Ar cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ar
Entrez Gene ID	24208
Full Name	androgen receptor
Synonyms	Andr,Tfm
General protein information	Preferred Names androgen receptor Names androgen receptor androgen receptor (Testicular feminization), same as Tfm dihydrotestosterone receptor nuclear receptor subfamily 3 group C member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	binds androgens and activates transcription; required for male sexual development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012502.1	NP_036634.1	androgen receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AR	NP_001231056.1
Homo sapiens (human)	AR	NP_000035.2
Canis lupus familiaris (dog)	AR	NP_001003053.1
Rattus norvegicus (Norway rat)	Ar	NP_036634.1
Mus musculus (house mouse)	Ar	NP_038504.1
	AR	NP_001028083.1
Gallus gallus (chicken)	AR	NP_001035179.1
Xenopus tropicalis (tropical clawed frog)	ar	XP_002941888.2

Gene Ontology
Bibliography

Related articles in PubMed

Cynanchum wilfordii Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Regulating 5?-Reductase and Androgen Receptor Activities in a Rat Model.
Lee G, Shin J, Choi H, Jo A, Pan S, Bae D, Lee Y, Choi C
Nutrients9(10)(2017 Sep)

Presence of Androgen Receptor Variant in Neuronal Lipid Rafts.
Garza-Contreras J, Duong P, Snyder BD, Schreihofer DA, Cunningham RL
eNeuro4(4)(2017 Jul-Aug)

Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.
Horibe A, Eid N, Ito Y, Hamaoka H, Tanaka Y, Kondo Y
International journal of molecular sciences18(5)(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The androgen receptor-mediated ERK1/2 MAP kinase-signaling pathway may be a key mechanism by which testosterone downregulates AT2R expression.
Title: Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta.

Suggest the potential involvement of altered Fgf10/Fgfr2/AR signaling in pathogenesis of anorectal malformations induced by di-n-butyl phthalate.
Title: Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP.

DHT activated AR inhibits gene transactivation by C/EBPdelta, and transgenic C/EBPdelta expression inhibits AR activity
Title: Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-? and IGF-I, and transcription factor C/EBP?.

Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic beta-Cells.(
Title: Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic ?-Cells.

These data suggest that the AR is toxic as a full-length protein, challenging the notion of polyglutamine protein fragment-associated toxicity by redefining the role of AR proteolysis in spinal and bulbar muscular atrophy pathogenesis.
Title: Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis.

The following Ar gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ar cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12714	NM_012502.1 Latest version!	Rattus norvegicus androgen receptor (Ar), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ar ( NM_012502.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036634.1 Rattus norvegicus androgen receptor (Ar), mRNA.

