Jund cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jund
Entrez Gene ID	24518
Full Name	JunD proto-oncogene, AP-1 transcription factor subunit
General protein information	Preferred Names JunD proto-oncogene, AP-1 transcription factor subunit Names transcription factor jun-D JunD-FL isoform jun D proto-oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138875.4	NP_620230.1	transcription factor jun-D isoform JunD-FL
NM_001286966.1	NP_001273895.1	transcription factor jun-D isoform deltaJunD

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	jund	NP_001121814.1
Mus musculus (house mouse)	Jund	NP_034722.1
Rattus norvegicus (Norway rat)	Jund	NP_620230.1
Homo sapiens (human)	JUND	NP_005345.3
Canis lupus familiaris (dog)	JUND	XP_852285.2
Bos taurus (cattle)	JUND	NP_001096723.1
Xenopus tropicalis (tropical clawed frog)	jund	XP_002937979.1

Gene Ontology
Bibliography

Related articles in PubMed

JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.
Zou T, Rao JN, Liu L, Xiao L, Chung HK, Li Y, Chen G, Gorospe M, Wang JY
American journal of physiology. Cell physiology308(10)C813-24(2015 May)

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA
Molecular and cellular biology33(8)1487-502(2013 Apr)

Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.
Yao ST, Gouraud SS, Qiu J, Cunningham JT, Paton JF, Murphy D
Journal of neuroendocrinology24(12)1542-52(2012 Dec)

Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion.
Xiao L, Rao JN, Zou T, Liu L, Yu TX, Zhu XY, Donahue JM, Wang JY
American journal of physiology. Cell physiology298(5)C1226-34(2010 May)

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E
Cell136(6)1122-35(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
Title: JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.

JunD is highly co-expressed with c-Fos in magnocellular neurons of the supraoptic nucleus following dehydration.
Title: Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.

These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of intestinal epithelial cell growth.
Title: Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion.

JunD is a major determinant of macrophage activity and is associated with glomerulonephritis susceptibility.
Title: Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.

Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
Title: Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.

The following Jund gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jund cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00038	NM_138875.4 Latest version!	Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa12317	NM_001286966.1 Latest version!	Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jund ( NM_138875.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620230.1 Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa00038
Clone ID Related Accession (Same CDS sequence)	NM_138875.4
Accession Version	NM_138875.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor jun-D isoform JunD-FL
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC062053.1. On Nov 21, 2013 this sequence version replaced NM_138875.3. Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the longer isoform (JunD-FL). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC062053.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACGC CCTTCTATGG CGAGGAGGCG CTGAGCGGCC TGGCTGCGGG TGCGTCGAGC 
GTCGCTGGTG CTGCTGGGGC CCCCGGCGGT GGTGGCTTCG CGCCCCCGGG CCGCGCTTTC 
CCCGGGGCGC CCCCAACGAG CAGCATGCTG AAGAAAGACG CGCTGACGCT CAGCCTGGCG 
GAGCAGGGAG CGGCGGGATT GAAACCAGGG TCGGCCACTG CACCTTCTGC ATTGCGCCCC 
GACGGCGCCC CCGACGGGCT GCTGGCTTCG CCGGATCTTG GGCTGCTCAA ACTCGCGTCG 
CCGGAGCTGG AAAGGCTGAT CATCCAGTCC AACGGGCTGG TGACCACCAC CCCGACCAGT 
ACGCAGTTCC TCTACCCTAA GGTGGCGGCC AGCGAGGAGC AGGAGTTCGC CGAAGGCTTC 
GTCAAGGCGC TGGAGGACCT GCACAAGCAG AGCCAGCTGG GTGCGGCCAC CGCGGCCACC 
TCAGGGGCTC CCGCGCCCCC CGCGCCCGCG GACCTGGCAG CCACCCCCGG GGCCACGGAG 
ACCCCGGTCT ACGCCAACCT GAGCAGTTTC GCGGGTGGCG CCGGGCCCCC TGGGGGCGCG 
GCCACAGTGG CCTTCGCCGC GGAGCCAGTG CCCTTCCCGC CGCCCCCGGG CGCGCTGGGG 
CCGCCGCCAC CTCCGCATCC ACCGCGTCTG GCCGCGCTCA AGGACGAGCC GCAGACCGTG 
CCGGACGTGC CGAGCTTCGG CGACAGCCCT CCACTGTCGC CCATCGACAT GGACACGCAG 
GAACGCATCA AGGCGGAGCG CAAGAGGCTG CGCAACCGCA TCGCCGCTTC CAAATGCCGC 
AAGCGCAAGC TGGAGCGTAT CTCGCGCCTG GAGGAGAAAG TCAAGACCCT CAAAAGCCAG 
AACACCGAGC TGGCGTCCAC CGCGAGCCTG CTGCGCGAGC AGGTGGCGCA GCTCAAACAG 
AAAGTCCTCA GCCACGTCAA CAGCGGCTGC CAGCTGCTGC CCCAGCACCA GGTCCCCGCG 
TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620230.1
CDS	108..1133
Translation	METPFYGEEALSGLAAGASSVAGAAGAPGGGGFAPPGRAFPGAPPTSSMLKKDALTLSLAEQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSTQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAATSGAPAPPAPADLAATPGATETPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGALGPPPPPHPPRLAALKDEPQTVPDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY

Target ORF information:

RefSeq Version	NM_138875.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138875.4

ORF Insert Sequence:

ATGGAAACGC CCTTCTATGG CGAGGAGGCG CTGAGCGGCC TGGCTGCGGG TGCGTCGAGC 
GTCGCTGGTG CTGCTGGGGC CCCCGGCGGT GGTGGCTTCG CGCCCCCGGG CCGCGCTTTC 
CCCGGGGCGC CCCCAACGAG CAGCATGCTG AAGAAAGACG CGCTGACGCT CAGCCTGGCG 
GAGCAGGGAG CGGCGGGATT GAAACCAGGG TCGGCCACTG CACCTTCTGC ATTGCGCCCC 
GACGGCGCCC CCGACGGGCT GCTGGCTTCG CCGGATCTTG GGCTGCTCAA ACTCGCGTCG 
CCGGAGCTGG AAAGGCTGAT CATCCAGTCC AACGGGCTGG TGACCACCAC CCCGACCAGT 
ACGCAGTTCC TCTACCCTAA GGTGGCGGCC AGCGAGGAGC AGGAGTTCGC CGAAGGCTTC 
GTCAAGGCGC TGGAGGACCT GCACAAGCAG AGCCAGCTGG GTGCGGCCAC CGCGGCCACC 
TCAGGGGCTC CCGCGCCCCC CGCGCCCGCG GACCTGGCAG CCACCCCCGG GGCCACGGAG 
ACCCCGGTCT ACGCCAACCT GAGCAGTTTC GCGGGTGGCG CCGGGCCCCC TGGGGGCGCG 
GCCACAGTGG CCTTCGCCGC GGAGCCAGTG CCCTTCCCGC CGCCCCCGGG CGCGCTGGGG 
CCGCCGCCAC CTCCGCATCC ACCGCGTCTG GCCGCGCTCA AGGACGAGCC GCAGACCGTG 
CCGGACGTGC CGAGCTTCGG CGACAGCCCT CCACTGTCGC CCATCGACAT GGACACGCAG 
GAACGCATCA AGGCGGAGCG CAAGAGGCTG CGCAACCGCA TCGCCGCTTC CAAATGCCGC 
AAGCGCAAGC TGGAGCGTAT CTCGCGCCTG GAGGAGAAAG TCAAGACCCT CAAAAGCCAG 
AACACCGAGC TGGCGTCCAC CGCGAGCCTG CTGCGCGAGC AGGTGGCGCA GCTCAAACAG 
AAAGTCCTCA GCCACGTCAA CAGCGGCTGC CAGCTGCTGC CCCAGCACCA GGTCCCCGCG 
TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jund ( NM_001286966.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001273895.1 Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12317
Clone ID Related Accession (Same CDS sequence)	NM_001286966.1
Accession Version	NM_001286966.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor jun-D isoform deltaJunD
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC062053.1. Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the shorter isoform (deltaJunD). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC062053.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:12105216) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGAAGA AAGACGCGCT GACGCTCAGC CTGGCGGAGC AGGGAGCGGC GGGATTGAAA 
CCAGGGTCGG CCACTGCACC TTCTGCATTG CGCCCCGACG GCGCCCCCGA CGGGCTGCTG 
GCTTCGCCGG ATCTTGGGCT GCTCAAACTC GCGTCGCCGG AGCTGGAAAG GCTGATCATC 
CAGTCCAACG GGCTGGTGAC CACCACCCCG ACCAGTACGC AGTTCCTCTA CCCTAAGGTG 
GCGGCCAGCG AGGAGCAGGA GTTCGCCGAA GGCTTCGTCA AGGCGCTGGA GGACCTGCAC 
AAGCAGAGCC AGCTGGGTGC GGCCACCGCG GCCACCTCAG GGGCTCCCGC GCCCCCCGCG 
CCCGCGGACC TGGCAGCCAC CCCCGGGGCC ACGGAGACCC CGGTCTACGC CAACCTGAGC 
AGTTTCGCGG GTGGCGCCGG GCCCCCTGGG GGCGCGGCCA CAGTGGCCTT CGCCGCGGAG 
CCAGTGCCCT TCCCGCCGCC CCCGGGCGCG CTGGGGCCGC CGCCACCTCC GCATCCACCG 
CGTCTGGCCG CGCTCAAGGA CGAGCCGCAG ACCGTGCCGG ACGTGCCGAG CTTCGGCGAC 
AGCCCTCCAC TGTCGCCCAT CGACATGGAC ACGCAGGAAC GCATCAAGGC GGAGCGCAAG 
AGGCTGCGCA ACCGCATCGC CGCTTCCAAA TGCCGCAAGC GCAAGCTGGA GCGTATCTCG 
CGCCTGGAGG AGAAAGTCAA GACCCTCAAA AGCCAGAACA CCGAGCTGGC GTCCACCGCG 
AGCCTGCTGC GCGAGCAGGT GGCGCAGCTC AAACAGAAAG TCCTCAGCCA CGTCAACAGC 
GGCTGCCAGC TGCTGCCCCA GCACCAGGTC CCCGCGTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273895.1
CDS	252..1133
Translation	MLKKDALTLSLAEQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSTQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAATSGAPAPPAPADLAATPGATETPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGALGPPPPPHPPRLAALKDEPQTVPDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY

Target ORF information:

RefSeq Version	NM_001286966.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor subunit (Jund), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286966.1

ORF Insert Sequence:

ATGCTGAAGA AAGACGCGCT GACGCTCAGC CTGGCGGAGC AGGGAGCGGC GGGATTGAAA 
CCAGGGTCGG CCACTGCACC TTCTGCATTG CGCCCCGACG GCGCCCCCGA CGGGCTGCTG 
GCTTCGCCGG ATCTTGGGCT GCTCAAACTC GCGTCGCCGG AGCTGGAAAG GCTGATCATC 
CAGTCCAACG GGCTGGTGAC CACCACCCCG ACCAGTACGC AGTTCCTCTA CCCTAAGGTG 
GCGGCCAGCG AGGAGCAGGA GTTCGCCGAA GGCTTCGTCA AGGCGCTGGA GGACCTGCAC 
AAGCAGAGCC AGCTGGGTGC GGCCACCGCG GCCACCTCAG GGGCTCCCGC GCCCCCCGCG 
CCCGCGGACC TGGCAGCCAC CCCCGGGGCC ACGGAGACCC CGGTCTACGC CAACCTGAGC 
AGTTTCGCGG GTGGCGCCGG GCCCCCTGGG GGCGCGGCCA CAGTGGCCTT CGCCGCGGAG 
CCAGTGCCCT TCCCGCCGCC CCCGGGCGCG CTGGGGCCGC CGCCACCTCC GCATCCACCG 
CGTCTGGCCG CGCTCAAGGA CGAGCCGCAG ACCGTGCCGG ACGTGCCGAG CTTCGGCGAC 
AGCCCTCCAC TGTCGCCCAT CGACATGGAC ACGCAGGAAC GCATCAAGGC GGAGCGCAAG 
AGGCTGCGCA ACCGCATCGC CGCTTCCAAA TGCCGCAAGC GCAAGCTGGA GCGTATCTCG 
CGCCTGGAGG AGAAAGTCAA GACCCTCAAA AGCCAGAACA CCGAGCTGGC GTCCACCGCG 
AGCCTGCTGC GCGAGCAGGT GGCGCAGCTC AAACAGAAAG TCCTCAGCCA CGTCAACAGC 
GGCTGCCAGC TGCTGCCCCA GCACCAGGTC CCCGCGTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.
American journal of physiology. Cell physiology308(10)C813-24(2015 May)
Zou T,Rao JN,Liu L,Xiao L,Chung HK,Li Y,Chen G,Gorospe M,Wang JY

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology33(8)1487-502(2013 Apr)
Armour SM,Bennett EJ,Braun CR,Zhang XY,McMahon SB,Gygi SP,Harper JW,Sinclair DA

Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.
Journal of neuroendocrinology24(12)1542-52(2012 Dec)
Yao ST,Gouraud SS,Qiu J,Cunningham JT,Paton JF,Murphy D

Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion.
American journal of physiology. Cell physiology298(5)C1226-34(2010 May)
Xiao L,Rao JN,Zou T,Liu L,Yu TX,Zhu XY,Donahue JM,Wang JY

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Cell136(6)1122-35(2009 Mar)
Ezhkova E,Pasolli HA,Parker JS,Stokes N,Su IH,Hannon G,Tarakhovsky A,Fuchs E

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Jund cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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