Gsta2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gsta2
Entrez Gene ID	24422
Full Name	glutathione S-transferase alpha 2
Synonyms	Gsta1
General protein information	Preferred Names glutathione S-transferase alpha 2 Names glutathione S-transferase alpha-1 GST 1-1 GST 1a-1a GST A1-1 GST B GST Ya1 Glutathione-S-transferase alpha type (Yc?) glutathione S-transferase A2 glutathione S-transferase Ya subunit glutathione S-transferase Ya-1 glutathione-S-transferase, alpha type2 ligandin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31
Summary	mRNA expression is induced by phenobarbital and by trans-stilbene oxide [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017013.4	NP_058709.2	glutathione S-transferase alpha-1
XM_017596098.1	XP_017451587.1	glutathione S-transferase alpha-1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GSTA1	XP_003311383.1
	GSTA1	XP_001108125.1
Bos taurus (cattle)	GSTA2	NP_803481.1
Homo sapiens (human)	GSTA1	NP_665683.1
Rattus norvegicus (Norway rat)	Gsta2	NP_058709.2

Gene Ontology
Bibliography

Related articles in PubMed

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.
Swain A, Turton J, Scudamore C, Maguire D, Pereira I, Freitas S, Smyth R, Munday M, Stamp C, Gandhi M, Sondh S, Ashall H, Francis I, Woodfine J, Bowles J, York M
Journal of applied toxicology : JAT32(6)417-28(2012 Jun)

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Buhrke T, Lengler I, Lampen A
Development, growth & differentiation53(3)411-26(2011 Apr)

Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.
Stella L, Pallottini V, Moreno S, Leoni S, De Maria F, Turella P, Federici G, Fabrini R, Dawood KF, Bello ML, Pedersen JZ, Ricci G
The Journal of biological chemistry282(9)6372-9(2007 Mar)

Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: crosstalk through C/EBPs.
Falkner KC, Prough RA
Drug metabolism reviews39(2-3)401-18(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1.
Title: Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.

a considerable amount of GSTs, in particular GSTA1-1, GSTA2-2, and GSTA3-3, corresponding to 10% of the cytosolic pool is electrostatically associated with the outer nuclear membrane, and a similar quantity is compartmentalized inside the nucleus
Title: Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.

C/EBP alpha and beta are involved in glucocorticoid-dependent repression of GSTA2 gene expression
Title: Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: crosstalk through C/EBPs.

dexamethasone antagonizes C/EBPbeta- and Nrf2-mediated GSTA2 gene induction via ligand-GR binding to the GRE, and steroid-mediated GSTA2 repression involves inactivation of C/EBPbeta and Nrf2 by SMRT recruited to steroid-GR complex
Title: Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.

P.893: Ceramide inhibits C/EBP-beta or Nrf2 activation, which contributes to repression of GSTA2 gene transactivation. P. 897: "...ceramide inhibition of... transcription factors contributes to the repression of the GSTA2 gene transactivation."
Title: Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression.

The following Gsta2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gsta2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02509	NM_017013.4 Latest version!	Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa62585	XM_017596098.1 Latest version!	Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gsta2 ( NM_017013.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058709.2 Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), mRNA.

