Igf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igf2
Entrez Gene ID	24483
Full Name	insulin-like growth factor 2
Synonyms	IGFII,RNIGF2
General protein information	Preferred Names insulin-like growth factor 2 Names insulin-like growth factor II IGF-II Insulin-like growth factor II (somatomedin A) MSA insulin-like growth factor II (IGF-II) insulin-like growth factor II isoform 2 variant 4 preprotein multiplication-stimulating activity multiplication-stimulating polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	a mitogenic growth factor; may have a role in fetal development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006230664.3	XP_006230726.1	insulin-like growth factor II isoform X1
XM_006230665.2	XP_006230727.1	insulin-like growth factor II isoform X3
NM_031511.2	NP_113699.2	insulin-like growth factor II isoform 1 preproprotein
NM_001190163.1	NP_001177092.1	insulin-like growth factor II isoform 2 preproprotein
XM_008760074.2	XP_008758296.1	insulin-like growth factor II isoform X2
NM_001190162.1	NP_001177091.1	insulin-like growth factor II isoform 2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	IGF2	NP_001121070.1
Mus musculus (house mouse)	Igf2	NP_034644.2
Pan troglodytes (chimpanzee)	IGF2	XP_001153640.3
Danio rerio (zebrafish)	igf2b	NP_001001815.1
Danio rerio (zebrafish)	igf2a	NP_571508.1
Bos taurus (cattle)	IGF2	NP_776512.2
Rattus norvegicus (Norway rat)	Igf2	NP_113699.2
	LOC721120	XP_002799486.1
Canis lupus familiaris (dog)	IGF2	NP_001182755.1
Xenopus tropicalis (tropical clawed frog)	igf2	NP_001107144.1
Gallus gallus (chicken)	IGF2	NP_001025513.1

Gene Ontology
Bibliography

Related articles in PubMed

Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region.
Agba OB, Lausser L, Huse K, Bergmeier C, Jahn N, Groth M, Bens M, Sahm A, Gall M, Witte OW, Kestler HA, Schwab M, Platzer M
Physiological genomics49(11)690-702(2017 Nov)

Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
Chen YF, Lee NH, Pai PY, Chung LC, Shen CY, Rajendran P, Chen YF, Chen RJ, Padma Viswanadha V, Kuo WW, Huang CY
Journal of receptor and signal transduction research37(5)493-499(2017 Oct)

Transgenerational pancreatic impairment with Igf2/H19 epigenetic alteration induced by p,p'-DDE exposure in early life.
Song Y, Yang L
Toxicology letters280222-231(2017 Oct)

IGF2 stimulates fetal growth in a sex- and organ-dependent manner.
White V, Jawerbaum A, Mazzucco MB, Gauster M, Desoye G, Hiden U
Pediatric research(2017 Oct)

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
Cedano Prieto DM, Cheng Y, Chang CC, Yu J, Takada YK, Takada Y
PloS one12(9)e0184285(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results showed that f1 offspring exposed to p,p'-DDE exhibited impaired glucose tolerance, abnormal insulin secretion, beta-cell dysfunction and altered Igf2 and H19 expression induced by Igf2/H19 hypomethylation, which could be transferred to the F3 offspring through the male germ line.
Title: Transgenerational pancreatic impairment with Igf2/H19 epigenetic alteration induced by p,p'-DDE exposure in early life.

The IGF2 was further de-regulated to assess its mechanism in miR-193-5p-downreuglation induced angiogenic regulation.
Title: MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy.

The hypomethylation observed at the H19 DMR corroborates with aberrant expression of Igf2 and H19 imprinted genes in the resorbed embryos sired by ERb agonist-treated males
Title: Estrogen signaling, through estrogen receptor ?, regulates DNA methylation and its machinery in male germ line in adult rats.

Post-weaning high-fat (HF) diet intake resulted in the reduction of small follicles in adulthood, whereas maternal HF diet had long-term deleterious consequences on female offspring steroidogenesis and coincided with alteration of the upregulation of the imprinted gene Igf2 and changes in ovarian circadian rhythms.
Title: Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock.

IGF2 expression in the rat brain both in basal condition and following learning predominantly derives from the maternal allele.
Title: Insulin Like Growth Factor 2 Expression in the Rat Brain Both in Basal Condition and following Learning Predominantly Derives from the Maternal Allele.

