Grm3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grm3
Entrez Gene ID	24416
Full Name	glutamate metabotropic receptor 3
Synonyms	mGluR3
General protein information	Preferred Names glutamate metabotropic receptor 3 Names metabotropic glutamate receptor 3 glutamate receptor, metabotropic 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q12
Summary	activation induces neuronal activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008762682.2	XP_008760904.1	metabotropic glutamate receptor 3 isoform X1
XM_017592440.1	XP_017447929.1	metabotropic glutamate receptor 3 isoform X1
NM_001105712.1	NP_001099182.1	metabotropic glutamate receptor 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRM3	NP_000831.2
Bos taurus (cattle)	GRM3	NP_001091592.1
Rattus norvegicus (Norway rat)	Grm3	NP_001099182.1
Pan troglodytes (chimpanzee)	GRM3	XP_001161278.1
	GRM3	XP_001107588.1
Mus musculus (house mouse)	Grm3	NP_862898.1
Danio rerio (zebrafish)	grm3	NP_001121815.1
Drosophila melanogaster (fruit fly)	mGluRA	NP_001259076.1
Xenopus tropicalis (tropical clawed frog)	grm3	XP_002935292.2
Canis lupus familiaris (dog)	GRM3	XP_005628844.1
Gallus gallus (chicken)	GRM3	XP_416842.3
Caenorhabditis elegans (roundworm)	mgl-1	NP_001123193.1

Gene Ontology
Bibliography

Related articles in PubMed

Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.
Durand D, Carniglia L, Turati J, Ram?rez D, Saba J, Caruso C, Lasaga M
Neuropharmacology123274-286(2017 Sep)

Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Ali I, Boets S, Janssens P, Van Eetveldt A, Amhaoul H, Langlois X, Dedeurwaerdere S
Epilepsy research12755-59(2016 Nov)

Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.
Wischhof L, Irrsack E, Dietz F, Koch M
Neuropharmacology97275-88(2015 Oct)

Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats.
Wang Y, Ma Y, Hu J, Cheng W, Jiang H, Zhang X, Li M, Ren J, Li X
Neuroscience301363-74(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest a time dependent evolving pattern of mGluR2/3 density during the pathogenesis of mesial temporal lobe epilepsy and provide insights for utilizing this data for in vivo imaging to predict the specific time points and responsiveness to the therapy targeting mGluR2/3.
Title: Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.

Study aimed at further characterizing the effects of prenatal immune activation on 5-HT2A and mGlu2/3 receptor function in male and female rat offspring
Title: Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.

This study demonstrated that the Male prenatal chronic mild stress rats expressed significantly higher mGluR2/3 in the prefrontal cortex but lower in female amygalda.
Title: Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats.

The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition.
Title: Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.

report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production
Title: Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.

The following Grm3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grm3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11230	NM_001105712.1 Latest version!	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa42910	XM_008762682.2 Latest version!	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa42910	XM_017592440.1 Latest version!	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grm3 ( NM_001105712.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099182.1 Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), mRNA.

Price & Availability↑

CloneID	ORa11230
Clone ID Related Accession (Same CDS sequence)	NM_001105712.1
Accession Version	NM_001105712.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	metabotropic glutamate receptor 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474013.1. On or before Oct 3, 2007 this sequence version replaced XM_001062001.1, XM_001069653.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M92076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTCCTC TGCAAGCACA 
TATGTCCCAA CAGTGTGCAA CGGAAGGGAA GTCCTGGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099182.1
CDS	224..2863
Translation	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL

Target ORF information:

RefSeq Version	NM_001105712.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105712.1

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTCCTC TGCAAGCACA 
TATGTCCCAA CAGTGTGCAA CGGAAGGGAA GTCCTGGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grm3 ( XM_008762682.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760904.1 Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa42910
Clone ID Related Accession (Same CDS sequence)	XM_008762682.2 , XM_017592440.1
Accession Version	XM_008762682.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2712bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	metabotropic glutamate receptor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762682.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTATCC TCCTTCCAAA 
GCAAGGCCAT ATCCGGAAGC CCAACCAACA CCACAGCATC ACAGCACCAA GAGACAAGCC 
TCTGCAAGCA CATATGTCCC AACAGTGTGC AACGGAAGGG AAGTCCTGGA CTCCACCACC 
TCATCTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760904.1
CDS	1158..3869
Translation	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQYPPSKARPYPEAQPTPQHHSTKRQASASTYVPTVCNGREVLDSTTSSL

Target ORF information:

RefSeq Version	XM_008762682.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762682.2

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTATCC TCCTTCCAAA 
GCAAGGCCAT ATCCGGAAGC CCAACCAACA CCACAGCATC ACAGCACCAA GAGACAAGCC 
TCTGCAAGCA CATATGTCCC AACAGTGTGC AACGGAAGGG AAGTCCTGGA CTCCACCACC 
TCATCTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grm3 ( XM_017592440.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447929.1 Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X2, mRNA.

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CloneID	ORa42910
Clone ID Related Accession (Same CDS sequence)	XM_008762682.2 , XM_017592440.1
Accession Version	XM_017592440.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2712bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	metabotropic glutamate receptor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTATCC TCCTTCCAAA 
GCAAGGCCAT ATCCGGAAGC CCAACCAACA CCACAGCATC ACAGCACCAA GAGACAAGCC 
TCTGCAAGCA CATATGTCCC AACAGTGTGC AACGGAAGGG AAGTCCTGGA CTCCACCACC 
TCATCTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447929.1
CDS	851..3562
Translation	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQYPPSKARPYPEAQPTPQHHSTKRQASASTYVPTVCNGREVLDSTTSSL

Target ORF information:

RefSeq Version	XM_017592440.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592440.1

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT ACAAATTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GAGATCACAA CTTTATGAGG AGGGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGAGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGGCGAATC 
AATGAAGACC GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATCGA CGAGATTAAC 
AAAGACAATT ACTTGCTCCC AGGAGTGAAG CTGGGTGTTC ATATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTAGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACTAAAGTG 
GATGAAGCCG AGTATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTG 
CTCATTGCAG GAGTCATTGG TGGTTCATAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGCGCCAA ACTCAGTGAC 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTT CTTCAACTGG ACCTATGTGT CCACCGTTGC CTCTGAGGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CACGGCTGCG TAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATA 
CGTGAGCTCC TGCAGAAACC CAATGCGCGG GTCGTGGTCC TGTTCATGCG CAGTGACGAC 
TCACGAGAGC TGATCGCGGC AGCCAACCGC GTGAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GTGCTCAGGA GAGCATAGTC AAGGGCAGTG AGCATGTAGC CTATGGCGCC 
ATCACCCTTG AGCTGGCATC TCACCCGGTT CGCCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGGTTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAGCAAGA ATCCAAGATT ATGTTTGTGG TGAATGCAGT GTACGCCATG 
GCGCATGCGC TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTAGATGG AAAGAAATTG TACAAGGAGT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTTTGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTGCAGCAGA CAGGTGGGAA GTATTCTTAC 
TTGAAGGTTG GCCACTGGGC AGAAACCTTG TCTCTAGATG TGGACTCTAT CCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCGAATGA AATGAAGAAC 
ATGCAGCCCG GGGATGTTTG CTGCTGGATC TGTATCCCCT GTGAGCCCTA TGAATACCTG 
GTCGATGAGT TCACCTGTAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AAATGGGAAG ACGCCTGGGC AATAGGCCCG 
GTCACCATTG CCTGCCTGGG CTTTCTGTGT ACATGCATAG TTATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGTCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCGTTGC GCCGACTTGG GCTTGGGACC TCTTTCGCCA TCTGTTATTC AGCGCTGCTG 
ACCAAGACAA ACTGCATTGC TCGCATCTTC GATGGGGTCA AGAACGGCGC TCAGAGGCCG 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATTTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CCGTGTGGCT TATCCTGGAG ACTCCAGGTA CTAGAAGATA CACCCTTCCA 
GAGAAGCGGG AAACAGTCAT CCTGAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTCCT GGTGATCCTA TGCACTGTGT ATGCCTTCAA AACGAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTT ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCCTGAGC GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATCGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGCGTCAG CGGAACTGCA ACCACCTATT CTCAGTATCC TCCTTCCAAA 
GCAAGGCCAT ATCCGGAAGC CCAACCAACA CCACAGCATC ACAGCACCAA GAGACAAGCC 
TCTGCAAGCA CATATGTCCC AACAGTGTGC AACGGAAGGG AAGTCCTGGA CTCCACCACC 
TCATCTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.
Neuropharmacology123274-286(2017 Sep)
Durand D,Carniglia L,Turati J,Ram?rez D,Saba J,Caruso C,Lasaga M

Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Epilepsy research12755-59(2016 Nov)
Ali I,Boets S,Janssens P,Van Eetveldt A,Amhaoul H,Langlois X,Dedeurwaerdere S

Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.
Neuropharmacology97275-88(2015 Oct)
Wischhof L,Irrsack E,Dietz F,Koch M

Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats.
Neuroscience301363-74(2015 Aug)
Wang Y,Ma Y,Hu J,Cheng W,Jiang H,Zhang X,Li M,Ren J,Li X

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Grm3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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