Atp7b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp7b
Entrez Gene ID	24218
Full Name	ATPase copper transporting beta
Synonyms	Hts,PINA,Wd
General protein information	Preferred Names ATPase copper transporting beta Names copper-transporting ATPase 2 ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease) PINA gene, promoter copper pump 2 pineal night-specific ATPase wilson disease-associated protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	plays a role in copper ion transport; partial gene deletion in the Long-Evans Cinnamon (LEC) strain is a model for Wilson disease [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599991.1	XP_017455480.1	copper-transporting ATPase 2 isoform X1
NM_012511.2	NP_036643.2	copper-transporting ATPase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Atp7b	NP_036643.2
Bos taurus (cattle)	ATP7B	XP_002691840.1
Danio rerio (zebrafish)	atp7b	XP_684415.5
Homo sapiens (human)	ATP7B	NP_000044.2
	ATP7B	XP_001103242.2
Mus musculus (house mouse)	Atp7b	NP_031537.2
Arabidopsis thaliana (thale cress)	RAN1	NP_199292.1
Oryza sativa (rice)	Os02g0172600	NP_001046033.1
Pan troglodytes (chimpanzee)	LOC452734	XP_003314205.1
Canis lupus familiaris (dog)	ATP7B	NP_001020438.1
Gallus gallus (chicken)	ATP7B	XP_417073.3
Xenopus tropicalis (tropical clawed frog)	atp7b	XP_002936778.2

Gene Ontology
Bibliography

Related articles in PubMed

Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model.
Papur OS, Terzioglu O, Koc A
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)3133-6(2015)

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.
Jain S, Far?as GG, Bonifacino JS
Molecular biology of the cell26(2)218-28(2015 Jan)

Regulation of copper transport crossing brain barrier systems by Cu-ATPases: effect of manganese exposure.
Fu X, Zhang Y, Jiang W, Monnot AD, Bates CA, Zheng W
Toxicological sciences : an official journal of the Society of Toxicology139(2)432-51(2014 Jun)

Subcellular targets of cisplatin cytotoxicity: an integrated view.
Sancho-Mart?nez SM, Prieto-Garc?a L, Prieto M, L?pez-Novoa JM, L?pez-Hern?ndez FJ
Pharmacology & therapeutics136(1)35-55(2012 Oct)

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.
Materia S, Cater MA, Klomp LW, Mercer JF, La Fontaine S
The Journal of biological chemistry287(4)2485-99(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate dileucine-dependent binding of the C-terminal tail of copper transporter ATP7B to sigma1 subunit of the clathrin adaptor AP-1.
Title: Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.
Title: Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.

Adult rat DRG tissue exhibits a specific pattern of expression of copper transporters with distinct subsets of peripheral sensory neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B.
Title: Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue.

Immunofluorescent studies in frozen sections of human and rat skin utilizing a Wilson protein antibody demonstrated abundant expression of the Wilson protein in the secretory and ductular epithelial cells of the sweat glands both in human and rat.
Title: Wilson protein expression, copper excretion and sweat production in sweat glands of Wilson disease patients and controls.

study concludes that liver ischemia and ischemia-reperfusion induction and trafficking Atp7b to the bile duct canaliculi may contribute to preferential iron transport into bile
Title: Liver ischemia and ischemia-reperfusion induces and trafficks the multi-specific metal transporter Atp7b to bile duct canaliculi: possible preferential transport of iron into bile.

The following Atp7b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp7b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00145	NM_012511.2 Latest version!	Rattus norvegicus ATPase copper transporting beta (Atp7b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
ORa37508	XM_017599991.1 Latest version!	Rattus norvegicus ATPase copper transporting beta (Atp7b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp7b ( NM_012511.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036643.2 Rattus norvegicus ATPase copper transporting beta (Atp7b), mRNA.

