Avp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Avp
Entrez Gene ID	24221
Full Name	arginine vasopressin
Synonyms	DI,VP,Vas
General protein information	Preferred Names arginine vasopressin Names vasopressin-neurophysin 2-copeptin AVP-NPII arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping) prepropressophysin preprovasopressin-neurophysin vasopressin vasopressin-neurophysin prepropeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q36
Summary	neuropeptide hormone; involved in vasoconstriction to regulate blood pressure and smooth muscle contraction during parturition and lactation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016992.2	NP_058688.2	vasopressin-neurophysin 2-copeptin preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AVP	XP_001160259.1
	AVP	XP_001115061.1
Rattus norvegicus (Norway rat)	Avp	NP_058688.2
Bos taurus (cattle)	AVP	NP_789824.1
Danio rerio (zebrafish)	oxt	NP_840076.1
Gallus gallus (chicken)	AVP	NP_990516.1
Xenopus tropicalis (tropical clawed frog)	avp	XP_002936404.1
Homo sapiens (human)	AVP	NP_000481.2
Canis lupus familiaris (dog)	AVP	NP_001184078.1
Mus musculus (house mouse)	Avp	NP_033862.1

Gene Ontology
Bibliography

Related articles in PubMed

Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rat.
Kim YB, Kim WB, Jung WW, Jin X, Kim YS, Kim B, Han HC, Block GD, Colwell CS, Kim YI
Diabetes(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aroclor-1254 may interfere with the activation of AVP mRNA transcript levels and protein, causing a central dysfunction of vasopressinergic system.
Title: Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats.

Under long term stressed conditions, the release of AVP and OXT from hypothalamus may vary depending on the content of the stressors. Central AVP appears to act oppositely to OXT by mediating CHeS-induced gastric motor maladaptation. Long term central AVP antagonism might be a pharmacological approach for the treatment of stress-related gastric motility disorders.
Title: Opposite effects of central oxytocin and arginine vasopressin on changes in gastric motor function induced by chronic stress.

This study deminstrated that Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats.
Title: Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats.

The present study suggests that the Avp gene plays an important role in social development.
Title: Atypical Social Development in Vasopressin-Deficient Brattleboro Rats.

The results of this study showed that arginine vasopressin increases in both sexs rats with aneurysmal subarachnoid hemorrhage.
Title: Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.

The following Avp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Avp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13580	NM_016992.2 Latest version!	Rattus norvegicus arginine vasopressin (Avp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Avp ( NM_016992.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058688.2 Rattus norvegicus arginine vasopressin (Avp), mRNA.

Price & Availability↑

CloneID	ORa13580
Clone ID Related Accession (Same CDS sequence)	NM_016992.2
Accession Version	NM_016992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Rattus norvegicus(Norway rat)
Product	vasopressin-neurophysin 2-copeptin preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M25646.1. On Mar 23, 2010 this sequence version replaced NM_016992.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M25646.1, CB794131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTCGCCA TGATGCTCAA CACTACGCTC TCTGCTTGCT TCCTGAGCCT GCTGGCCCTC 
ACCTCTGCCT GCTACTTCCA GAACTGCCCA AGAGGAGGCA AGAGGGCCAC ATCCGACATG 
GAGCTGAGAC AGTGTCTCCC CTGCGGCCCT GGCGGCAAAG GGCGCTGCTT CGGGCCGAGC 
ATCTGCTGCG CGGACGAGCT GGGCTGCTTC CTGGGCACCG CCGAGGCGCT GCGCTGCCAG 
GAGGAGAACT ACCTGCCCTC GCCCTGCCAG TCTGGCCAGA AGCCTTGCGG AAGCGGAGGC 
CGCTGCGCTG CCGCGGGCAT CTGCTGCAGC GATGAGAGCT GCGTGGCCGA GCCCGAGTGT 
CGAGAGGGTT TTTTCCGCCT CACCCGCGCT CGGGAGCAGA GCAACGCCAC GCAGCTGGAC 
GGGCCAGCCC GGGAGCTGCT GCTTAGGCTG GTACAGCTGG CTGGGACACA AGAGTCCGTG 
GATTCTGCCA AGCCCCGGGT CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058688.2
CDS	21..527
Translation	MLAMMLNTTLSACFLSLLALTSACYFQNCPRGGKRATSDMELRQCLPCGPGGKGRCFGPSICCADELGCFLGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSDESCVAEPECREGFFRLTRAREQSNATQLDGPARELLLRLVQLAGTQESVDSAKPRVY

Target ORF information:

RefSeq Version	NM_016992.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arginine vasopressin (Avp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016992.2

ORF Insert Sequence:

ATGCTCGCCA TGATGCTCAA CACTACGCTC TCTGCTTGCT TCCTGAGCCT GCTGGCCCTC 
ACCTCTGCCT GCTACTTCCA GAACTGCCCA AGAGGAGGCA AGAGGGCCAC ATCCGACATG 
GAGCTGAGAC AGTGTCTCCC CTGCGGCCCT GGCGGCAAAG GGCGCTGCTT CGGGCCGAGC 
ATCTGCTGCG CGGACGAGCT GGGCTGCTTC CTGGGCACCG CCGAGGCGCT GCGCTGCCAG 
GAGGAGAACT ACCTGCCCTC GCCCTGCCAG TCTGGCCAGA AGCCTTGCGG AAGCGGAGGC 
CGCTGCGCTG CCGCGGGCAT CTGCTGCAGC GATGAGAGCT GCGTGGCCGA GCCCGAGTGT 
CGAGAGGGTT TTTTCCGCCT CACCCGCGCT CGGGAGCAGA GCAACGCCAC GCAGCTGGAC 
GGGCCAGCCC GGGAGCTGCT GCTTAGGCTG GTACAGCTGG CTGGGACACA AGAGTCCGTG 
GATTCTGCCA AGCCCCGGGT CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rat.
Diabetes(2017 Dec)
Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI