Npr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npr1
Entrez Gene ID	24603
Full Name	natriuretic peptide receptor 1
Synonyms	Anpra,Gca,NPR-A,Npra
General protein information	Preferred Names natriuretic peptide receptor 1 Names atrial natriuretic peptide receptor 1 ANP-A ANPR-A GC-A atrial natriuretic peptide A-type receptor atrial natriuretic peptide receptor A atrial natriuretic peptide receptor type A guanylate cyclase A natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	receptor for atrial natriuretic peptide [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006232591.3	XP_006232653.1	atrial natriuretic peptide receptor 1 isoform X1
NM_012613.1	NP_036745.1	atrial natriuretic peptide receptor 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NPR1	XP_003308543.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008691	XP_314790.4
Canis lupus familiaris (dog)	NPR1	XP_547577.2
Danio rerio (zebrafish)	npr1a	NP_001038402.1
	NPR1	XP_002808282.1
Mus musculus (house mouse)	Npr1	NP_032753.5
Homo sapiens (human)	NPR1	NP_000897.3
Bos taurus (cattle)	NPR1	NP_001179680.1
Rattus norvegicus (Norway rat)	Npr1	NP_036745.1
Drosophila melanogaster (fruit fly)	CG3216	NP_726013.2

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.
Manivasagam S, Vellaichamy E
Biochemical and biophysical research communications491(2)250-256(2017 09)

Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during ?-adrenergic receptor activation-induced hypertrophic growth in rats.
Manivasagam S, Subramanian V, Tumala A, Vellaichamy E
Molecular and cellular endocrinology433117-29(2016 09)

Transforming growth factor ?1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of ?EF1.
Sen A, Kumar P, Garg R, Lindsey SH, Katakam PV, Bloodworth M, Pandey KN
The FEBS journal283(9)1767-81(2016 05)

Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
Lee CH, Ha GW, Kim JH, Kim SH
Digestive diseases and sciences61(4)1060-8(2016 Apr)

Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Sun F, Zhou K, Wang SJ, Liang PF, Zhu MZ, Qiu JH
Hearing research309103-12(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro.
Title: Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.

Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes.
Title: Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during ?-adrenergic receptor activation-induced hypertrophic growth in rats.

The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.
Title: Transforming growth factor ?1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of ?EF1.

augmentation of inhibitory effect on basal motility by ANP in experimental colitis may be due an increased expression of colonic natriuretic peptide receptor-A mRNA
Title: Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.

Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion.
Title: Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.

The following Npr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13701	NM_012613.1 Latest version!	Rattus norvegicus natriuretic peptide receptor 1 (Npr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
ORa24842	XM_006232591.3 Latest version!	Rattus norvegicus natriuretic peptide receptor 1 (Npr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npr1 ( NM_012613.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036745.1 Rattus norvegicus natriuretic peptide receptor 1 (Npr1), mRNA.

Price & Availability↑

CloneID	ORa13701
Clone ID Related Accession (Same CDS sequence)	NM_012613.1
Accession Version	NM_012613.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide receptor 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J05677.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC128742.1, X14773.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCGGGCT CCCGACGCGT CCGTCCGCGC CTAAGGGCGC TGCTGCTGCT GCCGCCGCTT 
CTGCTACTCC GGGGCGGCCA CGCGAGCGAC CTGACCGTGG CTGTGGTGCT GCCGCTGACC 
AACACCTCGT ACCCGTGGTC CTGGGCGCGT GTAGGGCCGG CCGTGGAACT GGCTCTCGCG 
CGGGTGAAGG CTCGGCCGGA CTTGCTGCCG GGTTGGACGG TCCGCATGGT GCTGGGCAGC 
AGTGAGAACG CGGCGGGCGT CTGCTCGGAC ACCGCCGCAC CGCTGGCCGC GGTGGACCTC 
AAGTGGGAGC ACAGCCCCGC GGTGTTCCTG GGCCCCGGCT GCGTCTACTC CGCTGCCCCG 
GTGGGGCGCT TCACCGCGCA CTGGCGGGTG CCGCTGCTGA CCGCCGGCGC CCCGGCTCTG 
GGCATCGGGG TCAAGGATGA GTATGCGCTA ACCACCCGCA CAGGACCCAG CCATGTCAAG 
CTGGGCGATT TCGTGACGGC GCTGCATCGA CGGCTGGGCT GGGAGCACCA GGCGCTGGTG 
CTCTATGCAG ATCGGCTGGG CGACGACCGG CCTTGCTTCT TCATAGTGGA GGGGCTGTAC 
ATGCGGGTGC GTGAACGCCT CAACATCACA GTGAATCACC AGGAGTTCGT CGAGGGCGAC 
CCGGACCACT ACCCCAAGCT ACTGCGGGCC GTGCGGCGAA AGGGCAGAGT TATCTACATC 
TGCAGTTCTC CGGATGCCTT CAGGAATCTG ATGCTTCTGG CCCTGAACGC TGGCCTGACT 
GGGGAGGACT ATGTTTTCTT CCACCTGGAT GTGTTTGGGC AAAGCCTTAA GAGTGCTCAG 
GGCCTTGTTC CCCAGAAACC CTGGGAAAGA GGAGATGGGC AGGACAGGAG TGCCCGCCAG 
GCCTTTCAGG CTGCCAAAAT TATTACTTAC AAAGAGCCTG ATAATCCTGA GTACTTGGAA 
TTCCTGAAGC AGCTGAAACT CTTGGCTGAC AAGAAGTTCA ACTTCACCGT GGAGGATGGC 
CTGAAGAATA TCATCCCAGC CTCCTTCCAC GACGGGCTCC TGCTCTATGT CCAGGCAGTG 
ACAGAGACTC TGGCACAGGG GGGAACTGTC ACAGATGGAG AGAACATCAC TCAGCGGATG 
TGGAACCGAA GCTTCCAAGG TGTGACAGGA TACCTGAAAA TTGATAGAAA CGGAGATCGG 
GACACCGATT TCTCTCTCTG GGATATGGAT CCAGAGACGG GTGCCTTCAG GGTTGTCCTG 
AACTATAATG GTACTTCCCA GGAGCTAATG GCTGTGTCAG AACACAAATT ATACTGGCCT 
CTGGGATATC CACCTCCTGA CGTCCCTAAA TGTGGCTTTG ACAATGAGGA CCCAGCCTGC 
AACCAAGACC ACTTTTCCAC ACTGGAGGTT CTGGCTTTGG TGGGCAGCCT CTCTCTGATT 
AGCTTTCTGA TTGTGTCTTT CTTCATATAC AGGAAGATGC AGCTGGAAAA GGAGCTGGTC 