Price & Availability↑

CloneID	ORa00145
Clone ID Related Accession (Same CDS sequence)	NM_012511.2
Accession Version	NM_012511.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Rattus norvegicus(Norway rat)
Product	copper-transporting ATPase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB017792.1 and AABR07026392.1. On Oct 11, 2007 this sequence version replaced NM_012511.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB017791.1, U08344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAAC AGGAGAGAAA GGTCACAGCC AAAGAGGCCA GTCGGAAAAT CTTATCTAAA 
CTTGCTTTGC CCACACGACC GTGGGGACAA TCAATGAAGC AGAGCTTCGC CTTCGATAAT 
GTTGGCTATG AAGGGGGCCT GGACAGCACC TGCTCATCCT CAACTACCAC CGGTGTGGTT 
AGCATCCTGG GCATGACTTG TCATTCTTGC GTCAAGTCCA TCGAGGACAG GATCTCCAGT 
CTGAAAGGCA TTGTGAGCAT CAAGGTTTCT CTGGAGCAGG GCAGCGCCAC TGTCAAATAT 
GTACCGTCAG TCTTGAACCT GCAGCAGATT TGCCTTCAGA TTGAGGACAT GGGCTTTGAG 
GCCAGCGCTG CAGAAGGAAA GGCTGCCTCC TGGCCTTCCA GGTCTTCCCC AGCCCAGGAG 
GCAGTGGTCA AGCTCCGGGT AGAGGGCATG ACCTGTCAGT CCTGTGTCAG CTCCATCGAA 
GGCAAGATCC GGAAGCTGCA AGGGGTTGTG AGAGTCAAAG TCTCCCTAAG CAACCAAGAG 
GCAGTCATTA CATATCAGCC TTACCTCATT CAACCCGAAG ACCTCAGGGA CCACATCTGC 
GACATGGGAT TCGAAGCTGC CATCAAGAAC AGAACAGCTC CCTTAAGGCT GGGACCAATT 
GATATCAACA AGTTAGAAAG CACTAACCTA AAGAGAGCAG CAGTCCCTCC TATCCAGAAT 
TCCAATCATT TGGAGACCCC GGGGCACCAG CAGAACCACC TGGCCACCCT CCCACTAAGA 
ATAGACGGGA TGCACTGTAA ATCATGTGTT TTGAATATCG AAGGAAATAT AGGCCAACTT 
CCAGGGGTTC AAAATATTCA TGTGTCCTTG GAGAACAAAA CCGCCCAAGT ACAGTATGAC 
TCTTCTTGTA TCACCCCCTT GTTCCTACAG ACAGCCATCG AGGCACTACC ACCTGGGTAC 
TTTAAAGTAT CCCTTCCCGA TGGCCTAGAG AAGGAGAGTG GATCTTCCAG TGTCCCCTCC 
CTTGGCTCCT CCCAGAGACA GCAGGAGCCA GGCCCATGCA GGACTGCGGT ACTCACCATC 
ACTGGCATTC CCCGTGACTC GTCTGTTCAG CCCATGGAAG ACATGCTGTC CCAGATGAAG 
GGTGTGCAGC AAATAGACAT CTCTTTGGCA GAGGGGACTG GAGCAGTTCT TTACGATCCC 
TCAGTAGTTA GCTCGGATGA ACTCCGGACG GCTGTAGAAG ACATGGGCTT TGAGGTGTCA 
GTGAATCCCG AAAACATTAC TACTAACCGT GTCAGCTCTG GGAATTCTGT GCCACAAGCC 
GTGGGTGATT CACCAGGGTC TGTGCAAAAT ATGGCTTCTG ACACTAGAGG ACTCCTCACA 
CACCAAGGCC CTGGCTACTT GTCAGACAGC CCACCATCCC CTGGAGGAAC AGCATCACAG 
AAGTGCTTTG TACAGATCAA AGGCATGACC TGTGCGTCCT GTGTGTCTAA CATAGAAAGG 
AGTCTGCAGA GACATGCCGG TATTCTCTCC GTGTTGGTCG CCTTGATGTC GGGAAAGGCA 
GAGGTCAAGT ATGACCCAGA GGTCATCCAG TCTCCCAGGA TAGCTCAGCT CATCGAGGAC 
CTGGGCTTCG AAGCAGCAAT CATGGAGGAC AACACAGTCT CTGAAGGTGA CATCGAACTG 
ATTATCACAG GGATGACCTG CGCTTCCTGT GTTCACAACA TAGAATCTAA GCTCACAAGG 
ACAAATGGCA TCACTTACGC CTCTGTGGCC CTCGCCACCA GCAAAGCCCA TGTGAAGTTT 
GACCCTGAAA TCATTGGTCC ACGTGACATC ATCAAGGTCA TCGAGGAAAT CGGCTTTCAT 
GCTTCCCTGG CCCACAGAAA CCCCAACGCT CATCACTTGG ACCACAAGAC GGAAATAAAA 
CAGTGGAAGA AATCTTTCCT GTGCAGCCTG GTGTTTGGCA TCCCCGTCAT GGGCTTGATG 
ATCTACATGC TAATCCCCAG CAGTAAGCCC CACGAGACCA TGGTCCTGGA CCACAACATC 
ATTCCAGGAC TGTCCGTTCT AAACCTCATT TTCTTCATCT TGTGTACCTT CGTCCAATTC 
CTGGGTGGGT GGTACTTCTA TGTCCAAGCC TACAAATCGC TGAGACACAA GTCAGCCAAC 
ATGGATGTGC TCATCGTACT CGCCACGACC ATTGCCTATG CCTACTCCCT GGTCATCCTG 
GTGGTTGCCA TAGCTGAAAA GGCGGAGAAG AGCCCAGTGA CCTTCTTTGA CACACCCCCC 
ATGCTCTTCG TCTTCATCGC CCTGGGACGG TGGCTGGAGC ACGTGGCAAA GAGCAAAACT 