Price & Availability↑

CloneID	ORa12714
Clone ID Related Accession (Same CDS sequence)	NM_012502.1
Accession Version	NM_012502.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	androgen receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M20133.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M20133.1, M23264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGTGC AGTTAGGGCT GGGAAGGGTC TACCCACGGC CCCCGTCCAA GACCTATCGA 
GGAGCGTTCC AGAATCTGTT CCAGAGCGTG CGCGAAGCGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGCTAGCAT AGCACCTCCC GGTGCCTGTT TACAGCAGCG GCAGGAGACT 
AGCCCCCGGC GGCGGCGGCG GCAGCAGCAC CCTGAGGATG GCTCTCCTCA AGCCCACATC 
AGAGGCACCA CAGGCTACCT GGCCCTGGAG GAGGAACAGC AGCCTTCACA GCAGCAGTCA 
GCCTCCGAGG GCCACCCTGA GAGCGGCTGC CTCCCGGAGC CTGGAGCTGC CACGGCTCCT 
GGCAAGGGGC TGCCGCAGCA GCCACCAGCT CCTCCAGATC AGGATGACTC AGCTGCCCCA 
TCCACGTTGT CCCTACTGGG CCCCACTTTC CCAGGCTTAA GCAGCTGCTC CGCAGACATT 
AAAGACATCC TGAGCGAGGC CGGCACCATG CAACTTCTTC AGCAGCAGCA GCAACAGCAA 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAACAGC AGCAGGAGGT AATATCCGAA 
GGCAGCAGCA GCGTGAGAGC AAGGGAGGCC ACTGGGGCTC CCTCTTCCTC CAAGGATAGT 
TACCTAGGGG GCAATTCGAC CATATCTGAC AGTGCCAAGG AGTTGTGTAA AGCAGTGTCT 
GTGTCCATGG GGTTGGGTGT GGAAGCACTG GAACATCTGA GTCCAGGGGA GCAGCTTCGG 
GGCGACTGCA TGTACGCGTC GCTCCTGGGA GGTCCACCCG CCGTGCGTCC CACTCCTTGT 
GCGCCTCTGG CCGAATGCAA AGGTCTTTCC CTGGACGAAG GCCCGGGCAA AGGCACTGAA 
GAGACTGCTG AGTATTCCTC TTTCAAGGGA GGTTACGCCA AAGGGTTGGA AGGTGAGAGT 
CTGGGCTGCT CTGGCAGCAG TGAAGCAGGT AGCTCTGGGA CACTTGAGAT CCCGTCCTCA 
CTGTCTCTGT ATAAGTCTGG AGCAGTAGAC GAGGCAGCAG CATACCAGAA TCGCGACTAC 
TACAACTTTC CGCTCGCTCT GTCCGGGCCG CCGCACCCCC CGCCCCCTAC CCATCCACAC 
GCCCGCATCA AGCTGGAGAA CCCGTCGGAC TACGGCAGCG CCTGGGCTGC GGCGGCAGCG 
CAATGCCGCT ATGGGGACTT GGCTAGCCTA CATGGAGGGA GTGTAGCCGG ACCCAGCACT 
GGATCGCCCC CAGCCACCGC CTCTTCTTCC TGGCATACTC TCTTCACAGC TGAAGAAGGC 
CAATTATATG GGCCAGGAGG CGGGGGCGGC AGCAGTAGCC CAAGCGATGC TGGGCCTGTA 
GCCCCCTATG GCTACACTCG GCCCCCTCAG GGGCTGGCAA GCCAGGAGGG TGACTTCTCT 
GCCTCTGAAG TGTGGTATCC TGGTGGAGTT GTGAACAGAG TCCCCTATCC CAGTCCCAGT 
TGTGTTAAAA GTGAAATGGG ACCTTGGATG GAGAACTACT CCGGACCTTA TGGGGACATG 
CGTTTGGACA GTACCAGGGA CCACGTTTTA CCCATCGACT ATTACTTCCC ACCCCAGAAG 
ACCTGCCTGA TCTGTGGAGA TGAAGCTTCT GGTTGTCACT ACGGAGCTCT CACTTGTGGC 
AGCTGCAAGG TCTTCTTCAA AAGAGCTGCG GAAGGGAAAC AGAAGTATCT ATGTGCCAGC 
AGAAATGATT GCACCATTGA TAAATTTCGG AGGAAAAATT GTCCATCGTG TCGTCTCCGG 
AAATGTTATG AAGCAGGGAT GACTCTGGGA GCTCGTAAGC TGAAGAAACT TGGAAATCTC 
AAACTACAGG AAGAAGGAGA AAACTCCAGT GCTGGTAGCC CCACTGAGGA CCCATCCCAG 
AAGATGACTG TATCACACAT TGAAGGCTAT GAATGTCAAC CTATCTTTCT TAATGTCCTG 
GAAGCCATTG AGCCAGGAGT GGTGTGTGCC GGACATGACA ACAACCAGCC TGATTCCTTT 
GCTGCCTTGT TATCTAGTCT CAACGAGCTT GGCGAGAGAC AGCTTGTACA TGTGGTCAAG 
TGGGCCAAGG CCTTGCCTGG CTTCCGCAAC TTGCATGTGG ATGACCAGAT GGCAGTCATT 
CAGTATTCCT GGATGGGACT GATGGTATTT GCCATGGGTT GGCGGTCCTT CACTAATGTC 
AACTCTAGGA TGCTCTACTT TGCACCTGAC CTGGTTTTCA ATGAGTATCG CATGCACAAG 
TCTCGAATGT ACAGCCAGTG CGTGAGGATG AGGCACCTTT CTCAAGAGTT TGGATGGCTC 
CAGATAACCC CCCAGGAATT CCTGTGCATG AAAGCACTGC TACTCTTCAG CATTATTCCA 
GTGGATGGGC TGAAAAATCA AAAATTCTTT GATGAACTTC GAATGAACTA CATCAAGGAA 
CTTGATCGCA TCATTGCATG CAAAAGAAAA AATCCCACAT CCTGCTCAAG GCGCTTCTAC 
CAGCTCACCA AGCTCCTGGA TTCTGTGCAG CCTATTGCAA GAGAGCTGCA TCAATTCACT 
TTTGACCTGC TAATCAAGTC CCATATGGTG AGCGTGGACT TTCCTGAAAT GATGGCAGAG 
ATCATCTCTG TGCAAGTGCC CAAGATCCTT TCTGGGAAAG TCAAGCCCAT CTATTTCCAC 
ACACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036634.1
CDS	994..3702
Translation	MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQETSPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQQQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPSTGSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Target ORF information:

RefSeq Version	NM_012502.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus androgen receptor (Ar), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012502.1

ORF Insert Sequence:

ATGGAGGTGC AGTTAGGGCT GGGAAGGGTC TACCCACGGC CCCCGTCCAA GACCTATCGA 
GGAGCGTTCC AGAATCTGTT CCAGAGCGTG CGCGAAGCGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGCTAGCAT AGCACCTCCC GGTGCCTGTT TACAGCAGCG GCAGGAGACT 
AGCCCCCGGC GGCGGCGGCG GCAGCAGCAC CCTGAGGATG GCTCTCCTCA AGCCCACATC 
AGAGGCACCA CAGGCTACCT GGCCCTGGAG GAGGAACAGC AGCCTTCACA GCAGCAGTCA 
GCCTCCGAGG GCCACCCTGA GAGCGGCTGC CTCCCGGAGC CTGGAGCTGC CACGGCTCCT 
GGCAAGGGGC TGCCGCAGCA GCCACCAGCT CCTCCAGATC AGGATGACTC AGCTGCCCCA 
TCCACGTTGT CCCTACTGGG CCCCACTTTC CCAGGCTTAA GCAGCTGCTC CGCAGACATT 
AAAGACATCC TGAGCGAGGC CGGCACCATG CAACTTCTTC AGCAGCAGCA GCAACAGCAA 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAACAGC AGCAGGAGGT AATATCCGAA 
GGCAGCAGCA GCGTGAGAGC AAGGGAGGCC ACTGGGGCTC CCTCTTCCTC CAAGGATAGT 
TACCTAGGGG GCAATTCGAC CATATCTGAC AGTGCCAAGG AGTTGTGTAA AGCAGTGTCT 
GTGTCCATGG GGTTGGGTGT GGAAGCACTG GAACATCTGA GTCCAGGGGA GCAGCTTCGG 
GGCGACTGCA TGTACGCGTC GCTCCTGGGA GGTCCACCCG CCGTGCGTCC CACTCCTTGT 
GCGCCTCTGG CCGAATGCAA AGGTCTTTCC CTGGACGAAG GCCCGGGCAA AGGCACTGAA 
GAGACTGCTG AGTATTCCTC TTTCAAGGGA GGTTACGCCA AAGGGTTGGA AGGTGAGAGT 
CTGGGCTGCT CTGGCAGCAG TGAAGCAGGT AGCTCTGGGA CACTTGAGAT CCCGTCCTCA 
CTGTCTCTGT ATAAGTCTGG AGCAGTAGAC GAGGCAGCAG CATACCAGAA TCGCGACTAC 
TACAACTTTC CGCTCGCTCT GTCCGGGCCG CCGCACCCCC CGCCCCCTAC CCATCCACAC 
GCCCGCATCA AGCTGGAGAA CCCGTCGGAC TACGGCAGCG CCTGGGCTGC GGCGGCAGCG 
CAATGCCGCT ATGGGGACTT GGCTAGCCTA CATGGAGGGA GTGTAGCCGG ACCCAGCACT 
GGATCGCCCC CAGCCACCGC CTCTTCTTCC TGGCATACTC TCTTCACAGC TGAAGAAGGC 
CAATTATATG GGCCAGGAGG CGGGGGCGGC AGCAGTAGCC CAAGCGATGC TGGGCCTGTA 
GCCCCCTATG GCTACACTCG GCCCCCTCAG GGGCTGGCAA GCCAGGAGGG TGACTTCTCT 
GCCTCTGAAG TGTGGTATCC TGGTGGAGTT GTGAACAGAG TCCCCTATCC CAGTCCCAGT 
TGTGTTAAAA GTGAAATGGG ACCTTGGATG GAGAACTACT CCGGACCTTA TGGGGACATG 
CGTTTGGACA GTACCAGGGA CCACGTTTTA CCCATCGACT ATTACTTCCC ACCCCAGAAG 