TCAGAGTTGT GGCGGGTGCG CTGGGAGGAC TTGCAGCCCA GCAGCCTGGA GAGGCATCTT 
CGGAGCGCTG GCAGCCGGCT GACCCTGAGT GGGCGAGGCT CCAATTATGG CTCCCTGCTA 
ACCACCGAGG GCCAGTTCCA AGTCTTTGCC AAGACAGCAT ACTATAAGGG CAACCTTGTG 
GCTGTGAAAC GTGTGAACCG GAAACGCATT GAGTTGACAC GAAAAGTCCT GTTTGAACTT 
AAACATATGC GGGATGTGCA GAATGAGCAC TTGACAAGAT TTGTGGGTGC TTGTACCGAC 
CCCCCCAACA TCTGTATCCT CACAGAGTAC TGTCCCCGTG GAAGCCTACA GGACATTCTA 
GAGAATGAGA GTATCACCCT GGACTGGATG TTTCGGTACT CGCTCACCAA TGACATTGTC 
AAGGGAATGC TCTTTCTACA CAATGGGGCC ATTTGTTCCC ATGGGAACCT CAAGTCATCC 
AACTGTGTGG TAGACGGGCG CTTCGTGTTA AAGATCACAG ACTACGGTCT TGAGAGCTTC 
AGAGACCCGG AGCCAGAGCA AGGACACACC CTCTTTGCCA AAAAATTGTG GACGGCACCT 
GAGCTCCTGC GAATGGCTTC GCCACCTGCC CGTGGCTCCC AAGCTGGGGA TGTGTACAGC 
TTTGGTATCA TCCTGCAGGA GATTGCCCTA AGAAGTGGGG TCTTCTATGT GGAAGGTTTG 
GACCTCAGCC CAAAAGAGAT CATTGAGCGT GTGACTCGGG GTGAGCAGCC CCCATTCCGA 
CCCTCCATGG ATCTGCAGAG CCACCTGGAG GAACTGGGGC AGCTGATGCA GCGGTGCTGG 
GCAGAGGACC CACAGGAGCG GCCACCCTTT CAGCAGATTC GCCTGGCGCT GCGCAAGTTC 
AACAAGGAGA ACAGCAGCAA CATCCTGGAC AACCTGCTGT CACGCATGGA GCAGTATGCT 
AACAACCTGG AGGAACTGGT AGAGGAGAGA ACACAAGCTT ATCTGGAGGA GAAGCGCAAA 
GCTGAGGCCT TGCTTTACCA GATTCTGCCT CACTCCGTGG CTGAGCAGCT GAAGAGAGGC 
GAGACAGTCC AGGCTGAGGC CTTTGATAGT GTTACCATCT ACTTCAGTGA TATTGTGGGC 
TTTACAGCTC TTTCAGCAGA AAGCACACCC ATGCAGGTGG TGACTCTGCT CAATGATCTG 
TACACCTGTT TTGATGCTGT CATAGACAAC TTTGATGTGT ACAAGGTGGA GACCATTGGT 
GATGCTTACA TGGTGGTGTC AGGGCTCCCA GTGCGGAATG GACAACTCCA CGCCCGAGAG 
GTGGCCCGAA TGGCACTTGC ACTACTGGAT GCTGTGCGCT CCTTCCGCAT CCGCCATAGG 
CCCCAGGAAC AGCTGCGCTT GCGCATTGGC ATCCACACAG GTCCTGTGTG TGCTGGTGTG 
GTAGGGCTAA AGATGCCCCG ATACTGCCTC TTTGGAGACA CAGTCAACAC AGCTTCAAGA 
ATGGAGTCTA ATGGAGAAGC CCTCAAGATC CACTTGTCTT CAGAGACCAA GGCTGTGCTG 
GAAGAGTTCG ATGGTTTCGA GCTGGAGCTC CGAGGGGATG TGGAAATGAA GGGCAAAGGC 
AAGGTTCGGA CCTATTGGCT CCTGGGGGAG CGGGGATGTA GCACTCGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036745.1
CDS	371..3544
Translation	MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG

Target ORF information:

RefSeq Version	NM_012613.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide receptor 1 (Npr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012613.1

ORF Insert Sequence:

ATGCCGGGCT CCCGACGCGT CCGTCCGCGC CTAAGGGCGC TGCTGCTGCT GCCGCCGCTT 
CTGCTACTCC GGGGCGGCCA CGCGAGCGAC CTGACCGTGG CTGTGGTGCT GCCGCTGACC 
AACACCTCGT ACCCGTGGTC CTGGGCGCGT GTAGGGCCGG CCGTGGAACT GGCTCTCGCG 
CGGGTGAAGG CTCGGCCGGA CTTGCTGCCG GGTTGGACGG TCCGCATGGT GCTGGGCAGC 
AGTGAGAACG CGGCGGGCGT CTGCTCGGAC ACCGCCGCAC CGCTGGCCGC GGTGGACCTC 
AAGTGGGAGC ACAGCCCCGC GGTGTTCCTG GGCCCCGGCT GCGTCTACTC CGCTGCCCCG 
GTGGGGCGCT TCACCGCGCA CTGGCGGGTG CCGCTGCTGA CCGCCGGCGC CCCGGCTCTG 
GGCATCGGGG TCAAGGATGA GTATGCGCTA ACCACCCGCA CAGGACCCAG CCATGTCAAG 
CTGGGCGATT TCGTGACGGC GCTGCATCGA CGGCTGGGCT GGGAGCACCA GGCGCTGGTG 
CTCTATGCAG ATCGGCTGGG CGACGACCGG CCTTGCTTCT TCATAGTGGA GGGGCTGTAC 
ATGCGGGTGC GTGAACGCCT CAACATCACA GTGAATCACC AGGAGTTCGT CGAGGGCGAC 
CCGGACCACT ACCCCAAGCT ACTGCGGGCC GTGCGGCGAA AGGGCAGAGT TATCTACATC 
TGCAGTTCTC CGGATGCCTT CAGGAATCTG ATGCTTCTGG CCCTGAACGC TGGCCTGACT 
GGGGAGGACT ATGTTTTCTT CCACCTGGAT GTGTTTGGGC AAAGCCTTAA GAGTGCTCAG 
GGCCTTGTTC CCCAGAAACC CTGGGAAAGA GGAGATGGGC AGGACAGGAG TGCCCGCCAG 
GCCTTTCAGG CTGCCAAAAT TATTACTTAC AAAGAGCCTG ATAATCCTGA GTACTTGGAA 
TTCCTGAAGC AGCTGAAACT CTTGGCTGAC AAGAAGTTCA ACTTCACCGT GGAGGATGGC 
CTGAAGAATA TCATCCCAGC CTCCTTCCAC GACGGGCTCC TGCTCTATGT CCAGGCAGTG 
ACAGAGACTC TGGCACAGGG GGGAACTGTC ACAGATGGAG AGAACATCAC TCAGCGGATG 
TGGAACCGAA GCTTCCAAGG TGTGACAGGA TACCTGAAAA TTGATAGAAA CGGAGATCGG 
GACACCGATT TCTCTCTCTG GGATATGGAT CCAGAGACGG GTGCCTTCAG GGTTGTCCTG 
AACTATAATG GTACTTCCCA GGAGCTAATG GCTGTGTCAG AACACAAATT ATACTGGCCT 
CTGGGATATC CACCTCCTGA CGTCCCTAAA TGTGGCTTTG ACAATGAGGA CCCAGCCTGC 
AACCAAGACC ACTTTTCCAC ACTGGAGGTT CTGGCTTTGG TGGGCAGCCT CTCTCTGATT 
AGCTTTCTGA TTGTGTCTTT CTTCATATAC AGGAAGATGC AGCTGGAAAA GGAGCTGGTC 
TCAGAGTTGT GGCGGGTGCG CTGGGAGGAC TTGCAGCCCA GCAGCCTGGA GAGGCATCTT 
CGGAGCGCTG GCAGCCGGCT GACCCTGAGT GGGCGAGGCT CCAATTATGG CTCCCTGCTA 
ACCACCGAGG GCCAGTTCCA AGTCTTTGCC AAGACAGCAT ACTATAAGGG CAACCTTGTG 
GCTGTGAAAC GTGTGAACCG GAAACGCATT GAGTTGACAC GAAAAGTCCT GTTTGAACTT 
AAACATATGC GGGATGTGCA GAATGAGCAC TTGACAAGAT TTGTGGGTGC TTGTACCGAC 
CCCCCCAACA TCTGTATCCT CACAGAGTAC TGTCCCCGTG GAAGCCTACA GGACATTCTA 
GAGAATGAGA GTATCACCCT GGACTGGATG TTTCGGTACT CGCTCACCAA TGACATTGTC 
AAGGGAATGC TCTTTCTACA CAATGGGGCC ATTTGTTCCC ATGGGAACCT CAAGTCATCC 
AACTGTGTGG TAGACGGGCG CTTCGTGTTA AAGATCACAG ACTACGGTCT TGAGAGCTTC 
AGAGACCCGG AGCCAGAGCA AGGACACACC CTCTTTGCCA AAAAATTGTG GACGGCACCT 
GAGCTCCTGC GAATGGCTTC GCCACCTGCC CGTGGCTCCC AAGCTGGGGA TGTGTACAGC 