TCAGAAGCCC TCGCAAAACT CATGTCACTC CAAGCCACAG AAGCCACAGT TGTGACCCTG 
GGAGAGGACA ACTTAATCCT CAGAGAGGAG CAAGTGCCCA TGGAGCTGGT GCAGCGAGGT 
GACATCATCA AGGTTGTCCC TGGGGGCAAG TTCCCAGTGG ACGGGAAAGT CCTGGAAGGC 
AACACCATGG CAGATGAGTC CCTCATCACA GGAGAGGCCA TGCCTGTCAC CAAGAAACCC 
GGGAGCATAG TGATTGCTGG CTCTATAAAT GCTCATGGCT CTGTGCTCAT TAAAGCTACC 
CATGTGGGCA ATGACACTAC TTTGGCTCAG ATTGTCAAGT TGGTGGAAGA GGCCCAGATG 
TCAAAGGCTC CCATTCAGCA GCTGGCTGAC CGGTTCAGTG GATATTTCGT CCCATTTATC 
ATCATTATTT CAACCTTAAC ATTGGTGGTG TGGATCATCA TCGGCTTTGT CGATTTTGGT 
ATTGTTCAGA AGTACTTTCC TAGCCCTAGC AAGCATATCT CACAGACAGA GGTGATCATC 
CGCTTTGCCT TCCAGACGTC CATCACCGTC CTGTGCATCG CCTGCCCCTG CTCCCTCGGG 
CTGGCCACAC CCACAGCAGT TATGGTGGGC ACTGGGGTGG CTGCCCAGAA CGGCGTCCTA 
ATCAAGGGAG GGAAGCCTCT GGAGATGGCA CACAAGATAA AGACCGTTAT GTTTGACAAA 
ACGGGCACCA TTACCCACGG GGTCCCCAGA GTCATGCGGT TTCTGCTGCT TGTGGACGTG 
GCTACCCTAT CCCTCAGGAA GGTTCTGGCT GTGGTGGGCA CCGCAGAGGC CAGCAGTGAG 
CACCCCTTAG GCGTGGCCGT CACTAAATAC TGCAAAGAGG AACTCGGGAC GGAGACCCTG 
GGGTACAGCA CGGACTTCCA GGCAGTGCCA GGGTGTGGAA TTAGCTGCAA AGTTAGCAAC 
GTGGAAAGTA TCCTGGCTCA CAGAGGTCCA ACCGCTCACC CGATTGGGGT TGGCAACCCT 
CCCATAGGAG AAGGTACAGG TCCCCAGACT TTCTCTGTGC TGATTGGAAA CCGGGAATGG 
ATGAGGCGCA ATGGTTTAAC CATCTCCAGT GACATCAGTG ACGCCATGAC AGATCATGAA 
ATGAAAGGAC AGACGGCCAT CCTGGTGGCC ATTGATGGTG TGCTGTGCGG GATGATCGCC 
ATTGCAGATG CTGTTAAACC AGAGGCTGCC CTGGCTATCT ACACCCTGAA AAGCATGGGC 
GTGGATGTGG CTCTGATCAC AGGGGACAAC CGGAAGACAG CCAGAGCCAT TGCCACTCAG 
GTTGGCATCA ACAAAGTCTT TGCTGAGGTA CTGCCTTCTC ACAAGGTGGC CAAGGTCCAG 
GAGCTTCAGA ACAAAGGGAA AAAAGTCGCC ATGGTGGGAG ACGGGGTGAA CGACTCCCCA 
GCCTTGGCCC AGGCTGACGT GGGCATTGCT ATTGGGACTG GGACAGATGT CGCCATCGAA 
GCAGCCGACG TGGTCCTTAT AAGAAATGAC TTACTGGACG TGGTGGCCAG CATTCATCTC 
TCCAAGAGGA CCGTCCGGAG GATCCGGGTC AATCTGGTGC TGGCGTTGAT TTATAACATG 
GTTGGGATAC CCATTGCTGC AGGTGTCTTC ATGCCCATTG GCATCGTGCT GCAGCCATGG 
ATGGGCTCAG CGGCCATGGC CGCCTCCTCT GTGTCCGTGG TGCTCTCCTC TCTTCAGCTC 
AAGTGCTACA GAAAGCCCGA CCTAGAGAGA TATGAGGCAC AGGCCCATGG ACGCATGAAG 
CCTCTGAGTG CATCCCAAGT CAGCGTGCAC GTTGGCATGG ATGACCGGCG GCGGGATTCT 
CCCAGGGCCA CACCCTGGGA CCAGGTCAGC TACGTGAGCC AAGTCTCTCT GTCTTCCCTG 
ACGTCAGACA GATTGTCTCG GCATGGCGGT ATGGCAGAGG ATGGTGGAGA CAAATGGTCC 
CTGCTCCTGA GTGACAGGGA TGAAGAGCAG TGCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036643.2
CDS	5..4363
Translation	MPEQERKVTAKEASRKILSKLALPTRPWGQSMKQSFAFDNVGYEGGLDSTCSSSTTTGVVSILGMTCHSCVKSIEDRISSLKGIVSIKVSLEQGSATVKYVPSVLNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLGPIDINKLESTNLKRAAVPPIQNSNHLETPGHQQNHLATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLPDGLEKESGSSSVPSLGSSQRQQEPGPCRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLAEGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRVSSGNSVPQAVGDSPGSVQNMASDTRGLLTHQGPGYLSDSPPSPGGTASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEIGFHASLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSSKPHETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSANMDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVESILAHRGPTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHGRMKPLSASQVSVHVGMDDRRRDSPRATPWDQVSYVSQVSLSSLTSDRLSRHGGMAEDGGDKWSLLLSDRDEEQCI