ACCTGCCTGA TCTGTGGAGA TGAAGCTTCT GGTTGTCACT ACGGAGCTCT CACTTGTGGC 
AGCTGCAAGG TCTTCTTCAA AAGAGCTGCG GAAGGGAAAC AGAAGTATCT ATGTGCCAGC 
AGAAATGATT GCACCATTGA TAAATTTCGG AGGAAAAATT GTCCATCGTG TCGTCTCCGG 
AAATGTTATG AAGCAGGGAT GACTCTGGGA GCTCGTAAGC TGAAGAAACT TGGAAATCTC 
AAACTACAGG AAGAAGGAGA AAACTCCAGT GCTGGTAGCC CCACTGAGGA CCCATCCCAG 
AAGATGACTG TATCACACAT TGAAGGCTAT GAATGTCAAC CTATCTTTCT TAATGTCCTG 
GAAGCCATTG AGCCAGGAGT GGTGTGTGCC GGACATGACA ACAACCAGCC TGATTCCTTT 
GCTGCCTTGT TATCTAGTCT CAACGAGCTT GGCGAGAGAC AGCTTGTACA TGTGGTCAAG 
TGGGCCAAGG CCTTGCCTGG CTTCCGCAAC TTGCATGTGG ATGACCAGAT GGCAGTCATT 
CAGTATTCCT GGATGGGACT GATGGTATTT GCCATGGGTT GGCGGTCCTT CACTAATGTC 
AACTCTAGGA TGCTCTACTT TGCACCTGAC CTGGTTTTCA ATGAGTATCG CATGCACAAG 
TCTCGAATGT ACAGCCAGTG CGTGAGGATG AGGCACCTTT CTCAAGAGTT TGGATGGCTC 
CAGATAACCC CCCAGGAATT CCTGTGCATG AAAGCACTGC TACTCTTCAG CATTATTCCA 
GTGGATGGGC TGAAAAATCA AAAATTCTTT GATGAACTTC GAATGAACTA CATCAAGGAA 
CTTGATCGCA TCATTGCATG CAAAAGAAAA AATCCCACAT CCTGCTCAAG GCGCTTCTAC 
CAGCTCACCA AGCTCCTGGA TTCTGTGCAG CCTATTGCAA GAGAGCTGCA TCAATTCACT 
TTTGACCTGC TAATCAAGTC CCATATGGTG AGCGTGGACT TTCCTGAAAT GATGGCAGAG 
ATCATCTCTG TGCAAGTGCC CAAGATCCTT TCTGGGAAAG TCAAGCCCAT CTATTTCCAC 
ACACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cynanchum wilfordii Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Regulating 5?-Reductase and Androgen Receptor Activities in a Rat Model.
Nutrients9(10)(2017 Sep)
Lee G,Shin J,Choi H,Jo A,Pan S,Bae D,Lee Y,Choi C

Presence of Androgen Receptor Variant in Neuronal Lipid Rafts.
eNeuro4(4)(2017 Jul-Aug)
Garza-Contreras J,Duong P,Snyder BD,Schreihofer DA,Cunningham RL

Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.
International journal of molecular sciences18(5)(2017 May)
Horibe A,Eid N,Ito Y,Hamaoka H,Tanaka Y,Kondo Y

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Ar cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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