Fabp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp1
Entrez Gene ID	24360
Full Name	fatty acid binding protein 1
Synonyms	Fabplg,L-FABP,SCP,SCP.,p14
General protein information	Preferred Names fatty acid binding protein 1 Names fatty acid-binding protein, liver Z-protein fatty acid binding protein 1, liver liver-type fatty acid-binding protein squalene- and sterol-carrier protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q31
Summary	binds oleic acid and other hydrophobic ligands; may play a role in hepatocyte cell proliferation; may transport activated chemical carcinogens [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012556.2	NP_036688.1	fatty acid-binding protein, liver

Pathways from BioSystems

Homologies

Homo sapiens (human)	FABP1	NP_001434.1
Xenopus tropicalis (tropical clawed frog)	fabp1	NP_001116883.1
Mus musculus (house mouse)	Fabp1	NP_059095.1
Gallus gallus (chicken)	FABP1	NP_989523.1
Canis lupus familiaris (dog)	FABP1	XP_005630521.1
Bos taurus (cattle)	FABP1	NP_787011.1
Danio rerio (zebrafish)	fabp1a	NP_001038177.1
Pan troglodytes (chimpanzee)	FABP1	XP_001140263.1
Rattus norvegicus (Norway rat)	Fabp1	NP_036688.1

Gene Ontology
Bibliography

Related articles in PubMed

Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.
Schroeder F, McIntosh AL, Martin GG, Huang H, Landrock D, Chung S, Landrock KK, Dangott LJ, Li S, Kaczocha M, Murphy EJ, Atshaves BP, Kier AB
Lipids51(6)655-76(2016 06)

Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4?.
McIntosh AL, Petrescu AD, Hostetler HA, Kier AB, Schroeder F
FEBS letters587(23)3787-91(2013 Nov)

Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
Lagakos WS, Guan X, Ho SY, Sawicki LR, Corsico B, Kodukula S, Murota K, Stark RE, Storch J
The Journal of biological chemistry288(27)19805-15(2013 Jul)

Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.
Siddiqi S, Mansbach CM 2nd
The Journal of biological chemistry287(13)10178-88(2012 Mar)

A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.
He Y, Estephan R, Yang X, Vela A, Wang H, Bernard C, Stark RE
Biochemistry50(8)1283-95(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced.
Title: Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.

L-FABP structurally and functionally interacts with HNF4alpha.
Title: Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4?.

These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG
Title: Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.

Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.
Title: Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.

NMR study of liver fatty acid-binding protein
Title: A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.

The following Fabp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12271	NM_012556.2 Latest version!	Rattus norvegicus fatty acid binding protein 1 (Fabp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp1 ( NM_012556.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036688.1 Rattus norvegicus fatty acid binding protein 1 (Fabp1), mRNA.

Price & Availability↑

CloneID	ORa12271
Clone ID Related Accession (Same CDS sequence)	NM_012556.2
Accession Version	NM_012556.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	fatty acid-binding protein, liver
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC086947.1. On Aug 18, 2012 this sequence version replaced NM_012556.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086947.1, FQ209859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGAACTTCT CCGGCAAGTA CCAAGTGCAG AGCCAAGAGA ACTTTGAGCC CTTCATGAAG 
GCGATGGGTC TGCCTGAGGA CCTCATCCAG AAAGGGAAGG ACATCAAGGG GGTGTCAGAA 
ATCGTGCATG AAGGGAAGAA AGTCAAACTC ACCATCACCT ATGGGTCCAA GGTGATCCAC 
AATGAGTTCA CCTTGGGGGA GGAGTGCGAA CTGGAGACCA TGACTGGGGA AAAGGTCAAG 
GCAGTGGTTA AGATGGAGGG TGACAATAAA ATGGTGACAA CTTTCAAAGG CATAAAGTCC 
GTGACTGAAT TCAATGGAGA CACAATCACC AATACCATGA CACTGGGTGA CATCGTCTAC 
AAGAGAGTCA GCAAGAGAAT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036688.1
CDS	39..422
Translation	MNFSGKYQVQSQENFEPFMKAMGLPEDLIQKGKDIKGVSEIVHEGKKVKLTITYGSKVIHNEFTLGEECELETMTGEKVKAVVKMEGDNKMVTTFKGIKSVTEFNGDTITNTMTLGDIVYKRVSKRI

Target ORF information:

RefSeq Version	NM_012556.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fatty acid binding protein 1 (Fabp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012556.2

ORF Insert Sequence:

ATGAACTTCT CCGGCAAGTA CCAAGTGCAG AGCCAAGAGA ACTTTGAGCC CTTCATGAAG 
GCGATGGGTC TGCCTGAGGA CCTCATCCAG AAAGGGAAGG ACATCAAGGG GGTGTCAGAA 
ATCGTGCATG AAGGGAAGAA AGTCAAACTC ACCATCACCT ATGGGTCCAA GGTGATCCAC 
AATGAGTTCA CCTTGGGGGA GGAGTGCGAA CTGGAGACCA TGACTGGGGA AAAGGTCAAG 
GCAGTGGTTA AGATGGAGGG TGACAATAAA ATGGTGACAA CTTTCAAAGG CATAAAGTCC 
GTGACTGAAT TCAATGGAGA CACAATCACC AATACCATGA CACTGGGTGA CATCGTCTAC 
AAGAGAGTCA GCAAGAGAAT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.
Lipids51(6)655-76(2016 06)
Schroeder F,McIntosh AL,Martin GG,Huang H,Landrock D,Chung S,Landrock KK,Dangott LJ,Li S,Kaczocha M,Murphy EJ,Atshaves BP,Kier AB

Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4?.
FEBS letters587(23)3787-91(2013 Nov)
McIntosh AL,Petrescu AD,Hostetler HA,Kier AB,Schroeder F

Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
The Journal of biological chemistry288(27)19805-15(2013 Jul)
Lagakos WS,Guan X,Ho SY,Sawicki LR,Corsico B,Kodukula S,Murota K,Stark RE,Storch J

Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.
The Journal of biological chemistry287(13)10178-88(2012 Mar)
Siddiqi S,Mansbach CM 2nd

A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.
Biochemistry50(8)1283-95(2011 Mar)
He Y,Estephan R,Yang X,Vela A,Wang H,Bernard C,Stark RE

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Fabp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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