Calm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Calm1
Entrez Gene ID	24242
Full Name	calmodulin 1
Synonyms	CaMI,Calm,Cam1
General protein information	Preferred Names calmodulin 1 Names calmodulin-1 Calmodulin 1 (phosphorylase kinase, delta) caM calmodulin I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	may mediate calcium-dependent modulation of KCNQ channels; exists in two alternative splice forms [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031969.2	NP_114175.1	calmodulin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CALM3	XP_533635.1
Bos taurus (cattle)	CALM3	NP_001039714.1
Mus musculus (house mouse)	Calm1	NP_033920.1
Mus musculus (house mouse)	Calm2	NP_031615.1
Rattus norvegicus (Norway rat)	Calm2	NP_059022.1
Danio rerio (zebrafish)	calm1b	NP_956376.1
Danio rerio (zebrafish)	calm3b	NP_955864.1
Canis lupus familiaris (dog)	CALM2	XP_864645.2
Mus musculus (house mouse)	Calm3	NP_031616.1
Drosophila melanogaster (fruit fly)	Cam	NP_001246276.1
Xenopus tropicalis (tropical clawed frog)	calm2	NP_001008160.1
Pan troglodytes (chimpanzee)	CALM1	NP_001104289.1
Canis lupus familiaris (dog)	CALM1	XP_537537.1
Bos taurus (cattle)	CALM1	NP_001229501.1
Rattus norvegicus (Norway rat)	Calm3	NP_036650.1
Rattus norvegicus (Norway rat)	Calm1	NP_114175.1
Danio rerio (zebrafish)	calm2a	NP_956290.1
Caenorhabditis elegans (roundworm)	cmd-1	NP_503386.1
Arabidopsis thaliana (thale cress)	CAM2	NP_001189724.1
Oryza sativa (rice)	Os01g0279300	NP_001042747.1
Xenopus tropicalis (tropical clawed frog)	LOC100496298	XP_002932424.1
	LOC706351	XP_001094720.1
Bos taurus (cattle)	CALM2	NP_001229516.1
Danio rerio (zebrafish)	calm1a	NP_998516.1
Danio rerio (zebrafish)	calm2b	NP_999901.1
Gallus gallus (chicken)	CALM	NP_990336.1
Danio rerio (zebrafish)	calm3a	NP_892012.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010957	XP_309749.4

Gene Ontology
Bibliography

Related articles in PubMed

Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.
Wang J, Qi C, Liu L, Zhao L, Cui W, Tian Y, Liu B, Li J
International heart journal(2017 Dec)

Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.
Strulovich R, Tobelaim WS, Attali B, Hirsch JA
Biochemistry55(38)5353-65(2016 09)

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.
Yu CC, Ko JS, Ai T, Tsai WC, Chen Z, Rubart M, Vatta M, Everett TH 4th, George AL Jr, Chen PS
Heart rhythm13(8)1716-23(2016 08)

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)

Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.
Furuya Y, Denda M, Sakane K, Ogusu T, Takahashi S, Magari M, Kanayama N, Morishita R, Tokumitsu H
Cell calcium60(1)32-40(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest a connection between Ca(2+)-signaling via excitation-contraction coupling and the regulation of STARS-mediated gene expression in muscles.
Title: Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.

Hydrogen peroxide reduces calmodulin binding to RYR2 in rat cardiomyocytes.
Title: Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.

Study reveals that apoCaM itself prominently regulates both voltage-gated Ca2+ and Na channels; ApoCaM binding to these channels enhances opening several-fold, matching the strongest forms of ion-channel regulation.
Title: Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation.

CK2-mediated phosphorylation of calmodulin regulates the M-current, which is tonically regulated by CK2 and PP1 anchored to the KCNQ2 channel complex.
Title: Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.

Disruption of calmodulin binding to KCNQ2 also impairs enrichment of heteromeric KCNQ2/KCNQ3 channels at the axonal surface by blocking their trafficking from the endoplasmic reticulum to the axon.
Title: Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.

The following Calm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Calm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08867	NM_031969.2 Latest version!	Rattus norvegicus calmodulin 1 (Calm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Calm1 ( NM_031969.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114175.1 Rattus norvegicus calmodulin 1 (Calm1), mRNA.

Price & Availability↑

CloneID	ORa08867
Clone ID Related Accession (Same CDS sequence)	NM_031969.2
Accession Version	NM_031969.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	calmodulin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X13933.1. On or before Jul 25, 2007 this sequence version replaced NM_001007614.1, NM_031969.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X13933.1, FQ225380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGATC AGCTGACTGA AGAACAGATT GCTGAATTCA AGGAAGCTTT CTCCCTATTT 
GATAAAGATG GGGACGGCAC CATCACAACA AAGGAGCTGG GGACTGTCAT GCGGTCACTG 
GGTCAGAACC CAACAGAGGC TGAACTGCAG GATATGATCA ACGAGGTGGA TGCCGACGGG 
AATGGCACCA TTGACTTCCC AGAGTTCTTG ACTATGATGG CTAGAAAAAT GAAAGACACA 
GATAGCGAAG AAGAAATCCG TGAGGCATTC CGAGTCTTTG ACAAGGATGG CAATGGCTAC 
ATCAGTGCGG CAGAACTGCG CCACGTCATG ACAAACCTCG GGGAAAAGCT AACAGATGAA 
GAAGTAGACG AAATGATCAG AGAAGCAGAT ATTGATGGAG ACGGACAGGT CAACTATGAA 
GAATTCGTAC AGATGATGAC TGCAAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114175.1
CDS	113..562
Translation	MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_031969.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calmodulin 1 (Calm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031969.2

ORF Insert Sequence:

ATGGCTGATC AGCTGACTGA AGAACAGATT GCTGAATTCA AGGAAGCTTT CTCCCTATTT 
GATAAAGATG GGGACGGCAC CATCACAACA AAGGAGCTGG GGACTGTCAT GCGGTCACTG 
GGTCAGAACC CAACAGAGGC TGAACTGCAG GATATGATCA ACGAGGTGGA TGCCGACGGG 
AATGGCACCA TTGACTTCCC AGAGTTCTTG ACTATGATGG CTAGAAAAAT GAAAGACACA 
GATAGCGAAG AAGAAATCCG TGAGGCATTC CGAGTCTTTG ACAAGGATGG CAATGGCTAC 
ATCAGTGCGG CAGAACTGCG CCACGTCATG ACAAACCTCG GGGAAAAGCT AACAGATGAA 
GAAGTAGACG AAATGATCAG AGAAGCAGAT ATTGATGGAG ACGGACAGGT CAACTATGAA 
GAATTCGTAC AGATGATGAC TGCAAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.
International heart journal(2017 Dec)
Wang J,Qi C,Liu L,Zhao L,Cui W,Tian Y,Liu B,Li J

Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.
Biochemistry55(38)5353-65(2016 09)
Strulovich R,Tobelaim WS,Attali B,Hirsch JA

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.
Heart rhythm13(8)1716-23(2016 08)
Yu CC,Ko JS,Ai T,Tsai WC,Chen Z,Rubart M,Vatta M,Everett TH 4th,George AL Jr,Chen PS

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)
Gomez-Hurtado N,Boczek NJ,Kryshtal DO,Johnson CN,Sun J,Nitu FR,Cornea RL,Chazin WJ,Calvert ML,Tester DJ,Ackerman MJ,Knollmann BC

Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.
Cell calcium60(1)32-40(2016 Jul)
Furuya Y,Denda M,Sakane K,Ogusu T,Takahashi S,Magari M,Kanayama N,Morishita R,Tokumitsu H

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Calm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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