Cyp1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp1a1
Entrez Gene ID	24296
Full Name	cytochrome P450, family 1, subfamily a, polypeptide 1
Synonyms	AHH,AHRR,CP11,CYP1,Cyp45c,Cypc45c,P-450MC,P1-450,P450-C,P450DX
General protein information	Preferred Names cytochrome P450, family 1, subfamily a, polypeptide 1 Names cytochrome P450 1A1 CYPIA1 P450MT2 P450form6 aryl hydrocarbon hydroxylase cytochrome P1-450 cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c) cytochrome P450, 1a1 cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c) cytochrome P450-C cytochrome P450MT2 dioxin-inducible flavoprotein-linked monooxygenase microsomal monooxygenase xenobiotic monooxygenase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	monooxygenase that plays a role in dioxin metabolism and detoxification which is 3-methylcholanthrene-inducible [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243150.2	XP_006243212.1	cytochrome P450 1A1 isoform X1
NM_012540.2	NP_036672.2	cytochrome P450 1A1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC453744	XP_001137654.1
Bos taurus (cattle)	CYP1A1	XP_005222075.1
Oryza sativa (rice)	Os04g0101400	NP_001051991.1
Xenopus tropicalis (tropical clawed frog)	cyp1a1	NP_001090813.1
Mus musculus (house mouse)	Cyp1a1	NP_001129531.1
Arabidopsis thaliana (thale cress)	CYP93D1	NP_196307.1
Oryza sativa (rice)	Os06g0613600	NP_001058072.1
	CYP1A1	NP_001035328.1
Gallus gallus (chicken)	CYP1A1	NP_990477.1
Danio rerio (zebrafish)	cyp1a	NP_571954.1
Homo sapiens (human)	CYP1A1	NP_000490.1
Canis lupus familiaris (dog)	CYP1A1	XP_003433938.1
Rattus norvegicus (Norway rat)	Cyp1a1	NP_036672.2
Gallus gallus (chicken)	CYP1A4	NP_990478.1
Oryza sativa (rice)	Os06g0102100	NP_001056533.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Li Y, Li Y, Zheng G, Zhu L, Wang J, Mu S, Ren Q, Feng F
Molecular medicine reports17(1)753-762(2018 Jan)

Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.
Navr?tilov? V, Palonc?ov? M, Berka K, Mise S, Haga Y, Matsumura C, Sakaki T, Inui H, Otyepka M
Biochimica et biophysica acta1861(11 Pt A)2852-2860(2017 11)

Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.
Dean A, Gregorc T, Docherty CK, Harvey KY, Nilsen M, Morrell NW, MacLean MR
American journal of respiratory cell and molecular biology(2017 Sep)

Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N
Xenobiotica; the fate of foreign compounds in biological systems1-11(2017 Sep)

Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.
Santes-Palacios R, Romo-Mancillas A, Camacho-Carranza R, Espinosa-Aguirre JJ
Toxicology letters258267-275(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that two inhibitors from grapefruit juice (naringenin and 6',7'-dihydroxybergamottin) block oxidation of 7-ethoxyresorufin via competitive binding to the active site of both human and rat CYP1A1.
Title: Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.

Hexachloronaphthalene was found to be a strong inducer of maternal and fetal CYP1A1 in liver and placenta.
Title: Developmental toxicity of hexachloronaphthalene in Wistar rats. A role of CYP1A1 expression.

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
Title: Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.

drugs acting as D2-dopamine receptor antagonists can modify several hormone systems that regulate the expression of CYP1A1, CYP1A2 and CYP1B1, and may affect the toxicity and carcinogenicity outcome of numerous toxicants and pre-carcinogenic substances
Title: Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.

Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs
Title: Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.

The following Cyp1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12540	NM_012540.2 Latest version!	Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa31217	XM_006243150.2 Latest version!	Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp1a1 ( NM_012540.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036672.2 Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), mRNA.

Price & Availability↑

CloneID	ORa12540
Clone ID Related Accession (Same CDS sequence)	NM_012540.2
Accession Version	NM_012540.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome P450 1A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X00469.1. On Apr 2, 2004 this sequence version replaced NM_012540.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X00469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGCCTTCTG TGTATGGATT CCCAGCCTTC ACATCAGCCA CAGAGCTGCT CTTGGCCGTC 
ACCACATTCT GCCTTGGATT CTGGGTGGTT AGAGTCACAA GAACCTGGGT TCCCAAAGGT 
CTGAAGAGTC CACCCGGACC CTGGGGCTTG CCCTTCATGG GGCACGTGCT GACCCTGGGG 
AAGAACCCAC ACCTGTCACT GACAAAACTG AGTCAGCAGT ATGGGGACGT GCTGCAGATC 
CGTATTGGCT CCACACCCGT GGTGGTGCTG AGCGGCCTGA ACACCATCAA GCAGGCCCTG 
GTGAAACAGG GGGATGACTT CAAAGGCCGG CCAGACCTCT ACAGCTTCAC ACTTATCGCT 
AATGGCCAGA GCATGACTTT CAACCCAGAC TCTGGACCGC TGTGGGCTGC CCGCCGGCGC 
CTGGCCCAGA ATGCGCTGAA GAGTTTCTCC ATAGCCTCAG ACCCAACACT GGCATCCTCT 
TGCTACTTGG AAGAGCACGT GAGCAAAGAG GCTGAATACT TAATCAGCAA GTTCCAGAAG 
CTGATGGCAG AGGTTGGCCA CTTCGACCCT TTCAAGTATT TGGTGGTGTC AGTGGCCAAT 
GTCATCTGTG CCATATGCTT TGGCAGACGT TATGACCACG ATGACCAAGA GCTGCTCAGC 
ATAGTCAATC TAAGCAATGA GTTTGGGGAG GTTACTGGTT CTGGATACCC AGCTGACTTC 
ATTCCTATCC TCCGTTACCT CCCTAACTCT TCCCTGGATG CCTTCAAGGA CTTGAATAAG 
AAGTTCTACA GTTTCATGAA GAAGCTAATC AAAGAGCACT ACAGGACATT TGAGAAGGGC 
CACATCCGGG ACATCACAGA CAGCCTCATT GAGCATTGTC AGGACAGGAG GCTGGACGAG 
AATGCCAATG TCCAGCTCTC AGATGATAAG GTCATTACGA TTGTTTTTGA CCTCTTTGGA 
GCTGGGTTTG ACACAATCAC AACTGCTATC TCTTGGAGCC TCATGTACCT GGTAACCAAC 
CCTAGGATAC AGAGAAAGAT CCAGGAGGAG TTAGACACAG TGATTGGCAG GGATCGGCAG 
CCCCGGCTTT CTGACAGACC TCAGCTGCCC TATCTGGAGG CCTTCATCCT GGAGACCTTC 
CGACATTCAT CCTTTGTCCC ATTCACCATC CCCCACAGCA CCATAAGAGA TACAAGTCTG 
AATGGCTTCT ATATCCCCAA GGGACACTGT GTCTTTGTGA ACCAGTGGCA GGTTAACCAT 
GACCAGGAAC TATGGGGTGA TCCAAACGAG TTCCGGCCTG AAAGGTTTCT TACCTCCAGT 
GGCACTCTGG ACAAACACCT GAGTGAGAAG GTCATTCTCT TTGGTTTGGG CAAGCGAAAG 
TGCATTGGGG AGACCATTGG CCGACTGGAG GTCTTTCTCT TCCTGGCCAT CCTGCTGCAG 
CAAATGGAAT TTAATGTGTC ACCAGGCGAG AAGGTGGATA TGACTCCTGC CTATGGGCTG 
ACTTTAAAAC ATGCCCGCTG TGAGCACTTC CAAGTGCAGA TGCGGTCTTC TGGTCCTCAG 
CATCTCCAGG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036672.2
CDS	73..1647
Translation	MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFMGHVLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTLKHARCEHFQVQMRSSGPQHLQA

Target ORF information:

RefSeq Version	NM_012540.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012540.2

ORF Insert Sequence:

ATGCCTTCTG TGTATGGATT CCCAGCCTTC ACATCAGCCA CAGAGCTGCT CTTGGCCGTC 
ACCACATTCT GCCTTGGATT CTGGGTGGTT AGAGTCACAA GAACCTGGGT TCCCAAAGGT 
CTGAAGAGTC CACCCGGACC CTGGGGCTTG CCCTTCATGG GGCACGTGCT GACCCTGGGG 
AAGAACCCAC ACCTGTCACT GACAAAACTG AGTCAGCAGT ATGGGGACGT GCTGCAGATC 
CGTATTGGCT CCACACCCGT GGTGGTGCTG AGCGGCCTGA ACACCATCAA GCAGGCCCTG 
GTGAAACAGG GGGATGACTT CAAAGGCCGG CCAGACCTCT ACAGCTTCAC ACTTATCGCT 
AATGGCCAGA GCATGACTTT CAACCCAGAC TCTGGACCGC TGTGGGCTGC CCGCCGGCGC 
CTGGCCCAGA ATGCGCTGAA GAGTTTCTCC ATAGCCTCAG ACCCAACACT GGCATCCTCT 
TGCTACTTGG AAGAGCACGT GAGCAAAGAG GCTGAATACT TAATCAGCAA GTTCCAGAAG 
CTGATGGCAG AGGTTGGCCA CTTCGACCCT TTCAAGTATT TGGTGGTGTC AGTGGCCAAT 
GTCATCTGTG CCATATGCTT TGGCAGACGT TATGACCACG ATGACCAAGA GCTGCTCAGC 
ATAGTCAATC TAAGCAATGA GTTTGGGGAG GTTACTGGTT CTGGATACCC AGCTGACTTC 
ATTCCTATCC TCCGTTACCT CCCTAACTCT TCCCTGGATG CCTTCAAGGA CTTGAATAAG 
AAGTTCTACA GTTTCATGAA GAAGCTAATC AAAGAGCACT ACAGGACATT TGAGAAGGGC 
CACATCCGGG ACATCACAGA CAGCCTCATT GAGCATTGTC AGGACAGGAG GCTGGACGAG 
AATGCCAATG TCCAGCTCTC AGATGATAAG GTCATTACGA TTGTTTTTGA CCTCTTTGGA 
GCTGGGTTTG ACACAATCAC AACTGCTATC TCTTGGAGCC TCATGTACCT GGTAACCAAC 
CCTAGGATAC AGAGAAAGAT CCAGGAGGAG TTAGACACAG TGATTGGCAG GGATCGGCAG 
CCCCGGCTTT CTGACAGACC TCAGCTGCCC TATCTGGAGG CCTTCATCCT GGAGACCTTC 
CGACATTCAT CCTTTGTCCC ATTCACCATC CCCCACAGCA CCATAAGAGA TACAAGTCTG 
AATGGCTTCT ATATCCCCAA GGGACACTGT GTCTTTGTGA ACCAGTGGCA GGTTAACCAT 
GACCAGGAAC TATGGGGTGA TCCAAACGAG TTCCGGCCTG AAAGGTTTCT TACCTCCAGT 
GGCACTCTGG ACAAACACCT GAGTGAGAAG GTCATTCTCT TTGGTTTGGG CAAGCGAAAG 
TGCATTGGGG AGACCATTGG CCGACTGGAG GTCTTTCTCT TCCTGGCCAT CCTGCTGCAG 
CAAATGGAAT TTAATGTGTC ACCAGGCGAG AAGGTGGATA TGACTCCTGC CTATGGGCTG 
ACTTTAAAAC ATGCCCGCTG TGAGCACTTC CAAGTGCAGA TGCGGTCTTC TGGTCCTCAG 
CATCTCCAGG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cyp1a1 ( XM_006243150.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243212.1 Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31217
Clone ID Related Accession (Same CDS sequence)	XM_006243150.2
