Cat cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cat
Entrez Gene ID	24248
Full Name	catalase
Synonyms	CS1,Cas1,Cat01,Catl,Cs-1
General protein information	Preferred Names catalase Names catalase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q32
Summary	functions as a hydrogen peroxide:hydrogen peroxide reductase [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012520.2	NP_036652.1	catalase

Pathways from BioSystems

Homologies

Homo sapiens (human)	CAT	NP_001743.1
Bos taurus (cattle)	CAT	NP_001030463.1
Rattus norvegicus (Norway rat)	Cat	NP_036652.1
Gallus gallus (chicken)	CAT	NP_001026386.1
Danio rerio (zebrafish)	cat	NP_570987.1
Eremothecium gossypii	AGOS_AGL256W	NP_986411.1
Arabidopsis thaliana (thale cress)	CAT2	NP_195235.1
Oryza sativa (rice)	Os03g0131200	NP_001048861.1
Mus musculus (house mouse)	Cat	NP_033934.2
Caenorhabditis elegans (roundworm)	ctl-3	NP_741058.1
Caenorhabditis elegans (roundworm)	ctl-2	NP_001022473.1
Saccharomyces cerevisiae (baker's yeast)	CTA1	NP_010542.1
Kluyveromyces lactis	KLLA0D11660g	XP_453581.1
	CAT	XP_001115625.1
Drosophila melanogaster (fruit fly)	Cat	NP_536731.1
Anopheles gambiae (African malaria mosquito)	CAT1	XP_314995.4
Schizosaccharomyces pombe (fission yeast)	ctt1	NP_587682.1
Xenopus tropicalis (tropical clawed frog)	cat.1	NP_001016716.1
Pan troglodytes (chimpanzee)	CAT	XP_001147928.1
Canis lupus familiaris (dog)	CAT	NP_001002984.1
Drosophila melanogaster (fruit fly)	CG9314	NP_001260268.1
Caenorhabditis elegans (roundworm)	ctl-1	NP_496979.2
Neurospora crassa	NCU05169	XP_961873.1
Arabidopsis thaliana (thale cress)	CAT1	NP_564121.1
Xenopus tropicalis (tropical clawed frog)	cat.2	NP_001072167.1

Gene Ontology
Bibliography

Related articles in PubMed

Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
Park C, Ji HM, Kim SJ, Kil SH, Lee JN, Kwak S, Choe SK, Park R
International journal of molecular medicine39(4)960-968(2017 Apr)

Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.
Ahn JH, Chen BH, Shin BN, Lee TK, Cho JH, Kim IH, Park JH, Lee JC, Tae HJ, Lee CH, Won MH, Lee YL, Choi SY, Hong S
Molecular medicine reports14(1)851-6(2016 Jul)

Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.
Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM
Hypertension (Dallas, Tex. : 1979)66(6)1240-50(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.

These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging.
Title: Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.

Catalase promoter region (-185 to +52) that contains binding sites for C/EBP-beta showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment
Title: Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-? in Adult Rats.

Data show that nuclear factor erythroid 2-related factor (Nrf2), superoxide dismutase Sod1 and catalase antioxidant systems are downregulated in isolated arteries and vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP).
Title: Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.

mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes.
Title: Influence of SkQ1 on Expression of Nrf2 Transcription Factor Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes.

The following Cat gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cat cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13645	NM_012520.2 Latest version!	Rattus norvegicus catalase (Cat), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cat ( NM_012520.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036652.1 Rattus norvegicus catalase (Cat), mRNA.

