Junb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Junb
Entrez Gene ID	24517
Full Name	JunB proto-oncogene, AP-1 transcription factor subunit
General protein information	Preferred Names JunB proto-oncogene, AP-1 transcription factor subunit Names transcription factor jun-B Jun-B oncogene jun B proto-oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q11
Summary	transcription factor; involved in transcriptional regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021836.2	NP_068608.2	transcription factor jun-B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	JUNB	XP_524126.2
Homo sapiens (human)	JUNB	NP_002220.1
Canis lupus familiaris (dog)	JUNB	XP_003639770.1
Rattus norvegicus (Norway rat)	Junb	NP_068608.2
Bos taurus (cattle)	JUNB	NP_001069124.1
Xenopus tropicalis (tropical clawed frog)	junb	NP_001037955.1
	JUNB	XP_001109775.2
Mus musculus (house mouse)	Junb	NP_032442.1

Gene Ontology
Bibliography

Related articles in PubMed

Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL
Molecular and cellular biology29(10)2748-61(2009 May)

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E
Cell136(6)1122-35(2009 Mar)

JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons.
Rylski M, Amborska R, Zybura K, Michaluk P, Bielinska B, Konopacki FA, Wilczynski GM, Kaczmarek L
Molecular and cellular neurosciences40(1)98-110(2009 Jan)

Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
Hansson AC, Fuxe K
Brain research12151-10(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study documents the active repressive influence of AP-1 onto MMP-9 transcriptional regulation by the engagement of JunB.
Title: JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons.

Corticosterone treatment gave rise to a delayed and significant reduction of junB mRNA signals after 2 h in all hippocampal regions, which reversed to increase at 4 h.
Title: Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.

Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
Title: Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.

plays key role in remodelling phenomena of bone and cartilage
Title: Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes.

Expressions of junB and c-fos were enhanced stepwise in 4NQO-induced carcinogenesis of rat tongue.
Title: Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers.

The following Junb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Junb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42599	NM_021836.2 Latest version!	Rattus norvegicus JunB proto-oncogene, AP-1 transcription factor subunit (Junb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Junb ( NM_021836.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068608.2 Rattus norvegicus JunB proto-oncogene, AP-1 transcription factor subunit (Junb), mRNA.

Price & Availability↑

CloneID	ORa42599
Clone ID Related Accession (Same CDS sequence)	NM_021836.2
Accession Version	NM_021836.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor jun-B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061862.1. On Dec 20, 2003 this sequence version replaced NM_021836.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061862.1 [ECO:0000332] ##Evidence-Data-END##

ATGTGCACGA AAATGGAACA GCCTTTCTAT CACGACGACT CATACGCAGC GGCAGGATAC 
GGTCGGAGCC CTGGCAGTCT TTCTCTTCAC GACTACAAAC TCCTGAAACC CACCTTAGCG 
CTCAACCTGG CAGATCCTTA TCGGGGTCTC AAGGGTCCTG GGGCGCGGGG TCCAGGCCCA 
GAGGGCAGTG GGGCAGGCAG CTACTTTTCG GGTCAGGGAT CAGACACAGG CGCATCTCTG 
AAGCTAGCCT CCACGGAACT GGAGCGCTTG ATCGTCCCCA ACAGCAACGG CGTGATCACG 
ACGACGCCCA CGCCTCCGGG ACAGTACTTT TACCCCCGTG GGGGCGGCAG CGGCGGAGGT 
ACAGGGGGCG GCGTCACCGA GGAGCAGGAG GGCTTTGCGG ACGGTTTTGT CAAAGCCCTG 
GACGACCTGC ACAAGATGAA CCACGTGACG CCCCCCAACG TGTCTCTGGG CGCCAGCGGG 
GGTCCCCAGG CCGGGCCTGG GGGCGTCTAT GCTGGTCCGG AGCCGCCTCC GGTCTACACC 
AACCTCAGCA GTTACTCCCC AGCCTCTGCA CCCTCTGGAG GTTCCGGGAC CGCCGTCGGG 
ACTGGGAGCT CATACCCGAC GGCCACCATC AGCTACCTCC CACATGCACC ACCCTTTGCG 
GGCGGCCACC CGGCGCAGCT GGGCTTGAGT CGCGGCGCTT CCGCCTTTAA AGAGGAACCG 
CAGACCGTAC CGGAGGCACG CAGCCGCGAC GCCACGCCGC CTGTGTCCCC CATCAACATG 
GAAGACCAGG AGCGCATCAA AGTGGAGCGA AAGCGGCTGC GGAACAGGCT GGCGGCCACC 
AAATGCCGGA AGCGGAAGCT GGAGCGCATC GCGCGCCTGG AGGACAAGGT GAAGACACTC 
AAGGCTGAGA ACGCGGGGCT GTCAAGTACT GCCGGCCTCC TACGGGAGCA AGTGGCGCAG 
CTCAAGCAGA AGGTCATGAC CCACGTCAGC AACGGCTGCC AGTTGCTGCT AGGGGTCAAG 
GGACACGCCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068608.2
CDS	271..1305
Translation	MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLADPYRGLKGPGARGPGPEGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGTGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASGGPQAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPPFAGGHPAQLGLSRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF

Target ORF information:

RefSeq Version	NM_021836.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus JunB proto-oncogene, AP-1 transcription factor subunit (Junb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021836.2

ORF Insert Sequence:

ATGTGCACGA AAATGGAACA GCCTTTCTAT CACGACGACT CATACGCAGC GGCAGGATAC 
GGTCGGAGCC CTGGCAGTCT TTCTCTTCAC GACTACAAAC TCCTGAAACC CACCTTAGCG 
CTCAACCTGG CAGATCCTTA TCGGGGTCTC AAGGGTCCTG GGGCGCGGGG TCCAGGCCCA 
GAGGGCAGTG GGGCAGGCAG CTACTTTTCG GGTCAGGGAT CAGACACAGG CGCATCTCTG 
AAGCTAGCCT CCACGGAACT GGAGCGCTTG ATCGTCCCCA ACAGCAACGG CGTGATCACG 
ACGACGCCCA CGCCTCCGGG ACAGTACTTT TACCCCCGTG GGGGCGGCAG CGGCGGAGGT 
ACAGGGGGCG GCGTCACCGA GGAGCAGGAG GGCTTTGCGG ACGGTTTTGT CAAAGCCCTG 
GACGACCTGC ACAAGATGAA CCACGTGACG CCCCCCAACG TGTCTCTGGG CGCCAGCGGG 
GGTCCCCAGG CCGGGCCTGG GGGCGTCTAT GCTGGTCCGG AGCCGCCTCC GGTCTACACC 
AACCTCAGCA GTTACTCCCC AGCCTCTGCA CCCTCTGGAG GTTCCGGGAC CGCCGTCGGG 
ACTGGGAGCT CATACCCGAC GGCCACCATC AGCTACCTCC CACATGCACC ACCCTTTGCG 
GGCGGCCACC CGGCGCAGCT GGGCTTGAGT CGCGGCGCTT CCGCCTTTAA AGAGGAACCG 
CAGACCGTAC CGGAGGCACG CAGCCGCGAC GCCACGCCGC CTGTGTCCCC CATCAACATG 
GAAGACCAGG AGCGCATCAA AGTGGAGCGA AAGCGGCTGC GGAACAGGCT GGCGGCCACC 
AAATGCCGGA AGCGGAAGCT GGAGCGCATC GCGCGCCTGG AGGACAAGGT GAAGACACTC 
AAGGCTGAGA ACGCGGGGCT GTCAAGTACT GCCGGCCTCC TACGGGAGCA AGTGGCGCAG 
CTCAAGCAGA AGGTCATGAC CCACGTCAGC AACGGCTGCC AGTTGCTGCT AGGGGTCAAG 
GGACACGCCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
Molecular and cellular biology29(10)2748-61(2009 May)
Abell AN,Granger DA,Johnson NL,Vincent-Jordan N,Dibble CF,Johnson GL

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Cell136(6)1122-35(2009 Mar)
Ezhkova E,Pasolli HA,Parker JS,Stokes N,Su IH,Hannon G,Tarakhovsky A,Fuchs E

JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons.
Molecular and cellular neurosciences40(1)98-110(2009 Jan)
Rylski M,Amborska R,Zybura K,Michaluk P,Bielinska B,Konopacki FA,Wilczynski GM,Kaczmarek L

Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
Brain research12151-10(2008 Jun)
Hansson AC,Fuxe K

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Junb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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