Cel cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cel
Entrez Gene ID	24254
Full Name	carboxyl ester lipase
Synonyms	Bal,Bssl
General protein information	Preferred Names carboxyl ester lipase Names bile salt-activated lipase bile salt-stimulated lipase cholesterol esterase pancreatic lysophospholipase sterol esterase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p12
Summary	member of the serine esterase gene family; may have a short half-life in vivo [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016997.2	NP_058693.2	bile salt-activated lipase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CEL	XP_003951607.1
Gallus gallus (chicken)	CEL	NP_001013015.1
	CEL	XP_001118455.2
Mus musculus (house mouse)	Cel	NP_034015.1
Danio rerio (zebrafish)	cel.2	XP_005161146.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001722	XP_321363.4
Xenopus tropicalis (tropical clawed frog)	LOC100492444	XP_002936238.2
Bos taurus (cattle)	CEL	NP_001013601.1
Homo sapiens (human)	CEL	NP_001798.2
Canis lupus familiaris (dog)	CEL	XP_548401.1
Rattus norvegicus (Norway rat)	Cel	NP_058693.2
Danio rerio (zebrafish)	cel.1	NP_955901.1
Anopheles gambiae (African malaria mosquito)	COEAE1A	XP_321362.2
Anopheles gambiae (African malaria mosquito)	COEAE6O	XP_312052.3
Xenopus tropicalis (tropical clawed frog)	cel	NP_001120027.1

Gene Ontology
Bibliography

Related articles in PubMed

Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
Li X, Lindquist S, Lowe M, Noppa L, Hernell O
Pediatric research62(5)537-41(2007 Nov)

Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.
Raeder H, Haldorsen IS, Ersland L, Gr?ner R, Taxt T, S?vik O, Molven A, Nj?lstad PR
Diabetes56(2)444-9(2007 Feb)

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG, Cooper GJ
Proteomics6(7)2208-16(2006 Apr)

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bj?rkhaug L, Sagen JV, Aksnes L, S?vik O, Lombardo D, Molven A, Nj?lstad PR
Nature genetics38(1)54-62(2006 Jan)

Identity of a cytosolic neutral cholesterol esterase in rat liver with the bile salt stimulated cholesterol esterase in pancreas.
Camulli ED, Linke MJ, Brockman HL, Hui DY
Biochimica et biophysica acta1005(2)177-82(1989 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bile salt-stimulated lipase (BSSL) and PLRP2 is responsible for fat digestion as long as milk is the main food. Milk-borne BSSL is able to compensate for a slower ontogeny of pancreatic BSSL expression in the mouse.
Title: Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.

the distal basic cluster may represent the nonspecific (or pre-micellar) bile salt-binding site susceptible to accommodate primary and secondary bile salts.
Title: Site-directed mutagenesis of the distal basic cluster of pancreatic bile salt-dependent lipase.

The following Cel gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cel cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02437	NM_016997.2 Latest version!	Rattus norvegicus carboxyl ester lipase (Cel), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cel ( NM_016997.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058693.2 Rattus norvegicus carboxyl ester lipase (Cel), mRNA.

