Crygc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crygc
Entrez Gene ID	24277
Full Name	crystallin, gamma C
Synonyms	Cryg,Cryg3,Len
General protein information	Preferred Names crystallin, gamma C Names gamma-crystallin C crystallin, gamma polypeptide 3 gamma-C-crystallin gamma-crystallin 2-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q32
Summary	putative protein of the lens of the eye; human homolog is lens protein likely involved in some forms of cataracts [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001081660.1	NP_001075129.1	gamma-crystallin C isoform 2
NM_033483.1	NP_264077.1	gamma-crystallin C isoform 1

Pathways from BioSystems

Homologies

	CRYGC	NP_001076433.1
Pan troglodytes (chimpanzee)	CRYGC	NP_001129133.1
Mus musculus (house mouse)	Crygc	NP_001076042.1
Homo sapiens (human)	CRYGC	NP_066269.1
Bos taurus (cattle)	CRYGC	NP_001013613.1
Rattus norvegicus (Norway rat)	Crygc	NP_264077.1
Danio rerio (zebrafish)	si:dkey-57a22.15	NP_001116783.1

Gene Ontology
Bibliography

Related articles in PubMed

A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family.
Yao K, Jin C, Zhu N, Wang W, Wu R, Jiang J, Shentu X
Molecular vision141272-6(2008 Jul)

Evaluation of three canine gamma-crystallins (CRYGB, CRYGC, and CRYGS) as candidates for hereditary cataracts in the dachshund.
M?ller C, W?hlke A, Distl O
Molecular vision13125-32(2007 Jan)

Genetic, age and light mediated effects on crystallin protein expression in the retina.
Organisciak D, Darrow R, Gu X, Barsalou L, Crabb JW
Photochemistry and photobiology82(4)1088-96(2006 Jul-Aug)

Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin.
Pigaga V, Quinlan RA
Experimental cell research312(1)51-62(2006 Jan)

Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.
Graw J, Neuh?user-Klaus A, Klopp N, Selby PB, L?ster J, Favor J
Investigative ophthalmology & visual science45(4)1202-13(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Crygc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crygc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42630	NM_001081660.1 Latest version!	Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa42796	NM_033483.1 Latest version!	Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crygc ( NM_001081660.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001075129.1 Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa42630
Clone ID Related Accession (Same CDS sequence)	NM_001081660.1
Accession Version	NM_001081660.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	gamma-crystallin C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M19359.1. On or before Feb 24, 2007 this sequence version replaced XM_217421.4, XM_001072315.1. Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAAGA TCACCTTCTA CGAGGACCGA GGCTTCCAGG GCCGCTGCTA TGAGTGCAGC 
AGCGACTGCC CCAACCTGCA GACCTACTTC AGCCGCTGCA ACTCCATCCG CGTGGACAGT 
GGCTGCTGGA TGCTCTATGA GCGCCCCAAC TACCAGGGCC ACCAGTACTT CCTGCGACGC 
GGGGACTACC CTGACTACCA GCAGTGGATG GGTTTCAGCG ACTCCATTCG CTCCTGCCGC 
CTCATCCCCC ATACAGGTTC CCACAGGATG CGTCTGTATG AGAAAGAAGA TCACAAAGGC 
GTCATGATGG AGCTGAGTGA AGACTGCTCC TGCATCCAGG ACCGCTTCCA CCTCAGTGAG 
GTGCGCTCGC TGCACGTGCT AGAGGGCTGC TGGGTCCTCT ATGAGATGCC TAACTACCGA 
GGCCGGCAGT ATCTGCTGAG GCCTCAAGAG TACCGGCGCT ACCACGACTG GGGCGCTGTA 
GATGCTAAGG CAGGCTCTTT GCGGAGGGTG GTAGATTTAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075129.1
CDS	28..552
Translation	MGKITFYEDRGFQGRCYECSSDCPNLQTYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRRGDYPDYQQWMGFSDSIRSCRLIPHTGSHRMRLYEKEDHKGVMMELSEDCSCIQDRFHLSEVRSLHVLEGCWVLYEMPNYRGRQYLLRPQEYRRYHDWGAVDAKAGSLRRVVDLY

Target ORF information:

RefSeq Version	NM_001081660.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081660.1

ORF Insert Sequence:

ATGGGGAAGA TCACCTTCTA CGAGGACCGA GGCTTCCAGG GCCGCTGCTA TGAGTGCAGC 
AGCGACTGCC CCAACCTGCA GACCTACTTC AGCCGCTGCA ACTCCATCCG CGTGGACAGT 
GGCTGCTGGA TGCTCTATGA GCGCCCCAAC TACCAGGGCC ACCAGTACTT CCTGCGACGC 
GGGGACTACC CTGACTACCA GCAGTGGATG GGTTTCAGCG ACTCCATTCG CTCCTGCCGC 
CTCATCCCCC ATACAGGTTC CCACAGGATG CGTCTGTATG AGAAAGAAGA TCACAAAGGC 
GTCATGATGG AGCTGAGTGA AGACTGCTCC TGCATCCAGG ACCGCTTCCA CCTCAGTGAG 
GTGCGCTCGC TGCACGTGCT AGAGGGCTGC TGGGTCCTCT ATGAGATGCC TAACTACCGA 
GGCCGGCAGT ATCTGCTGAG GCCTCAAGAG TACCGGCGCT ACCACGACTG GGGCGCTGTA 
GATGCTAAGG CAGGCTCTTT GCGGAGGGTG GTAGATTTAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Crygc ( NM_033483.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_264077.1 Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa42796
Clone ID Related Accession (Same CDS sequence)	NM_033483.1
Accession Version	NM_033483.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	gamma-crystallin C isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF523642.1, BG371711.1 and AI717452.1. On or before Oct 11, 2007 this sequence version replaced XM_343582.3, XM_001072287.1. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAAGA TCACCTTCTA CGAGGACCGA GGCTTCCAGG GCCGCTGCTA TGAGTGCAGC 
AGCGACTGCC CCAACCTGCA GACCTACTTC AGCCGCTGCA ACTCCGTCCG CGTGGACAGT 
GGCTGCTGGA TGCTCTATGA GCGACCCAAC TACCAGGGCC ACCAGTACTT CCTGCGACGC 
GGGGACTACC CTGACTACCA GCAGTGGATG GGTTTCAGCG ACTCCATTCG CTCCTGCCGC 
CTCATCCCCC ATCAGACAGG TTCCCACAGG ATGCGTCTGT ATGAGAAAGA AGATCACAAA 
GGCGTCATGA TGGAGCTGAG TGAAGACTGC TCCTGCATCC AGGACCGCTT CCACCTCAGT 
GAGGTGCGCT CGCTGCACGT GCTAGAGGGC TGCTGGGTCC TCTATGAGAT GTCTAACTAC 
CGAGGCCGGC AGTATCTGCT GAGGCCTCAA GAGTACCGGC GCTACCACGA CTGGGGCGCT 
GTAGATGCTA AGGCAGGCTC TTTGCGGAGG GTGGTAGATT TATACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_264077.1
CDS	8..535
Translation	MGKITFYEDRGFQGRCYECSSDCPNLQTYFSRCNSVRVDSGCWMLYERPNYQGHQYFLRRGDYPDYQQWMGFSDSIRSCRLIPHQTGSHRMRLYEKEDHKGVMMELSEDCSCIQDRFHLSEVRSLHVLEGCWVLYEMSNYRGRQYLLRPQEYRRYHDWGAVDAKAGSLRRVVDLY

Target ORF information:

RefSeq Version	NM_033483.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus crystallin, gamma C (Crygc), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033483.1

ORF Insert Sequence:

ATGGGGAAGA TCACCTTCTA CGAGGACCGA GGCTTCCAGG GCCGCTGCTA TGAGTGCAGC 
AGCGACTGCC CCAACCTGCA GACCTACTTC AGCCGCTGCA ACTCCGTCCG CGTGGACAGT 
GGCTGCTGGA TGCTCTATGA GCGACCCAAC TACCAGGGCC ACCAGTACTT CCTGCGACGC 
GGGGACTACC CTGACTACCA GCAGTGGATG GGTTTCAGCG ACTCCATTCG CTCCTGCCGC 
CTCATCCCCC ATCAGACAGG TTCCCACAGG ATGCGTCTGT ATGAGAAAGA AGATCACAAA 
GGCGTCATGA TGGAGCTGAG TGAAGACTGC TCCTGCATCC AGGACCGCTT CCACCTCAGT 
GAGGTGCGCT CGCTGCACGT GCTAGAGGGC TGCTGGGTCC TCTATGAGAT GTCTAACTAC 
CGAGGCCGGC AGTATCTGCT GAGGCCTCAA GAGTACCGGC GCTACCACGA CTGGGGCGCT 
GTAGATGCTA AGGCAGGCTC TTTGCGGAGG GTGGTAGATT TATACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family.
Molecular vision141272-6(2008 Jul)
Yao K,Jin C,Zhu N,Wang W,Wu R,Jiang J,Shentu X

Evaluation of three canine gamma-crystallins (CRYGB, CRYGC, and CRYGS) as candidates for hereditary cataracts in the dachshund.
Molecular vision13125-32(2007 Jan)
M?ller C,W?hlke A,Distl O

Genetic, age and light mediated effects on crystallin protein expression in the retina.
Photochemistry and photobiology82(4)1088-96(2006 Jul-Aug)
Organisciak D,Darrow R,Gu X,Barsalou L,Crabb JW

Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin.
Experimental cell research312(1)51-62(2006 Jan)
Pigaga V,Quinlan RA

Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.
Investigative ophthalmology & visual science45(4)1202-13(2004 Apr)
Graw J,Neuh?user-Klaus A,Klopp N,Selby PB,L?ster J,Favor J