Target ORF information:

RefSeq Version	NM_012511.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase copper transporting beta (Atp7b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012511.2

ORF Insert Sequence:

ATGCCTGAAC AGGAGAGAAA GGTCACAGCC AAAGAGGCCA GTCGGAAAAT CTTATCTAAA 
CTTGCTTTGC CCACACGACC GTGGGGACAA TCAATGAAGC AGAGCTTCGC CTTCGATAAT 
GTTGGCTATG AAGGGGGCCT GGACAGCACC TGCTCATCCT CAACTACCAC CGGTGTGGTT 
AGCATCCTGG GCATGACTTG TCATTCTTGC GTCAAGTCCA TCGAGGACAG GATCTCCAGT 
CTGAAAGGCA TTGTGAGCAT CAAGGTTTCT CTGGAGCAGG GCAGCGCCAC TGTCAAATAT 
GTACCGTCAG TCTTGAACCT GCAGCAGATT TGCCTTCAGA TTGAGGACAT GGGCTTTGAG 
GCCAGCGCTG CAGAAGGAAA GGCTGCCTCC TGGCCTTCCA GGTCTTCCCC AGCCCAGGAG 
GCAGTGGTCA AGCTCCGGGT AGAGGGCATG ACCTGTCAGT CCTGTGTCAG CTCCATCGAA 
GGCAAGATCC GGAAGCTGCA AGGGGTTGTG AGAGTCAAAG TCTCCCTAAG CAACCAAGAG 
GCAGTCATTA CATATCAGCC TTACCTCATT CAACCCGAAG ACCTCAGGGA CCACATCTGC 
GACATGGGAT TCGAAGCTGC CATCAAGAAC AGAACAGCTC CCTTAAGGCT GGGACCAATT 
GATATCAACA AGTTAGAAAG CACTAACCTA AAGAGAGCAG CAGTCCCTCC TATCCAGAAT 
TCCAATCATT TGGAGACCCC GGGGCACCAG CAGAACCACC TGGCCACCCT CCCACTAAGA 
ATAGACGGGA TGCACTGTAA ATCATGTGTT TTGAATATCG AAGGAAATAT AGGCCAACTT 
CCAGGGGTTC AAAATATTCA TGTGTCCTTG GAGAACAAAA CCGCCCAAGT ACAGTATGAC 
TCTTCTTGTA TCACCCCCTT GTTCCTACAG ACAGCCATCG AGGCACTACC ACCTGGGTAC 
TTTAAAGTAT CCCTTCCCGA TGGCCTAGAG AAGGAGAGTG GATCTTCCAG TGTCCCCTCC 
CTTGGCTCCT CCCAGAGACA GCAGGAGCCA GGCCCATGCA GGACTGCGGT ACTCACCATC 
ACTGGCATTC CCCGTGACTC GTCTGTTCAG CCCATGGAAG ACATGCTGTC CCAGATGAAG 
GGTGTGCAGC AAATAGACAT CTCTTTGGCA GAGGGGACTG GAGCAGTTCT TTACGATCCC 
TCAGTAGTTA GCTCGGATGA ACTCCGGACG GCTGTAGAAG ACATGGGCTT TGAGGTGTCA 
GTGAATCCCG AAAACATTAC TACTAACCGT GTCAGCTCTG GGAATTCTGT GCCACAAGCC 
GTGGGTGATT CACCAGGGTC TGTGCAAAAT ATGGCTTCTG ACACTAGAGG ACTCCTCACA 
CACCAAGGCC CTGGCTACTT GTCAGACAGC CCACCATCCC CTGGAGGAAC AGCATCACAG 
AAGTGCTTTG TACAGATCAA AGGCATGACC TGTGCGTCCT GTGTGTCTAA CATAGAAAGG 
AGTCTGCAGA GACATGCCGG TATTCTCTCC GTGTTGGTCG CCTTGATGTC GGGAAAGGCA 
GAGGTCAAGT ATGACCCAGA GGTCATCCAG TCTCCCAGGA TAGCTCAGCT CATCGAGGAC 
CTGGGCTTCG AAGCAGCAAT CATGGAGGAC AACACAGTCT CTGAAGGTGA CATCGAACTG 
ATTATCACAG GGATGACCTG CGCTTCCTGT GTTCACAACA TAGAATCTAA GCTCACAAGG 
ACAAATGGCA TCACTTACGC CTCTGTGGCC CTCGCCACCA GCAAAGCCCA TGTGAAGTTT 
GACCCTGAAA TCATTGGTCC ACGTGACATC ATCAAGGTCA TCGAGGAAAT CGGCTTTCAT 
GCTTCCCTGG CCCACAGAAA CCCCAACGCT CATCACTTGG ACCACAAGAC GGAAATAAAA 
CAGTGGAAGA AATCTTTCCT GTGCAGCCTG GTGTTTGGCA TCCCCGTCAT GGGCTTGATG 
ATCTACATGC TAATCCCCAG CAGTAAGCCC CACGAGACCA TGGTCCTGGA CCACAACATC 
ATTCCAGGAC TGTCCGTTCT AAACCTCATT TTCTTCATCT TGTGTACCTT CGTCCAATTC 
CTGGGTGGGT GGTACTTCTA TGTCCAAGCC TACAAATCGC TGAGACACAA GTCAGCCAAC 
ATGGATGTGC TCATCGTACT CGCCACGACC ATTGCCTATG CCTACTCCCT GGTCATCCTG 
GTGGTTGCCA TAGCTGAAAA GGCGGAGAAG AGCCCAGTGA CCTTCTTTGA CACACCCCCC 
ATGCTCTTCG TCTTCATCGC CCTGGGACGG TGGCTGGAGC ACGTGGCAAA GAGCAAAACT 
TCAGAAGCCC TCGCAAAACT CATGTCACTC CAAGCCACAG AAGCCACAGT TGTGACCCTG 
GGAGAGGACA ACTTAATCCT CAGAGAGGAG CAAGTGCCCA TGGAGCTGGT GCAGCGAGGT 
GACATCATCA AGGTTGTCCC TGGGGGCAAG TTCCCAGTGG ACGGGAAAGT CCTGGAAGGC 
AACACCATGG CAGATGAGTC CCTCATCACA GGAGAGGCCA TGCCTGTCAC CAAGAAACCC 
GGGAGCATAG TGATTGCTGG CTCTATAAAT GCTCATGGCT CTGTGCTCAT TAAAGCTACC 
CATGTGGGCA ATGACACTAC TTTGGCTCAG ATTGTCAAGT TGGTGGAAGA GGCCCAGATG 
TCAAAGGCTC CCATTCAGCA GCTGGCTGAC CGGTTCAGTG GATATTTCGT CCCATTTATC 
ATCATTATTT CAACCTTAAC ATTGGTGGTG TGGATCATCA TCGGCTTTGT CGATTTTGGT 
ATTGTTCAGA AGTACTTTCC TAGCCCTAGC AAGCATATCT CACAGACAGA GGTGATCATC 
CGCTTTGCCT TCCAGACGTC CATCACCGTC CTGTGCATCG CCTGCCCCTG CTCCCTCGGG 
CTGGCCACAC CCACAGCAGT TATGGTGGGC ACTGGGGTGG CTGCCCAGAA CGGCGTCCTA 
ATCAAGGGAG GGAAGCCTCT GGAGATGGCA CACAAGATAA AGACCGTTAT GTTTGACAAA 
ACGGGCACCA TTACCCACGG GGTCCCCAGA GTCATGCGGT TTCTGCTGCT TGTGGACGTG 
GCTACCCTAT CCCTCAGGAA GGTTCTGGCT GTGGTGGGCA CCGCAGAGGC CAGCAGTGAG 
CACCCCTTAG GCGTGGCCGT CACTAAATAC TGCAAAGAGG AACTCGGGAC GGAGACCCTG 