Price & Availability↑

CloneID	ORa02437
Clone ID Related Accession (Same CDS sequence)	NM_016997.2
Accession Version	NM_016997.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Rattus norvegicus(Norway rat)
Product	bile salt-activated lipase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC129847.5. On Jul 31, 2010 this sequence version replaced NM_016997.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M15893.1, X16054.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCGCC TGGAGGTTCT GTTTCTTGGC CTCACCTGCT GCTTGGCAGC TGCTTGTGCT 
GCAAAGTTGG GTGCTGTGTA CACAGAAGGC GGTTTTGTGG AGGGCGTCAA CAAGAAACTC 
AGTCTCTTGG GTGGTGACTC TGTTGACATC TTCAAGGGCA TCCCCTTTGC TACCGCCAAG 
ACCCTGGAGA ATCCTCAGCG TCACCCTGGC TGGCAAGGGA CACTGAAGGC TACAGACTTC 
AAGAAACGAT GTCTACAAGC CACCATCACC CAGGATGATA CCTATGGGCA AGAAGACTGC 
CTCTATCTCA ACATCTGGGT CCCTCAGGGC AGGAAGCAAG TGTCTCATGA CCTGCCTGTG 
ATGGTCTGGA TCTATGGAGG TGCCTTCCTC ATGGGGTCTG GCCAGGGAGC CAATTTTCTC 
AAGAATTACC TGTATGATGG GGAAGAGATC GCCACTAGAG GCAATGTCAT TGTGGTCACC 
TTCAACTACC GTGTCGGACC CTTGGGTTTC CTTAGCACCG GAGATGCTAA CCTTCCAGGT 
AACTTTGGAC TTCGAGATCA GCACATGGCT ATTGCCTGGG TGAAGAGGAA CATTGCAGCC 
TTTGGAGGAG ACCCCGATAA CATCACCATC TTTGGGGAAT CTGCTGGAGC TGCCAGTGTC 
TCTCTGCAGA CCCTCTCCCC ATACAACAAG GGCCTCATCC GGCGAGCCAT CAGTCAGAGT 
GGTGTGGCAC TGAGCCCCTG GGCCATCCAG GAGAATCCAC TTTTCTGGGC CAAAACGATC 
GCTAAGAAGG TGGGATGCCC CACAGAGGAT ACCGCCAAGA TGGCTGGGTG TCTGAAGATC 
ACAGATCCCC GAGCCTTGAC ACTGGCCTAT AGGTTGCCCT TGAAAAGCCA GGAGTACCCC 
ATTGTGCACT ACCTGGCCTT CATCCCTGTC GTCGATGGTG ACTTCATTCC TGATGATCCC 
ATCAACCTGT ACGACAACGC TGCTGACATT GACTACTTAG CGGGTATTAA TGACATGGAT 
GGCCACCTGT TTGCTACAGT TGACGTGCCC GCCATCGACA AGGCCAAGCA GGATGTCACA 
GAGGAGGACT TCTACAGGCT AGTCAGTGGA CACACTGTCG CCAAGGGGCT TAAAGGCACC 
CAAGCCACCT TTGACATCTA CACTGAGTCC TGGGCCCAGG ACCCGTCCCA GGAGAACATG 
AAGAAGACAG TGGTGGCCTT TGAGACTGAC ATACTCTTCC TGATCCCCAC AGAGATGGCT 
CTGGCCCAGC ACAGAGCCCA TGCCAAGAGT GCCAAGACCT ACTCTTACCT GTTTTCCCAC 
CCTTCACGAA TGCCTATCTA CCCAAAATGG ATGGGGGCAG ACCACGCTGA TGACCTCCAG 
TACGTCTTTG GGAAGCCCTT TGCCACCCCA CTGGGCTACC GGGCCCAAGA CAGGACTGTC 
TCCAAGGCCA TGATTGCCTA CTGGACCAAC TTTGCCAAGA GTGGGGACCC CAACATGGGC 
AACTCACCCG TGCCCACACA CTGGTACCCT TATACCACGG AGAATGGTAA CTACCTGGAC 
ATCAATAAGA AAATAACCAG CACCTCCATG AAGGAGCACC TAAGGGAAAA GTTCCTCAAG 
TTCTGGGCTG TGACATTCGA GATGCTGCCC ACTGTGGTTG GTGACCACAC TCCCCCTGAG 
GATGACTCAG AGGCTGCCCC CGTCCCACCT ACAGACGACT CCCAGGTTGT TCCTGTCCCA 
CCTACAGATG ACTCTCAGAC AACACCGGTG CCCCCAACAG ACAACTCTCA GGCTGGTGAC 
TCTGTGGAGG CTCAGATGCC TGTCGCCATT GGCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058693.2
CDS	22..1860
Translation	MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQVVPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPVAIGF

Target ORF information:

RefSeq Version	NM_016997.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus carboxyl ester lipase (Cel), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016997.2

ORF Insert Sequence:

