)

BH3 domains other than Bim and Bid can directly activate Bax/Bak.
Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T
The Journal of biological chemistry286(1)491-501(2011 Jan)

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH
The Journal of biological chemistry285(46)36199-206(2010 Nov)

MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.
Gramantieri L, Fornari F, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Croce CM, Bolondi L, Negrini M
Clinical cancer research : an official journal of the American Association for Cancer Research15(16)5073-81(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer.
Title: Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.

Studies suggest that overexpression of DN-HNF1A induces bioenergetic stress and activation of AMPK, and this in turn mediates the transcriptional activation of BMF, coupling prolonged energy stress to apoptosis activation.
Title: AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

Activation of MAPK8 and redistribution of BMF may be integrally involved in the mechanism by which specific germ cells undergo programmed cell death in response to their detachment from Sertoli cells.
Title: Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is associated with germ cell apoptosis and redistribution of the Bcl2-modifying factor (BMF).

Bmf may well be involved in germ cell apoptosis and/or anoikis in response to decreased intratesticular testosterone concentration.
Title: Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone.

The following Bmf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02320	NM_139258.1 Latest version!	Rattus norvegicus Bcl2 modifying factor (Bmf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa44409	XM_008762079.2 Latest version!	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa26197	XM_006234723.3 Latest version!	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa26198	XM_006234724.3 Latest version!	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmf ( NM_139258.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_640351.1 Rattus norvegicus Bcl2 modifying factor (Bmf), mRNA.

Price & Availability↑

CloneID	ORa02320
Clone ID Related Accession (Same CDS sequence)	NM_139258.1
Accession Version	NM_139258.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-modifying factor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF506761.1. ##Evidence-Data-START## Transcript exon combination :: AF506761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906357 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCAC CTCAGTGTGT GGAGGAACTA GAAGATGATG TGTTCCAGCC AGAGGATGGG 
GAGCCAGGGA CACAGCCTGG GAGCTTGCTC TCTGCTGACC TGTTTGCCCA GAGCCAGCTG 
GATTGTCCCC TCAGTCGGCT TCAGCTCTTC CCGCTTACCC ACTGCTGTGG TCCTGGGCTC 
CGGCCTGTAA GCCAGGAAGA CAAGGCCACC CAGACCCTCA GCCCAGCCTC CCCAAGCCAG 
GGTGTCATGC TGCCTTGTGG GGTGACAGAG GAACCCCAGA GACTCTTTTA CGGCAACGCT 
GGCTACAGGC TTCCTCTCCC TGCCAGTTTC CCCGCAGGCT CAGCCCTTGG GGAGCAGCCC 
CCTGAAGGAC AGTTCCTTCA GCACCGAGCA GAGGTACAGA TCGCCAGAAA GCTTCAGTGC 
ATTGCAGACC AGTTCCATCG GCTTCATATG CAACAACACC AGCAGAACCG AGACCGAGCA 
TGGCGGCAGG TCTTCCTCTT CCTTCAAAAC CTGGCCTTGA ACAGACGAGA AAACAGGGAA 
GGGGTGGGTC CCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_640351.1
CDS	242..799
Translation	MEPPQCVEELEDDVFQPEDGEPGTQPGSLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPVSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAGSALGEQPPEGQFLQHRAEVQIARKLQCIADQFHRLHMQQHQQNRDRAWRQVFLFLQNLALNRRENREGVGPW

Target ORF information:

RefSeq Version	NM_139258.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2 modifying factor (Bmf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139258.1

ORF Insert Sequence:

ATGGAGCCAC CTCAGTGTGT GGAGGAACTA GAAGATGATG TGTTCCAGCC AGAGGATGGG 
GAGCCAGGGA CACAGCCTGG GAGCTTGCTC TCTGCTGACC TGTTTGCCCA GAGCCAGCTG 
GATTGTCCCC TCAGTCGGCT TCAGCTCTTC CCGCTTACCC ACTGCTGTGG TCCTGGGCTC 
CGGCCTGTAA GCCAGGAAGA CAAGGCCACC CAGACCCTCA GCCCAGCCTC CCCAAGCCAG 
GGTGTCATGC TGCCTTGTGG GGTGACAGAG GAACCCCAGA GACTCTTTTA CGGCAACGCT 
GGCTACAGGC TTCCTCTCCC TGCCAGTTTC CCCGCAGGCT CAGCCCTTGG GGAGCAGCCC 
CCTGAAGGAC AGTTCCTTCA GCACCGAGCA GAGGTACAGA TCGCCAGAAA GCTTCAGTGC 
ATTGCAGACC AGTTCCATCG GCTTCATATG CAACAACACC AGCAGAACCG AGACCGAGCA 
TGGCGGCAGG TCTTCCTCTT CCTTCAAAAC CTGGCCTTGA ACAGACGAGA AAACAGGGAA 
GGGGTGGGTC CCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmf ( XM_008762079.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760301.1 Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44409
Clone ID Related Accession (Same CDS sequence)	XM_008762079.2
Accession Version	XM_008762079.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-modifying factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762079.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG CACCAGCAGA ACCGAGACCG AGCATGGCGG CAGGTCTTCC TCTTCCTTCA 
AAACCTGGCC TTGAACAGAC GAGAAAACAG GGAAGGGGTG GGTCCCTGGT GAGACTGGGC 
TGCTCTTGTC GGATAGATCG CCCGGAATGC AGTCTGGAAC AGACATTCTG GGAGGACAGA 
TACTGTCTTG TCAAGTTTTG TCATTCTGAA TTTTCTTTCC ATGTGTACAT ATTACATACC 
CCAGTGGGAT CTTTTTTCCC CGTTCAGAAC GTCTCCTGGG GATGGGGGCC TTTGTCAAAC 
ACTGTTGAAG GAGAGGCAGC TGTGTCTGCT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760301.1
CDS	22..897
Translation	MPGAGVFWKQYRAVRGGLLPRQLTPTAVAARARATTSHRSPLEFVPFFPIECGRQVPRVFVTLDPGAEPWHHDSEAETLSWSHPGDMEPPQCVEELEDDVFQPEDGEPGTQPGSLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPVSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYAPAEPRPSMAAGLPLPSKPGLEQTRKQGRGGSLVRLGCSCRIDRPECSLEQTFWEDRYCLVKFCHSEFSFHVYILHTPVGSFFPVQNVSWGWGPLSNTVEGEAAVSAG

Target ORF information:

RefSeq Version	XM_008762079.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762079.2

ORF Insert Sequence:

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG CACCAGCAGA ACCGAGACCG AGCATGGCGG CAGGTCTTCC TCTTCCTTCA 
AAACCTGGCC TTGAACAGAC GAGAAAACAG GGAAGGGGTG GGTCCCTGGT GAGACTGGGC 
TGCTCTTGTC GGATAGATCG CCCGGAATGC AGTCTGGAAC AGACATTCTG GGAGGACAGA 
TACTGTCTTG TCAAGTTTTG TCATTCTGAA TTTTCTTTCC ATGTGTACAT ATTACATACC 
CCAGTGGGAT CTTTTTTCCC CGTTCAGAAC GTCTCCTGGG GATGGGGGCC TTTGTCAAAC 
ACTGTTGAAG GAGAGGCAGC TGTGTCTGCT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmf ( XM_006234723.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234785.1 Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa26197
Clone ID Related Accession (Same CDS sequence)	XM_006234723.3
Accession Version	XM_006234723.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-modifying factor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234723.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG GCAACGCTGG CTACAGGCTT CCTCTCCCTG CCAGTTTCCC CGCAGGCTCA 
GCCCTTGGGG AGCAGCCCCC TGAAGGACAG TTCCTTCAGC ACCGAGCAGA GGTACAGATC 
GCCAGAAAGC TTCAGTGCAT TGCAGACCAG TTCCATCGGC TTCATATGCA ACAACACCAG 
CAGAACCGAG ACCGAGCATG GCGGCAGGTC TTCCTCTTCC TTCAAAACCT GGCCTTGAAC 
AGACGAGAAA ACAGGGAAGG GGTGGGTCCC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234785.1
CDS	21..836
Translation	MPGAGVFWKQYRAVRGGLLPRQLTPTAVAARARATTSHRSPLEFVPFFPIECGRQVPRVFVTLDPGAEPWHHDSEAETLSWSHPGDMEPPQCVEELEDDVFQPEDGEPGTQPGSLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPVSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAGSALGEQPPEGQFLQHRAEVQIARKLQCIADQFHRLHMQQHQQNRDRAWRQVFLFLQNLALNRRENREGVGPW

Target ORF information:

RefSeq Version	XM_006234723.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234723.3

ORF Insert Sequence:

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG GCAACGCTGG CTACAGGCTT CCTCTCCCTG CCAGTTTCCC CGCAGGCTCA 
GCCCTTGGGG AGCAGCCCCC TGAAGGACAG TTCCTTCAGC ACCGAGCAGA GGTACAGATC 
GCCAGAAAGC TTCAGTGCAT TGCAGACCAG TTCCATCGGC TTCATATGCA ACAACACCAG 
CAGAACCGAG ACCGAGCATG GCGGCAGGTC TTCCTCTTCC TTCAAAACCT GGCCTTGAAC 
AGACGAGAAA ACAGGGAAGG GGTGGGTCCC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmf ( XM_006234724.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234786.1 Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa26198
Clone ID Related Accession (Same CDS sequence)	XM_006234724.3
Accession Version	XM_006234724.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-modifying factor isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234724.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG GCAACGCTGG CTACAGGCTT CCTCTCCCTG CCAGTTTCCC CGCAGGCTCA 
GCCCTTGGGG AGCAGCCCCC TGAAGGACAG TTCCTTCAGC ACCGAGCAGA GCACCAGCAG 
AACCGAGACC GAGCATGGCG GCAGGTCTTC CTCTTCCTTC AAAACCTGGC CTTGAACAGA 
CGAGAAAACA GGGAAGGGGT GGGTCCCTGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234786.1
CDS	25..777
Translation	MPGAGVFWKQYRAVRGGLLPRQLTPTAVAARARATTSHRSPLEFVPFFPIECGRQVPRVFVTLDPGAEPWHHDSEAETLSWSHPGDMEPPQCVEELEDDVFQPEDGEPGTQPGSLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPVSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAGSALGEQPPEGQFLQHRAEHQQNRDRAWRQVFLFLQNLALNRRENREGVGPW

Target ORF information:

RefSeq Version	XM_006234724.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234724.3

ORF Insert Sequence:

ATGCCCGGAG CGGGCGTATT TTGGAAACAA TACCGCGCGG TGCGCGGTGG CCTCCTCCCG 
CGCCAGCTCA CGCCCACAGC AGTCGCTGCC CGAGCCCGCG CCACCACCTC CCACCGCAGC 
CCGCTGGAGT TTGTCCCCTT CTTCCCAATC GAGTGTGGGC GCCAAGTCCC CCGAGTGTTC 
GTCACCCTGG ACCCTGGCGC AGAGCCCTGG CATCACGACT CGGAGGCTGA GACGCTGTCC 
TGGAGTCACC CAGGAGACAT GGAGCCACCT CAGTGTGTGG AGGAACTAGA AGATGATGTG 
TTCCAGCCAG AGGATGGGGA GCCAGGGACA CAGCCTGGGA GCTTGCTCTC TGCTGACCTG 
TTTGCCCAGA GCCAGCTGGA TTGTCCCCTC AGTCGGCTTC AGCTCTTCCC GCTTACCCAC 
TGCTGTGGTC CTGGGCTCCG GCCTGTAAGC CAGGAAGACA AGGCCACCCA GACCCTCAGC 
CCAGCCTCCC CAAGCCAGGG TGTCATGCTG CCTTGTGGGG TGACAGAGGA ACCCCAGAGA 
CTCTTTTACG GCAACGCTGG CTACAGGCTT CCTCTCCCTG CCAGTTTCCC CGCAGGCTCA 
GCCCTTGGGG AGCAGCCCCC TGAAGGACAG TTCCTTCAGC ACCGAGCAGA GCACCAGCAG 
AACCGAGACC GAGCATGGCG GCAGGTCTTC CTCTTCCTTC AAAACCTGGC CTTGAACAGA 
CGAGAAAACA GGGAAGGGGT GGGTCCCTGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Cancer letters381(2)341-8(2016 10)
Wang R,Kang Y,L?hr CV,Fischer KA,Bradford CS,Johnson G,Dashwood WM,Williams DE,Ho E,Dashwood RH

Deacetylation of p53 induces autophagy by suppressing Bmf expression.
The Journal of cell biology201(3)427-37(2013 Apr)
Contreras AU,Mebratu Y,Delgado M,Montano G,Hu CA,Ryter SW,Choi AM,Lin Y,Xiang J,Chand H,Tesfaigzi Y

BH3 domains other than Bim and Bid can directly activate Bax/Bak.
The Journal of biological chemistry286(1)491-501(2011 Jan)
Du H,Wolf J,Schafer B,Moldoveanu T,Chipuk JE,Kuwana T

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
The Journal of biological chemistry285(46)36199-206(2010 Nov)
Kilbride SM,Farrelly AM,Bonner C,Ward MW,Nyhan KC,Concannon CG,Wollheim CB,Byrne MM,Prehn JH

MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.
Clinical cancer research : an official journal of the American Association for Cancer Research15(16)5073-81(2009 Aug)
Gramantieri L,Fornari F,Ferracin M,Veronese A,Sabbioni S,Calin GA,Grazi GL,Croce CM,Bolondi L,Negrini M

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Bmf cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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