GGGTACAGCA CGGACTTCCA GGCAGTGCCA GGGTGTGGAA TTAGCTGCAA AGTTAGCAAC 
GTGGAAAGTA TCCTGGCTCA CAGAGGTCCA ACCGCTCACC CGATTGGGGT TGGCAACCCT 
CCCATAGGAG AAGGTACAGG TCCCCAGACT TTCTCTGTGC TGATTGGAAA CCGGGAATGG 
ATGAGGCGCA ATGGTTTAAC CATCTCCAGT GACATCAGTG ACGCCATGAC AGATCATGAA 
ATGAAAGGAC AGACGGCCAT CCTGGTGGCC ATTGATGGTG TGCTGTGCGG GATGATCGCC 
ATTGCAGATG CTGTTAAACC AGAGGCTGCC CTGGCTATCT ACACCCTGAA AAGCATGGGC 
GTGGATGTGG CTCTGATCAC AGGGGACAAC CGGAAGACAG CCAGAGCCAT TGCCACTCAG 
GTTGGCATCA ACAAAGTCTT TGCTGAGGTA CTGCCTTCTC ACAAGGTGGC CAAGGTCCAG 
GAGCTTCAGA ACAAAGGGAA AAAAGTCGCC ATGGTGGGAG ACGGGGTGAA CGACTCCCCA 
GCCTTGGCCC AGGCTGACGT GGGCATTGCT ATTGGGACTG GGACAGATGT CGCCATCGAA 
GCAGCCGACG TGGTCCTTAT AAGAAATGAC TTACTGGACG TGGTGGCCAG CATTCATCTC 
TCCAAGAGGA CCGTCCGGAG GATCCGGGTC AATCTGGTGC TGGCGTTGAT TTATAACATG 
GTTGGGATAC CCATTGCTGC AGGTGTCTTC ATGCCCATTG GCATCGTGCT GCAGCCATGG 
ATGGGCTCAG CGGCCATGGC CGCCTCCTCT GTGTCCGTGG TGCTCTCCTC TCTTCAGCTC 
AAGTGCTACA GAAAGCCCGA CCTAGAGAGA TATGAGGCAC AGGCCCATGG ACGCATGAAG 
CCTCTGAGTG CATCCCAAGT CAGCGTGCAC GTTGGCATGG ATGACCGGCG GCGGGATTCT 
CCCAGGGCCA CACCCTGGGA CCAGGTCAGC TACGTGAGCC AAGTCTCTCT GTCTTCCCTG 
ACGTCAGACA GATTGTCTCG GCATGGCGGT ATGGCAGAGG ATGGTGGAGA CAAATGGTCC 
CTGCTCCTGA GTGACAGGGA TGAAGAGCAG TGCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atp7b ( XM_017599991.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455480.1 Rattus norvegicus ATPase copper transporting beta (Atp7b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37508
Clone ID Related Accession (Same CDS sequence)	XM_017599991.1
Accession Version	XM_017599991.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	copper-transporting ATPase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAAG CTCAGGGCAA GATGCACCAA ACTCCGGAGC AGTCATTCCT GGCAAGTCTG 
AGTAACCCAC AGGTGACATT GCTGTCCGTG CAGAAGAGGT GCACCTTCAG GAGGAGCTCC 
GGGCTTGGGA GCTTGGCCAG ATCGGACTCT TCAGACGAGA AAGATCCTCC CCAGCCAGAG 
GAAGAATCAT CACCGGGTGT TTTAGCTAGA ACCCCGGAAA GGAGGTCCCA GATCTTATCT 
AAACTTGCTT TGCCCACACG ACCGTGGGGA CAATCAATGA AGCAGAGCTT CGCCTTCGAT 
AATGTTGGCT ATGAAGGGGG CCTGGACAGC ACCTGCTCAT CCTCAACTAC CACCGGTGTG 
GTTAGCATCC TGGGCATGAC TTGTCATTCT TGCGTCAAGT CCATCGAGGA CAGGATCTCC 
AGTCTGAAAG GCATTGTGAG CATCAAGGTT TCTCTGGAGC AGGGCAGCGC CACTGTCAAA 
TATGTACCGT CAGTCTTGAA CCTGCAGCAG ATTTGCCTTC AGATTGAGGA CATGGGCTTT 
GAGGCCAGCG CTGCAGAAGG AAAGGCTGCC TCCTGGCCTT CCAGGTCTTC CCCAGCCCAG 
GAGGCAGTGG TCAAGCTCCG GGTAGAGGGC ATGACCTGTC AGTCCTGTGT CAGCTCCATC 
GAAGGCAAGA TCCGGAAGCT GCAAGGGGTT GTGAGAGTCA AAGTCTCCCT AAGCAACCAA 
GAGGCAGTCA TTACATATCA GCCTTACCTC ATTCAACCCG AAGACCTCAG GGACCACATC 
TGCGACATGG GATTCGAAGC TGCCATCAAG AACAGAACAG CTCCCTTAAG GCTGGGACCA 
ATTGATATCA ACAAGTTAGA AAGCACTAAC CTAAAGAGAG CAGCAGTCCC TCCTATCCAG 
AATTCCAATC ATTTGGAGAC CCCGGGGCAC CAGCAGAACC ACCTGGCCAC CCTCCCACTA 
AGAATAGACG GGATGCACTG TAAATCATGT GTTTTGAATA TCGAAGGAAA TATAGGCCAA 
CTTCCAGGGG TTCAAAATAT TCATGTGTCC TTGGAGAACA AAACCGCCCA AGTACAGTAT 
GACTCTTCTT GTATCACCCC CTTGTTCCTA CAGACAGCCA TCGAGGCACT ACCACCTGGG 
TACTTTAAAG TATCCCTTCC CGATGGCCTA GAGAAGGAGA GTGGATCTTC CAGTGTCCCC 
TCCCTTGGCT CCTCCCAGAG ACAGCAGGAG CCAGGCCCAT GCAGGACTGC GGTACTCACC 
ATCACTGGCA TTCCCCGTGA CTCGTCTGTT CAGCCCATGG AAGACATGCT GTCCCAGATG 
AAGGGTGTGC AGCAAATAGA CATCTCTTTG GCAGAGGGGA CTGGAGCAGT TCTTTACGAT 
CCCTCAGTAG TTAGCTCGGA TGAACTCCGG ACGGCTGTAG AAGACATGGG CTTTGAGGTG 
TCAGTGAATC CCGAAAACAT TACTACTAAC CGTGTCAGCT CTGGGAATTC TGTGCCACAA 
GCCGTGGGTG ATTCACCAGG GTCTGTGCAA AATATGGCTT CTGACACTAG AGGACTCCTC 
ACACACCAAG GCCCTGGCTA CTTGTCAGAC AGCCCACCAT CCCCTGGAGG AACAGCATCA 
CAGAAGTGCT TTGTACAGAT CAAAGGCATG ACCTGTGCGT CCTGTGTGTC TAACATAGAA 
AGGAGTCTGC AGAGACATGC CGGTATTCTC TCCGTGTTGG TCGCCTTGAT GTCGGGAAAG 
GCAGAGGTCA AGTATGACCC AGAGGTCATC CAGTCTCCCA GGATAGCTCA GCTCATCGAG 
GACCTGGGCT TCGAAGCAGC AATCATGGAG GACAACACAG TCTCTGAAGG TGACATCGAA 
CTGATTATCA CAGGGATGAC CTGCGCTTCC TGTGTTCACA ACATAGAATC TAAGCTCACA 
AGGACAAATG GCATCACTTA CGCCTCTGTG GCCCTCGCCA CCAGCAAAGC CCATGTGAAG 
TTTGACCCTG AAATCATTGG TCCACGTGAC ATCATCAAGG TCATCGAGGA AATCGGCTTT 
CATGCTTCCC TGGCCCACAG AAACCCCAAC GCTCATCACT TGGACCACAA GACGGAAATA 
AAACAGTGGA AGAAATCTTT CCTGTGCAGC CTGGTGTTTG GCATCCCCGT CATGGGCTTG 
ATGATCTACA TGCTAATCCC CAGCAGTAAG CCCCACGAGA CCATGGTCCT GGACCACAAC 
ATCATTCCAG GACTGTCCGT TCTAAACCTC ATTTTCTTCA TCTTGTGTAC CTTCGTCCAA 
TTCCTGGGTG GGTGGTACTT CTATGTCCAA GCCTACAAAT CGCTGAGACA CAAGTCAGCC 
AACATGGATG TGCTCATCGT ACTCGCCACG ACCATTGCCT ATGCCTACTC CCTGGTCATC 
CTGGTGGTTG CCATAGCTGA AAAGGCGGAG AAGAGCCCAG TGACCTTCTT TGACACACCC 
CCCATGCTCT TCGTCTTCAT CGCCCTGGGA CGGTGGCTGG AGCACGTGGC AAAGAGCAAA 
ACTTCAGAAG CCCTCGCAAA ACTCATGTCA CTCCAAGCCA CAGAAGCCAC AGTTGTGACC 
CTGGGAGAGG ACAACTTAAT CCTCAGAGAG GAGCAAGTGC CCATGGAGCT GGTGCAGCGA 
GGTGACATCA TCAAGGTTGT CCCTGGGGGC AAGTTCCCAG TGGACGGGAA AGTCCTGGAA 
GGCAACACCA TGGCAGATGA GTCCCTCATC ACAGGAGAGG CCATGCCTGT CACCAAGAAA 
CCCGGGAGCA TAGTGATTGC TGGCTCTATA AATGCTCATG GCTCTGTGCT CATTAAAGCT 
ACCCATGTGG GCAATGACAC TACTTTGGCT CAGATTGTCA AGTTGGTGGA AGAGGCCCAG 
ATGTCAAAGG CTCCCATTCA GCAGCTGGCT GACCGGTTCA GTGGATATTT CGTCCCATTT 
ATCATCATTA TTTCAACCTT AACATTGGTG GTGTGGATCA TCATCGGCTT TGTCGATTTT 
GGTATTGTTC AGAAGTACTT TCCTAGCCCT AGCAAGCATA TCTCACAGAC AGAGGTGATC 
ATCCGCTTTG CCTTCCAGAC GTCCATCACC GTCCTGTGCA TCGCCTGCCC CTGCTCCCTC 
GGGCTGGCCA CACCCACAGC AGTTATGGTG GGCACTGGGG TGGCTGCCCA GAACGGCGTC 
CTAATCAAGG GAGGGAAGCC TCTGGAGATG GCACACAAGA TAAAGACCGT TATGTTTGAC 
AAAACGGGCA CCATTACCCA CGGGGTCCCC AGAGTCATGC GGTTTCTGCT GCTTGTGGAC 
GTGGCTACCC TATCCCTCAG GAAGGTTCTG GCTGTGGTGG GCACCGCAGA GGCCAGCAGT 
GAGCACCCCT TAGGCGTGGC CGTCACTAAA TACTGCAAAG AGGAACTCGG GACGGAGACC 
CTGGGGTACA GCACGGACTT CCAGGCAGTG CCAGGGTGTG GAATTAGCTG CAAAGTTAGC 
AACGTGGAAA GTATCCTGGC TCACAGAGGT CCAACCGCTC ACCCGATTGG GGTTGGCAAC 
CCTCCCATAG GAGAAGGTAC AGGTCCCCAG ACTTTCTCTG TGCTGATTGG AAACCGGGAA 
TGGATGAGGC GCAATGGTTT AACCATCTCC AGTGACATCA GTGACGCCAT GACAGATCAT 
GAAATGAAAG GACAGACGGC CATCCTGGTG GCCATTGATG GTGTGCTGTG CGGGATGATC 
GCCATTGCAG ATGCTGTTAA ACCAGAGGCT GCCCTGGCTA TCTACACCCT GAAAAGCATG 
GGCGTGGATG TGGCTCTGAT CACAGGGGAC AACCGGAAGA CAGCCAGAGC CATTGCCACT 
CAGGTTGGCA TCAACAAAGT CTTTGCTGAG GTACTGCCTT CTCACAAGGT GGCCAAGGTC 
CAGGAGCTTC AGAACAAAGG GAAAAAAGTC GCCATGGTGG GAGACGGGGT GAACGACTCC 
CCAGCCTTGG CCCAGGCTGA CGTGGGCATT GCTATTGGGA CTGGGACAGA TGTCGCCATC 
GAAGCAGCCG ACGTGGTCCT TATAAGAAAT GACTTACTGG ACGTGGTGGC CAGCATTCAT 
CTCTCCAAGA GGACCGTCCG GAGGATCCGG GTCAATCTGG TGCTGGCGTT GATTTATAAC 
ATGGTTGGGA TACCCATTGC TGCAGGTGTC TTCATGCCCA TTGGCATCGT GCTGCAGCCA 
TGGATGGGCT CAGCGGCCAT GGCCGCCTCC TCTGTGTCCG TGGTGCTCTC CTCTCTTCAG 
CTCAAGTGCT ACAGAAAGCC CGACCTAGAG AGATATGAGG CACAGGCCCA TGGACGCATG 
AAGCCTCTGA GTGCATCCCA AGTCAGCGTG CACGTTGGCA TGGATGACCG GCGGCGGGAT 
TCTCCCAGGG CCACACCCTG GGACCAGGTC AGCTACGTGA GCCAAGTCTC TCTGTCTTCC 
CTGACGTCAG ACAGATTGTC TCGGCATGGC GGTATGGCAG AGGATGGTGG AGACAAATGG 
TCCCTGCTCC TGAGTGACAG GGATGAAGAG CAGTGCATCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455480.1
CDS	755..5296
Translation	MEKAQGKMHQTPEQSFLASLSNPQVTLLSVQKRCTFRRSSGLGSLARSDSSDEKDPPQPEEESSPGVLARTPERRSQILSKLALPTRPWGQSMKQSFAFDNVGYEGGLDSTCSSSTTTGVVSILGMTCHSCVKSIEDRISSLKGIVSIKVSLEQGSATVKYVPSVLNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLGPIDINKLESTNLKRAAVPPIQNSNHLETPGHQQNHLATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLPDGLEKESGSSSVPSLGSSQRQQEPGPCRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLAEGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRVSSGNSVPQAVGDSPGSVQNMASDTRGLLTHQGPGYLSDSPPSPGGTASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEIGFHASLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSSKPHETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSANMDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVESILAHRGPTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHGRMKPLSASQVSVHVGMDDRRRDSPRATPWDQVSYVSQVSLSSLTSDRLSRHGGMAEDGGDKWSLLLSDRDEEQCI