TTTGGTATCA TCCTGCAGGA GATTGCCCTA AGAAGTGGGG TCTTCTATGT GGAAGGTTTG 
GACCTCAGCC CAAAAGAGAT CATTGAGCGT GTGACTCGGG GTGAGCAGCC CCCATTCCGA 
CCCTCCATGG ATCTGCAGAG CCACCTGGAG GAACTGGGGC AGCTGATGCA GCGGTGCTGG 
GCAGAGGACC CACAGGAGCG GCCACCCTTT CAGCAGATTC GCCTGGCGCT GCGCAAGTTC 
AACAAGGAGA ACAGCAGCAA CATCCTGGAC AACCTGCTGT CACGCATGGA GCAGTATGCT 
AACAACCTGG AGGAACTGGT AGAGGAGAGA ACACAAGCTT ATCTGGAGGA GAAGCGCAAA 
GCTGAGGCCT TGCTTTACCA GATTCTGCCT CACTCCGTGG CTGAGCAGCT GAAGAGAGGC 
GAGACAGTCC AGGCTGAGGC CTTTGATAGT GTTACCATCT ACTTCAGTGA TATTGTGGGC 
TTTACAGCTC TTTCAGCAGA AAGCACACCC ATGCAGGTGG TGACTCTGCT CAATGATCTG 
TACACCTGTT TTGATGCTGT CATAGACAAC TTTGATGTGT ACAAGGTGGA GACCATTGGT 
GATGCTTACA TGGTGGTGTC AGGGCTCCCA GTGCGGAATG GACAACTCCA CGCCCGAGAG 
GTGGCCCGAA TGGCACTTGC ACTACTGGAT GCTGTGCGCT CCTTCCGCAT CCGCCATAGG 
CCCCAGGAAC AGCTGCGCTT GCGCATTGGC ATCCACACAG GTCCTGTGTG TGCTGGTGTG 
GTAGGGCTAA AGATGCCCCG ATACTGCCTC TTTGGAGACA CAGTCAACAC AGCTTCAAGA 
ATGGAGTCTA ATGGAGAAGC CCTCAAGATC CACTTGTCTT CAGAGACCAA GGCTGTGCTG 
GAAGAGTTCG ATGGTTTCGA GCTGGAGCTC CGAGGGGATG TGGAAATGAA GGGCAAAGGC 
AAGGTTCGGA CCTATTGGCT CCTGGGGGAG CGGGGATGTA GCACTCGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npr1 ( XM_006232591.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232653.1 Rattus norvegicus natriuretic peptide receptor 1 (Npr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa24842
Clone ID Related Accession (Same CDS sequence)	XM_006232591.3
Accession Version	XM_006232591.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232591.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGGCT CCCGACGCGT CCGTCCGCGC CTAAGGGCGC TGCTGCTGCT GCCGCCGCTT 
CTGCTACTCC GGGGCGGCCA CGCGAGCGAC CTGACCGTGG CTGTGGTGCT GCCGCTGACC 
AACACCTCGT ACCCGTGGTC CTGGGCGCGT GTAGGGCCGG CCGTGGAACT GGCTCTCGCG 
CGGGTGAAGG CTCGGCCGGA CTTGCTGCCG GGTTGGACGG TCCGCATGGT GCTGGGCAGC 
AGTGAGAACG CGGCGGGCGT CTGCTCGGAC ACCGCCGCAC CGCTGGCCGC GGTGGACCTC 
AAGTGGGAGC ACAGCCCCGC GGTGTTCCTG GGCCCCGGCT GCGTCTACTC CGCTGCCCCG 
GTGGGGCGCT TCACCGCGCA CTGGCGGGTG CCGCTGCTGA CCGCCGGCGC CCCGGCTCTG 
GGCATCGGGG TCAAGGATGA GTATGCGCTA ACCACCCGCA CAGGACCCAG CCATGTCAAG 
CTGGGCGATT TCGTGACGGC GCTGCATCGA CGGCTGGGCT GGGAGCACCA GGCGCTGGTG 
CTCTATGCAG ATCGGCTGGG CGACGACCGG CCTTGCTTCT TCATAGTGGA GGGGCTGTAC 
ATGCGGGTGC GTGAACGCCT CAACATCACA GTGAATCACC AGGAGTTCGT CGAGGGCGAC 
CCGGACCACT ACCCCAAGCT ACTGCGGGCC GTGCGGCGAA AGGGCAGAGT TATCTACATC 
TGCAGTTCTC CGGATGCCTT CAGGAATCTG ATGCTTCTGG CCCTGAACGC TGGCCTGACT 
GGGGAGGACT ATGTTTTCTT CCACCTGGAT GTGTTTGGGC AAAGCCTTAA GAGTGCTCAG 
GGCCTTGTTC CCCAGAAACC CTGGGAAAGA GGAGATGGGC AGGACAGGAG TGCCCGCCAG 
GCCTTTCAGG CTGCCAAAAT TATTACTTAC AAAGAGCCTG ATAATCCTGA GTACTTGGAA 
TTCCTGAAGC AGCTGAAACT CTTGGCTGAC AAGAAGTTCA ACTTCACCGT GGAGGATGGC 
CTGAAGAATA TCATCCCAGC CTCCTTCCAC GACGGGCTCC TGCTCTATGT CCAGGCAGTG 
ACAGAGACTC TGGCACAGGG GGGAACTGTC ACAGATGGAG AGAACATCAC TCAGCGGATG 
TGGAACCGAA GCTTCCAAGG TGTGACAGGA TACCTGAAAA TTGATAGAAA CGGAGATCGG 
GACACCGATT TCTCTCTCTG GGATATGGAT CCAGAGACGG GTGCCTTCAG GGTTGTCCTG 
AACTATAATG GTACTTCCCA GGAGCTAATG GCTGTGTCAG AACACAAATT ATACTGGCCT 
CTGGGATATC CACCTCCTGA CGTCCCTAAA TGTGGCTTTG ACAATGAGGA CCCAGCCTGC 
AACCAAGACC ACTTTTCCAC ACTGGAGGTT CTGGCTTTGG TGGGCAGCCT CTCTCTGATT 
AGCTTTCTGA TTGTGTCTTT CTTCATATAC AGGAAGATGC AGCTGGAAAA GGAGCTGGTC 
TCAGAGTTGT GGCGGGTGCG CTGGGAGGAC TTGCAGCCCA GCAGCCTGGA GAGGCATCTT 
CGGAGCGCTG GCAGCCGGCT GACCCTGAGT GGGCGAGGCT CCAATTATGG CTCCCTGCTA 
ACCACCGAGG GCCAGTTCCA AGTCTTTGCC AAGACAGCAT ACTATAAGGG CAACCTTGTG 
GCTGTGAAAC GTGTGAACCG GAAACGCATT GAGTTGACAC GAAAAGTCCT GTTTGAACTT 
AAACATATGC GGGATGTGCA GAATGAGCAC TTGACAAGAT TTGTGGGTGC TTGTACCGAC 
CCCCCCAACA TCTGTATCCT CACAGAGTAC TGTCCCCGTG GAAGCCTACA GGACATTCTA 
GAGAATGAGA GTATCACCCT GGACTGGATG TTTCGGTACT CGCTCACCAA TGACATTGTC 
AAGGGAATGC TCTTTCTACA CAATGGGGCC ATTTGTTCCC ATGGGAACCT CAAGTCATCC 
AACTGTGTGG TAGACGGGCG CTTCGTGTTA AAGATCACAG ACTACGGTCT TGAGAGCTTC 
AGAGACCCGG AGCCAGAGCA AGGGCACACC CTCTTTGCCA AAAAATTGTG GACGGCACCT 
GAGCTCCTGC GAATGGCTTC GCCACCTGCC CGTGGCTCCC AAGCTGGGGA TGTGTACAGC 
TTTGGTATCA TCCTGCAGGA GATTGCCCTA AGAAGTGGGG TCTTCTATGT GGAAGGTTTG 
GACCTCAGCC CAAAAGAGAT CATTGAGCGT GTGACTCGGG GTGAGCAGCC CCCATTCCGA 
CCCTCCATGG ATCTGCAGAG CCACCTGGAG GAACTGGGGC AGCTGATGCA GCGGTGCTGG 
GCAGAGGACC CACAGGAGCG GCCACCCTTT CAGCAGATCC GCCTGGCGCT GCGCAAGTTC 
AACAAGGAGA ACAGCAGCAA CATCCTGGAC AACCTGCTGT CACGCATGGA GCAGTATGCT 
AACAACCTGG AGGAACTGGT AGAGGAGAGA ACACAAGCTT ATCTGGAGGA GAAGCGCAAA 
GCTGAGGCCT TGCTTTACCA GATTCTGCCT CACTCCGTGG CTGAGCAGCT GAAGAGAGGC 
GAGACAGTCC AGGCTGAGGC CTTTGATAGT GTTACCATCT ACTTCAGTGA TATTGTGGGC 
TTTACAGCTC TTTCAGCAGA AAGCACACCC ATGCAGGTGG TGACTCTGCT CAATGATCTG 
TACACCTGTT TTGATGCTGT CATAGACAAC TTTGATGTGT ACAAGGTGGA GACCATTGGT 
GATGCTTACA TGGTGGTGTC AGGGCTCCCA GTGCGGAATG GACAACTCCA CGCCCGAGAG 
GTGGCCCGAA TGGCACTTGC ACTACTGGAT GCTGTGCGCT CCTTCCGCAT CCGCCATAGG 
CCCCAGGAAC AGCTGCGCTT GCGCATTGGC ATCCACACAG GTCCTGTGTG TGCTGGTGTG 
GTAGGGCTAA AGATGCCCCG ATACTGCCTC TTTGGAGACA CAGTCAACAC AGCTTCAAGA 
ATGGAGTCTA ATGGAGAAGC CCTCAAGATC CACTTGTCTT CAGAGACCAA GGCTGTGCTG 
GAAGAGTTCG ATGGTTTCGA GCTGGAGCTC CGAGGGGATG TGGAAATGAA GGGCAAAGGC 
AAGGTTCGGA CCTATTGGCT CCTGGGGGAG CGGGGATGTA GCACTCGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232653.1
CDS	870..4043
Translation	MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG

Target ORF information:

RefSeq Version	XM_006232591.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide receptor 1 (Npr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232591.3

ORF Insert Sequence:

ATGCCGGGCT CCCGACGCGT CCGTCCGCGC CTAAGGGCGC TGCTGCTGCT GCCGCCGCTT 
CTGCTACTCC GGGGCGGCCA CGCGAGCGAC CTGACCGTGG CTGTGGTGCT GCCGCTGACC 
AACACCTCGT ACCCGTGGTC CTGGGCGCGT GTAGGGCCGG CCGTGGAACT GGCTCTCGCG 
CGGGTGAAGG CTCGGCCGGA CTTGCTGCCG GGTTGGACGG TCCGCATGGT GCTGGGCAGC 
AGTGAGAACG CGGCGGGCGT CTGCTCGGAC ACCGCCGCAC CGCTGGCCGC GGTGGACCTC 
AAGTGGGAGC ACAGCCCCGC GGTGTTCCTG GGCCCCGGCT GCGTCTACTC CGCTGCCCCG 
GTGGGGCGCT TCACCGCGCA CTGGCGGGTG CCGCTGCTGA CCGCCGGCGC CCCGGCTCTG 
GGCATCGGGG TCAAGGATGA GTATGCGCTA ACCACCCGCA CAGGACCCAG CCATGTCAAG 
CTGGGCGATT TCGTGACGGC GCTGCATCGA CGGCTGGGCT GGGAGCACCA GGCGCTGGTG 
CTCTATGCAG ATCGGCTGGG CGACGACCGG CCTTGCTTCT TCATAGTGGA GGGGCTGTAC 
ATGCGGGTGC GTGAACGCCT CAACATCACA GTGAATCACC AGGAGTTCGT CGAGGGCGAC 
CCGGACCACT ACCCCAAGCT ACTGCGGGCC GTGCGGCGAA AGGGCAGAGT TATCTACATC 
TGCAGTTCTC CGGATGCCTT CAGGAATCTG ATGCTTCTGG CCCTGAACGC TGGCCTGACT 
GGGGAGGACT ATGTTTTCTT CCACCTGGAT GTGTTTGGGC AAAGCCTTAA GAGTGCTCAG 
GGCCTTGTTC CCCAGAAACC CTGGGAAAGA GGAGATGGGC AGGACAGGAG TGCCCGCCAG 
GCCTTTCAGG CTGCCAAAAT TATTACTTAC AAAGAGCCTG ATAATCCTGA GTACTTGGAA 
TTCCTGAAGC AGCTGAAACT CTTGGCTGAC AAGAAGTTCA ACTTCACCGT GGAGGATGGC 
CTGAAGAATA TCATCCCAGC CTCCTTCCAC GACGGGCTCC TGCTCTATGT CCAGGCAGTG 
ACAGAGACTC TGGCACAGGG GGGAACTGTC ACAGATGGAG AGAACATCAC TCAGCGGATG 
TGGAACCGAA GCTTCCAAGG TGTGACAGGA TACCTGAAAA TTGATAGAAA CGGAGATCGG 
GACACCGATT TCTCTCTCTG GGATATGGAT CCAGAGACGG GTGCCTTCAG GGTTGTCCTG 
AACTATAATG GTACTTCCCA GGAGCTAATG GCTGTGTCAG AACACAAATT ATACTGGCCT 
CTGGGATATC CACCTCCTGA CGTCCCTAAA TGTGGCTTTG ACAATGAGGA CCCAGCCTGC 
AACCAAGACC ACTTTTCCAC ACTGGAGGTT CTGGCTTTGG TGGGCAGCCT CTCTCTGATT 
AGCTTTCTGA TTGTGTCTTT CTTCATATAC AGGAAGATGC AGCTGGAAAA GGAGCTGGTC 
TCAGAGTTGT GGCGGGTGCG CTGGGAGGAC TTGCAGCCCA GCAGCCTGGA GAGGCATCTT 
CGGAGCGCTG GCAGCCGGCT GACCCTGAGT GGGCGAGGCT CCAATTATGG CTCCCTGCTA 
ACCACCGAGG GCCAGTTCCA AGTCTTTGCC AAGACAGCAT ACTATAAGGG CAACCTTGTG 
GCTGTGAAAC GTGTGAACCG GAAACGCATT GAGTTGACAC GAAAAGTCCT GTTTGAACTT 
AAACATATGC GGGATGTGCA GAATGAGCAC TTGACAAGAT TTGTGGGTGC TTGTACCGAC 
CCCCCCAACA TCTGTATCCT CACAGAGTAC TGTCCCCGTG GAAGCCTACA GGACATTCTA 
GAGAATGAGA GTATCACCCT GGACTGGATG TTTCGGTACT CGCTCACCAA TGACATTGTC 