Price & Availability↑

CloneID	ORa02509
Clone ID Related Accession (Same CDS sequence)	NM_017013.4
Accession Version	NM_017013.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	glutathione S-transferase alpha-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from K01931.1 and BC078706.1. On or before Jun 26, 2012 this sequence version replaced XM_003750543.1, NM_017013.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K01931.1, FQ217939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906351, SAMN01906354 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGGA AGCCAGTGCT TCACTACTTC AATGCCCGGG GCAGAATGGA GTGCATCCGG 
TGGCTCCTGG CTGCAGCAGG AGTGGAGTTT GATGAGAAGT TTATACAGAG TCCAGAAGAC 
TTGGAAAAGC TAAAGAAAGA CGGGAATTTG ATGTTTGACC AAGTGCCCAT GGTGGAGATT 
GACGGGATGA AGCTGGCACA GACCAGAGCC ATTCTCAACT ACATCGCCAC CAAATATGAC 
CTCTATGGGA AGGACATGAA GGAGAGAGCC CTGATTGACA TGTACACCGA AGGCATTTTA 
GATCTGACTG AAATGATTAT GCAATTGGTA ATATGTCCCC CAGACCAAAA AGAAGCCAAG 
ACCGCCTTGG CAAAAGACAG GACCAAAAAC CGGTACTTGC CTGCCTTTGA AAAGGTGTTG 
AAGAGCCATG GCCAAGACTA CCTTGTAGGT AACAGGCTGA CCCGGGTAGA CATCCACCTG 
CTGGAACTTC TCCTCTATGT TGAAGAGTTT GATGCCAGCC TTCTGACCTC TTTCCCTCTG 
CTGAAGGCCT TCAAGAGCAG AATCAGCAGC CTCCCCAATG TGAAGAAGTT CCTGCAGCCT 
GGCAGTCAGA GAAAGCTTCC CGTGGATGCA AAACAAATCG AAGAAGCAAG GAAGATTTTC 
AAGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058709.2
CDS	64..732
Translation	MSGKPVLHYFNARGRMECIRWLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPVDAKQIEEARKIFKF

Target ORF information:

RefSeq Version	NM_017013.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017013.4

ORF Insert Sequence:

ATGTCTGGGA AGCCAGTGCT TCACTACTTC AATGCCCGGG GCAGAATGGA GTGCATCCGG 
TGGCTCCTGG CTGCAGCAGG AGTGGAGTTT GATGAGAAGT TTATACAGAG TCCAGAAGAC 
TTGGAAAAGC TAAAGAAAGA CGGGAATTTG ATGTTTGACC AAGTGCCCAT GGTGGAGATT 
GACGGGATGA AGCTGGCACA GACCAGAGCC ATTCTCAACT ACATCGCCAC CAAATATGAC 
CTCTATGGGA AGGACATGAA GGAGAGAGCC CTGATTGACA TGTACACCGA AGGCATTTTA 
GATCTGACTG AAATGATTAT GCAATTGGTA ATATGTCCCC CAGACCAAAA AGAAGCCAAG 
ACCGCCTTGG CAAAAGACAG GACCAAAAAC CGGTACTTGC CTGCCTTTGA AAAGGTGTTG 
AAGAGCCATG GCCAAGACTA CCTTGTAGGT AACAGGCTGA CCCGGGTAGA CATCCACCTG 
CTGGAACTTC TCCTCTATGT TGAAGAGTTT GATGCCAGCC TTCTGACCTC TTTCCCTCTG 
CTGAAGGCCT TCAAGAGCAG AATCAGCAGC CTCCCCAATG TGAAGAAGTT CCTGCAGCCT 
GGCAGTCAGA GAAAGCTTCC CGTGGATGCA AAACAAATCG AAGAAGCAAG GAAGATTTTC 
AAGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gsta2 ( XM_017596098.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451587.1 Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa62585
Clone ID Related Accession (Same CDS sequence)	XM_017596098.1
Accession Version	XM_017596098.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	glutathione S-transferase alpha-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) and transcript sequence (FJ179397.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## assembly gap :: added 87 transcript bases to patch genome assembly gap ##RefSeq-Attributes-END##