Accession Version	XM_006243150.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome P450 1A1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006243150.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTCTG TGTATGGATT CCCAGCCTTC ACATCAGCCA CAGAGCTGCT CCTGGCCGTC 
ACCACATTCT GCCTTGGATT CTGGGTGGTT AGAGTCACAA GAACCTGGGT TCCCAAAGGT 
CTGAAGAGTC CACCCGGACC CTGGGGCTTG CCCTTCATAG GGCACGTGCT GACCCTGGGG 
AAGAACCCAC ACCTGTCACT GACAAAACTG AGTCAGCAGT ATGGGGACGT GCTGCAGATC 
CGTATTGGCT CCACACCCGT GGTGGTGCTG AGCGGCCTGA ACACCATCAA GCAGGCCCTG 
GTGAAACAGG GGGATGACTT CAAAGGCCGG CCAGACCTCT ACAGCTTCAC ACTTATCGCT 
AATGGCCAGA GCATGACTTT CAACCCAGAC TCTGGACCGC TGTGGGCTGC CCGCCGGCGC 
CTGGCCCAGA ATGCGCTGAA GAGTTTCTCC ATAGCCTCAG ACCCAACACT GGCATCCTCT 
TGCTACTTGG AAGAGCACGT GAGCAAAGAG GCTGAATACT TAATCAGCAA GTTCCAGAAG 
CTGATGGCAG AGGTTGGCCA CTTCGACCCT TTCAAGTATT TGGTGGTGTC AGTGGCCAAT 
GTCATCTGTG CCATATGCTT TGGCAGACGT TATGACCACG ATGACCAAGA GCTGCTCAGC 
ATAGTCAATC TAAGCAATGA GTTTGGGGAG GTTACTGGTT CTGGATACCC AGCTGACTTC 
ATTCCTATCC TCCGTTACCT CCCTAACTCT TCCCTGGATG CCTTCAAGGA CTTGAATAAG 
AAGTTCTACA GTTTCATGAA GAAGCTAATC AAAGAGCACT ACAGGACATT TGAGAAGGGC 
CACATCCGGG ACATCACAGA CAGCCTCATT GAGCATTGTC AGGACAGGAG GCTGGACGAG 
AATGCCAATG TCCAGCTCTC AGATGATAAG GTCATTACGA TTGTTTTTGA CCTCTTTGGA 
GCTGGGTTTG ACACAATCAC AACTGCTATC TCTTGGAGCC TCATGTACCT GGTAACCAAC 
CCTAGGATAC AGAGAAAGAT CCAGGAGGAG TTAGACACAG TGATTGGCAG GGATCGGCAG 
CCCCGGCTTT CTGACAGACC TCAGCTGCCC TATCTGGAGG CCTTCATCCT GGAGACCTTC 
CGACATTCAT CCTTTGTCCC ATTCACCATC CCCCACAGCA CCATAAGAGA TACAAGTCTG 
AATGGCTTCT ATATCCCCAA GGGACACTGT GTCTTTGTGA ACCAGTGGCA GGTTAACCAT 
GACCAGGAAC TATGGGGTGA TCCAAACGAG TTCCGGCCTG AAAGGTTTCT TACCTCCAGT 
GGCACTCTGG ACAAACACCT GAGTGAGAAG GTCATTCTCT TTGGTTTGGG CAAGCGAAAG 
TGCATTGGGG AGACCATTGG CCGACTGGAG GTCTTTCTCT TCCTGGCCAT CTTGCTGCAG 
CAAATGGAAT TTAATGTGTC ACCAGGCGAG AAGGTGGATA TGACTCCTGC CTATGGGCTG 
ACTTTAAAAC ATGCCCGCTG TGAGCACTTC CAAGTGCAGA TGCGGTCTTC TGGTCCTCAG 
CATCTCCAGG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243212.1
CDS	70..1644
Translation	MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTLKHARCEHFQVQMRSSGPQHLQA