AAGGGAATGC TCTTTCTACA CAATGGGGCC ATTTGTTCCC ATGGGAACCT CAAGTCATCC 
AACTGTGTGG TAGACGGGCG CTTCGTGTTA AAGATCACAG ACTACGGTCT TGAGAGCTTC 
AGAGACCCGG AGCCAGAGCA AGGGCACACC CTCTTTGCCA AAAAATTGTG GACGGCACCT 
GAGCTCCTGC GAATGGCTTC GCCACCTGCC CGTGGCTCCC AAGCTGGGGA TGTGTACAGC 
TTTGGTATCA TCCTGCAGGA GATTGCCCTA AGAAGTGGGG TCTTCTATGT GGAAGGTTTG 
GACCTCAGCC CAAAAGAGAT CATTGAGCGT GTGACTCGGG GTGAGCAGCC CCCATTCCGA 
CCCTCCATGG ATCTGCAGAG CCACCTGGAG GAACTGGGGC AGCTGATGCA GCGGTGCTGG 
GCAGAGGACC CACAGGAGCG GCCACCCTTT CAGCAGATCC GCCTGGCGCT GCGCAAGTTC 
AACAAGGAGA ACAGCAGCAA CATCCTGGAC AACCTGCTGT CACGCATGGA GCAGTATGCT 
AACAACCTGG AGGAACTGGT AGAGGAGAGA ACACAAGCTT ATCTGGAGGA GAAGCGCAAA 
GCTGAGGCCT TGCTTTACCA GATTCTGCCT CACTCCGTGG CTGAGCAGCT GAAGAGAGGC 
GAGACAGTCC AGGCTGAGGC CTTTGATAGT GTTACCATCT ACTTCAGTGA TATTGTGGGC 
TTTACAGCTC TTTCAGCAGA AAGCACACCC ATGCAGGTGG TGACTCTGCT CAATGATCTG 
TACACCTGTT TTGATGCTGT CATAGACAAC TTTGATGTGT ACAAGGTGGA GACCATTGGT 
GATGCTTACA TGGTGGTGTC AGGGCTCCCA GTGCGGAATG GACAACTCCA CGCCCGAGAG 
GTGGCCCGAA TGGCACTTGC ACTACTGGAT GCTGTGCGCT CCTTCCGCAT CCGCCATAGG 
CCCCAGGAAC AGCTGCGCTT GCGCATTGGC ATCCACACAG GTCCTGTGTG TGCTGGTGTG 
GTAGGGCTAA AGATGCCCCG ATACTGCCTC TTTGGAGACA CAGTCAACAC AGCTTCAAGA 
ATGGAGTCTA ATGGAGAAGC CCTCAAGATC CACTTGTCTT CAGAGACCAA GGCTGTGCTG 
GAAGAGTTCG ATGGTTTCGA GCTGGAGCTC CGAGGGGATG TGGAAATGAA GGGCAAAGGC 
AAGGTTCGGA CCTATTGGCT CCTGGGGGAG CGGGGATGTA GCACTCGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.
Biochemical and biophysical research communications491(2)250-256(2017 09)
Manivasagam S,Vellaichamy E

Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during ?-adrenergic receptor activation-induced hypertrophic growth in rats.
Molecular and cellular endocrinology433117-29(2016 09)
Manivasagam S,Subramanian V,Tumala A,Vellaichamy E

Transforming growth factor ?1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of ?EF1.
The FEBS journal283(9)1767-81(2016 05)
Sen A,Kumar P,Garg R,Lindsey SH,Katakam PV,Bloodworth M,Pandey KN

Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
Digestive diseases and sciences61(4)1060-8(2016 Apr)
Lee CH,Ha GW,Kim JH,Kim SH

Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Hearing research309103-12(2014 Mar)
Sun F,Zhou K,Wang SJ,Liang PF,Zhu MZ,Qiu JH

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Npr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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