ATGTCTGGGA AGCCAGTGCT TCACTACTTC AATGCCCGGG GCAGAATGGA GTGCATCCGG 
TGGCTCCTGG CTGCAGCAGG AGTGGAGTTT GATGAGAAGT TTATACAGAG TCCAGAAGAC 
TTGGAAAAGC TAAAGAAAGA CGGGAATTTG ATGTTTGACC AAGTGCCCAT GGTGGAGATT 
GACGGGATGA AGCTGGCACA GACCAGAGCC ATTCTCAACT ACATCGCCAC CAAATATGAC 
CTCTATGGGA AGGACATGAA GGAGAGAGCC CTGATTGACA TGTATTCAGA GGGTATTTTA 
GATCTGACTG AAATGATTAT CCAATTGGTA ATATGTCCCC CAGACCAAAG AGAAGCCAAG 
ACCGCCTTGG CAAAAGACAG GACCAAAAAC CGGTACTTGC CTGCCTTTGA AAAGGTGTTG 
AAGAGCCATG GCCAAGACTA CCTTGTAGGC AACAGGCTGA CCCGGGTAGA CATCCACCTG 
CTGGAACTTC TCCTCTATGT TGAAGAGTTT GATGCCAGCC TTCTGACCCC TTTCCCTCTG 
CTGAAGGCCT TCAAGAGCAG AATCAGCAGC CTCCCCAATG TGAAGAAGTT CCTGCAGCCT 
GGCAGTCAGA GAAAGCCAGC CATGGATGCA AAACAAATCG AAGAAGCAAG GAAGGTTTTC 
AAGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451587.1
CDS	1..669
Translation	MSGKPVLHYFNARGRMECIRWLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIIQLVICPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEFDASLLTPFPLLKAFKSRISSLPNVKKFLQPGSQRKPAMDAKQIEEARKVFKF

Target ORF information:

RefSeq Version	XM_017596098.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596098.1

ORF Insert Sequence:

ATGTCTGGGA AGCCAGTGCT TCACTACTTC AATGCCCGGG GCAGAATGGA GTGCATCCGG 
TGGCTCCTGG CTGCAGCAGG AGTGGAGTTT GATGAGAAGT TTATACAGAG TCCAGAAGAC 
TTGGAAAAGC TAAAGAAAGA CGGGAATTTG ATGTTTGACC AAGTGCCCAT GGTGGAGATT 
GACGGGATGA AGCTGGCACA GACCAGAGCC ATTCTCAACT ACATCGCCAC CAAATATGAC 
CTCTATGGGA AGGACATGAA GGAGAGAGCC CTGATTGACA TGTATTCAGA GGGTATTTTA 
GATCTGACTG AAATGATTAT CCAATTGGTA ATATGTCCCC CAGACCAAAG AGAAGCCAAG 
ACCGCCTTGG CAAAAGACAG GACCAAAAAC CGGTACTTGC CTGCCTTTGA AAAGGTGTTG 
AAGAGCCATG GCCAAGACTA CCTTGTAGGC AACAGGCTGA CCCGGGTAGA CATCCACCTG 
CTGGAACTTC TCCTCTATGT TGAAGAGTTT GATGCCAGCC TTCTGACCCC TTTCCCTCTG 
CTGAAGGCCT TCAAGAGCAG AATCAGCAGC CTCCCCAATG TGAAGAAGTT CCTGCAGCCT 
GGCAGTCAGA GAAAGCCAGC CATGGATGCA AAACAAATCG AAGAAGCAAG GAAGGTTTTC 
AAGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.
Journal of applied toxicology : JAT32(6)417-28(2012 Jun)
Swain A,Turton J,Scudamore C,Maguire D,Pereira I,Freitas S,Smyth R,Munday M,Stamp C,Gandhi M,Sondh S,Ashall H,Francis I,Woodfine J,Bowles J,York M

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Development, growth & differentiation53(3)411-26(2011 Apr)
Buhrke T,Lengler I,Lampen A

Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.
The Journal of biological chemistry282(9)6372-9(2007 Mar)
Stella L,Pallottini V,Moreno S,Leoni S,De Maria F,Turella P,Federici G,Fabrini R,Dawood KF,Bello ML,Pedersen JZ,Ricci G

Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: crosstalk through C/EBPs.
Drug metabolism reviews39(2-3)401-18(2007)
Falkner KC,Prough RA

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Gsta2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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