Hmgcs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmgcs2
Entrez Gene ID	24450
Full Name	3-hydroxy-3-methylglutaryl-CoA synthase 2
Synonyms	Hmgcs1,Mt3h3mg
General protein information	Preferred Names 3-hydroxy-3-methylglutaryl-CoA synthase 2 Names hydroxymethylglutaryl-CoA synthase, mitochondrial 3-hydroxy-3-methylglutary-Coenzyme A synthase 2 3-hydroxy-3-methylglutaryl coenzyme A synthase 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) HMG-CoA synthase hydroxymethylglutaryl-CoA synthase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	HMG-CoA cycle enzyme that catalyzes a step in ketone-body biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006233002.3	XP_006233064.1	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
NM_173094.2	NP_775117.2	hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HMGCS2	XP_849878.1
Mus musculus (house mouse)	Hmgcs2	NP_032282.2
Rattus norvegicus (Norway rat)	Hmgcs2	NP_775117.2
Pan troglodytes (chimpanzee)	HMGCS2	XP_513693.1
	HMGCS2	XP_001114146.1
Homo sapiens (human)	HMGCS2	NP_005509.1
Bos taurus (cattle)	HMGCS2	NP_001039348.1
Gallus gallus (chicken)	HMGCS2	XP_422225.3

Gene Ontology
Bibliography

Related articles in PubMed

miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
Su SG, Yang M, Zhang MF, Peng QZ, Li MY, Liu LP, Bao SY
The international journal of biochemistry & cell biology91(Pt A)53-59(2017 Oct)

HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.
Wang F, Xiang H, Fischer G, Liu Z, Dupont MJ, Hogan QH, Yu H
Brain research165262-70(2016 12)

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
Martin J, Balmer ML, Rajendran S, Maurhofer O, Dufour JF, St-Pierre MV
American journal of physiology. Gastrointestinal and liver physiology310(7)G497-509(2016 Apr)

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E
Cell metabolism18(6)920-33(2013 Dec)

Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.
Satoh M, Haruta-Satoh E, Yamada M, Kado S, Nomura F
Pancreas42(3)475-82(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify 3-hydroxy-3-methylglutaryl coenzyme A synthase isoenzymes 1 and 2 as the alternative markers for satellite glial cells (SGCs) in dorsal root ganglia (DRGs). Downregulated HMGCS1 expression in DRGs after spinal nerve injury may reflect a potential role of abnormal sterol metabolism of SGCs in the nerve injured-induced neuropathic pain.
Title: HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.

Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats.
Title: Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.

mRNA steady-state levels of CPT I and mit HMG-CoA are not changed in rat DMBA-induced mammary cancer
Title: Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.

Intestinsal flora, through butyrate production, can control the expression of colonic mHMGCoA synthase and glutaminase
Title: Expression of mitochondrial HMGCoA synthase and glutaminase in the colonic mucosa is modulated by bacterial species.

The following Hmgcs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgcs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12275	NM_173094.2 Latest version!	Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00
ORa12275	XM_006233002.3 Latest version!	Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmgcs2 ( NM_173094.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775117.2 Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), mRNA.