The following Igf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06756	NM_001190163.1 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa06756	NM_001190162.1 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa07953	NM_031511.2 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa06756	XM_006230665.2 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa23680	XM_006230664.3 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa42912	XM_008760074.2 Latest version!	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igf2 ( NM_001190163.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001177092.1 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa06756
Clone ID Related Accession (Same CDS sequence)	XM_006230665.2 , NM_001190163.1 , NM_001190162.1
Accession Version	NM_001190163.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform 2 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X14833.1 and AC098563.6. Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X14833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177092.1
CDS	77..619
Translation	MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ

Target ORF information:

RefSeq Version	NM_001190163.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190163.1

ORF Insert Sequence:

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igf2 ( NM_001190162.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001177091.1 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa06756
Clone ID Related Accession (Same CDS sequence)	XM_006230665.2 , NM_001190163.1 , NM_001190162.1
Accession Version	NM_001190162.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform 2 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X13101.1 and AC098563.6. Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X13101.1, FN802819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177091.1
CDS	89..631
Translation	MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ

Target ORF information:

RefSeq Version	NM_001190162.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190162.1

ORF Insert Sequence:

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igf2 ( NM_031511.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113699.2 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa07953
Clone ID Related Accession (Same CDS sequence)	NM_031511.2
Accession Version	NM_031511.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform 1 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC098563.6 and X14834.1. On Jun 9, 2010 this sequence version replaced NM_031511.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X00911.1, X14834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGCA GCGTCGCCGG CTTCCAGGTA CCAATGGGGA TCCCAGTGGG GAAGTCGATG 
TTGGTGCTTC TCATCTCTTT GGCCTTCGCC TTGTGCTGCA TCGCTGCTTA CCGCCCCAGC 
GAGACTCTGT GCGGAGGGGA GCTTGTTGAC ACGCTTCAGT TTGTCTGTTC GGACCGCGGC 
TTCTACTTCA GCAGGCCTTC AAGCCGTGCC AACCGTCGCA GCCGTGGCAT CGTGGAAGAG 
TGCTGCTTCC GCAGCTGCGA CTTGGCCCTC CTGGAGACAT ACTGTGCCAC CCCCGCCAAG 
TCCGAGAGGG ACGTGTCTAC CTCTCAGGCC GTACTTCCGG ACGACTTCCC CAGATACCCC 
GTGGGCAAGT TCTTCAAATT CGACACCTGG AGACAGTCCG CGGGACGCCT GCGCAGAGGC 
CTGCCTGCCC TCCTGCGTGC CCGCCGGGGT CGCATGCTTG CCAAAGAGCT CGAAGCGTTC 
AGAGAGGCCA AGCGCCACCG TCCCCTGATC GTGTTACCAC CCAAAGACCC CGCCCACGGG 
GGAGCCTCTT CGGAGATGTC CAGCAACCAT CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113699.2
CDS	1031..1606
Translation	MGGSVAGFQVPMGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ

Target ORF information:

RefSeq Version	NM_031511.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031511.2

ORF Insert Sequence:

ATGGGCGGCA GCGTCGCCGG CTTCCAGGTA CCAATGGGGA TCCCAGTGGG GAAGTCGATG 
TTGGTGCTTC TCATCTCTTT GGCCTTCGCC TTGTGCTGCA TCGCTGCTTA CCGCCCCAGC 
GAGACTCTGT GCGGAGGGGA GCTTGTTGAC ACGCTTCAGT TTGTCTGTTC GGACCGCGGC 
TTCTACTTCA GCAGGCCTTC AAGCCGTGCC AACCGTCGCA GCCGTGGCAT CGTGGAAGAG 
TGCTGCTTCC GCAGCTGCGA CTTGGCCCTC CTGGAGACAT ACTGTGCCAC CCCCGCCAAG 
TCCGAGAGGG ACGTGTCTAC CTCTCAGGCC GTACTTCCGG ACGACTTCCC CAGATACCCC 
GTGGGCAAGT TCTTCAAATT CGACACCTGG AGACAGTCCG CGGGACGCCT GCGCAGAGGC 
CTGCCTGCCC TCCTGCGTGC CCGCCGGGGT CGCATGCTTG CCAAAGAGCT CGAAGCGTTC 
AGAGAGGCCA AGCGCCACCG TCCCCTGATC GTGTTACCAC CCAAAGACCC CGCCCACGGG 
GGAGCCTCTT CGGAGATGTC CAGCAACCAT CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igf2 ( XM_006230665.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230727.1 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa06756
Clone ID Related Accession (Same CDS sequence)	XM_006230665.2 , NM_001190163.1 , NM_001190162.1
Accession Version	XM_006230665.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006230665.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230727.1
CDS	69..611
Translation	MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ

Target ORF information:

RefSeq Version	XM_006230665.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230665.2

ORF Insert Sequence:

ATGGGGATCC CAGTGGGGAA GTCGATGTTG GTGCTTCTCA TCTCTTTGGC CTTCGCCTTG 
TGCTGCATCG CTGCTTACCG CCCCAGCGAG ACTCTGTGCG GAGGGGAGCT TGTTGACACG 
CTTCAGTTTG TCTGTTCGGA CCGCGGCTTC TACTTCAGCA GGCCTTCAAG CCGTGCCAAC 
CGTCGCAGCC GTGGCATCGT GGAAGAGTGC TGCTTCCGCA GCTGCGACTT GGCCCTCCTG 
GAGACATACT GTGCCACCCC CGCCAAGTCC GAGAGGGACG TGTCTACCTC TCAGGCCGTA 
CTTCCGGACG ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCAAATTCGA CACCTGGAGA 
CAGTCCGCGG GACGCCTGCG CAGAGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCGC 
ATGCTTGCCA AAGAGCTCGA AGCGTTCAGA GAGGCCAAGC GCCACCGTCC CCTGATCGTG 
TTACCACCCA AAGACCCCGC CCACGGGGGA GCCTCTTCGG AGATGTCCAG CAACCATCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igf2 ( XM_006230664.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230726.1 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23680
Clone ID Related Accession (Same CDS sequence)	XM_006230664.3
Accession Version	XM_006230664.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230664.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCTC ATTCAAGTCC TCCTACTTTG GGCCACTCAT TCCCAGGGCC GCAAATCAGA 
CAAGGGTCTG ATTTGGGATC CCCGAAATTT GATCATTGTT TCCGCTGGCC ACTTTCGGCA 
GCTTCCCGTC CTGCGCATAA CATCGATATC GGCCTCTTCA CTTCTCCTAC GGTGTCCCAG 
CGGCAGCTCA GATTTTGGAA AAGTGTGTGT GCCCCAAACA CGCACCGGAC ACTGCGCGGC 
GGCCAGGACG TGGGCAGTGC TGCTCCCGTG TCCAGGAAAA CCACTGGGCA TTGCCCCCAG 
TTTCCCCCAA ATTTGGGCAT TGTCCCCGGG TCTTCCAACG GACTGGGCGT TGCCCCGGGA 
CACTGGGGAC TGCCTTTGGG GTCTCGCTCA CCTTCAGCAA CGTCCACTTC AGCAGCTCCC 
ACTTCTGCAG CTCTCCCGCC CTTCTCCGAT CCTCCTGCGC CAGCGGACCC GACCTTCGGC 
CTTGCGGTAC CAATGGGGAT CCCAGTGGGG AAGTCGATGT TGGTGCTTCT CATCTCTTTG 
GCCTTCGCCT TGTGCTGCAT CGCTGCTTAC CGCCCCAGCG AGACTCTGTG CGGAGGGGAG 
CTTGTTGACA CGCTTCAGTT TGTCTGTTCG GACCGCGGCT TCTACTTCAG CAGGCCTTCA 
AGCCGTGCCA ACCGTCGCAG CCGTGGCATC GTGGAAGAGT GCTGCTTCCG CAGCTGCGAC 
TTGGCCCTCC TGGAGACATA CTGTGCCACC CCCGCCAAGT CCGAGAGGGA CGTGTCTACC 
TCTCAGGCCG TACTTCCGGA CGACTTCCCC AGATACCCCG TGGGCAAGTT CTTCAAATTC 
GACACCTGGA GACAGTCCGC GGGACGCCTG CGCAGAGGCC TGCCTGCCCT CCTGCGTGCC 
CGCCGGGGTC GCATGCTTGC CAAAGAGCTC GAAGCGTTCA GAGAGGCCAA GCGCCACCGT 
CCCCTGATCG TGTTACCACC CAAAGACCCC GCCCACGGGG GAGCCTCTTC GGAGATGTCC 
AGCAACCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230726.1
CDS	358..1392
Translation	MESHSSPPTLGHSFPGPQIRQGSDLGSPKFDHCFRWPLSAASRPAHNIDIGLFTSPTVSQRQLRFWKSVCAPNTHRTLRGGQDVGSAAPVSRKTTGHCPQFPPNLGIVPGSSNGLGVAPGHWGLPLGSRSPSATSTSAAPTSAALPPFSDPPAPADPTFGLAVPMGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ

Target ORF information:

RefSeq Version	XM_006230664.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230664.3

ORF Insert Sequence:

ATGGAGTCTC ATTCAAGTCC TCCTACTTTG GGCCACTCAT TCCCAGGGCC GCAAATCAGA 
CAAGGGTCTG ATTTGGGATC CCCGAAATTT GATCATTGTT TCCGCTGGCC ACTTTCGGCA 
GCTTCCCGTC CTGCGCATAA CATCGATATC GGCCTCTTCA CTTCTCCTAC GGTGTCCCAG 
CGGCAGCTCA GATTTTGGAA AAGTGTGTGT GCCCCAAACA CGCACCGGAC ACTGCGCGGC 
GGCCAGGACG TGGGCAGTGC TGCTCCCGTG TCCAGGAAAA CCACTGGGCA TTGCCCCCAG 
TTTCCCCCAA ATTTGGGCAT TGTCCCCGGG TCTTCCAACG GACTGGGCGT TGCCCCGGGA 
CACTGGGGAC TGCCTTTGGG GTCTCGCTCA CCTTCAGCAA CGTCCACTTC AGCAGCTCCC 
ACTTCTGCAG CTCTCCCGCC CTTCTCCGAT CCTCCTGCGC CAGCGGACCC GACCTTCGGC 
CTTGCGGTAC CAATGGGGAT CCCAGTGGGG AAGTCGATGT TGGTGCTTCT CATCTCTTTG 
GCCTTCGCCT TGTGCTGCAT CGCTGCTTAC CGCCCCAGCG AGACTCTGTG CGGAGGGGAG 
CTTGTTGACA CGCTTCAGTT TGTCTGTTCG GACCGCGGCT TCTACTTCAG CAGGCCTTCA 
AGCCGTGCCA ACCGTCGCAG CCGTGGCATC GTGGAAGAGT GCTGCTTCCG CAGCTGCGAC 
TTGGCCCTCC TGGAGACATA CTGTGCCACC CCCGCCAAGT CCGAGAGGGA CGTGTCTACC 
TCTCAGGCCG TACTTCCGGA CGACTTCCCC AGATACCCCG TGGGCAAGTT CTTCAAATTC 
GACACCTGGA GACAGTCCGC GGGACGCCTG CGCAGAGGCC TGCCTGCCCT CCTGCGTGCC 
CGCCGGGGTC GCATGCTTGC CAAAGAGCTC GAAGCGTTCA GAGAGGCCAA GCGCCACCGT 
CCCCTGATCG TGTTACCACC CAAAGACCCC GCCCACGGGG GAGCCTCTTC GGAGATGTCC 
AGCAACCATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Igf2 ( XM_008760074.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758296.1 Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X2, mRNA.

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CloneID	ORa42912
Clone ID Related Accession (Same CDS sequence)	XM_008760074.2
Accession Version	XM_008760074.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor II isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760074.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCTC ATTCAAGTCC TCCTACTTTG GGCCACTCAT TCCCAGGGCC GCAAATCAGA 
CAAGGGTCTG ATTTGGGATC CCCGAAATTT GATCATTGTT TCCGCTGGCC ACTTTCGGCA 
GCTTCCCGTC CTGCGCATAA CATCGATATC GGCCTCTTCA CTTCTCCTAC GGTGTCCCAG 
CGGCAGCTCA GATTTTGGAA AAGTGTGTGT GCCCCAAACA CGCACCGGAC ACTGCGCGGC 
GGCCAGGACG TGGGCAGTGC TGCTCCCGTG TCCAGGAAAA CCACTGGGCA TTGCCCCCAG 
TTTCCCCCAA ATTTGGGCAT TGTCCCCGGG TCTTCCAACG GACTGGGCGT TGCCCCGGGA 
CACTGGGGAC TGCCTTTGGG GTCTCGCTCA CCTTCAGCAA CGTCCACTTC AGCAGCTCCC 
ACTTCTGCAG CTCTCCCGCC CTTCTCCGAT CCTCCTGCGC CAGCGGACCC GACCTTCGGC 
CTTGCGGTAC CAATGGGGAT CCCAGTGGGG AAGTCGATGT TGGTGCTTCT CATCTCTTTG 
GCCTTCGCCT TGTGCTGCAT CGCTGCTTAC CGCCCCAGCG AGACTCTGTG CGGAGGGGAG 
CTTGTTGACA CGCTTCAGTT TGTCTGTTCG GACCGCGGCT TCTACTTCAG CAGGCCTTCA 
AGCCGTGCCA ACCGTCGCAG CCGTGGCATC GTGGAAGAGT GCTGCTTCCG CAGCTGCGAC 
TTGGCCCTCC TGGAGACATA CTGTGCCACC CCCGCCAAGT CCGAGAGGGA CGTGTCTACC 
TCTCAGGCCG TACTTCCGCA CCTCCTCTCC AGGACGACTT CCCCAGATAC CCCGTGGGCA 
AGTTCTTCAA ATTCGACACC TGGAGACAGT CCGCGGGACG CCTGCGCAGA GGCCTGCCTG 
CCCTCCTGCG TGCCCGCCGG GGTCGCATGC TTGCCAAAGA GCTCGAAGCG TTCAGAGAGG 
CCAAGCGCCA CCGTCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758296.1
CDS	367..1347
Translation	MESHSSPPTLGHSFPGPQIRQGSDLGSPKFDHCFRWPLSAASRPAHNIDIGLFTSPTVSQRQLRFWKSVCAPNTHRTLRGGQDVGSAAPVSRKTTGHCPQFPPNLGIVPGSSNGLGVAPGHWGLPLGSRSPSATSTSAAPTSAALPPFSDPPAPADPTFGLAVPMGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPHLLSRTTSPDTPWASSSNSTPGDSPRDACAEACLPSCVPAGVACLPKSSKRSERPSATVP

Target ORF information:

RefSeq Version	XM_008760074.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760074.2

ORF Insert Sequence:

ATGGAGTCTC ATTCAAGTCC TCCTACTTTG GGCCACTCAT TCCCAGGGCC GCAAATCAGA 
CAAGGGTCTG ATTTGGGATC CCCGAAATTT GATCATTGTT TCCGCTGGCC ACTTTCGGCA 
GCTTCCCGTC CTGCGCATAA CATCGATATC GGCCTCTTCA CTTCTCCTAC GGTGTCCCAG 
CGGCAGCTCA GATTTTGGAA AAGTGTGTGT GCCCCAAACA CGCACCGGAC ACTGCGCGGC 
GGCCAGGACG TGGGCAGTGC TGCTCCCGTG TCCAGGAAAA CCACTGGGCA TTGCCCCCAG 
TTTCCCCCAA ATTTGGGCAT TGTCCCCGGG TCTTCCAACG GACTGGGCGT TGCCCCGGGA 
CACTGGGGAC TGCCTTTGGG GTCTCGCTCA CCTTCAGCAA CGTCCACTTC AGCAGCTCCC 
ACTTCTGCAG CTCTCCCGCC CTTCTCCGAT CCTCCTGCGC CAGCGGACCC GACCTTCGGC 
CTTGCGGTAC CAATGGGGAT CCCAGTGGGG AAGTCGATGT TGGTGCTTCT CATCTCTTTG 
GCCTTCGCCT TGTGCTGCAT CGCTGCTTAC CGCCCCAGCG AGACTCTGTG CGGAGGGGAG 
CTTGTTGACA CGCTTCAGTT TGTCTGTTCG GACCGCGGCT TCTACTTCAG CAGGCCTTCA 
AGCCGTGCCA ACCGTCGCAG CCGTGGCATC GTGGAAGAGT GCTGCTTCCG CAGCTGCGAC 
TTGGCCCTCC TGGAGACATA CTGTGCCACC CCCGCCAAGT CCGAGAGGGA CGTGTCTACC 
TCTCAGGCCG TACTTCCGCA CCTCCTCTCC AGGACGACTT CCCCAGATAC CCCGTGGGCA 
AGTTCTTCAA ATTCGACACC TGGAGACAGT CCGCGGGACG CCTGCGCAGA GGCCTGCCTG 
CCCTCCTGCG TGCCCGCCGG GGTCGCATGC TTGCCAAAGA GCTCGAAGCG TTCAGAGAGG 
CCAAGCGCCA CCGTCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region.
Physiological genomics49(11)690-702(2017 Nov)
Agba OB,Lausser L,Huse K,Bergmeier C,Jahn N,Groth M,Bens M,Sahm A,Gall M,Witte OW,Kestler HA,Schwab M,Platzer M

Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
Journal of receptor and signal transduction research37(5)493-499(2017 Oct)
Chen YF,Lee NH,Pai PY,Chung LC,Shen CY,Rajendran P,Chen YF,Chen RJ,Padma Viswanadha V,Kuo WW,Huang CY

Transgenerational pancreatic impairment with Igf2/H19 epigenetic alteration induced by p,p'-DDE exposure in early life.
Toxicology letters280222-231(2017 Oct)
Song Y,Yang L

IGF2 stimulates fetal growth in a sex- and organ-dependent manner.
Pediatric research(2017 Oct)
White V,Jawerbaum A,Mazzucco MB,Gauster M,Desoye G,Hiden U

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
PloS one12(9)e0184285(2017)
Cedano Prieto DM,Cheng Y,Chang CC,Yu J,Takada YK,Takada Y

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Igf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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