Orm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Orm1
Entrez Gene ID	24614
Full Name	orosomucoid 1
Synonyms	AGP,Agpa1,OMD,Orm
General protein information	Preferred Names orosomucoid 1 Names alpha-1-acid glycoprotein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	an acute phase reactant protein; may have a role in the acute inflammation response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053288.2	NP_445740.1	alpha-1-acid glycoprotein precursor

Pathways from BioSystems

Homologies

	LOC703984	XP_001100289.1
Homo sapiens (human)	ORM1	NP_000598.2
Bos taurus (cattle)	ORM1	NP_001035592.1
Pan troglodytes (chimpanzee)	ORM1	XP_003312295.1
Rattus norvegicus (Norway rat)	Orm1	NP_445740.1
Canis lupus familiaris (dog)	ORM1	XP_003431634.1

Gene Ontology
Bibliography

Related articles in PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Lei H, Sun Y, Luo Z, Yourek G, Gui H, Yang Y, Su DF, Liu X
Scientific reports618839(2016 Jan)

The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process.
Gemelli C, Martello A, Montanari M, Zanocco Marani T, Salsi V, Zappavigna V, Parenti S, Vignudelli T, Selmi T, Ferrari S, Grande A
Experimental cell research319(20)3201-13(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway.
Title: Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.

context-dependent nature of ORM1 angioregulatory function is further demonstrated in the CAM assay where ORM1 stimulates developmental angiogenesis without exerting any inhibitory activity
Title: The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties.

Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Title: Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.

Orm1 gene expression highly induced in cardiomyocytes overexpressing mineralocorticoid receptor and treated with aldosterone.
Title: Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling?

Surprisingly, AGP-over-expressing mice were not protected against renal ischemia-reperfusion injury.
Title: Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis.

The following Orm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Orm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09187	NM_053288.2 Latest version!	Rattus norvegicus orosomucoid 1 (Orm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Orm1 ( NM_053288.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445740.1 Rattus norvegicus orosomucoid 1 (Orm1), mRNA.

Price & Availability↑

CloneID	ORa09187
Clone ID Related Accession (Same CDS sequence)	NM_053288.2
Accession Version	NM_053288.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Rattus norvegicus(Norway rat)
Product	alpha-1-acid glycoprotein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J00696.1. On Aug 30, 2012 this sequence version replaced NM_053288.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J00696.1, V01216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTGC ACATGGTTCT TGTCGTTTTG AGCCTCCTGC CCTTGTTGGA AGCTCAGAAC 
CCAGAACCTG CCAACATCAC CCTAGGCATA CCTATTACCA ATGAGACCCT GAAATGGCTC 
TCAGACAAAT GGTTTTACAT GGGAGCAGCT TTCCGAGACC CCGTGTTCAA GCAGGCAGTT 
CAAACGATAC AGACGGAATA TTTTTACCTT ACCCCCAACT TGATAAACGA CACAATTGAA 
CTTCGGGAGT TTCAGACCAC AGACGACCAG TGTGTCTATA ACTTCACCCA TCTAGGAGTC 
CAGAGAGAGA ATGGGACCTT ATCCAAGTGT GCAGGAGCAG TGAAAATCTT TGCCCATTTG 
ATAGTGCTGA AGAAACATGG GACCTTCATG CTTGCCTTTA ACCTGACAGA TGAGAACCGG 
GGGCTGTCCT TCTATGCTAA AAAGCCAGAC TTGTCCCCAG AGCTGCGGAA AATATTCCAG 
CAGGCTGTCA AAGATGTGGG CATGGATGAA TCAGAAATCG TATTTGTCGA CTGGACAAAG 
GATAAGTGCA GTGAGCAGCA GAAGCAGCAG CTGGAGCTGG AGAAGGAGAC TAAGAAGGAG 
ACCAAGAAGG ATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445740.1
CDS	36..653
Translation	MALHMVLVVLSLLPLLEAQNPEPANITLGIPITNETLKWLSDKWFYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQRENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQQAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP

Target ORF information:

RefSeq Version	NM_053288.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus orosomucoid 1 (Orm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053288.2

ORF Insert Sequence:

ATGGCGCTGC ACATGGTTCT TGTCGTTTTG AGCCTCCTGC CCTTGTTGGA AGCTCAGAAC 
CCAGAACCTG CCAACATCAC CCTAGGCATA CCTATTACCA ATGAGACCCT GAAATGGCTC 
TCAGACAAAT GGTTTTACAT GGGAGCAGCT TTCCGAGACC CCGTGTTCAA GCAGGCAGTT 
CAAACGATAC AGACGGAATA TTTTTACCTT ACCCCCAACT TGATAAACGA CACAATTGAA 
CTTCGGGAGT TTCAGACCAC AGACGACCAG TGTGTCTATA ACTTCACCCA TCTAGGAGTC 
CAGAGAGAGA ATGGGACCTT ATCCAAGTGT GCAGGAGCAG TGAAAATCTT TGCCCATTTG 
ATAGTGCTGA AGAAACATGG GACCTTCATG CTTGCCTTTA ACCTGACAGA TGAGAACCGG 
GGGCTGTCCT TCTATGCTAA AAAGCCAGAC TTGTCCCCAG AGCTGCGGAA AATATTCCAG 
CAGGCTGTCA AAGATGTGGG CATGGATGAA TCAGAAATCG TATTTGTCGA CTGGACAAAG 
GATAAGTGCA GTGAGCAGCA GAAGCAGCAG CTGGAGCTGG AGAAGGAGAC TAAGAAGGAG 
ACCAAGAAGG ATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Scientific reports618839(2016 Jan)
Lei H,Sun Y,Luo Z,Yourek G,Gui H,Yang Y,Su DF,Liu X

The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process.
Experimental cell research319(20)3201-13(2013 Dec)
Gemelli C,Martello A,Montanari M,Zanocco Marani T,Salsi V,Zappavigna V,Parenti S,Vignudelli T,Selmi T,Ferrari S,Grande A

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Orm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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