ATGGGGCGCC TGGAGGTTCT GTTTCTTGGC CTCACCTGCT GCTTGGCAGC TGCTTGTGCT 
GCAAAGTTGG GTGCTGTGTA CACAGAAGGC GGTTTTGTGG AGGGCGTCAA CAAGAAACTC 
AGTCTCTTGG GTGGTGACTC TGTTGACATC TTCAAGGGCA TCCCCTTTGC TACCGCCAAG 
ACCCTGGAGA ATCCTCAGCG TCACCCTGGC TGGCAAGGGA CACTGAAGGC TACAGACTTC 
AAGAAACGAT GTCTACAAGC CACCATCACC CAGGATGATA CCTATGGGCA AGAAGACTGC 
CTCTATCTCA ACATCTGGGT CCCTCAGGGC AGGAAGCAAG TGTCTCATGA CCTGCCTGTG 
ATGGTCTGGA TCTATGGAGG TGCCTTCCTC ATGGGGTCTG GCCAGGGAGC CAATTTTCTC 
AAGAATTACC TGTATGATGG GGAAGAGATC GCCACTAGAG GCAATGTCAT TGTGGTCACC 
TTCAACTACC GTGTCGGACC CTTGGGTTTC CTTAGCACCG GAGATGCTAA CCTTCCAGGT 
AACTTTGGAC TTCGAGATCA GCACATGGCT ATTGCCTGGG TGAAGAGGAA CATTGCAGCC 
TTTGGAGGAG ACCCCGATAA CATCACCATC TTTGGGGAAT CTGCTGGAGC TGCCAGTGTC 
TCTCTGCAGA CCCTCTCCCC ATACAACAAG GGCCTCATCC GGCGAGCCAT CAGTCAGAGT 
GGTGTGGCAC TGAGCCCCTG GGCCATCCAG GAGAATCCAC TTTTCTGGGC CAAAACGATC 
GCTAAGAAGG TGGGATGCCC CACAGAGGAT ACCGCCAAGA TGGCTGGGTG TCTGAAGATC 
ACAGATCCCC GAGCCTTGAC ACTGGCCTAT AGGTTGCCCT TGAAAAGCCA GGAGTACCCC 
ATTGTGCACT ACCTGGCCTT CATCCCTGTC GTCGATGGTG ACTTCATTCC TGATGATCCC 
ATCAACCTGT ACGACAACGC TGCTGACATT GACTACTTAG CGGGTATTAA TGACATGGAT 
GGCCACCTGT TTGCTACAGT TGACGTGCCC GCCATCGACA AGGCCAAGCA GGATGTCACA 
GAGGAGGACT TCTACAGGCT AGTCAGTGGA CACACTGTCG CCAAGGGGCT TAAAGGCACC 
CAAGCCACCT TTGACATCTA CACTGAGTCC TGGGCCCAGG ACCCGTCCCA GGAGAACATG 
AAGAAGACAG TGGTGGCCTT TGAGACTGAC ATACTCTTCC TGATCCCCAC AGAGATGGCT 
CTGGCCCAGC ACAGAGCCCA TGCCAAGAGT GCCAAGACCT ACTCTTACCT GTTTTCCCAC 
CCTTCACGAA TGCCTATCTA CCCAAAATGG ATGGGGGCAG ACCACGCTGA TGACCTCCAG 
TACGTCTTTG GGAAGCCCTT TGCCACCCCA CTGGGCTACC GGGCCCAAGA CAGGACTGTC 
TCCAAGGCCA TGATTGCCTA CTGGACCAAC TTTGCCAAGA GTGGGGACCC CAACATGGGC 
AACTCACCCG TGCCCACACA CTGGTACCCT TATACCACGG AGAATGGTAA CTACCTGGAC 
ATCAATAAGA AAATAACCAG CACCTCCATG AAGGAGCACC TAAGGGAAAA GTTCCTCAAG 
TTCTGGGCTG TGACATTCGA GATGCTGCCC ACTGTGGTTG GTGACCACAC TCCCCCTGAG 
GATGACTCAG AGGCTGCCCC CGTCCCACCT ACAGACGACT CCCAGGTTGT TCCTGTCCCA 
CCTACAGATG ACTCTCAGAC AACACCGGTG CCCCCAACAG ACAACTCTCA GGCTGGTGAC 
TCTGTGGAGG CTCAGATGCC TGTCGCCATT GGCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
Pediatric research62(5)537-41(2007 Nov)
Li X,Lindquist S,Lowe M,Noppa L,Hernell O

Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.
Diabetes56(2)444-9(2007 Feb)
Raeder H,Haldorsen IS,Ersland L,Gr?ner R,Taxt T,S?vik O,Molven A,Nj?lstad PR

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Proteomics6(7)2208-16(2006 Apr)
Palmer DJ,Kelly VC,Smit AM,Kuy S,Knight CG,Cooper GJ

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
Nature genetics38(1)54-62(2006 Jan)
Raeder H,Johansson S,Holm PI,Haldorsen IS,Mas E,Sbarra V,Nermoen I,Eide SA,Grevle L,Bj?rkhaug L,Sagen JV,Aksnes L,S?vik O,Lombardo D,Molven A,Nj?lstad PR

Identity of a cytosolic neutral cholesterol esterase in rat liver with the bile salt stimulated cholesterol esterase in pancreas.
Biochimica et biophysica acta1005(2)177-82(1989 Sep)
Camulli ED,Linke MJ,Brockman HL,Hui DY

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Cel cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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