Gstm2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gstm2
Entrez Gene ID	24424
Full Name	glutathione S-transferase mu 2
Synonyms	GSTA4
General protein information	Preferred Names glutathione S-transferase mu 2 Names glutathione S-transferase Mu 2 GST 4-4 GST Yb2 GSTM2-2 Glutathione-S-transferase, mu type 2 (Yb2) glutathione S-transferase M2 glutathione S-transferase Yb-2 glutathione S-transferase Yb2 subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	subunit of glutathione S-transferase, which may play a role in xenobiotic metabolism and response to oxidative stress [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017590627.1	XP_017446116.1	glutathione S-transferase Mu 2 isoform X1
NM_177426.1	NP_803175.1	glutathione S-transferase Mu 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GSTM1	NP_001073823.1
Mus musculus (house mouse)	Gstm2	NP_032209.1
	GSTM1	XP_001096049.1
Rattus norvegicus (Norway rat)	Gstm2	NP_803175.1
Pan troglodytes (chimpanzee)	GSTM1	XP_001165087.2
Xenopus tropicalis (tropical clawed frog)	gstm1	NP_001004964.1
Homo sapiens (human)	GSTM1	NP_000552.2

Gene Ontology
Bibliography

Related articles in PubMed

The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.
Hewawasam RP, Liu D, Casarotto MG, Board PG, Dulhunty AF
PloS one11(9)e0162415(2016)

Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes.
Stanley JA, Sivakumar KK, Nithy TK, Arosh JA, Hoyer PB, Burghardt RC, Banu SK
Free radical biology & medicine61179-96(2013 Aug)

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.
Liu D, Hewawasam R, Karunasekara Y, Casarotto MG, Dulhunty AF, Board PG
Biochemical pharmacology83(11)1523-9(2012 Jun)

Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration.
G?ven M, G?rg?n E, ?nal M, Yenerel M, Batar B, K???men B, Din? UA, G?ven GS, Ulus T, Y?ksel A
Ophthalmic research46(1)31-7(2011)

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.
Northwood EL, Elliott F, Forman D, Barrett JH, Wilkie MJ, Carey FA, Steele RJ, Wolf R, Bishop T, Smith G
Pharmacogenetics and genomics20(5)315-26(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GSTM2C is translocated into the cytoplasm of neonatal cardiomyocytes and is effective in reducing spontaneous contractility and that its actions on field stimulated Ca2+ release and contraction is very similar to that reported for adult cardiomyocytes.
Title: The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.

These data suggest that it maybe a reduction in antioxidant defenses, evident by a reduced expression and activity of GSTM2, in the left ventricles and aortas of SHR that leads to increased levels of superoxide anion and activation of NADPH oxidase.
Title: Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat.

The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium
Title: Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons.

Data describe the conformational stability of the chimeric homodimers M(12)-(12) and M(21)-(21) constructed from glutathione transferases M1-1 and M2-2.
Title: Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases.

The following Gstm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gstm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13340	NM_177426.1 Latest version!	Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa59624	XM_017590627.1 Latest version!	Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gstm2 ( NM_177426.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_803175.1 Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), mRNA.

Price & Availability↑

CloneID	ORa13340
Clone ID Related Accession (Same CDS sequence)	NM_177426.1
Accession Version	NM_177426.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	glutathione S-transferase Mu 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J03914.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ179402.1, FQ209513.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCTATGA CACTGGGTTA CTGGGACATC CGTGGGCTGG CTCACGCCAT TCGCCTGTTC 
CTGGAGTATA CAGACACAAG CTATGAGGAC AAGAAGTACA GCATGGGGGA TGCTCCCGAC 
TATGACAGAA GCCAGTGGCT GAGTGAGAAG TTCAAACTGG GCCTGGACTT CCCCAATCTG 
CCCTACTTAA TTGATGGGTC ACACAAGATC ACCCAGAGCA ATGCCATCCT GCGCTACCTT 
GGCCGGAAGC ACAACCTTTG TGGGGAGACA GAGGAGGAGA GGATTCGTGT GGACGTTTTG 
GAGAACCAGG CTATGGACAC CCGCCTACAG TTGGCCATGG TCTGCTACAG CCCTGACTTT 
GAGAGAAAGA AGCCAGAGTA CTTAGAGGGT CTCCCTGAGA AGATGAAGCT TTACTCCGAA 
TTCCTGGGCA AGCAGCCATG GTTTGCAGGG AACAAGATTA CGTATGTGGA TTTTCTTGTT 
TACGATGTCC TTGATCAACA CCGTATATTT GAACCCAAGT GCCTGGACGC CTTCCCAAAC 
CTGAAGGACT TCGTGGCTCG GTTTGAGGGC CTGAAGAAGA TATCTGACTA CATGAAGAGC 
GGCCGCTTCC TCTCCAAGCC AATCTTTGCA AAGATGGCCT TTTGGAACCC AAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803175.1
CDS	1..657
Translation	MPMTLGYWDIRGLAHAIRLFLEYTDTSYEDKKYSMGDAPDYDRSQWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLGRKHNLCGETEEERIRVDVLENQAMDTRLQLAMVCYSPDFERKKPEYLEGLPEKMKLYSEFLGKQPWFAGNKITYVDFLVYDVLDQHRIFEPKCLDAFPNLKDFVARFEGLKKISDYMKSGRFLSKPIFAKMAFWNPK

Target ORF information:

RefSeq Version	NM_177426.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177426.1

ORF Insert Sequence:

ATGCCTATGA CACTGGGTTA CTGGGACATC CGTGGGCTGG CTCACGCCAT TCGCCTGTTC 
CTGGAGTATA CAGACACAAG CTATGAGGAC AAGAAGTACA GCATGGGGGA TGCTCCCGAC 
TATGACAGAA GCCAGTGGCT GAGTGAGAAG TTCAAACTGG GCCTGGACTT CCCCAATCTG 
CCCTACTTAA TTGATGGGTC ACACAAGATC ACCCAGAGCA ATGCCATCCT GCGCTACCTT 
GGCCGGAAGC ACAACCTTTG TGGGGAGACA GAGGAGGAGA GGATTCGTGT GGACGTTTTG 
GAGAACCAGG CTATGGACAC CCGCCTACAG TTGGCCATGG TCTGCTACAG CCCTGACTTT 
GAGAGAAAGA AGCCAGAGTA CTTAGAGGGT CTCCCTGAGA AGATGAAGCT TTACTCCGAA 
TTCCTGGGCA AGCAGCCATG GTTTGCAGGG AACAAGATTA CGTATGTGGA TTTTCTTGTT 
TACGATGTCC TTGATCAACA CCGTATATTT GAACCCAAGT GCCTGGACGC CTTCCCAAAC 
CTGAAGGACT TCGTGGCTCG GTTTGAGGGC CTGAAGAAGA TATCTGACTA CATGAAGAGC 
GGCCGCTTCC TCTCCAAGCC AATCTTTGCA AAGATGGCCT TTTGGAACCC AAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gstm2 ( XM_017590627.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446116.1 Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59624
Clone ID Related Accession (Same CDS sequence)	XM_017590627.1
Accession Version	XM_017590627.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	glutathione S-transferase Mu 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGATG CTCCCGACTA TGACAGAAGC CAGTGGCTGA GTGAGAAGTT CAAACTGGGC 
CTGGACTTCC CCAATCTGCC CTACTTAATT GATGGGTCAC ACAAGATCAC CCAGAGCAAT 
GCCATCCTGC GCTACCTTGG CCGGAAGCAC AACCTTTGTG GGGAGACAGA GGAGGAGAGG 
ATTCGTGTGG ACGTTTTGGA GAACCAGGCT ATGGACACCC GCCTACAGTT GGCCATGGTC 
TGCTACAGCC CTGACTTTGA GAGAAAGAAG CCAGAGTACT TAGAGGGTCT CCCTGAGAAG 
ATGAAGCTTT ACTCCGAATT CCTGGGCAAG CAGCCATGGT TTGCAGGGAA CAAGATTACG 
TATGTGGATT TTCTTGTTTA CGATGTCCTT GATCAACACC GTATATTTGA ACCCAAGTGC 
CTGGACGCCT TCCCAAACCT GAAGGACTTC GTGGCTCGGT TTGAGGGCCT GAAGAAGATA 
TCTGACTACA TGAAGAGCGG CCGCTTCCTC TCCAAGCCAA TCTTTGCAAA GATGGCCTTT 
TGGAACCCAA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446116.1
CDS	97..651
Translation	MGDAPDYDRSQWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLGRKHNLCGETEEERIRVDVLENQAMDTRLQLAMVCYSPDFERKKPEYLEGLPEKMKLYSEFLGKQPWFAGNKITYVDFLVYDVLDQHRIFEPKCLDAFPNLKDFVARFEGLKKISDYMKSGRFLSKPIFAKMAFWNPK

Target ORF information:

RefSeq Version	XM_017590627.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590627.1

ORF Insert Sequence:

ATGGGGGATG CTCCCGACTA TGACAGAAGC CAGTGGCTGA GTGAGAAGTT CAAACTGGGC 
CTGGACTTCC CCAATCTGCC CTACTTAATT GATGGGTCAC ACAAGATCAC CCAGAGCAAT 
GCCATCCTGC GCTACCTTGG CCGGAAGCAC AACCTTTGTG GGGAGACAGA GGAGGAGAGG 
ATTCGTGTGG ACGTTTTGGA GAACCAGGCT ATGGACACCC GCCTACAGTT GGCCATGGTC 
TGCTACAGCC CTGACTTTGA GAGAAAGAAG CCAGAGTACT TAGAGGGTCT CCCTGAGAAG 
ATGAAGCTTT ACTCCGAATT CCTGGGCAAG CAGCCATGGT TTGCAGGGAA CAAGATTACG 
TATGTGGATT TTCTTGTTTA CGATGTCCTT GATCAACACC GTATATTTGA ACCCAAGTGC 
CTGGACGCCT TCCCAAACCT GAAGGACTTC GTGGCTCGGT TTGAGGGCCT GAAGAAGATA 
TCTGACTACA TGAAGAGCGG CCGCTTCCTC TCCAAGCCAA TCTTTGCAAA GATGGCCTTT 
TGGAACCCAA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.
PloS one11(9)e0162415(2016)
Hewawasam RP,Liu D,Casarotto MG,Board PG,Dulhunty AF

Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes.
Free radical biology & medicine61179-96(2013 Aug)
Stanley JA,Sivakumar KK,Nithy TK,Arosh JA,Hoyer PB,Burghardt RC,Banu SK

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.
Biochemical pharmacology83(11)1523-9(2012 Jun)
Liu D,Hewawasam R,Karunasekara Y,Casarotto MG,Dulhunty AF,Board PG

Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration.
Ophthalmic research46(1)31-7(2011)
G?ven M,G?rg?n E,?nal M,Yenerel M,Batar B,K???men B,Din? UA,G?ven GS,Ulus T,Y?ksel A

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.
Pharmacogenetics and genomics20(5)315-26(2010 May)
Northwood EL,Elliott F,Forman D,Barrett JH,Wilkie MJ,Carey FA,Steele RJ,Wolf R,Bishop T,Smith G

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Gstm2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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