Hspa8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspa8
Entrez Gene ID	24468
Full Name	heat shock protein family A (Hsp70) member 8
Synonyms	Hsc70
General protein information	Preferred Names heat shock protein family A (Hsp70) member 8 Names heat shock cognate 71 kDa protein Heat shock cognate protein 70 heat shock 70kD protein 8 heat shock 70kDa protein 8 heat shock protein 8 heat shock protein A8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q22
Summary	member of the hsp70 protein; expressed in unstressed cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024351.2	NP_077327.1	heat shock cognate 71 kDa protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSPA8	NP_006588.1
	HSPA8	XP_002799868.1
Canis lupus familiaris (dog)	HSPA8	XP_005619707.1
Bos taurus (cattle)	HSPA8	NP_776770.2
Rattus norvegicus (Norway rat)	Hspa8	NP_077327.1
Gallus gallus (chicken)	HSPA8	NP_990334.1
Caenorhabditis elegans (roundworm)	hsp-1	NP_503068.1
Mus musculus (house mouse)	Hspa8	NP_112442.2
Danio rerio (zebrafish)	hspa8	NP_001103873.1
Xenopus tropicalis (tropical clawed frog)	hspa8	XP_004916187.1
Pan troglodytes (chimpanzee)	HSPA8	XP_003313441.2
Drosophila melanogaster (fruit fly)	Hsc70-1	NP_524063.1
Arabidopsis thaliana (thale cress)	AT3G09440	NP_001189847.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004944	XP_315042.3

Gene Ontology
Bibliography

Related articles in PubMed

Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S
The Journal of cell biology216(7)2059-2074(2017 Jul)

Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
Yagi H, Takabayashi T, Xie MJ, Kuroda K, Sato M
PloS one12(2)e0172257(2017)

The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.
Parra LA, Baust TB, Smith AD, Jaumotte JD, Zigmond MJ, Torres S, Leak RK, Pino JA, Torres GE
The Journal of biological chemistry291(34)17510-22(2016 08)

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC
Journal of virology90(3)1397-413(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Synapsin is part of a multiprotein complex enriched in chaperones/cochaperones including Hsc70. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
Title: Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.

these data demonstrate a novel interaction between Hsc70 and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 in dopamine homeostasis.
Title: The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.

Pulsed electromagnetic wave exposure induced ultrastructural damage and the overexpression of HSP70 in the nuclei in the adenohypophysis.
Title: Pulsed electromagnetic wave exposure induces ultrastructural damage and upregulated expression of heat shock protein 70 in the rat adenohypophysis.

These findings demonstrate that Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance.
Title: Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.

these data provide evidence for Hsc70 as a novel neuronal interactor of NF-kappaB p65.
Title: Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.

The following Hspa8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspa8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06909	NM_024351.2 Latest version!	Rattus norvegicus heat shock protein family A (Hsp70) member 8 (Hspa8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspa8 ( NM_024351.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077327.1 Rattus norvegicus heat shock protein family A (Hsp70) member 8 (Hspa8), mRNA.