Target ORF information:

RefSeq Version	XM_017599991.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase copper transporting beta (Atp7b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599991.1

ORF Insert Sequence:

ATGGAGAAAG CTCAGGGCAA GATGCACCAA ACTCCGGAGC AGTCATTCCT GGCAAGTCTG 
AGTAACCCAC AGGTGACATT GCTGTCCGTG CAGAAGAGGT GCACCTTCAG GAGGAGCTCC 
GGGCTTGGGA GCTTGGCCAG ATCGGACTCT TCAGACGAGA AAGATCCTCC CCAGCCAGAG 
GAAGAATCAT CACCGGGTGT TTTAGCTAGA ACCCCGGAAA GGAGGTCCCA GATCTTATCT 
AAACTTGCTT TGCCCACACG ACCGTGGGGA CAATCAATGA AGCAGAGCTT CGCCTTCGAT 
AATGTTGGCT ATGAAGGGGG CCTGGACAGC ACCTGCTCAT CCTCAACTAC CACCGGTGTG 
GTTAGCATCC TGGGCATGAC TTGTCATTCT TGCGTCAAGT CCATCGAGGA CAGGATCTCC 
AGTCTGAAAG GCATTGTGAG CATCAAGGTT TCTCTGGAGC AGGGCAGCGC CACTGTCAAA 
TATGTACCGT CAGTCTTGAA CCTGCAGCAG ATTTGCCTTC AGATTGAGGA CATGGGCTTT 
GAGGCCAGCG CTGCAGAAGG AAAGGCTGCC TCCTGGCCTT CCAGGTCTTC CCCAGCCCAG 
GAGGCAGTGG TCAAGCTCCG GGTAGAGGGC ATGACCTGTC AGTCCTGTGT CAGCTCCATC 
GAAGGCAAGA TCCGGAAGCT GCAAGGGGTT GTGAGAGTCA AAGTCTCCCT AAGCAACCAA 
GAGGCAGTCA TTACATATCA GCCTTACCTC ATTCAACCCG AAGACCTCAG GGACCACATC 
TGCGACATGG GATTCGAAGC TGCCATCAAG AACAGAACAG CTCCCTTAAG GCTGGGACCA 
ATTGATATCA ACAAGTTAGA AAGCACTAAC CTAAAGAGAG CAGCAGTCCC TCCTATCCAG 
AATTCCAATC ATTTGGAGAC CCCGGGGCAC CAGCAGAACC ACCTGGCCAC CCTCCCACTA 
AGAATAGACG GGATGCACTG TAAATCATGT GTTTTGAATA TCGAAGGAAA TATAGGCCAA 
CTTCCAGGGG TTCAAAATAT TCATGTGTCC TTGGAGAACA AAACCGCCCA AGTACAGTAT 
GACTCTTCTT GTATCACCCC CTTGTTCCTA CAGACAGCCA TCGAGGCACT ACCACCTGGG 
TACTTTAAAG TATCCCTTCC CGATGGCCTA GAGAAGGAGA GTGGATCTTC CAGTGTCCCC 
TCCCTTGGCT CCTCCCAGAG ACAGCAGGAG CCAGGCCCAT GCAGGACTGC GGTACTCACC 
ATCACTGGCA TTCCCCGTGA CTCGTCTGTT CAGCCCATGG AAGACATGCT GTCCCAGATG 
AAGGGTGTGC AGCAAATAGA CATCTCTTTG GCAGAGGGGA CTGGAGCAGT TCTTTACGAT 
CCCTCAGTAG TTAGCTCGGA TGAACTCCGG ACGGCTGTAG AAGACATGGG CTTTGAGGTG 
TCAGTGAATC CCGAAAACAT TACTACTAAC CGTGTCAGCT CTGGGAATTC TGTGCCACAA 
GCCGTGGGTG ATTCACCAGG GTCTGTGCAA AATATGGCTT CTGACACTAG AGGACTCCTC 
ACACACCAAG GCCCTGGCTA CTTGTCAGAC AGCCCACCAT CCCCTGGAGG AACAGCATCA 
CAGAAGTGCT TTGTACAGAT CAAAGGCATG ACCTGTGCGT CCTGTGTGTC TAACATAGAA 
AGGAGTCTGC AGAGACATGC CGGTATTCTC TCCGTGTTGG TCGCCTTGAT GTCGGGAAAG 
GCAGAGGTCA AGTATGACCC AGAGGTCATC CAGTCTCCCA GGATAGCTCA GCTCATCGAG 
GACCTGGGCT TCGAAGCAGC AATCATGGAG GACAACACAG TCTCTGAAGG TGACATCGAA 
CTGATTATCA CAGGGATGAC CTGCGCTTCC TGTGTTCACA ACATAGAATC TAAGCTCACA 
AGGACAAATG GCATCACTTA CGCCTCTGTG GCCCTCGCCA CCAGCAAAGC CCATGTGAAG 
TTTGACCCTG AAATCATTGG TCCACGTGAC ATCATCAAGG TCATCGAGGA AATCGGCTTT 
CATGCTTCCC TGGCCCACAG AAACCCCAAC GCTCATCACT TGGACCACAA GACGGAAATA 
AAACAGTGGA AGAAATCTTT CCTGTGCAGC CTGGTGTTTG GCATCCCCGT CATGGGCTTG 
ATGATCTACA TGCTAATCCC CAGCAGTAAG CCCCACGAGA CCATGGTCCT GGACCACAAC 
ATCATTCCAG GACTGTCCGT TCTAAACCTC ATTTTCTTCA TCTTGTGTAC CTTCGTCCAA 
TTCCTGGGTG GGTGGTACTT CTATGTCCAA GCCTACAAAT CGCTGAGACA CAAGTCAGCC 
AACATGGATG TGCTCATCGT ACTCGCCACG ACCATTGCCT ATGCCTACTC CCTGGTCATC 
CTGGTGGTTG CCATAGCTGA AAAGGCGGAG AAGAGCCCAG TGACCTTCTT TGACACACCC 
CCCATGCTCT TCGTCTTCAT CGCCCTGGGA CGGTGGCTGG AGCACGTGGC AAAGAGCAAA 
ACTTCAGAAG CCCTCGCAAA ACTCATGTCA CTCCAAGCCA CAGAAGCCAC AGTTGTGACC 
CTGGGAGAGG ACAACTTAAT CCTCAGAGAG GAGCAAGTGC CCATGGAGCT GGTGCAGCGA 