Target ORF information:

RefSeq Version	XM_006243150.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243150.2

ORF Insert Sequence:

ATGCCTTCTG TGTATGGATT CCCAGCCTTC ACATCAGCCA CAGAGCTGCT CCTGGCCGTC 
ACCACATTCT GCCTTGGATT CTGGGTGGTT AGAGTCACAA GAACCTGGGT TCCCAAAGGT 
CTGAAGAGTC CACCCGGACC CTGGGGCTTG CCCTTCATAG GGCACGTGCT GACCCTGGGG 
AAGAACCCAC ACCTGTCACT GACAAAACTG AGTCAGCAGT ATGGGGACGT GCTGCAGATC 
CGTATTGGCT CCACACCCGT GGTGGTGCTG AGCGGCCTGA ACACCATCAA GCAGGCCCTG 
GTGAAACAGG GGGATGACTT CAAAGGCCGG CCAGACCTCT ACAGCTTCAC ACTTATCGCT 
AATGGCCAGA GCATGACTTT CAACCCAGAC TCTGGACCGC TGTGGGCTGC CCGCCGGCGC 
CTGGCCCAGA ATGCGCTGAA GAGTTTCTCC ATAGCCTCAG ACCCAACACT GGCATCCTCT 
TGCTACTTGG AAGAGCACGT GAGCAAAGAG GCTGAATACT TAATCAGCAA GTTCCAGAAG 
CTGATGGCAG AGGTTGGCCA CTTCGACCCT TTCAAGTATT TGGTGGTGTC AGTGGCCAAT 
GTCATCTGTG CCATATGCTT TGGCAGACGT TATGACCACG ATGACCAAGA GCTGCTCAGC 
ATAGTCAATC TAAGCAATGA GTTTGGGGAG GTTACTGGTT CTGGATACCC AGCTGACTTC 
ATTCCTATCC TCCGTTACCT CCCTAACTCT TCCCTGGATG CCTTCAAGGA CTTGAATAAG 
AAGTTCTACA GTTTCATGAA GAAGCTAATC AAAGAGCACT ACAGGACATT TGAGAAGGGC 
CACATCCGGG ACATCACAGA CAGCCTCATT GAGCATTGTC AGGACAGGAG GCTGGACGAG 
AATGCCAATG TCCAGCTCTC AGATGATAAG GTCATTACGA TTGTTTTTGA CCTCTTTGGA 
GCTGGGTTTG ACACAATCAC AACTGCTATC TCTTGGAGCC TCATGTACCT GGTAACCAAC 
CCTAGGATAC AGAGAAAGAT CCAGGAGGAG TTAGACACAG TGATTGGCAG GGATCGGCAG 
CCCCGGCTTT CTGACAGACC TCAGCTGCCC TATCTGGAGG CCTTCATCCT GGAGACCTTC 
CGACATTCAT CCTTTGTCCC ATTCACCATC CCCCACAGCA CCATAAGAGA TACAAGTCTG 
AATGGCTTCT ATATCCCCAA GGGACACTGT GTCTTTGTGA ACCAGTGGCA GGTTAACCAT 
GACCAGGAAC TATGGGGTGA TCCAAACGAG TTCCGGCCTG AAAGGTTTCT TACCTCCAGT 
GGCACTCTGG ACAAACACCT GAGTGAGAAG GTCATTCTCT TTGGTTTGGG CAAGCGAAAG 
TGCATTGGGG AGACCATTGG CCGACTGGAG GTCTTTCTCT TCCTGGCCAT CTTGCTGCAG 
CAAATGGAAT TTAATGTGTC ACCAGGCGAG AAGGTGGATA TGACTCCTGC CTATGGGCTG 
ACTTTAAAAC ATGCCCGCTG TGAGCACTTC CAAGTGCAGA TGCGGTCTTC TGGTCCTCAG 
CATCTCCAGG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Molecular medicine reports17(1)753-762(2018 Jan)
Li Y,Li Y,Zheng G,Zhu L,Wang J,Mu S,Ren Q,Feng F

Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.
Biochimica et biophysica acta1861(11 Pt A)2852-2860(2017 11)
Navr?tilov? V,Palonc?ov? M,Berka K,Mise S,Haga Y,Matsumura C,Sakaki T,Inui H,Otyepka M

Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.
American journal of respiratory cell and molecular biology(2017 Sep)
Dean A,Gregorc T,Docherty CK,Harvey KY,Nilsen M,Morrell NW,MacLean MR

Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Xenobiotica; the fate of foreign compounds in biological systems1-11(2017 Sep)
Yilmaz Y,Umehara K,Williams G,Faller T,Schiller H,Walles M,Kraehenbuehl S,Camenisch G,Manevski N

Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.
Toxicology letters258267-275(2016 Sep)
Santes-Palacios R,Romo-Mancillas A,Camacho-Carranza R,Espinosa-Aguirre JJ

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Cyp1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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