Price & Availability↑

CloneID	ORa13645
Clone ID Related Accession (Same CDS sequence)	NM_012520.2
Accession Version	NM_012520.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	catalase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM043772.1 and BC081853.1. On Aug 18, 2012 this sequence version replaced NM_012520.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081853.1, M11670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906351, SAMN01906353 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACA GCCGGGACCC AGCCAGCGAC CAGATGAAGC AGTGGAAGGA GCAGCGGGCC 
CCTCAGAAAC CCGATGTCCT GACCACCGGA GGCGGGAACC CAATAGGAGA TAAACTTAAT 
ATCATGACTG CGGGGCCCCG AGGGCCCCTC CTCGTTCAAG ATGTGGTTTT CACCGACGAG 
ATGGCACACT TTGACAGAGA GCGGATTCCT GAGAGAGTGG TACATGCAAA GGGAGCAGGT 
GCTTTTGGAT ACTTTGAGGT CACCCACGAT ATTACCAGAT ACTCCAAGGC AAAGGTGTTT 
GAGCATATTG GGAAGAGGAC TCCTATTGCC GTCCGATTCT CCACAGTCGC TGGAGAGTCA 
GGCTCAGCTG ACACAGTTCG TGACCCTCGT GGGTTTGCAG TGAAATTCTA CACTGAAGAT 
GGTAACTGGG ACCTTGTGGG AAACAACACC CCTATTTTCT TCATCAGGGA TGCCATGTTG 
TTTCCATCCT TTATCCATAG CCAGAAGAGA AACCCACAAA CTCACCTGAA GGACCCTGAC 
ATGGTCTGGG ACTTCTGGAG TCTTTGTCCA GAGTCTCTCC ATCAGGTTAC TTTCTTGTTC 
AGCGACCGAG GGATTCCAGA TGGACATCGG CACATGAATG GCTATGGCTC ACACACCTTC 
AAGCTGGTTA ATGCGAATGG AGAGGCAGTG TACTGCAAGT TCCATTACAA GACTGACCAG 
GGCATCAAAA ACTTGCCTGT TGAAGAGGCA GGAAGACTTG CACAGGAAGA CCCGGATTAT 
GGCCTCCGAG ATCTTTTCAA TGCCATCGCC AGTGGCAATT ACCCATCCTG GACTTTTTAC 
ATCCAGGTCA TGACTTTCAA GGAGGCAGAA ACCTTCCCAT TTAATCCATT TGACCTGACC 
AAGGTTTGGC CTCACAAGGA CTACCCTCTT ATACCAGTTG GCAAACTGGT CTTAAACAGA 
AATCCTGCTA ATTATTTTGC TGAAGTTGAA CAGATGGCTT TTGACCCAAG CAACATGCCC 
CCTGGCATTG AGCCCAGCCC GGACAAGATG CTCCAGGGCC GCCTTTTTGC TTACCCAGAC 
ACTCACCGCC ACCGCCTGGG ACCAAACTAT CTGCAGATAC CTGTGAACTG TCCCTACCGT 
GCTCGCGTGG CCAACTACCA GCGCGATGGC CCCATGTGCA TGCATGACAA CCAGGGTGGT 
GCTCCCAACT ACTACCCCAA CAGCTTCAGC GCACCAGAGC AGCAGGGCTC GGCCCTGGAG 
CACCATAGCC AGTGCTCTGC AGATGTGAAG CGCTTCAACA GTGCTAATGA AGACAACGTC 
ACTCAGGTGC GGACATTCTA TACGAAGGTG TTGAATGAGG AGGAGAGGAA ACGCCTGTGT 
GAGAACATTG CCAACCACCT GAAAGATGCT CAGCTTTTCA TTCAGAGGAA AGCGGTCAAG 
AATTTCACTG ACGTCCACCC TGACTACGGG GCCCGAGTCC AGGCTCTTCT GGACCAGTAC 
AACTCCCAGA AGCCTAAGAA TGCAATTCAC ACCTACGTAC AGGCCGGCTC TCACATAGCT 
GCCAAGGGAA AAGCTAACCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036652.1
CDS	133..1716
Translation	MADSRDPASDQMKQWKEQRAPQKPDVLTTGGGNPIGDKLNIMTAGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAMLFPSFIHSQKRNPQTHLKDPDMVWDFWSLCPESLHQVTFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLPVEEAGRLAQEDPDYGLRDLFNAIASGNYPSWTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPANYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQGSALEHHSQCSADVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIANHLKDAQLFIQRKAVKNFTDVHPDYGARVQALLDQYNSQKPKNAIHTYVQAGSHIAAKGKANL

Target ORF information:

RefSeq Version	NM_012520.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus catalase (Cat), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012520.2

ORF Insert Sequence:

ATGGCGGACA GCCGGGACCC AGCCAGCGAC CAGATGAAGC AGTGGAAGGA GCAGCGGGCC 
CCTCAGAAAC CCGATGTCCT GACCACCGGA GGCGGGAACC CAATAGGAGA TAAACTTAAT 
ATCATGACTG CGGGGCCCCG AGGGCCCCTC CTCGTTCAAG ATGTGGTTTT CACCGACGAG 
ATGGCACACT TTGACAGAGA GCGGATTCCT GAGAGAGTGG TACATGCAAA GGGAGCAGGT 
GCTTTTGGAT ACTTTGAGGT CACCCACGAT ATTACCAGAT ACTCCAAGGC AAAGGTGTTT 
GAGCATATTG GGAAGAGGAC TCCTATTGCC GTCCGATTCT CCACAGTCGC TGGAGAGTCA 
GGCTCAGCTG ACACAGTTCG TGACCCTCGT GGGTTTGCAG TGAAATTCTA CACTGAAGAT 
GGTAACTGGG ACCTTGTGGG AAACAACACC CCTATTTTCT TCATCAGGGA TGCCATGTTG 
TTTCCATCCT TTATCCATAG CCAGAAGAGA AACCCACAAA CTCACCTGAA GGACCCTGAC 
ATGGTCTGGG ACTTCTGGAG TCTTTGTCCA GAGTCTCTCC ATCAGGTTAC TTTCTTGTTC 
AGCGACCGAG GGATTCCAGA TGGACATCGG CACATGAATG GCTATGGCTC ACACACCTTC 
AAGCTGGTTA ATGCGAATGG AGAGGCAGTG TACTGCAAGT TCCATTACAA GACTGACCAG 
GGCATCAAAA ACTTGCCTGT TGAAGAGGCA GGAAGACTTG CACAGGAAGA CCCGGATTAT 
GGCCTCCGAG ATCTTTTCAA TGCCATCGCC AGTGGCAATT ACCCATCCTG GACTTTTTAC 
ATCCAGGTCA TGACTTTCAA GGAGGCAGAA ACCTTCCCAT TTAATCCATT TGACCTGACC 
AAGGTTTGGC CTCACAAGGA CTACCCTCTT ATACCAGTTG GCAAACTGGT CTTAAACAGA 
AATCCTGCTA ATTATTTTGC TGAAGTTGAA CAGATGGCTT TTGACCCAAG CAACATGCCC 
CCTGGCATTG AGCCCAGCCC GGACAAGATG CTCCAGGGCC GCCTTTTTGC TTACCCAGAC 
ACTCACCGCC ACCGCCTGGG ACCAAACTAT CTGCAGATAC CTGTGAACTG TCCCTACCGT 
GCTCGCGTGG CCAACTACCA GCGCGATGGC CCCATGTGCA TGCATGACAA CCAGGGTGGT 
GCTCCCAACT ACTACCCCAA CAGCTTCAGC GCACCAGAGC AGCAGGGCTC GGCCCTGGAG 
CACCATAGCC AGTGCTCTGC AGATGTGAAG CGCTTCAACA GTGCTAATGA AGACAACGTC 
ACTCAGGTGC GGACATTCTA TACGAAGGTG TTGAATGAGG AGGAGAGGAA ACGCCTGTGT 
GAGAACATTG CCAACCACCT GAAAGATGCT CAGCTTTTCA TTCAGAGGAA AGCGGTCAAG 
AATTTCACTG ACGTCCACCC TGACTACGGG GCCCGAGTCC AGGCTCTTCT GGACCAGTAC 
AACTCCCAGA AGCCTAAGAA TGCAATTCAC ACCTACGTAC AGGCCGGCTC TCACATAGCT 
GCCAAGGGAA AAGCTAACCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
International journal of molecular medicine39(4)960-968(2017 Apr)
Park C,Ji HM,Kim SJ,Kil SH,Lee JN,Kwak S,Choe SK,Park R

Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.
Molecular medicine reports14(1)851-6(2016 Jul)
Ahn JH,Chen BH,Shin BN,Lee TK,Cho JH,Kim IH,Park JH,Lee JC,Tae HJ,Lee CH,Won MH,Lee YL,Choi SY,Hong S

Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.
Hypertension (Dallas, Tex. : 1979)66(6)1240-50(2015 Dec)
Lopes RA,Neves KB,Tostes RC,Montezano AC,Touyz RM

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Cat cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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