GGTGACATCA TCAAGGTTGT CCCTGGGGGC AAGTTCCCAG TGGACGGGAA AGTCCTGGAA 
GGCAACACCA TGGCAGATGA GTCCCTCATC ACAGGAGAGG CCATGCCTGT CACCAAGAAA 
CCCGGGAGCA TAGTGATTGC TGGCTCTATA AATGCTCATG GCTCTGTGCT CATTAAAGCT 
ACCCATGTGG GCAATGACAC TACTTTGGCT CAGATTGTCA AGTTGGTGGA AGAGGCCCAG 
ATGTCAAAGG CTCCCATTCA GCAGCTGGCT GACCGGTTCA GTGGATATTT CGTCCCATTT 
ATCATCATTA TTTCAACCTT AACATTGGTG GTGTGGATCA TCATCGGCTT TGTCGATTTT 
GGTATTGTTC AGAAGTACTT TCCTAGCCCT AGCAAGCATA TCTCACAGAC AGAGGTGATC 
ATCCGCTTTG CCTTCCAGAC GTCCATCACC GTCCTGTGCA TCGCCTGCCC CTGCTCCCTC 
GGGCTGGCCA CACCCACAGC AGTTATGGTG GGCACTGGGG TGGCTGCCCA GAACGGCGTC 
CTAATCAAGG GAGGGAAGCC TCTGGAGATG GCACACAAGA TAAAGACCGT TATGTTTGAC 
AAAACGGGCA CCATTACCCA CGGGGTCCCC AGAGTCATGC GGTTTCTGCT GCTTGTGGAC 
GTGGCTACCC TATCCCTCAG GAAGGTTCTG GCTGTGGTGG GCACCGCAGA GGCCAGCAGT 
GAGCACCCCT TAGGCGTGGC CGTCACTAAA TACTGCAAAG AGGAACTCGG GACGGAGACC 
CTGGGGTACA GCACGGACTT CCAGGCAGTG CCAGGGTGTG GAATTAGCTG CAAAGTTAGC 
AACGTGGAAA GTATCCTGGC TCACAGAGGT CCAACCGCTC ACCCGATTGG GGTTGGCAAC 
CCTCCCATAG GAGAAGGTAC AGGTCCCCAG ACTTTCTCTG TGCTGATTGG AAACCGGGAA 
TGGATGAGGC GCAATGGTTT AACCATCTCC AGTGACATCA GTGACGCCAT GACAGATCAT 
GAAATGAAAG GACAGACGGC CATCCTGGTG GCCATTGATG GTGTGCTGTG CGGGATGATC 
GCCATTGCAG ATGCTGTTAA ACCAGAGGCT GCCCTGGCTA TCTACACCCT GAAAAGCATG 
GGCGTGGATG TGGCTCTGAT CACAGGGGAC AACCGGAAGA CAGCCAGAGC CATTGCCACT 
CAGGTTGGCA TCAACAAAGT CTTTGCTGAG GTACTGCCTT CTCACAAGGT GGCCAAGGTC 
CAGGAGCTTC AGAACAAAGG GAAAAAAGTC GCCATGGTGG GAGACGGGGT GAACGACTCC 
CCAGCCTTGG CCCAGGCTGA CGTGGGCATT GCTATTGGGA CTGGGACAGA TGTCGCCATC 
GAAGCAGCCG ACGTGGTCCT TATAAGAAAT GACTTACTGG ACGTGGTGGC CAGCATTCAT 
CTCTCCAAGA GGACCGTCCG GAGGATCCGG GTCAATCTGG TGCTGGCGTT GATTTATAAC 
ATGGTTGGGA TACCCATTGC TGCAGGTGTC TTCATGCCCA TTGGCATCGT GCTGCAGCCA 
TGGATGGGCT CAGCGGCCAT GGCCGCCTCC TCTGTGTCCG TGGTGCTCTC CTCTCTTCAG 
CTCAAGTGCT ACAGAAAGCC CGACCTAGAG AGATATGAGG CACAGGCCCA TGGACGCATG 
AAGCCTCTGA GTGCATCCCA AGTCAGCGTG CACGTTGGCA TGGATGACCG GCGGCGGGAT 
TCTCCCAGGG CCACACCCTG GGACCAGGTC AGCTACGTGA GCCAAGTCTC TCTGTCTTCC 
CTGACGTCAG ACAGATTGTC TCGGCATGGC GGTATGGCAG AGGATGGTGG AGACAAATGG 
TCCCTGCTCC TGAGTGACAG GGATGAAGAG CAGTGCATCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)3133-6(2015)
Papur OS,Terzioglu O,Koc A

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.
Molecular biology of the cell26(2)218-28(2015 Jan)
Jain S,Far?as GG,Bonifacino JS

Regulation of copper transport crossing brain barrier systems by Cu-ATPases: effect of manganese exposure.
Toxicological sciences : an official journal of the Society of Toxicology139(2)432-51(2014 Jun)
Fu X,Zhang Y,Jiang W,Monnot AD,Bates CA,Zheng W

Subcellular targets of cisplatin cytotoxicity: an integrated view.
Pharmacology & therapeutics136(1)35-55(2012 Oct)
Sancho-Mart?nez SM,Prieto-Garc?a L,Prieto M,L?pez-Novoa JM,L?pez-Hern?ndez FJ

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.
The Journal of biological chemistry287(4)2485-99(2012 Jan)
Materia S,Cater MA,Klomp LW,Mercer JF,La Fontaine S

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Atp7b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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