Price & Availability↑

CloneID	ORa06909
Clone ID Related Accession (Same CDS sequence)	NM_024351.2
Accession Version	NM_024351.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1941bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Rattus norvegicus(Norway rat)
Product	heat shock cognate 71 kDa protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061547.1 and BC098914.1. On or before Jun 25, 2006 this sequence version replaced XM_001053026.1, NM_024351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGTCTAAGG GACCTGCAGT TGGCATTGAT CTTGGCACCA CCTACTCCTG TGTGGGTGTC 
TTCCAGCATG GAAAGGTGGA AATAATTGCC AATGACCAGG GTAACCGCAC CACGCCGAGC 
TATGTTGCTT TCACCGACAC AGAACGATTA ATTGGGGATG CGGCCAAGAA TCAGGTTGCA 
ATGAACCCCA CCAACACAGT TTTTGATGCC AAACGTCTGA TCGGACGTAG GTTCGATGAT 
GCTGTTGTTC AGTCTGACAT GAAGCACTGG CCCTTCATGG TGGTGAACGA TGCAGGCAGG 
CCCAAGGTCC AAGTCGAATA CAAAGGGGAG ACAAAAAGTT TCTATCCTGA GGAAGTGTCT 
TCAATGGTTC TGACAAAAAT GAAGGAAATT GCAGAAGCTT ACCTTGGAAA GACTGTTACC 
AATGCCGTGG TCACCGTGCC AGCTTACTTC AATGACTCTC AGCGACAGGC AACAAAAGAT 
GCTGGAACTA TTGCTGGCCT CAACGTACTT CGAATTATCA ATGAGCCAAC TGCTGCTGCT 
ATTGCCTATG GCTTAGATAA GAAGGTCGGG GCTGAAAGGA ATGTGCTCAT TTTTGACTTG 
GGAGGTGGCA CTTTTGATGT GTCAATCCTC ACTATCGAGG ATGGAATTTT TGAAGTCAAA 
TCAACAGCTG GAGACACCCA CTTGGGCGGA GAAGACTTTG ACAACCGAAT GGTCAACCAT 
TTCATTGCTG AGTTTAAGCG AAAGCACAAG AAGGACATCA GTGAGAACAA GAGAGCTGTC 
AGGCGTCTCC GCACTGCCTG TGAGCGGGCC AAGCGCACCC TCTCCTCCAG CACCCAGGCC 
AGTATTGAGA TTGATTCTCT CTATGAGGGA ATTGACTTCT ACACCTCCAT TACCCGTGCT 
CGATTTGAGG AGTTGAATGC TGACCTGTTC CGTGGCACAC TGGACCCTGT AGAGAAGGCC 
CTTCGAGATG CCAAACTAGA CAAGTCACAG ATCCATGATA TTGTCCTGGT GGGTGGTTCT 
ACCAGAATCC CCAAGATCCA GAAACTTCTG CAAGACTTCT TCAATGGAAA AGAGCTGAAT 
AAGAGCATTA ACCCCGATGA AGCTGTTGCC TATGGTGCAG CTGTCCAGGC AGCCATTCTA 
TCTGGAGACA AGTCTGAGAA TGTTCAGGAT TTGCTGCTCT TGGATGTCAC TCCTCTTTCC 
CTTGGGATTG AAACTGCTGG TGGAGTCATG ACTGTCCTCA TCAAGCGCAA TACCACCATT 
CCCACCAAGC AGACCCAGAC TTTCACCACC TACTCTGACA ACCAGCCAGG TGTACTCATC 
CAGGTGTATG AAGGTGAAAG GGCCATGACC AAGGACAACA ACCTGCTTGG GAAGTTTGAG 
CTCACAGGCA TACCTCCAGC ACCCCGTGGG GTTCCTCAGA TTGAGGTTAC TTTTGACATT 
GATGCCAATG GCATCCTCAA TGTTTCTGCT GTAGATAAGA GCACAGGAAA GGAGAACAAG 
ATCACCATCA CCAATGACAA GGGCCGCTTG AGTAAGGAGG ATATTGAGCG CATGGTCCAA 
GAAGCTGAGA AGTACAAAGC TGAGGATGAG AAGCAGAGAG ATAAGGTTTC CTCTAAGAAC 
TCGCTGGAGT CTTATGCTTT CAACATGAAA GCAACTGTTG AGGATGAGAA ACTTCAAGGC 
AAGATCAATG ATGAAGACAA ACAGAAGATT CTTGACAAGT GCAACGAAAT CATCAGCTGG 
CTGGATAAGA ACCAGACTGC GGAGAAGGAA GAATTTGAGC ATCAGCAGAA AGAACTGGAG 
AAGGTCTGCA ACCCTATCAT CACCAAGCTG TACCAGAGTG CTGGTGGCAT GCCTGGAGGA 
ATGCCTGGTG GCTTCCCTGG TGGAGGAGCT CCTCCATCTG GTGGTGCTTC TTCAGGCCCC 
ACCATTGAAG AGGTCGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077327.1
CDS	81..2021
Translation	MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD

Target ORF information:

RefSeq Version	NM_024351.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein family A (Hsp70) member 8 (Hspa8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024351.2

ORF Insert Sequence:

ATGTCTAAGG GACCTGCAGT TGGCATTGAT CTTGGCACCA CCTACTCCTG TGTGGGTGTC 
TTCCAGCATG GAAAGGTGGA AATAATTGCC AATGACCAGG GTAACCGCAC CACGCCGAGC 
TATGTTGCTT TCACCGACAC AGAACGATTA ATTGGGGATG CGGCCAAGAA TCAGGTTGCA 
ATGAACCCCA CCAACACAGT TTTTGATGCC AAACGTCTGA TCGGACGTAG GTTCGATGAT 
GCTGTTGTTC AGTCTGACAT GAAGCACTGG CCCTTCATGG TGGTGAACGA TGCAGGCAGG 
CCCAAGGTCC AAGTCGAATA CAAAGGGGAG ACAAAAAGTT TCTATCCTGA GGAAGTGTCT 
TCAATGGTTC TGACAAAAAT GAAGGAAATT GCAGAAGCTT ACCTTGGAAA GACTGTTACC 
AATGCCGTGG TCACCGTGCC AGCTTACTTC AATGACTCTC AGCGACAGGC AACAAAAGAT 
GCTGGAACTA TTGCTGGCCT CAACGTACTT CGAATTATCA ATGAGCCAAC TGCTGCTGCT 
ATTGCCTATG GCTTAGATAA GAAGGTCGGG GCTGAAAGGA ATGTGCTCAT TTTTGACTTG 
GGAGGTGGCA CTTTTGATGT GTCAATCCTC ACTATCGAGG ATGGAATTTT TGAAGTCAAA 
TCAACAGCTG GAGACACCCA CTTGGGCGGA GAAGACTTTG ACAACCGAAT GGTCAACCAT 
TTCATTGCTG AGTTTAAGCG AAAGCACAAG AAGGACATCA GTGAGAACAA GAGAGCTGTC 
AGGCGTCTCC GCACTGCCTG TGAGCGGGCC AAGCGCACCC TCTCCTCCAG CACCCAGGCC 
AGTATTGAGA TTGATTCTCT CTATGAGGGA ATTGACTTCT ACACCTCCAT TACCCGTGCT 
CGATTTGAGG AGTTGAATGC TGACCTGTTC CGTGGCACAC TGGACCCTGT AGAGAAGGCC 
CTTCGAGATG CCAAACTAGA CAAGTCACAG ATCCATGATA TTGTCCTGGT GGGTGGTTCT 
ACCAGAATCC CCAAGATCCA GAAACTTCTG CAAGACTTCT TCAATGGAAA AGAGCTGAAT 
AAGAGCATTA ACCCCGATGA AGCTGTTGCC TATGGTGCAG CTGTCCAGGC AGCCATTCTA 
TCTGGAGACA AGTCTGAGAA TGTTCAGGAT TTGCTGCTCT TGGATGTCAC TCCTCTTTCC 
CTTGGGATTG AAACTGCTGG TGGAGTCATG ACTGTCCTCA TCAAGCGCAA TACCACCATT 
CCCACCAAGC AGACCCAGAC TTTCACCACC TACTCTGACA ACCAGCCAGG TGTACTCATC 
CAGGTGTATG AAGGTGAAAG GGCCATGACC AAGGACAACA ACCTGCTTGG GAAGTTTGAG 
CTCACAGGCA TACCTCCAGC ACCCCGTGGG GTTCCTCAGA TTGAGGTTAC TTTTGACATT 
GATGCCAATG GCATCCTCAA TGTTTCTGCT GTAGATAAGA GCACAGGAAA GGAGAACAAG 
ATCACCATCA CCAATGACAA GGGCCGCTTG AGTAAGGAGG ATATTGAGCG CATGGTCCAA 
GAAGCTGAGA AGTACAAAGC TGAGGATGAG AAGCAGAGAG ATAAGGTTTC CTCTAAGAAC 
TCGCTGGAGT CTTATGCTTT CAACATGAAA GCAACTGTTG AGGATGAGAA ACTTCAAGGC 
AAGATCAATG ATGAAGACAA ACAGAAGATT CTTGACAAGT GCAACGAAAT CATCAGCTGG 
CTGGATAAGA ACCAGACTGC GGAGAAGGAA GAATTTGAGC ATCAGCAGAA AGAACTGGAG 
AAGGTCTGCA ACCCTATCAT CACCAAGCTG TACCAGAGTG CTGGTGGCAT GCCTGGAGGA 
ATGCCTGGTG GCTTCCCTGG TGGAGGAGCT CCTCCATCTG GTGGTGCTTC TTCAGGCCCC 
ACCATTGAAG AGGTCGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
The Journal of cell biology216(7)2059-2074(2017 Jul)
Ganguly A,Han X,Das U,Wang L,Loi J,Sun J,Gitler D,Caillol G,Leterrier C,Yates JR 3rd,Roy S

Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
PloS one12(2)e0172257(2017)
Yagi H,Takabayashi T,Xie MJ,Kuroda K,Sato M

The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.
The Journal of biological chemistry291(34)17510-22(2016 08)
Parra LA,Baust TB,Smith AD,Jaumotte JD,Zigmond MJ,Torres S,Leak RK,Pino JA,Torres GE

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Journal of virology90(3)1397-413(2015 Nov)
Salinas E,Byrum SD,Moreland LE,Mackintosh SG,Tackett AJ,Forrest JC

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Hspa8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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