Price & Availability↑

CloneID	ORa12275
Clone ID Related Accession (Same CDS sequence)	XM_006233002.3 , NM_173094.2
Accession Version	NM_173094.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Rattus norvegicus(Norway rat)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083543.1. On Aug 16, 2012 this sequence version replaced NM_173094.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083543.1, M33648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCAGCGGC TTTTGGCTCC AGCAAGGCGG GTCCTGCAAG TGAAGAGAGT GATGCAGGAA 
TCTTCGCTCT CACCCGCTCA CCTGCTCCCC GCAGCCCAGC AGAGGTTTTC TACAATCCCT 
CCTGCTCCCC TGGCCAAAAC TGATACATGG CCAAAAGATG TGGGCATCCT TGCCCTGGAG 
GTCTACTTTC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTTCAA CAATGTGGAA 
GCAGGGAAGT ACACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGTTC GGTCCAGGAG 
GACATCAACT CCCTGTGCCT CACAGTGGTG CAGAGGCTGA TGGAACGCAC AAAGCTGCCA 
TGGGATGCCG TAGGCCGCCT GGAAGTGGGC ACGGAAACCA TCATTGACAA GTCCAAGGCT 
GTCAAGACAG TGCTCATGGA GCTCTTCCAG GATTCAGGCA ACACTGACAT CGAGGGCATA 
GATACCACCA ACGCCTGCTA TGGTGGCACT GCCTCCCTCT TCAACGCTGC CAACTGGATG 
GAGTCCAGCT ACTGGGATGG TCGCTATGCC CTGGTGGTCT GTGGTGATAT CGCAGTCTAC 
CCAAGTGGTA ACGCCCGCCC CACAGGTGGT GCCGGGGCTG TGGCAATGCT GATTGGGCCC 
AAGGCCCCGC TAGTCCTGGA ACAAGGGCTG AGGGGAACCC ACATGGAGAA CGCCTATGAC 
TTCTACAAAC CAAACTTGGC CTCAGAGTAT CCACTGGTGG ATGGGAAGCT GTCTATCCAG 
TGCTACCTGC GGGCCTTGGA CCGATGCTAT GCAGCTTACC GCAGGAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGAAACAA CCAGCCTTTC ACCCTCGATG ACGTGCAATA TATGATCTTC 
CACACACCCT TTTGCAAGAT GGTCCAGAAA TCCCTAGCTC GGCTGATGTT CAATGACTTC 
CTGTCATCTA GCAGTGACAA GCAGAACAAC TTATACAAGG GTCTAGAGGC CTTCAAGGGT 
CTAAAGCTGG AAGAAACCTA CACCAACAAG GATGTTGACA AGGCTCTGCT GAAGGCCTCC 
CTGGACATGT TCAACAAGAA AACCAAGGCC TCCCTTTACC TCTCCACAAA CAATGGGAAC 
ATGTACACCT CGTCCCTCTA CGGGTGCCTG GCCTCACTTC TCTCCCACCA CTCTGCCCAA 
GAATTGGCCG GCTCCAGGAT TGGAGCATTC TCCTACGGCT CAGGCTTAGC AGCAAGTTTC 
TTCTCATTTC GAGTGTCCAA GGACGCTTCC CCAGGTTCCC CTCTGGAGAA GCTGGTGTCT 
AGTGTGTCAG ATCTGCCCAA ACGTCTAGAC TCCCGGAGAC GCATGTCCCC TGAGGAATTC 
ACAGAAATAA TGAATCAGAG AGAGCAATTT TACCACAAGG TGAACTTCTC TCCCCCTGGT 
GACACAAGCA ACCTCTTCCC AGGCACTTGG TACCTTGAAC GAGTGGATGA GATGCACCGC 
AGAAAATATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775117.2
CDS	32..1558
Translation	MQRLLAPARRVLQVKRVMQESSLSPAHLLPAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARRPV

Target ORF information:

RefSeq Version	NM_173094.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173094.2

ORF Insert Sequence:

ATGCAGCGGC TTTTGGCTCC AGCAAGGCGG GTCCTGCAAG TGAAGAGAGT GATGCAGGAA 
TCTTCGCTCT CACCCGCTCA CCTGCTCCCC GCAGCCCAGC AGAGGTTTTC TACAATCCCT 
CCTGCTCCCC TGGCCAAAAC TGATACATGG CCAAAAGATG TGGGCATCCT TGCCCTGGAG 
GTCTACTTTC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTTCAA CAATGTGGAA 
GCAGGGAAGT ACACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGTTC GGTCCAGGAG 
GACATCAACT CCCTGTGCCT CACAGTGGTG CAGAGGCTGA TGGAACGCAC AAAGCTGCCA 
TGGGATGCCG TAGGCCGCCT GGAAGTGGGC ACGGAAACCA TCATTGACAA GTCCAAGGCT 
GTCAAGACAG TGCTCATGGA GCTCTTCCAG GATTCAGGCA ACACTGACAT CGAGGGCATA 
GATACCACCA ACGCCTGCTA TGGTGGCACT GCCTCCCTCT TCAACGCTGC CAACTGGATG 
GAGTCCAGCT ACTGGGATGG TCGCTATGCC CTGGTGGTCT GTGGTGATAT CGCAGTCTAC 
CCAAGTGGTA ACGCCCGCCC CACAGGTGGT GCCGGGGCTG TGGCAATGCT GATTGGGCCC 
AAGGCCCCGC TAGTCCTGGA ACAAGGGCTG AGGGGAACCC ACATGGAGAA CGCCTATGAC 
TTCTACAAAC CAAACTTGGC CTCAGAGTAT CCACTGGTGG ATGGGAAGCT GTCTATCCAG 
TGCTACCTGC GGGCCTTGGA CCGATGCTAT GCAGCTTACC GCAGGAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGAAACAA CCAGCCTTTC ACCCTCGATG ACGTGCAATA TATGATCTTC 
CACACACCCT TTTGCAAGAT GGTCCAGAAA TCCCTAGCTC GGCTGATGTT CAATGACTTC 
CTGTCATCTA GCAGTGACAA GCAGAACAAC TTATACAAGG GTCTAGAGGC CTTCAAGGGT 
CTAAAGCTGG AAGAAACCTA CACCAACAAG GATGTTGACA AGGCTCTGCT GAAGGCCTCC 
CTGGACATGT TCAACAAGAA AACCAAGGCC TCCCTTTACC TCTCCACAAA CAATGGGAAC 
ATGTACACCT CGTCCCTCTA CGGGTGCCTG GCCTCACTTC TCTCCCACCA CTCTGCCCAA 
GAATTGGCCG GCTCCAGGAT TGGAGCATTC TCCTACGGCT CAGGCTTAGC AGCAAGTTTC 
TTCTCATTTC GAGTGTCCAA GGACGCTTCC CCAGGTTCCC CTCTGGAGAA GCTGGTGTCT 
AGTGTGTCAG ATCTGCCCAA ACGTCTAGAC TCCCGGAGAC GCATGTCCCC TGAGGAATTC 
ACAGAAATAA TGAATCAGAG AGAGCAATTT TACCACAAGG TGAACTTCTC TCCCCCTGGT 
GACACAAGCA ACCTCTTCCC AGGCACTTGG TACCTTGAAC GAGTGGATGA GATGCACCGC 
AGAAAATATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hmgcs2 ( XM_006233002.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233064.1 Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12275
Clone ID Related Accession (Same CDS sequence)	XM_006233002.3 , NM_173094.2
Accession Version	XM_006233002.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233002.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCGGC TTTTGGCTCC AGCAAGGCGG GTCCTGCAAG TGAAGAGAGT GATGCAGGAA 
TCTTCGCTCT CACCCGCTCA CCTGCTCCCC GCAGCCCAGC AGAGGTTTTC TACAATCCCT 
CCTGCTCCCC TGGCCAAAAC TGATACATGG CCAAAAGATG TGGGCATCCT TGCCCTGGAG 
GTCTACTTTC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTTCAA CAATGTGGAA 
GCAGGGAAGT ACACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGTTC GGTCCAGGAG 
GACATCAACT CCCTGTGCCT CACAGTGGTG CAGAGGCTGA TGGAACGCAC AAAGCTGCCA 
TGGGATGCCG TAGGCCGCCT GGAAGTGGGC ACGGAAACCA TCATTGACAA GTCCAAGGCT 
GTCAAGACAG TGCTCATGGA GCTCTTCCAG GATTCAGGCA ACACTGACAT CGAGGGCATA 
GATACCACCA ACGCCTGCTA TGGTGGCACT GCCTCCCTCT TCAACGCTGC CAACTGGATG 
GAGTCCAGCT ACTGGGATGG TCGCTATGCC CTGGTGGTCT GTGGTGATAT CGCAGTCTAC 
CCAAGTGGTA ACGCCCGCCC CACAGGTGGT GCCGGGGCTG TGGCAATGCT GATTGGGCCC 
AAGGCCCCGC TAGTCCTGGA ACAAGGGCTG AGGGGAACCC ACATGGAGAA CGCCTATGAC 
TTCTACAAAC CAAACTTGGC CTCAGAGTAT CCACTGGTGG ATGGGAAGCT GTCTATCCAG 
TGCTACCTGC GGGCCTTGGA CCGATGCTAT GCAGCTTACC GCAGGAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGAAACAA CCAGCCTTTC ACCCTCGATG ACGTGCAATA TATGATCTTC 
CACACACCCT TTTGCAAGAT GGTCCAGAAA TCCCTAGCTC GGCTGATGTT CAATGACTTC 
CTGTCATCTA GCAGTGACAA GCAGAACAAC TTATACAAGG GTCTAGAGGC CTTCAAGGGT 
CTAAAGCTGG AAGAAACCTA CACCAACAAG GATGTTGACA AGGCTCTGCT GAAGGCCTCC 
CTGGACATGT TCAACAAGAA AACCAAGGCC TCCCTTTACC TCTCCACAAA CAATGGGAAC 
ATGTACACCT CGTCCCTCTA CGGGTGCCTG GCCTCACTTC TCTCCCACCA CTCTGCCCAA 
GAATTGGCCG GCTCCAGGAT TGGAGCATTC TCCTACGGCT CAGGCTTAGC AGCAAGTTTC 
TTCTCATTTC GAGTGTCCAA GGACGCTTCC CCAGGTTCCC CTCTGGAGAA GCTGGTGTCT 
AGTGTGTCAG ATCTGCCCAA ACGTCTAGAC TCCCGGAGAC GCATGTCCCC TGAGGAATTC 
ACAGAAATAA TGAATCAGAG AGAGCAATTT TACCACAAGG TGAACTTCTC TCCCCCTGGT 
GACACAAGCA ACCTCTTCCC AGGCACTTGG TACCTTGAAC GAGTGGATGA GATGCACCGC 
AGAAAATATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233064.1
CDS	57..1583
Translation	MQRLLAPARRVLQVKRVMQESSLSPAHLLPAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARRPV

Target ORF information:

RefSeq Version	XM_006233002.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233002.3

ORF Insert Sequence:

ATGCAGCGGC TTTTGGCTCC AGCAAGGCGG GTCCTGCAAG TGAAGAGAGT GATGCAGGAA 
TCTTCGCTCT CACCCGCTCA CCTGCTCCCC GCAGCCCAGC AGAGGTTTTC TACAATCCCT 
CCTGCTCCCC TGGCCAAAAC TGATACATGG CCAAAAGATG TGGGCATCCT TGCCCTGGAG 
GTCTACTTTC CAGCCCAATA TGTGGACCAA ACTGACCTGG AGAAGTTCAA CAATGTGGAA 
GCAGGGAAGT ACACAGTGGG CTTGGGCCAG ACCCGTATGG GCTTCTGTTC GGTCCAGGAG 
GACATCAACT CCCTGTGCCT CACAGTGGTG CAGAGGCTGA TGGAACGCAC AAAGCTGCCA 
TGGGATGCCG TAGGCCGCCT GGAAGTGGGC ACGGAAACCA TCATTGACAA GTCCAAGGCT 
GTCAAGACAG TGCTCATGGA GCTCTTCCAG GATTCAGGCA ACACTGACAT CGAGGGCATA 
GATACCACCA ACGCCTGCTA TGGTGGCACT GCCTCCCTCT TCAACGCTGC CAACTGGATG 
GAGTCCAGCT ACTGGGATGG TCGCTATGCC CTGGTGGTCT GTGGTGATAT CGCAGTCTAC 
CCAAGTGGTA ACGCCCGCCC CACAGGTGGT GCCGGGGCTG TGGCAATGCT GATTGGGCCC 
AAGGCCCCGC TAGTCCTGGA ACAAGGGCTG AGGGGAACCC ACATGGAGAA CGCCTATGAC 
TTCTACAAAC CAAACTTGGC CTCAGAGTAT CCACTGGTGG ATGGGAAGCT GTCTATCCAG 
TGCTACCTGC GGGCCTTGGA CCGATGCTAT GCAGCTTACC GCAGGAAAAT CCAGAATCAG 
TGGAAGCAAG CTGGAAACAA CCAGCCTTTC ACCCTCGATG ACGTGCAATA TATGATCTTC 
CACACACCCT TTTGCAAGAT GGTCCAGAAA TCCCTAGCTC GGCTGATGTT CAATGACTTC 
CTGTCATCTA GCAGTGACAA GCAGAACAAC TTATACAAGG GTCTAGAGGC CTTCAAGGGT 
CTAAAGCTGG AAGAAACCTA CACCAACAAG GATGTTGACA AGGCTCTGCT GAAGGCCTCC 
CTGGACATGT TCAACAAGAA AACCAAGGCC TCCCTTTACC TCTCCACAAA CAATGGGAAC 
ATGTACACCT CGTCCCTCTA CGGGTGCCTG GCCTCACTTC TCTCCCACCA CTCTGCCCAA 
GAATTGGCCG GCTCCAGGAT TGGAGCATTC TCCTACGGCT CAGGCTTAGC AGCAAGTTTC 
TTCTCATTTC GAGTGTCCAA GGACGCTTCC CCAGGTTCCC CTCTGGAGAA GCTGGTGTCT 
AGTGTGTCAG ATCTGCCCAA ACGTCTAGAC TCCCGGAGAC GCATGTCCCC TGAGGAATTC 
ACAGAAATAA TGAATCAGAG AGAGCAATTT TACCACAAGG TGAACTTCTC TCCCCCTGGT 
GACACAAGCA ACCTCTTCCC AGGCACTTGG TACCTTGAAC GAGTGGATGA GATGCACCGC 
AGAAAATATG CCCGGCGTCC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
The international journal of biochemistry & cell biology91(Pt A)53-59(2017 Oct)
Su SG,Yang M,Zhang MF,Peng QZ,Li MY,Liu LP,Bao SY

HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.
Brain research165262-70(2016 12)
Wang F,Xiang H,Fischer G,Liu Z,Dupont MJ,Hogan QH,Yu H

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
American journal of physiology. Gastrointestinal and liver physiology310(7)G497-509(2016 Apr)
Martin J,Balmer ML,Rajendran S,Maurhofer O,Dufour JF,St-Pierre MV

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Cell metabolism18(6)920-33(2013 Dec)
Rardin MJ,He W,Nishida Y,Newman JC,Carrico C,Danielson SR,Guo A,Gut P,Sahu AK,Li B,Uppala R,Fitch M,Riiff T,Zhu L,Zhou J,Mulhern D,Stevens RD,Ilkayeva OR,Newgard CB,Jacobson MP,Hellerstein M,Goetzman ES,Gibson BW,Verdin E

Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.
Pancreas42(3)475-82(2013 Apr)
Satoh M,Haruta-Satoh E,Yamada M,Kado S,Nomura F

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Hmgcs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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