Gnal cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gnal
Entrez Gene ID	24611
Full Name	G protein subunit alpha L
Synonyms	Golf,Olf,RGD1305940
General protein information	Preferred Names G protein subunit alpha L Names guanine nucleotide-binding protein G(olf) subunit alpha Olf-alpha protein (olfactory neuron-specific G protein) adenylate cyclase-stimulating G alpha protein, olfactory type guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type guanine nucleotide binding protein, alpha stimulating, olfactory type guanine nucleotide-binding protein G(olf), alpha subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	alpha subunit of GTP-binding protein, first identified in the olfactory system; implicated in the signal transduction for odorant and visual stimuli and for one or more hormones/neurotransmitters [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191836.2	NP_001178765.1	guanine nucleotide-binding protein G(olf) subunit alpha

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gnal	NP_796111.2
Danio rerio (zebrafish)	gnal	NP_001007340.1
Xenopus tropicalis (tropical clawed frog)	gnal	NP_001135669.1
Homo sapiens (human)	GNAL	NP_001135811.1
Canis lupus familiaris (dog)	GNAL	XP_005623148.1
Bos taurus (cattle)	GNAL	NP_001096024.1
Gallus gallus (chicken)	GNAL	NP_001008746.1
Pan troglodytes (chimpanzee)	GNAL	XP_001172063.1
Rattus norvegicus (Norway rat)	Gnal	NP_001178765.1

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury.
Song H, Fang S, Gao J, Wang J, Cao Z, Guo Z, Huang Q, Qu Y, Zhou H, Yu J
Journal of proteome research(2017 Dec)

'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
Gon?alves I, Hubbard PC, Tom?s J, Quintela T, Tavares G, Caria S, Barreiros D, Santos CR
The FEBS journal283(9)1748-66(2016 05)

New genetic insights highlight 'old' ideas on motor dysfunction in dystonia.
Goodchild RE, Grundmann K, Pisani A
Trends in neurosciences36(12)717-25(2013 Dec)

G?(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Alcacer C, Santini E, Valjent E, Gaven F, Girault JA, Herv? D
The Journal of neuroscience : the official journal of the Society for Neuroscience32(17)5900-10(2012 Apr)

[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].
Cai DS, Chen Y, Chen G, Luo M
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology17(1)21-4(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
Title: 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.

Golf immunoreactivity is exclusively localized to giant cell trophoblasts and spongiotrophoblast cells
Title: Expression of Golf in the rat placenta: Possible implication in olfactory receptor transduction.

golfalpha was found in both the end organs and the ganglia and could serve unique roles in the physiology of the vestibular neuroepithelium
Title: G-protein Golfalpha (GNAL) is expressed in the vestibular end organs and primary afferent neurons of Rattus norvegicus.

Sulfhydryl groups on subunits of this protein are alkylated by ethylmaleimide and regulated by guanine nucleotides
Title: Alkylation of sulfhydryl groups on Galpha(s/olf) subunits by N-ethylmaleimide: regulation by guanine nucleotides.

Thyroid hormone can down-regulate Goalpha gene transcription in the hippocampus and dentate gyrus during early brain development.
Title: [Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].

The following Gnal gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gnal cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39896	NM_001191836.2 Latest version!	Rattus norvegicus G protein subunit alpha L (Gnal), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gnal ( NM_001191836.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178765.1 Rattus norvegicus G protein subunit alpha L (Gnal), mRNA.

Price & Availability↑

CloneID	ORa39896
Clone ID Related Accession (Same CDS sequence)	NM_001191836.2
Accession Version	NM_001191836.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	guanine nucleotide-binding protein G(olf) subunit alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07032361.1, AABR07032362.1, S80376.1 and AABR07032363.1. On Feb 26, 2015 this sequence version replaced NM_001191836.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCTGT GCTACAGCCT ACGGCCGCTG CTCTTCGGGA GCTCGGGGGA CGCCCCCTGT 
GAGGACTCTG AGCCGTGCGC TGAGGATGCT CAGCCCAGCG CCGCCCGGGC CCCGGCCCCG 
GCCCCGATCC CAGCCCCGGC TCCGGTGGGG ACCCTGCTCC GGCGAGGCGA CGGCCGGATC 
CCCGCAAGCG CGAGGTCGCC AGTCGAGCTG CAGAACCGCC GGCGACAGGA GCAGCTGCGA 
GCCGAGGAGC GCGAGGCAGC TAAGGAGGCG AGGAAAGTAA GCCGGGGTAT CGACCGCATG 
CTGCGCGAAC AGAAGCGCGA CCTGCAGCAG ACGCACCGGC TCCTGCTCTT GGGGGCTGGT 
GAGTCCGGGA AAAGCACTAT AGTCAAACAG ATGAGGATCC TACACGTCAA TGGCTTCAAC 
CCCGAGGAAA AGAAGCAGAA AATTCTGGAC ATCAGGAAAA ATGTCAAAGA TGCTATTGTG 
ACAATCGTTT CAGCAATGAG TACCATAATA CCTCCAGTTC CACTGGCCAA CCCTGAGAAC 
CAGTTTCGGT CAGATTACAT CAAGAGCATA GCCCCTATCA CTGACTTTGA ATATTCCCAG 
GAGTTCTTTG ACCACGTGAA GAAGCTGTGG GATGATGAGG GAGTGAAGGC CTGCTTTGAG 
AGATCCAACG AGTACCAGCT GATCGACTGT GCACAATACT TCCTGGAAAG GATTGACAGC 
GTGAGTCTGG TTGACTACAC ACCCACAGAC CAGGACCTAC TCAGATGCAG AGTGCTGACA 
TCAGGGATCT TTGAGACACG ATTCCAAGTG GACAAAGTGA ACTTTCACAT GTTTGACGTT 
GGAGGCCAGA GGGATGAGAG AAGAAAATGG ATCCAGTGTT TTAACGATGT CACTGCCATC 
ATCTATGTGG CAGCCTGCAG CAGCTACAAC ATGGTGATCC GGGAAGATAA CAACACCAAC 
AGACTCCGGG AGTCGCTGGA CCTGTTTGAA AGCATCTGGA ATAACAGGTG GTTACGAACC 
ATTTCCATCA TCCTGTTCTT GAACAAACAA GATATGCTGG CAGAAAAAGT CTTGGCAGGG 
AAGTCAAAAA TTGAAGACTA TTTCCCGGAG TATGCCAACT ATACTGTCCC TGAAGATGCA 
ACACCAGATG CAGGAGAAGA TCCCAAAGTT ACAAGAGCCA AGTTCTTTAT CCGGGATCTG 
TTCTTGAGGA TCAGCACAGC CACGGGTGAT GGCAAACATT ACTGCTACCC TCACTTCACC 
TGCGCCGTGG ACACAGAGAA CATCCGCAGA GTGTTCAACG ATTGTCGTGA CATCATCCAG 
AGAATGCACC TCAAGCAGTA CGAACTCTTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178765.1
CDS	175..1527
Translation	MGLCYSLRPLLFGSSGDAPCEDSEPCAEDAQPSAARAPAPAPIPAPAPVGTLLRRGDGRIPASARSPVELQNRRRQEQLRAEEREAAKEARKVSRGIDRMLREQKRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL

Target ORF information:

RefSeq Version	NM_001191836.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein subunit alpha L (Gnal), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191836.2

ORF Insert Sequence:

ATGGGCCTGT GCTACAGCCT ACGGCCGCTG CTCTTCGGGA GCTCGGGGGA CGCCCCCTGT 
GAGGACTCTG AGCCGTGCGC TGAGGATGCT CAGCCCAGCG CCGCCCGGGC CCCGGCCCCG 
GCCCCGATCC CAGCCCCGGC TCCGGTGGGG ACCCTGCTCC GGCGAGGCGA CGGCCGGATC 
CCCGCAAGCG CGAGGTCGCC AGTCGAGCTG CAGAACCGCC GGCGACAGGA GCAGCTGCGA 
GCCGAGGAGC GCGAGGCAGC TAAGGAGGCG AGGAAAGTAA GCCGGGGTAT CGACCGCATG 
CTGCGCGAAC AGAAGCGCGA CCTGCAGCAG ACGCACCGGC TCCTGCTCTT GGGGGCTGGT 
GAGTCCGGGA AAAGCACTAT AGTCAAACAG ATGAGGATCC TACACGTCAA TGGCTTCAAC 
CCCGAGGAAA AGAAGCAGAA AATTCTGGAC ATCAGGAAAA ATGTCAAAGA TGCTATTGTG 
ACAATCGTTT CAGCAATGAG TACCATAATA CCTCCAGTTC CACTGGCCAA CCCTGAGAAC 
CAGTTTCGGT CAGATTACAT CAAGAGCATA GCCCCTATCA CTGACTTTGA ATATTCCCAG 
GAGTTCTTTG ACCACGTGAA GAAGCTGTGG GATGATGAGG GAGTGAAGGC CTGCTTTGAG 
AGATCCAACG AGTACCAGCT GATCGACTGT GCACAATACT TCCTGGAAAG GATTGACAGC 
GTGAGTCTGG TTGACTACAC ACCCACAGAC CAGGACCTAC TCAGATGCAG AGTGCTGACA 
TCAGGGATCT TTGAGACACG ATTCCAAGTG GACAAAGTGA ACTTTCACAT GTTTGACGTT 
GGAGGCCAGA GGGATGAGAG AAGAAAATGG ATCCAGTGTT TTAACGATGT CACTGCCATC 
ATCTATGTGG CAGCCTGCAG CAGCTACAAC ATGGTGATCC GGGAAGATAA CAACACCAAC 
AGACTCCGGG AGTCGCTGGA CCTGTTTGAA AGCATCTGGA ATAACAGGTG GTTACGAACC 
ATTTCCATCA TCCTGTTCTT GAACAAACAA GATATGCTGG CAGAAAAAGT CTTGGCAGGG 
AAGTCAAAAA TTGAAGACTA TTTCCCGGAG TATGCCAACT ATACTGTCCC TGAAGATGCA 
ACACCAGATG CAGGAGAAGA TCCCAAAGTT ACAAGAGCCA AGTTCTTTAT CCGGGATCTG 
TTCTTGAGGA TCAGCACAGC CACGGGTGAT GGCAAACATT ACTGCTACCC TCACTTCACC 
TGCGCCGTGG ACACAGAGAA CATCCGCAGA GTGTTCAACG ATTGTCGTGA CATCATCCAG 
AGAATGCACC TCAAGCAGTA CGAACTCTTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury.
Journal of proteome research(2017 Dec)
Song H,Fang S,Gao J,Wang J,Cao Z,Guo Z,Huang Q,Qu Y,Zhou H,Yu J

'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
The FEBS journal283(9)1748-66(2016 05)
Gon?alves I,Hubbard PC,Tom?s J,Quintela T,Tavares G,Caria S,Barreiros D,Santos CR

New genetic insights highlight 'old' ideas on motor dysfunction in dystonia.
Trends in neurosciences36(12)717-25(2013 Dec)
Goodchild RE,Grundmann K,Pisani A

G?(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(17)5900-10(2012 Apr)
Alcacer C,Santini E,Valjent E,Gaven F,Girault JA,Herv? D

[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology17(1)21-4(2001 Feb)
Cai DS,Chen Y,Chen G,Luo M

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Gnal cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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